phenobarbital has been researched along with Anoxia, Brain in 20 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital data were collected between 2008 and 2010." | 2.77 | Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach. ( de Vries, LS; Egberts, AC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG; van Straaten, HL, 2012) |
| "Phenobarbital treatment had no significant effect on CBF 60 min after loading dosage (20 mg/kg i." | 2.67 | The effect of phenobarbital on cerebral blood flow in newborn infants with foetal distress. ( Andersen, K; Ebbesen, F; Jensen, KA, 1994) |
| "Post-anoxic myoclonus is a rare movement disorder manifested by diffuse action-triggered jerking movements that may result in significant disability." | 1.33 | Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting. ( Polesin, A; Stern, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (75.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van den Broek, MP | 1 |
| Groenendaal, F | 1 |
| Toet, MC | 1 |
| van Straaten, HL | 1 |
| van Hasselt, JG | 1 |
| Huitema, AD | 1 |
| de Vries, LS | 1 |
| Egberts, AC | 1 |
| Rademaker, CM | 1 |
| CELESIA, GG | 1 |
| ANDERMANN, F | 1 |
| MULLAN, D | 1 |
| PLATTS, M | 1 |
| RIDGWAY, B | 1 |
| HUGHES, JR | 1 |
| SCHLAGENHAUFF, RE | 1 |
| Polesin, A | 1 |
| Stern, M | 1 |
| Di Trapani, G | 1 |
| Lazari, M | 1 |
| Sbriccioli, A | 1 |
| Cavaliere, F | 1 |
| Sabato, AF | 1 |
| Fredholm, BB | 1 |
| Lindgren, E | 1 |
| Lindström, K | 1 |
| Vernet, L | 1 |
| Finer, NN | 1 |
| Robertson, CM | 1 |
| Peters, KL | 1 |
| Coward, JH | 1 |
| Steer, CR | 1 |
| Sanberg, PR | 1 |
| Willow, M | 1 |
| Andersen, K | 1 |
| Jensen, KA | 1 |
| Ebbesen, F | 1 |
| Wertheim, D | 1 |
| Mercuri, E | 1 |
| Faundez, JC | 1 |
| Rutherford, M | 1 |
| Acolet, D | 1 |
| Dubowitz, L | 1 |
| Vannucci, RC | 1 |
| Perlman, JM | 1 |
| Graham, AN | 1 |
| Ibrahim, MZ | 1 |
| Blank, WF | 1 |
| Kirshner, HS | 1 |
| Hill, A | 1 |
| Lhermitte, F | 1 |
| Peterfalvi, M | 1 |
| Marteau, R | 1 |
| Gazengel, J | 1 |
| Serdaru, M | 1 |
| Rosen, MG | 2 |
| McLaughlin, A | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial of Therapeutic Hypothermia During Transport for Hypoxic Ischemic Encephalopathy (HIE): Device-regulated Cooling Versus Standard Practice.[NCT01683383] | 101 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants in target temperature range (33-34 C) anytime during transport (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Participants (Number) |
|---|---|
| Control (Standard Cooling) | 24 |
| Device (Servo-regulated Cooling) | 41 |
Percentage of participants in target range (33°-34°C) one hour after cooling initiation by the transport team (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Percentage of participants (Number) |
|---|---|
| Control (Standard Cooling) | 8 |
| Device (Servo-regulated Cooling) | 28 |
The percentage of temperatures in the target range (33°-34°C) during transport after cooling initiation by the transport team. (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Percentage of temperatures (Median) |
|---|---|
| Control (Standard Cooling) | 0 |
| Device (Servo-regulated Cooling) | 73 |
Time to the target temperature range (33°-34°C) from initiation of cooling by the transport team (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Minutes (Mean) |
|---|---|
| Control (Standard Cooling) | 63 |
| Device (Servo-regulated Cooling) | 44 |
The incidence, intervention and outcome of cardiac arrhythmia, major bleeding, altered skin integrity, pulmonary hypertension, device-related events, death, and other serious adverse events from the time of initiation of transport cooling to the time of completion will be monitored. (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Participants (Number) | |||||
|---|---|---|---|---|---|---|
| Cardiac arrhythmia | Major bleeding (pulmonary hemorrhage) | Altered skin integrity | Pulmonary hypertension | Device-related events | Death | |
| Control (Standard Cooling) | 0 | 0 | 0 | 0 | 0 | 6 |
| Device (Servo-regulated Cooling) | 0 | 1 | 0 | 0 | 2 | 9 |
3 reviews available for phenobarbital and Anoxia, Brain
| Article | Year |
|---|---|
Barbiturate therapy in the management of cerebral ischaemia.
Topics: Animals; Barbiturates; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dogs; Humans | 1982 |
Interventions for perinatal hypoxic-ischemic encephalopathy.
Topics: Animals; Asphyxia Neonatorum; Brain Damage, Chronic; Brain Ischemia; Calcium Channel Blockers; Excit | 1997 |
Pharmacologic considerations in the management of the asphyxiated newborn.
Topics: Asphyxia Neonatorum; Barbiturates; Brain; Brain Edema; Brain Ischemia; Free Radicals; Humans; Hypoxi | 1985 |
2 trials available for phenobarbital and Anoxia, Brain
| Article | Year |
|---|---|
Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach.
Topics: Anticonvulsants; Asphyxia Neonatorum; Drug Administration Schedule; Electroencephalography; Fluoresc | 2012 |
The effect of phenobarbital on cerebral blood flow in newborn infants with foetal distress.
Topics: Brain Ischemia; Cerebrovascular Circulation; Fetal Distress; Humans; Hypoxia, Brain; Infant, Newborn | 1994 |
15 other studies available for phenobarbital and Anoxia, Brain
| Article | Year |
|---|---|
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK.
Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions, | 1964 |
BARBITURATE INTOXICATION.
Topics: Amobarbital; Barbiturates; Coma; Diagnosis; Electrocardiography; Hypnotics and Sedatives; Hypoxia, B | 1965 |
THE PERIODICALLY RECURRING FOCAL DISCHARGE.
Topics: Animals; Cerebrovascular Disorders; Child; Drug Therapy; Electrocardiography; Electroencephalography | 1965 |
Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting.
Topics: Anticonvulsants; Clonazepam; Diazepam; Female; Heart Arrest; Humans; Hypoxia, Brain; Isoxazoles; Lev | 2006 |
Experimental acute hypoxia. Brain preservation by phenobarbital pretreatment. Histological study in guinea pigs.
Topics: Animals; Brain; Guinea Pigs; Hypoxia, Brain; Phenobarbital; Premedication | 1984 |
The effect of some drugs with purported antianoxic effect on veratridine-induced purine release from isolated rat hypothalamic synaptosomes.
Topics: Animals; Brain; Dihydroergotamine; Hypothalamus; Hypoxia, Brain; In Vitro Techniques; Male; Phenobar | 1983 |
Factors affecting outcome in hypoxic-ischemic encephalopathy in term infants.
Topics: Adolescent; Adult; Brain Ischemia; Dexamethasone; Electroencephalography; Female; Follow-Up Studies; | 1983 |
Dose-dependent effects of taurine on convulsions induced by hypoxia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Hypoxia, Brain; Male; Phenobarbital; Rats; Rats, Inbred S | 1980 |
Prognostic value of continuous electroencephalographic recording in full term infants with hypoxic ischaemic encephalopathy.
Topics: Brain Damage, Chronic; Brain Ischemia; Diagnosis, Computer-Assisted; Electroencephalography; Follow- | 1994 |
Near-drowning in an infant: case report.
Topics: Child, Preschool; Dexamethasone; Drug Therapy, Combination; Humans; Hypoxia, Brain; Immersion; Infus | 1978 |
Glycogen and its related enzymes of metabolism in the central nervous system.
Topics: 1,4-alpha-Glucan Branching Enzyme; Adenine Nucleotides; Adrenal Cortex Hormones; Animals; Blood Gluc | 1975 |
The kinetics of extracellular potassium changes during hypoxia and anoxia in the cat cerebral cortex.
Topics: Animals; Biological Transport; Blood Pressure; Brain; Cats; Cerebral Cortex; Chloralose; Electrophys | 1977 |
[Pharmacological analysis of a case of postanoxic intention and action myoclonus].
Topics: 5-Hydroxytryptophan; Alcohols; Anticonvulsants; Benzoates; Carbamazepine; Chlorpromazine; Diazepam; | 1971 |
Maternal and fetal electroencephalography in the guinea pig.
Topics: Animals; Electroencephalography; Female; Fetal Diseases; Fetus; Guinea Pigs; Hypoxia, Brain; Phenoba | 1966 |
Maternal and fetal electroencephalography in the guinea pig.
Topics: Animals; Electroencephalography; Female; Fetal Diseases; Fetus; Guinea Pigs; Hypoxia, Brain; Phenoba | 1966 |