phenobarbital has been researched along with Anoxia, Fetal in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to compare the effect of phenobarbital given to pregnant rabbits and of epileptic seizures on the course of pregnancy, the physical state, and central nervous system development of newborns." | 3.66 | [Comparison of the transplacental effect of luminal and epileptic seizures in pregnant rabbits on the development of the fetal nervous system]. ( Bryłko-Chmielik, J; Dambska, M; Danielewicz-Kotowicz, A; Dydyk, L; Maślińska, D; Onyszkiewicz, J, 1979) |
| "Percentage of recurrences in phenobarbital treated cases (4 +/- 0,6 mg/Kg/d) was 18,67%, versus 55,89% in untreated children (p less than 0." | 1.27 | [Efficacy and failure of phenobarbital in the prevention of febrile convulsions. Importance of familial antecedents]. ( Blanco, A; Cilleruelo, ML; Palencia, R; Tresierra, F, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stola, A | 1 |
| Perlman, J | 1 |
| Palencia, R | 1 |
| Cilleruelo, ML | 1 |
| Tresierra, F | 1 |
| Blanco, A | 1 |
| Vannucci, RC | 1 |
| Perlman, JM | 1 |
| Wilds, PL | 1 |
| Dambska, M | 1 |
| Bryłko-Chmielik, J | 1 |
| Danielewicz-Kotowicz, A | 1 |
| Dydyk, L | 1 |
| Maślińska, D | 1 |
| Onyszkiewicz, J | 1 |
| Gaxiola-Logan, MA | 1 |
| Aguilar-Guerrero, A | 1 |
| Forero-Gómez, J | 1 |
| Salazar-Barba, G | 1 |
| Games-Eternod, J | 1 |
| Vidal-Balboa, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial of Therapeutic Hypothermia During Transport for Hypoxic Ischemic Encephalopathy (HIE): Device-regulated Cooling Versus Standard Practice.[NCT01683383] | 101 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants in target temperature range (33-34 C) anytime during transport (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Participants (Number) |
|---|---|
| Control (Standard Cooling) | 24 |
| Device (Servo-regulated Cooling) | 41 |
Percentage of participants in target range (33°-34°C) one hour after cooling initiation by the transport team (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Percentage of participants (Number) |
|---|---|
| Control (Standard Cooling) | 8 |
| Device (Servo-regulated Cooling) | 28 |
The percentage of temperatures in the target range (33°-34°C) during transport after cooling initiation by the transport team. (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Percentage of temperatures (Median) |
|---|---|
| Control (Standard Cooling) | 0 |
| Device (Servo-regulated Cooling) | 73 |
Time to the target temperature range (33°-34°C) from initiation of cooling by the transport team (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Minutes (Mean) |
|---|---|
| Control (Standard Cooling) | 63 |
| Device (Servo-regulated Cooling) | 44 |
The incidence, intervention and outcome of cardiac arrhythmia, major bleeding, altered skin integrity, pulmonary hypertension, device-related events, death, and other serious adverse events from the time of initiation of transport cooling to the time of completion will be monitored. (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Participants (Number) | |||||
|---|---|---|---|---|---|---|
| Cardiac arrhythmia | Major bleeding (pulmonary hemorrhage) | Altered skin integrity | Pulmonary hypertension | Device-related events | Death | |
| Control (Standard Cooling) | 0 | 0 | 0 | 0 | 0 | 6 |
| Device (Servo-regulated Cooling) | 0 | 1 | 0 | 0 | 2 | 9 |
2 reviews available for phenobarbital and Anoxia, Fetal
| Article | Year |
|---|---|
Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia-ischemia.
Topics: Anticonvulsants; Blood Pressure; Female; Fetal Hypoxia; Fluid Therapy; Humans; Hyperglycemia; Hypogl | 2008 |
Interventions for perinatal hypoxic-ischemic encephalopathy.
Topics: Animals; Asphyxia Neonatorum; Brain Damage, Chronic; Brain Ischemia; Calcium Channel Blockers; Excit | 1997 |
4 other studies available for phenobarbital and Anoxia, Fetal
| Article | Year |
|---|---|
[Efficacy and failure of phenobarbital in the prevention of febrile convulsions. Importance of familial antecedents].
Topics: Age Factors; Epilepsy; Female; Fetal Hypoxia; Humans; Male; Phenobarbital; Pregnancy; Recurrence; Se | 1983 |
Observations of intrauterine fetal breathing movements--a review.
Topics: Adrenocorticotropic Hormone; Animals; Blood; Blood Glucose; Blood Pressure; Carbon Dioxide; Circadia | 1978 |
[Comparison of the transplacental effect of luminal and epileptic seizures in pregnant rabbits on the development of the fetal nervous system].
Topics: Anencephaly; Animals; Brain Stem; Cerebral Cortex; Epilepsy, Tonic-Clonic; Female; Fetal Growth Reta | 1979 |
[Serum levels of phenobarbital in the newborn infant using different doses calculated for obtaining a predetermined level].
Topics: Apgar Score; Female; Fetal Hypoxia; Gestational Age; Humans; Infant, Newborn; Male; Phenobarbital; P | 1985 |