phenobarbital has been researched along with Anxiety in 57 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)." | 7.78 | Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012) |
| "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions." | 7.68 | Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. ( Calzetti, S; Fava, R; Perucca, E; Sasso, E, 1990) |
| " Exposure to phenobarbital during this period has been associated with deficits in learning and memory, anxiety-like behavior, and social behavior, among other domains." | 3.83 | Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats. ( Forcelli, PA; Frankel, S; Gutherz, S; Kondratyev, A; Kulick, C; Medvedeva, N, 2016) |
| "An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)." | 3.78 | Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012) |
| "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions." | 3.68 | Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. ( Calzetti, S; Fava, R; Perucca, E; Sasso, E, 1990) |
| "Seizures are common during the neonatal period, often due to hypoxic-ischemic encephalopathy and may contribute to acute brain injury and the subsequent development of cognitive deficits and childhood epilepsy." | 1.42 | Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice. ( Boylan, GB; Dunleavy, M; Henshall, DC; Jimenez-Mateos, EM; Rodriguez-Alvarez, N; Waddington, JL, 2015) |
| "The families of 42 children with febrile seizures were recruited after pediatric or neuropediatric consultation." | 1.31 | Treatment of febrile seizures: the influence of treatment efficacy and side-effect profile on value to parents. ( Camfield, CS; Camfield, PR; Dooley, JM; Gordon, KE; MacSween, J, 2001) |
| "0 mg/kg AOAA significantly potentiated the effects of diazepam, as indicated by a significant shift to the left in the diazepam dose-response curve relative to diazepam alone." | 1.27 | Potentiation of the anticonflict effects of diazepam, but not pentobarbital and phenobarbital, by aminooxyacetic acid (AOAA). ( Beshears, JF; Commissaris, RL; Halas, NA; McCloskey, TC, 1988) |
| " Chronic administration dissociated the pattern of results produced by sodium phenobarbitone (35 mg/kg) from that produced by flurazepam (0." | 1.26 | A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants. ( File, SE; Hyde, JR, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (77.19) | 18.7374 |
| 1990's | 5 (8.77) | 18.2507 |
| 2000's | 4 (7.02) | 29.6817 |
| 2010's | 4 (7.02) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tomczuk, BE | 1 |
| Taylor, CR | 1 |
| Moses, LM | 1 |
| Sutherland, DB | 1 |
| Lo, YS | 1 |
| Johnson, DN | 1 |
| Kinnier, WB | 1 |
| Kilpatrick, BF | 1 |
| Rodriguez-Alvarez, N | 1 |
| Jimenez-Mateos, EM | 1 |
| Dunleavy, M | 1 |
| Waddington, JL | 1 |
| Boylan, GB | 1 |
| Henshall, DC | 1 |
| Frankel, S | 1 |
| Medvedeva, N | 1 |
| Gutherz, S | 1 |
| Kulick, C | 1 |
| Kondratyev, A | 1 |
| Forcelli, PA | 1 |
| Assad, T | 1 |
| Khan, RA | 1 |
| Maschio, M | 1 |
| Dinapoli, L | 1 |
| Sperati, F | 1 |
| Pace, A | 1 |
| Fabi, A | 1 |
| Vidiri, A | 1 |
| Pompili, A | 1 |
| Carapella, CM | 1 |
| VAN DER MERWE, AB | 1 |
| THOMPSON, LJ | 1 |
| PROCTOR, RC | 1 |
| ROSNER, H | 1 |
| LEVINE, S | 1 |
| HESS, H | 1 |
| KAYE, H | 1 |
| UHLENHUTH, EH | 2 |
| CANTER, A | 1 |
| NEUSTADT, JO | 1 |
| PAYSON, HE | 1 |
| FELDMAN, RS | 1 |
| LEWIS, E | 1 |
| WHITMAN, RM | 1 |
| O'DONNELL, M | 1 |
| LEVY, HA | 1 |
| BODI, T | 1 |
| SIEGLER, PE | 1 |
| SLAP, J | 1 |
| NODINE, JH | 1 |
| STRINGER, CG | 1 |
| RICKELS, K | 2 |
| SNOW, L | 1 |
| LANCE, JW | 1 |
| CURRAN, DA | 1 |
| CHARRIOT, G | 1 |
| LAMBERT, PA | 1 |
| PFEIFFER, CC | 2 |
| GOLDSTEIN, L | 2 |
| REYNOLDS, E | 1 |
| JOYCE, CR | 1 |
| SWIFT, JL | 1 |
| TOOLEY, PH | 1 |
| WEATHERALL, M | 1 |
| WALLER, ME | 1 |
| HEUYER, G | 1 |
| LEBOVICI, S | 1 |
| ROUMAJON, J | 1 |
| Kemp, S | 1 |
| Feely, M | 1 |
| Hay, A | 1 |
| Wild, H | 1 |
| Cooper, C | 1 |
| Ago, Y | 1 |
| Takahashi, K | 1 |
| Nakamura, S | 1 |
| Hashimoto, H | 1 |
| Baba, A | 1 |
| Matsuda, T | 1 |
| Petersen, EN | 1 |
| Paschelke, G | 1 |
| Kehr, W | 1 |
| Nielsen, M | 1 |
| Braestrup, C | 1 |
| Rodríguez-Martos, A | 1 |
| Singh, KP | 1 |
| Singh, M | 1 |
| Jaiswal, AK | 1 |
| Atkins, AL | 1 |
| Rustay, NR | 1 |
| Crabbe, JC | 1 |
| Gordon, KE | 1 |
| Dooley, JM | 1 |
| Camfield, PR | 1 |
| Camfield, CS | 1 |
| MacSween, J | 1 |
| Kazarian, SS | 1 |
| Tekatch, GM | 1 |
| Ifabumuyi, OI | 1 |
| Deinum, EJ | 1 |
| Merskey, H | 1 |
| File, SE | 2 |
| Hyde, JR | 1 |
| Shusterman, NH | 1 |
| Samet, CM | 1 |
| Cohen, J | 1 |
| Gomez, E | 1 |
| Hoell, NL | 1 |
| Kotin, J | 1 |
| Rickman, EE | 1 |
| Roessler, RL | 1 |
| Kopchia, KL | 1 |
| Altman, HJ | 1 |
| Commissaris, RL | 2 |
| Sasso, E | 1 |
| Perucca, E | 1 |
| Fava, R | 1 |
| Calzetti, S | 1 |
| Johnston, AL | 1 |
| Kilfoil, T | 1 |
| Michel, A | 1 |
| Montgomery, D | 1 |
| Whiting, RL | 1 |
| McCloskey, TC | 1 |
| Beshears, JF | 1 |
| Halas, NA | 1 |
| Bainbridge, JG | 1 |
| Greenwood, DT | 1 |
| Milkovich, L | 1 |
| van den Berg, BJ | 1 |
| Ihamäki, T | 1 |
| Salmi, HJ | 1 |
| Tarpila, S | 1 |
| Jussila, J | 1 |
| Kalima, T | 1 |
| Siurala, M | 1 |
| Schomburg, P | 1 |
| van Zwieten, PA | 1 |
| Arnaudow, M | 1 |
| Lipman, RS | 2 |
| Garcia, CR | 1 |
| Fisher, E | 1 |
| Covi, L | 1 |
| Pattison, JH | 1 |
| Derogatis, LR | 1 |
| Hollister, LE | 1 |
| Wheatley, D | 2 |
| Egbert, LD | 1 |
| Daneman, EA | 1 |
| Kasich, AM | 1 |
| Descloux, A | 1 |
| Zapella, DG | 1 |
| Wodinsky, A | 1 |
| Benson, WH | 1 |
| Harley, LM | 1 |
1 review available for phenobarbital and Anxiety
| Article | Year |
|---|---|
Psychological support for surgical patients.
Topics: Adaptation, Psychological; Anesthesiology; Anxiety; Communication; Defense Mechanisms; Emotions; Hum | 1967 |
12 trials available for phenobarbital and Anxiety
| Article | Year |
|---|---|
Treatment of anxiety: phenobarbital versus the benzodiazepines.
Topics: Anxiety; Benzothiadiazines; Clinical Trials as Topic; Humans; Phenobarbital | 1978 |
The evaluation of Bellergal Tablets compared to librium and placebo in the treatment of symptoms of anxiety tension states associated with functional gastrointestinal disorders.
Topics: Adult; Aged; Anxiety; Belladonna Alkaloids; Chlordiazepoxide; Clinical Trials as Topic; Drug Combina | 1976 |
Diazepam and phenobarbital in the treatment of anxiety: a controlled multicenter study using physician and patient rating scales.
Topics: Adolescent; Adult; Anxiety; Clinical Trials as Topic; Diazepam; Female; Humans; Male; Middle Aged; P | 1976 |
[Comparitive studies on the effect of sedatives on anxiety caused by vegetative reactions].
Topics: Adolescent; Adult; Anxiety; Atropa belladonna; Chlordiazepoxide; Ergotamine; Ethanol; Female; Humans | 1972 |
Evaluating clinical improvement in anxious outpatients: a comparison of normal and treated neurotic patients.
Topics: Anxiety; Clinical Trials as Topic; Diazepam; Emotions; Evaluation Studies as Topic; Factor Analysis, | 1972 |
Length of treatment with anxiolytic sedatives and response to their sudden withdrawal.
Topics: Adolescent; Adult; Aged; Anxiety; Chlordiazepoxide; Clinical Trials as Topic; Drug Tolerance; Female | 1973 |
[Prudent use of drugs against anxiety].
Topics: Anxiety; Chemical Phenomena; Chemistry; Depression; Diazepam; Evaluation Studies as Topic; Humans; H | 1973 |
A comparative trial of imipramine and phenobarbital in depressed patients seen in general practice.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Anxiety; Child; Clinical Trials as Topic; Depression; | 1969 |
A comparative trial of medazepam (nobrium) in anxiety-depressive states.
Topics: Anxiety; Benzazepines; Clinical Trials as Topic; Depression; Humans; Phenobarbital; Tranquilizing Ag | 1969 |
Quantitative EEG analysis of single-dose effect relationships in normal volunteers of Pacinox (capuride), a new antianxiety drug.
Topics: Administration, Oral; Adult; Anxiety; Blood Pressure; Brain; Chlordiazepoxide; Clinical Trials as To | 1971 |
A double-blind study of heteronium bromide and amobarbital in the management of gastrointestinal conditions associated with anxiety.
Topics: Adult; Aged; Amobarbital; Anxiety; Clinical Trials as Topic; Colonic Diseases, Functional; Duodenal | 1968 |
Diazepam, phenobarbital and placebo in the treatment of psychiatric patients.
Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Diazepam; Female; Humans; Male; Middle A | 1967 |
44 other studies available for phenobarbital and Anxiety
| Article | Year |
|---|---|
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cereb | 1991 |
Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Cerebral Cortex; Electroencep | 2015 |
Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Carbamates; Cognition; Dose-R | 2016 |
Effect of methanol extract of Trigonella foenum-graecum L. seeds on anxiety, sedation and motor coordination.
Topics: Animals; Anxiety; Diazepam; Female; Hypnotics and Sedatives; Male; Methanol; Mice; Muscle Relaxants, | 2017 |
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr | 2012 |
The effect of bellergal and hydergine on the subjective symptoms and the peripheral vasomotor reactions in anxiety states.
Topics: Anxiety; Barbiturates; Belladonna Alkaloids; Drug Combinations; Ergoloid Mesylates; Ergot Alkaloids; | 1953 |
Depressive and anxiety reactions treated with nicotinic acid and phenobarbital.
Topics: Anxiety; Barbiturates; Depression; Humans; Niacin; Nicotinic Acids; North Carolina; Phenobarbital | 1953 |
A comparative study of the effect on anxiety of chlorpromazine, reserpine, phenobarbital, and a placebo.
Topics: Anxiety; Anxiety Disorders; Barbiturates; Chlorpromazine; Humans; Phenobarbital; Reserpine; Secologa | 1955 |
The symptomatic relief of anxiety with meprobamate, phenobarbital and placebo.
Topics: Anxiety; Anxiety Disorders; Humans; Meprobamate; Phenobarbital; Placebos | 1959 |
Response differences of psychotropic drugs in rats during chronic anxiety states.
Topics: Animals; Anxiety; Chlordiazepoxide; Chlorpromazine; Conditioning, Classical; Conditioning, Psycholog | 1962 |
DRUGS, DREAMS AND THE EXPERIMENTAL SUBJECT.
Topics: Anxiety; Dreams; Humans; Hypnosis; Imipramine; Phenobarbital; Prochlorperazine; Sexual Behavior; Sle | 1963 |
PHENOBARBITONE COMPARED WITH AN INACTIVE PLACEBO IN ANXIETY STATES.
Topics: Anxiety; Humans; Phenobarbital | 1964 |
CHLORPROTHIXENE: A NEW NON-PHENOTHIAZINE ATARACTIC AGENT: SPECTRUM IN THE OUTPATIENT THERAPY OF PSYCHONEUROSIS.
Topics: Alcoholism; Anxiety; Anxiety Disorders; Chlorprothixene; Fluphenazine; Humans; Neurotic Disorders; O | 1963 |
METHYLPENTYNOL COMPARED WITH PHENOBARBITONE IN ANXIETY.
Topics: Anxiety; Anxiety Disorders; Humans; Pentanols; Phenobarbital | 1964 |
MEPROBAMATE AND PHENOBARBITAL SODIUM IN ANXIOUS NEUROTIC PSYCHIATRIC AND MEDICAL CLINIC OUTPATIENTS. A CONTROLLED STUDY.
Topics: Anxiety; Anxiety Disorders; Biomedical Research; Drug Therapy; Humans; Meprobamate; Neurotic Disorde | 1964 |
TREATMENT OF CHRONIC TENSION HEADACHE.
Topics: Amitriptyline; Amobarbital; Anxiety; Anxiety Disorders; Biomedical Research; Chlordiazepoxide; Diaze | 1964 |
[THERAPEUTIC EFFECTS OF A HYPNOTIC COMPOUND WITH TRANQUILIZING PROPERTIES].
Topics: Anxiety; Anxiety Disorders; Depression; Humans; Hypnotics and Sedatives; Meprobamate; Neurotic Disor | 1964 |
PANEL DISCUSSION. 3. THE FUTURE OF TRANQUILIZER RESEARCH AND THE THERAPY OF ANXIETY. ASSAY OF ANTI-ANXIETY DRUGS BY QUANTITATIVE ELECTROENCEPHALOGRAPHY.
Topics: Alcohols; Amphetamine; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Biomedical Research; Chlordi | 1964 |
PSYCHOLOGICAL AND CLINICAL INVESTIGATION OF THE TREATMENT OF ANXIOUS OUT-PATIENT WITH THREE BARBITURATES AND PLACEBO.
Topics: Amobarbital; Anxiety; Anxiety Disorders; Barbiturates; Biomedical Research; Drug Therapy; Humans; Me | 1965 |
OFFICE TREATMENT OF THE NERVOUS PATIENT.
Topics: Anxiety; Drug Therapy; Ergotamine; Mental Disorders; Parasympatholytics; Phenobarbital; Psychosomati | 1965 |
[Anxiety in an 8 year old boy; comitial electroencephalogram; effect of gardenal].
Topics: Anxiety; Anxiety Disorders; Electroencephalography; Humans; Male; Neurotic Disorders; Phenobarbital | 1950 |
Psychological factors and use of antiepileptic drugs: pilot work using an objective measure of adherence.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Anxiety; Culture; Depression; Drug Monitoring; Drug Therap | 2007 |
Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Central N | 2007 |
Does the reversal of the anticonflict effect of phenobarbital by beta-CCE and FG 7142 indicate benzodiazepine receptor-mediated anxiogenic properties?
Topics: Animals; Anxiety; Carbolines; Conflict, Psychological; Diazepam; Flunitrazepam; Humans; Indoles; Mal | 1982 |
[Anxiolytic agents in alcoholism].
Topics: Alcoholism; Anti-Anxiety Agents; Anxiety; Barbiturates; Drug Combinations; Humans; Phenobarbital; Ps | 1994 |
Effect of phenobarbitone administration to pregnant rats on anxiety in offsprings.
Topics: Animals; Anxiety; Brain; Exploratory Behavior; Female; Male; Maze Learning; Phenobarbital; Pregnancy | 1999 |
Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice.
Topics: Alcohol Withdrawal Seizures; Animals; Anxiety; Arousal; Ethanol; Female; Genotype; Male; Mice; Mice, | 2000 |
Treatment of febrile seizures: the influence of treatment efficacy and side-effect profile on value to parents.
Topics: Adult; Anticonvulsants; Anxiety; Attitude; Child, Preschool; Diazepam; Educational Status; Female; H | 2001 |
Effects of antianxiety agents on relaxation training: a preliminary investigation.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Diazepam; Female; Flurazepam; Humans; Male; M | 1978 |
A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Central Nervous System Stimulants; Flu | 1979 |
Effects of lesions of the central nucleus of the amygdala on anxiety-like behaviors in the rat.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbamazepine; Chlordiazepoxide; Conditioning, Operant | 1992 |
Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis.
Topics: Aged; Anxiety; Computers; Female; Humans; Male; Middle Aged; Phenobarbital; Primidone; Prospective S | 1990 |
Sodium phenobarbitone reverses the anxiogenic effects of compounds acting at three different central sites.
Topics: Animals; Anxiety; Appetite Depressants; Carbolines; Exploratory Behavior; Male; Pentylenetetrazole; | 1989 |
Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Chlordiazepoxide; Disease Models, Animal; Explorat | 1989 |
Potentiation of the anticonflict effects of diazepam, but not pentobarbital and phenobarbital, by aminooxyacetic acid (AOAA).
Topics: Acetates; Aminooxyacetic Acid; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam | 1988 |
Tranquillizing effects of propranolol demonstrated in rats.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Anxiety; Atropine; Central Nervous Syste | 1971 |
Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development.
Topics: Abnormalities, Drug-Induced; Aluminum; Anxiety; Child, Preschool; Chlordiazepoxide; Embryo, Mammalia | 1974 |
Premedication for endoscopy: a controlled trial.
Topics: Anesthesia, Local; Anxiety; Atropine; Diazepam; Endoscopy; Esophagoscopy; Gastroscopy; Humans; Nause | 1974 |
Antianxiety drugs in organic and functional syndromes.
Topics: Angina Pectoris; Anxiety; Chlordiazepoxide; Colonic Diseases, Functional; Diazepam; Evaluation Studi | 1972 |
Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Anxiety; Brain; Chlordiazepoxide; Depression, Chemical; | 1973 |
Benzodiazepines and anxiety states.
Topics: Amobarbital; Anxiety; Benzazepines; Chlordiazepoxide; Humans; Imipramine; Phenobarbital | 1973 |
[Treatment of the psychosyndrome of alcoholic withdrawal using Atrium].
Topics: Aggression; Alcoholism; Anxiety; Barbiturates; Depression; Drug Combinations; Drug Evaluation; Human | 1971 |
Comparative evaluation of diazepam (Valium) and phenobarbital.
Topics: Adult; Aged; Anxiety; Diazepam; Female; Humans; Male; Middle Aged; Myocardial Infarction; Phenobarbi | 1971 |
Fussing and crying in young infants. Clinical considerations and practical management.
Topics: Anxiety; Child Behavior; Colic; Environment; Feeding Behavior; Humans; Infant; Infant Care; Infant, | 1969 |