phenobarbital and Anesthesia studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

Excerpt	Relevance	Reference
"The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions."	7.69	Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994)
"The effects of chloramphenicol, cimetidine and phenobarbital on the xylazine-ketamine anesthesia and the development of tolerance to xylazine-ketamine and xylazine were studied in dogs."	7.68	Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. ( Amouzadeh, HR; Nossaman, BC; Sangiah, S, 1990)
"Progesterone (P), 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OHP), prolactin (PRL), LH and FSH in peripheral blood plasma were measured during the early stages of phenobarbital-induced pseudopregnancy (PHB-PSP; Furudate, 1975) and the changes in these hormone levels were compared with those during the 5-day estrous cycle and early stages of ordinary pseudopregnancy (PSP) induced by cervical stimulation."	7.66	Changes in plasma progestin, prolactin, LH and FSH at luteal activation with phenobarbital anesthesia in the rat. ( Kaneko, S, 1980)
"The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions."	3.69	Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994)
"The mechanism of prolongation of sleeping (anesthesia) time after phenobarbital (PB) treatment was assessed in mice with ethionine (ET)-induced liver disorders (ET-treated group)."	3.69	Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice. ( Kawai, Y; Noguchi, M, 1996)
"The effects of chloramphenicol, cimetidine and phenobarbital on the xylazine-ketamine anesthesia and the development of tolerance to xylazine-ketamine and xylazine were studied in dogs."	3.68	Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. ( Amouzadeh, HR; Nossaman, BC; Sangiah, S, 1990)
"Progesterone (P), 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OHP), prolactin (PRL), LH and FSH in peripheral blood plasma were measured during the early stages of phenobarbital-induced pseudopregnancy (PHB-PSP; Furudate, 1975) and the changes in these hormone levels were compared with those during the 5-day estrous cycle and early stages of ordinary pseudopregnancy (PSP) induced by cervical stimulation."	3.66	Changes in plasma progestin, prolactin, LH and FSH at luteal activation with phenobarbital anesthesia in the rat. ( Kaneko, S, 1980)
"Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal."	1.38	The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. ( Borland, S; Ewart, L; Kirk, S; Lainée, P; Marks, L; Philp, K; Skinner, M; Valentin, JP, 2012)
"Nifedipine was administered i."	1.28	A comparison of the effects of acute versus chronic administration of phenoxybenzamine on pressor responses elicited by the selective alpha 1-adrenoceptor agonist cirazoline in the pithed rat preparation. ( Tabrizchi, R; Triggle, CR, 1992)
" Chronic administration of a small dose to the rat for 70 days had no effect on blood glucose, blood urea nitrogen, hemoglobin, or microhematocrit values."	1.26	Pharmacological assessment of 3-tert-butylsydnone. ( Bulger, WH; Roche, EB; Wells, PR, 1976)
"Phenobarbital treatment enhanced production of fluroxene metabolites, including the highly toxic trifluoroethanol."	1.25	Fluroxene toxicity induced by phenobarbital. ( Embro, WJ; Fiserova-Bergerova, V; Holaday, DA; Malagodi, MH; Munson, ES; Perry, JC; Shields, RP; Tham, MK, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	90 (90.00)	18.7374
1990's	7 (7.00)	18.2507
2000's	2 (2.00)	29.6817
2010's	1 (1.00)	24.3611
2020's	0 (0.00)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779]				12 participants (Actual)	Observational	2017-08-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Some considerations on the use of sodium phenobarbital and sodium pentothal. Contact point, 1947, Volume: 26, Issue:4 Topics: Anesthesia; Anesthesiology; Barbital; Barbiturates; Phenobarbital; Sodium; Thiopental	1947
The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. Toxicology and applied pharmacology, 2012, Sep-01, Volume: 263, Issue:2 Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Drug E	2012
[Lowering of pain and shortening of the birth process with causat]. Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;	1956
[Lowering of pain and shortening of the birth process with causat]. Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;	1956
[Lowering of pain and shortening of the birth process with causat]. Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;	1956
[Lowering of pain and shortening of the birth process with causat]. Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;	1956
[Development and valuation of proscalun, a new oral depot preparation for daily sedation]. Die Medizinische, 1957, Feb-09, Issue:6 Topics: Anesthesia; Atropine Derivatives; Delayed-Action Preparations; Phenobarbital	1957
[Inhibition of lactation by diencephalic sedation]. Geburtshilfe und Frauenheilkunde, 1957, Volume: 17, Issue:3 Topics: Anesthesia; Breast Feeding; Diencephalon; Female; Humans; Lactation; Phenobarbital	1957
[Labor relief in obstetrical practice]. Medizinische Klinik, 1958, Oct-24, Volume: 53, Issue:43 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Humans; Niacin; Nicotinic Acids; Pain; Pa	1958
[Bellafolin-phenobarbital premedication in tonsillectomy under local anesthesia]. Monatsschrift fur Ohrenheilkunde und Laryngo-Rhinologie, 1961, Volume: 95 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Local; Anesthesiology; Atropa belladonn	1961
Pentobarbital anesthesia in the dog following preanesthetic administration of promazine and meperidine in clinical practice. The Cornell veterinarian, 1963, Volume: 53 Topics: Anesthesia; Anesthesiology; Animals; Dogs; Meperidine; Pentobarbital; Phenobarbital; Preanesthetic M	1963
[Potentiated local anesthesia in otorhinolaryngology]. Ful-, orr-, gegegyogyazat, 1962, Volume: 8 Topics: Anesthesia; Anesthesia, Local; Anesthesiology; Chlorpromazine; Humans; Meperidine; Otolaryngology; P	1962
[THE USE OF CURARE IN CATARACT SURGERY. CLINICO-STATISTICAL CONTRIBUTION]. Annali di ottalmologia e clinica oculistica, 1963, Volume: 89 Topics: Anesthesia; Anesthesiology; Cataract; Cataract Extraction; Chlorpromazine; Curare; Hibernation; Huma	1963
[THE EFFECT OF ANESTHESIA ON RESPIRATION AND RESPIRATORY IN METABOLISM RATS]. Der Anaesthesist, 1964, Volume: 13 Topics: Anesthesia; Blood Gas Analysis; Heart; Hypoxia; Metabolism; Oximetry; Phenobarbital; Pregnanediones;	1964
THE RADIOGRAPHER AND THE ANAESTHETIST. Radiography, 1964, Volume: 30 Topics: Amobarbital; Anesthesia; Anesthesia, Endotracheal; Anesthesia, Inhalation; Anesthesia, Intravenous;	1964
[SAFE ANESTHESIA IN INTRAOCULAR OPERATIONS (COMBINATION OF POTENTIATED ANESTHESIA WITH MY 301)]. Hellenike iatrike, 1964, Volume: 33 Topics: Anesthesia; Anesthesiology; Cataract Extraction; Chlorpromazine; Ergotamine; Glaucoma; Guaifenesin;	1964
[BRIEF INTRAVENOUS ANESTHESIA]. Das Deutsche Gesundheitswesen, 1964, Feb-06, Volume: 19 Topics: Anesthesia; Anesthesia, Intravenous; Barbiturates; Hexobarbital; Humans; Pharmacology; Phenobarbital	1964
[ASSISTED SPINAL ANESTHESIA]. Lyon chirurgical, 1964, Volume: 60 Topics: Anesthesia; Anesthesia, Spinal; Atropine; Blood Circulation; Ephedrine; Glucose; Heart Rate; Humans;	1964
TWO CASES OF BILATERAL PHAEOCHROMOCYTOMA WITH A DISCUSSION ON ANAESTHETIC MANAGEMENT OF CHROMATIN TUMOURS. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1964, Aug-01, Volume: 38 Topics: Adrenalectomy; Anesthesia; Anesthetics; Arrhythmias, Cardiac; Blood Pressure; Catecholamines; Child;	1964
BLEEDING IN A HEMOPHILIAC AFTER INFERIOR ALVEOLAR NERVE BLOCK. Journal of the American Dental Association (1939), 1964, Volume: 69 Topics: Anesthesia; Anesthesia, Conduction; Anesthesia, Dental; Antigen-Antibody Reactions; Factor VIII; gam	1964
THE GLUCOSE CONTENT OF BRAIN IN ANAESTHESIA. Journal of neurochemistry, 1964, Volume: 11 Topics: Anesthesia; Animals; Blood Glucose; Brain; Chloroform; Chlorpromazine; Ether; Glucose; Lactates; Mic	1964
STUDIES IN HYPOTHERMIA. II. THE INFLUENCE OF DEEP HYPOTHERMIA ON THE FORMATION OF FLUID EXUDATE IN ACUTE INFLAMMATION IN MICE. Acta anaesthesiologica Scandinavica, 1964, Volume: 8 Topics: Anesthesia; Anesthesia, Intravenous; Anesthesiology; Animals; Body Fluids; Capillary Permeability; E	1964
[PORPHYRIA AND ANESTHESIA]. Acta anaesthesiologica Belgica, 1963, Volume: 14 Topics: Anesthesia; Barbiturates; Humans; Phenobarbital; Porphyrias; Thiopental; Toxicology	1963
[A CASE OF TETANUS]. Acta anaesthesiologica Belgica, 1963, Volume: 14 Topics: Anesthesia; Anesthesia, Intravenous; Anesthesiology; Apnea; Ascorbic Acid; Calcium; Gluconates; Huma	1963
ALTERATIONS IN THE ACTIVITY OF PENTOTHAL, PHENOBARBITAL, PENTYLENETETRAZOL, AND STRYCHNINE BY CHOLINESTERASE INHIBITORS. Journal of pharmaceutical sciences, 1964, Volume: 53 Topics: Acetylcholine; Anesthesia; Atropine; Cholinesterase Inhibitors; Isoflurophate; Mice; Neostigmine; Pe	1964
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR. Obstetrics and gynecology, 1964, Volume: 24 Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms;	1964
GASEOUS METABOLISM IN THE INFANT: THE EFFECT OF SEDATION AND OF WAKEFULNESS. Canadian Medical Association journal, 1964, Oct-31, Volume: 91 Topics: Anesthesia; Blood Gas Analysis; Chloral Hydrate; Chlorpromazine; Hemodynamics; Humans; Infant; Meper	1964
[ANESTHESIA IN OPERATIONS FOR AORTIC COARCTATION]. Vestnik khirurgii imeni I. I. Grekova, 1964, Volume: 92 Topics: Adolescent; Anesthesia; Anesthesia, Intravenous; Aortic Coarctation; Blood Transfusion; Child; Elect	1964
URETHANE ANESTHESIA AND PITUITARY-ADRENAL FUNCTION IN THE RAT. The Journal of pharmacy and pharmacology, 1964, Volume: 16 Topics: Adrenal Glands; Anesthesia; Ascorbic Acid; Blood Chemical Analysis; Corticosterone; Epinephrine; Pha	1964
A LINEAR DISTRIBUTED FEEDBACK MODEL FOR PREPYRIFORM CORTEX. Experimental neurology, 1964, Volume: 10 Topics: Anesthesia; Brain; Cats; Cerebral Cortex; Computers; Electric Stimulation; Electroencephalography; E	1964
HYPERBARIC OXYGENATION. FACTORS INFLUENCING CLINICAL OXYGEN TOXICITY. Annals of the New York Academy of Sciences, 1965, Jan-21, Volume: 117 Topics: Adrenal Glands; Anesthesia; Cerebrovascular Circulation; Chlorpromazine; Dry Ice; Ganglionic Blocker	1965
HYPERBARIC OXYGENATIN. THE SMALL PATIENT CHAMBER, RADIOTHERAPY. Annals of the New York Academy of Sciences, 1965, Jan-21, Volume: 117 Topics: Anesthesia; Anesthesia, Intravenous; Equipment and Supplies; Humans; Hyperbaric Oxygenation; Meperid	1965
THE HYPERALGESIC ACTION OF BARBITURATES IN MICE. British journal of pharmacology and chemotherapy, 1965, Volume: 24 Topics: Anesthesia; Anesthesia, Intravenous; Anesthesiology; Barbiturates; Bemegride; Chloral Hydrate; Glute	1965
OBSTRUCTING GASTRODUODENAL ULCERS. EFFECTS OF TREATMENT ON MORBIDITY AND MORTALITY. Archives of surgery (Chicago, Ill. : 1960), 1965, Volume: 91 Topics: Anesthesia; Antacids; Anti-Bacterial Agents; Atropa belladonna; Blood Transfusion; Diet; Diet Therap	1965
THE EFFECTS OF ANAESTHESIA INDUCED BY URETHANE OR PHENOBARBITONE UPON THE DISTRIBUTION OF PERIPHERAL CATECHOL AMINES IN THE RAT. British journal of pharmacology and chemotherapy, 1965, Volume: 24 Topics: Adrenal Glands; Amines; Anesthesia; Anesthesia, General; Catechols; Epinephrine; Myocardium; Norepin	1965
The effect of iodides on phenobarbital narcosis. Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1951, Volume: 40, Issue:10 Topics: Administration, Intravenous; Anesthesia; Anesthesia, Intravenous; Barbiturates; Iodides; Phenobarbit	1951
Evaluation of sedation on electroencephalographic spectral edge frequency 95 in dogs sedated by acupuncture at GV20 or Yintang and sedative combination. Acupuncture & electro-therapeutics research, 2006, Volume: 31, Issue:3-4 Topics: Acepromazine; Acupuncture Analgesia; Anesthesia; Animals; Brain; Butorphanol; Diazepam; Dogs; Drug C	2006
Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome. Neuroscience, 2008, Apr-09, Volume: 152, Issue:4 Topics: Anesthesia; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Temperature; Body	2008
Mean carbon dioxide tension in the brain after carbonic anhydrase inhibition. The Journal of physiology, 1967, Volume: 188, Issue:1 Topics: Acetazolamide; Anesthesia; Animals; Carbon Dioxide; Cats; Cerebral Cortex; Hydrogen-Ion Concentratio	1967
Phospholipids as ion exchangers: implications for a possible role in biological membrane excitability and anesthesia. Biochimica et biophysica acta, 1967, Sep-09, Volume: 135, Issue:4 Topics: Anesthesia; Binding Sites; Calcium; Chloroform; Hydrogen-Ion Concentration; Ion Exchange; Membranes,	1967
Some characteristics of the long-latency component of the evoked muscle response induced by administration of catechol to the anaesthetized rat: a neurophysiological and neuropharmacological investigation. British journal of pharmacology, 1984, Volume: 83, Issue:1 Topics: Anesthesia; Animals; Catechols; Cholinesterase Inhibitors; Electric Stimulation; Electromyography; E	1984
Barbiturates in the treatment of status epilepticus. Advances in neurology, 1983, Volume: 34 Topics: Anesthesia; Animals; Haplorhini; Humans; Kinetics; Phenobarbital; Status Epilepticus	1983
Chronobiological studies on the hypotensive effect of prostaglandin E2 and arachidonic acid in the rat. Chronobiology international, 1984, Volume: 1, Issue:4 Topics: Anesthesia; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Circadian Rhythm; Depressi	1984
Changes in plasma progestin, prolactin, LH and FSH at luteal activation with phenobarbital anesthesia in the rat. Endocrinologia japonica, 1980, Volume: 27, Issue:4 Topics: Anesthesia; Animals; Barbiturates; Bromocriptine; Corpus Luteum; Diestrus; Estrus; Female; Follicle	1980
Spontaneous unit activity in the globus pallidus following cumulative injections of morphine in phenobarbital- or chloral hydrate-anesthetized rats. Neuropharmacology, 1983, Volume: 22, Issue:2 Topics: Action Potentials; Anesthesia; Animals; Chloral Hydrate; Globus Pallidus; Male; Morphine; Naloxone;	1983
Effects of insulin administered into cerebrospinal fluid spaces on blood glucose in unanaesthetized and anaesthetized dogs. The Indian journal of medical research, 1982, Volume: 75 Topics: Anesthesia; Animals; Blood Glucose; Brain; Cats; Dogs; Hyperglycemia; Hypoglycemia; Injections, Intr	1982
Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats. Anesthesiology, 1982, Volume: 56, Issue:3 Topics: Anesthesia; Animals; Deuterium; Enzyme Induction; Fluorides; Kidney; Kidney Diseases; Male; Methoxyf	1982
Cyclosporin increases the CNS sensitivity to the hypnotic effect of phenobarbitone but not ethanol in rats. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:9 Topics: Anesthesia; Animals; Brain; Cyclosporine; Drug Interactions; Ethanol; Hypnosis, Anesthetic; Infusion	1994
Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. Pharmaceutical research, 1994, Volume: 11, Issue:4 Topics: Anesthesia; Animals; Histiocytoma, Benign Fibrous; Male; Paraplegia; Pentylenetetrazole; Phenobarbit	1994
Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice. The Journal of toxicological sciences, 1996, Volume: 21, Issue:2 Topics: Anesthesia; Anesthesia Recovery Period; Animals; Brain Chemistry; Carcinogens; Chemical and Drug Ind	1996
Exposure to sublethal blast overpressure reduces the food intake and exercise performance of rats. Toxicology, 1997, Jul-25, Volume: 121, Issue:1 Topics: Air Pressure; Anesthesia; Animals; Blast Injuries; Digestive System; Eating; Explosions; Lung; Lung	1997
Fluroxene toxicity induced by phenobarbital. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:6 Topics: Anesthesia; Animals; Ethers; Fluorides; Fluorine; Haplorhini; Lung; Macaca mulatta; Male; Phenobarbi	1975
The role of cytochrome P-450 in the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether) anaesthesia in vivo. Biochemical pharmacology, 1976, Apr-01, Volume: 25, Issue:7 Topics: Allylisopropylacetamide; Anesthesia; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme I	1976
Effects of cord section and pithing on spontaneously hypertensive rats. The Japanese journal of physiology, 1977, Volume: 27, Issue:6 Topics: Age Factors; Anesthesia; Animals; Blood Pressure; Female; Hexamethonium Compounds; Hypertension; Mal	1977
Restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after 30 minutes of complete ischemia in rats anaesthetized with nitrous oxide or phenobarbital. Journal of neurochemistry, 1978, Volume: 30, Issue:2 Topics: Amino Acids; Anesthesia; Animals; Brain; Citric Acid Cycle; Energy Metabolism; Glycolysis; Ischemic	1978
The effect of anesthesia on brain mitochondrial hexokinase. Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 298, Issue:3 Topics: Anesthesia; Animals; Brain; Halothane; Hexokinase; In Vitro Techniques; Male; Mitochondria; Pentylen	1977
Glomerular filtration rate and effective renal plasma flow following treatment with phenobarbital. Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 223, Issue:1 Topics: Anesthesia; Animals; Creatinine; Diuretics; Glomerular Filtration Rate; Inulin; Kidney; Male; p-Amin	1976
Hepatic blood flow and enzyme induction in the rat. Biochemical pharmacology, 1975, Jan-15, Volume: 24, Issue:2 Topics: Anesthesia; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Liver; Liver Circu	1975
Analysis of the action of CNS depressant drugs on somato-somatic reflexes in the cat. Neuropharmacology, 1975, Volume: 14, Issue:7 Topics: Action Potentials; Anesthesia; Animals; Cats; Cerebellum; Chlorpromazine; Diazepam; Female; Male; Ne	1975
Metabolism of (14C-1)-halothane in vivo--effects of multiple halothane anesthesia, phenobarbital and carbon tetrachloride pretreatment. Biochemical pharmacology, 1975, Nov-15, Volume: 24, Issue:22 Topics: Anesthesia; Animals; Carbon Tetrachloride; Halothane; Liver; Male; Microsomes, Liver; Phenobarbital;	1975
On the activation of the corpus luteum of the rat estrous cycle with phenobarbital anesthesia. I. Induction of pseudopregnancy by a single subcutaneous injection of phenobarbital. The Kitasato archives of experimental medicine, 1975, Volume: 48, Issue:2-3 Topics: Anesthesia; Animals; Corpus Luteum; Estrus; Female; Injections, Subcutaneous; Phenobarbital; Pregnan	1975
[Acute tolerance and time changes in ketamine-induced sleep under the effect of phenobarbital and chlorophenicol. Experimental study]. Revista espanola de anestesiologia y reanimacion, 1976, Volume: 23, Issue:1 Topics: Anesthesia; Animals; Chloramphenicol; Ketamine; Male; Phenobarbital; Preanesthetic Medication; Rats;	1976
Pharmacological assessment of 3-tert-butylsydnone. Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:1 Topics: Anesthesia; Animals; Convulsants; Dogs; Eye; Female; In Vitro Techniques; Methacholine Compounds; Mi	1976
A comparison of the effects of acute versus chronic administration of phenoxybenzamine on pressor responses elicited by the selective alpha 1-adrenoceptor agonist cirazoline in the pithed rat preparation. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:6 Topics: Adaptation, Physiological; Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Calcium;	1992
Prolactin response to anesthetic stress and beta-endorphin is altered in female rats treated neonatally with monosodium glutamate. Neuropeptides, 1992, Volume: 22, Issue:2 Topics: Anesthesia; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Female; Immu	1992
Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. Veterinary and human toxicology, 1990, Volume: 32, Issue:3 Topics: Anesthesia; Animals; Behavior, Animal; Chloramphenicol; Cimetidine; Consciousness; Dogs; Dose-Respon	1990
Deuterium isotope effects on ethanol oxidation in perfused rat liver and in rats and rabbits in vivo: application to determine the contribution of various pathways. Pharmacology & toxicology, 1989, Volume: 65, Issue:1 Topics: Acetaldehyde; Acetone; Amides; Anesthesia; Animals; Deuterium; Ethanol; Female; Kinetics; Liver; Mic	1989
Cardiovascular characterization of DA-1 and DA-2 dopamine receptor agonists in anesthetized rats. Clinical and experimental hypertension. Part A, Theory and practice, 1987, Volume: 9, Issue:5-6 Topics: Anesthesia; Animals; Benzazepines; Blood Pressure; Drug Interactions; Electric Stimulation; Ergoline	1987
Lymphatic and portal venous absorption of phenobarbital and thiopental in the dog. Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 288, Issue:1 Topics: Anesthesia; Animals; Biotransformation; Chylomicrons; Dogs; Female; Hydrogen-Ion Concentration; Lipi	1987
Prolonged hypothermia after phenobarbital-induced anesthesia in adrenalectomized rats. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:6 Topics: Adrenalectomy; Anesthesia; Animals; Body Temperature; Brain; Glucocorticoids; Hypnotics and Sedative	1986
[D-Ala2]-methionine enkephalinamide (DALA): characterization of antinociceptive, cardiovascular, and autonomic nervous system actions in conscious and pentobarbital-anesthetized rats. Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:3 Topics: Anesthesia; Animals; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Enkephalin, Me	1986
Renal responses to saline loading in conscious and anesthetized rats. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1985, Volume: 84, Issue:11 Topics: Anesthesia; Animals; Body Water; Female; Kidney; Phenobarbital; Potassium; Rats; Sodium; Sodium Chlo	1985
Enzyme induction in sheep: effects of phenobarbital on in vivo and in vitro drug metabolism. American journal of veterinary research, 1972, Volume: 33, Issue:5 Topics: Anesthesia; Aniline Compounds; Animals; Antipyrine; Cytochromes; Dicumarol; Enzyme Induction; Female	1972
[Influence of amphetamine and phenobarbital treatment on hexobarbital narcosis]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1967, Volume: 257, Issue:1 Topics: Amphetamine; Anesthesia; Animals; Drug Synergism; Female; Hexobarbital; Phenobarbital; Rats	1967
Effect of starvation on the in vivo metabolism and effect of drugs in female and male rats. Japanese journal of pharmacology, 1967, Volume: 17, Issue:2 Topics: Amides; Anesthesia; Animals; Barbiturates; Body Weight; Carisoprodol; Diphosphates; Female; Hexobarb	1967
The effect of blood sugar level on the histamine-stimulated gastric secretion in shay-rats. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 179, Issue:2 Topics: Anesthesia; Animals; Blood Glucose; Ethyl Ethers; Gastric Juice; Glucose; Histamine; Histamine H1 An	1969
The action of sympatholytic drugs in experimental intestinal paralysis. Acta chirurgica Academiae Scientiarum Hungaricae, 1971, Volume: 12, Issue:4 Topics: Anesthesia; Animals; Cats; Chlorpromazine; Disease Models, Animal; Ganglionic Blockers; Gastrointest	1971
Inhalation studies on the biotransformation and elimination of [14C] trichlorofluoromethane and [14C] dichlorodifluoromethane in beagles. Toxicology and applied pharmacology, 1974, Volume: 30, Issue:3 Topics: Anesthesia; Animals; Biotransformation; Blood Gas Analysis; Carbon Dioxide; Carbon Radioisotopes; Do	1974
Vagal control of heart rate during hypoxia in the cat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 147, Issue:2 Topics: Anesthesia; Animals; Blood Pressure; Cats; Cordotomy; Denervation; Glossopharyngeal Nerve; Heart; He	1974
Effects of dietary protein quality on drug metabolism in the rat. The Journal of nutrition, 1973, Volume: 103, Issue:10 Topics: Anesthesia; Aniline Compounds; Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Dealky	1973
Effects of anesthesia on the energy and acid-base status of the rat brain. Acta anaesthesiologica Scandinavica, 1973, Volume: 17, Issue:2 Topics: Acid-Base Equilibrium; Adenine Nucleotides; Anesthesia; Anesthesia, Inhalation; Animals; Bicarbonate	1973
Optimal freezing conditions for cerebral metabolites in rats. Journal of neurochemistry, 1973, Volume: 21, Issue:5 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthesia; Animals; Autolys	1973
Corneal absorption of fluorometholone in rabbits. A comparative evaluation of corneal drug transport characteristics in anesthetized and unanesthetized rabbits. Archives of ophthalmology (Chicago, Ill. : 1960), 1974, Volume: 92, Issue:3 Topics: Anesthesia; Animals; Aqueous Humor; Biological Transport; Cornea; Fluorometholone; Injections, Intra	1974
Effect of abdominal pressure rise on the urethral profile. An experimental study on dogs. Investigative urology, 1974, Volume: 12, Issue:1 Topics: Abdomen; Age Factors; Anesthesia; Animals; Curare; Dogs; Electric Stimulation; Female; Male; Muscle	1974
The lactate-pyruvate ratios of cerebrospinal fluid of rats and cats related to the lactate-pyruvate, the ATP-ADP, and the phosphocreatine-creatine ratios of brain tissue. Acta physiologica Scandinavica, 1968, Volume: 74, Issue:3 Topics: Adenine Nucleotides; Adenosine Triphosphate; Anesthesia; Animals; Brain Chemistry; Cats; Cerebral Co	1968
A new method for measuring gastric acid secretion in unanesthetized rats. Gastroenterology, 1971, Volume: 61, Issue:3 Topics: Anesthesia; Animals; Appetitive Behavior; Atropine; Behavior, Animal; Evaluation Studies as Topic; G	1971
[Gaschromatopraphic, biochemical and ultramicroscopy studies in rats following repeated single- and combined doses of phenobarbital and halothane]. Der Anaesthesist, 1972, Volume: 21, Issue:8 Topics: Anesthesia; Animals; Bicarbonates; Carbon Dioxide; Chromatography, Gas; Drug Synergism; Endoplasmic	1972
Metabolic factors which influence triethyl phosphate-induced narcosis in rats. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 179, Issue:2 Topics: Age Factors; Anesthesia; Animals; Brain; Brain Chemistry; Chromatography, Gas; Colorimetry; Drug Int	1971
Metabolite flux in single neurons during ischemia and anesthesia. Current problems in clinical biochemistry, 1971, Volume: 3 Topics: Adenosine Triphosphate; Anesthesia; Animals; Brain; Creatine; Electric Stimulation; Glucose; Glycoge	1971
The effect of intestinal obstruction on liver microsomal enzymes in rats. Acta chirurgica Scandinavica. Supplementum, 1968, Volume: 402 Topics: Anesthesia; Animals; Body Temperature; Body Weight; Chlorpromazine; Hematocrit; Intestinal Obstructi	1968
Drug metabolism in tumor-bearing rats. II. In vivo metabolisms and effects of drugs in tumor-bearing rats. Japanese journal of pharmacology, 1968, Volume: 18, Issue:2 Topics: Anesthesia; Animals; Carcinoma 256, Walker; Carisoprodol; Cholinesterase Inhibitors; Female; Injecti	1968
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats. Japanese journal of pharmacology, 1968, Volume: 18, Issue:4 Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecti	1968
Lack of inhibitory action of aflatoxin on the induction of drug-metabolizing activities of liver microsomes by phenobarbital. Japanese journal of pharmacology, 1969, Volume: 19, Issue:3 Topics: Aflatoxins; Aminopyrine; Anesthesia; Animals; Injections, Intraperitoneal; Male; Microsomes, Liver;	1969
[Treatment principles of tetanus fromte anesthesiological viewpoint]. Langenbecks Archiv fur Chirurgie, 1969, Volume: 325 Topics: Anesthesia; Child; Diazepam; Female; Humans; Phenobarbital; Respiration, Artificial; Succinylcholine	1969
Alteration of thiopental metabolism in phenobarbital-treated calves. Toxicology and applied pharmacology, 1970, Volume: 17, Issue:2 Topics: Anesthesia; Animals; Cattle; Cornea; Male; Microsomes, Liver; Motor Activity; Phenobarbital; Protein	1970
The influence of barbiturate anaesthesia upon the energy state and upon acid-base parameters of the brain in arterial hypotension and in asphyxia. Acta neurologica Scandinavica, 1971, Volume: 47, Issue:2 Topics: Acid-Base Equilibrium; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anest	1971
Factors influencing dimethoate and triethyl phosphate-induced narcosis in rats and mice. Toxicology and applied pharmacology, 1971, Volume: 18, Issue:4 Topics: Age Factors; Anesthesia; Animals; Brain; Cholinesterase Inhibitors; Female; Glycolates; Insecticides	1971
Changes in ovarian intravascular compartment prior to superovulation in x-irradiated rats. Radiation research, 1971, Volume: 46, Issue:1 Topics: Anesthesia; Animals; Estrus; Ethers; Female; Gonadotropins, Pituitary; Ovary; Ovulation; Phenobarbit	1971
Effect of light and dark adaptation on the ERG of unanesthetized and anesthetized chicks. Poultry science, 1971, Volume: 50, Issue:2 Topics: Adaptation, Ocular; Adaptation, Physiological; Anesthesia; Animals; Chickens; Dark Adaptation; Elect	1971
Responses of the circulatory system towards the vasoactive drugs in hypothermia under different anesthesia. Die Naturwissenschaften, 1967, Volume: 54, Issue:9 Topics: Acetylcholine; Anesthesia; Animals; Blood Circulation; Cats; Epinephrine; Ergonovine; Heart; Histami	1967
[Determination of histamine based on low blood pressure induction in anesthetized rats]. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1965, Volume: 83 Topics: Anesthesia; Animals; Biological Assay; Blood Pressure; Female; Histamine; Male; Phenobarbital; Rats;	1965
Regional energy reserves in mouse brain and changes with ischaemia and anaesthesia. Journal of neurochemistry, 1966, Volume: 13, Issue:3 Topics: Acetates; Adenosine Triphosphate; Anesthesia; Animals; Brain; Cerebellar Cortex; Cerebral Cortex; Gl	1966

phenobarbital and Anesthesia

Research Excerpts

Research

Studies (100)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Other Studies

Authors	Studies
DUCK, L	1
Marks, L	1
Borland, S	1
Philp, K	1
Ewart, L	1
Lainée, P	1
Skinner, M	1
Kirk, S	1
Valentin, JP	1
KRAUSE, HJ	2
KORTUM, G	1
MORARI, M	1
KRUGER, EH	1
WIESER, F	1
CLIFFORD, DH	1
KOOK, CC	1
DEVALD, J	1
TOLNAY, S	1
CESA, R	1
MARTINELLI, G	1
BAEDEKER, WD	1
BENTLEY, HB	1
GEORGIADES, G	1
ARGALIAS, A	1
SCHAEDLICH, M	1
FAGARASANU, I	1
LEVIN, J	1
BULL, AB	1
EVANS, RE	1
LEAKE, D	1
MAYMAN, CI	1
GATFIELD, PD	2
BRECKENRIDGE, BM	1
SVANES, K	1
LEONARD, JM	1
MAURY, H	1
GREEN, VA	1
MARX, GF	1
SCHEINBERG, L	1
ROMNEY, SL	1
LEES, MH	1
MEDVEDEV, Ia	1
ROVINA, AK	1
OSTAPENKO, GI	1
SPRIGGS, TL	2
STOCKHAM, MA	1
FREEMAN, WJ	1
BEAN, JW	1
CHURCHILL-DAVIDSON, I	1
NEAL, MJ	1
KOZOLL, DD	1
MITTELPUNKT, AL	1
MEYER, KA	1
KRANTZ, JC	1
FASSEL, MJ	1
Kim, MS	1
Soh, KS	1
Nam, TC	1
Seo, KM	1
Litscher, G	1
Rothstein, S	1
Simkins, T	1
Nuñez, JL	1
Brzezinski, J	1
Kjällquist, A	1
Siesjö, BK	4
Blaustein, MP	1
Dewhurst, DG	1
Goldberg, MA	1
McIntyre, HB	1
Bleck, TP	1
Doré, F	1
Labrecque, G	1
Bélanger, PM	1
d'Auteuil, C	1
Kaneko, S	1
Napier, TC	1
Pirch, JH	1
Peterson, SL	1
Ajaya, B	1
Haranath, PS	1
Baden, JM	1
Rice, SA	1
Mazze, RI	1
Hoffman, A	2
Habib, G	1
Gilhar, D	1
Zohar, H	1
Alfon, J	1
Siegal, T	2
Noguchi, M	1
Kawai, Y	1
Bauman, RA	1
Elsayed, N	1
Petras, JM	1
Widholm, J	1
Munson, ES	1
Malagodi, MH	1
Shields, RP	1
Tham, MK	1
Fiserova-Bergerova, V	1
Holaday, DA	1
Perry, JC	1
Embro, WJ	1
Ivanetich, KM	1
Bradshaw, JJ	1
Marsh, JA	1
Harrison, GG	1
Kaminsky, LS	1
Iriuchijima, J	1
Numao, Y	1
Nordström, CH	1
Rehncrona, S	1
Bielicki, L	1
Krieglstein, J	1
Ohnhaus, EE	1
Siegl, H	1
Denis, P	1
Ossenberg, FW	1
Benhamou, JP	1
Schlosser, W	1
Zavatsky, E	1
Franco, S	1
Sigg, EB	1
Reynolds, ES	1
Moslen, MT	1
Furudate, S	1
Carlos García, R	1
Rodríguez Sasiain, JM	1
Santafé Oroz, J	1
Quintana Loyola, A	1
Segarra Doménech, J	1
Bulger, WH	1
Wells, PR	1
Roche, EB	1
Tabrizchi, R	1
Triggle, CR	1
Clough, RW	1
Aravich, PF	1
Phelps, CJ	1
Nossaman, BC	1
Amouzadeh, HR	1
Sangiah, S	1
Lundquist, F	1
Quistorff, B	1
Huang, MT	1
Cavero, I	1
Thiry, C	1
Pratz, J	1
Lawson, K	1
Lowrimore, MG	1
Porter, AB	1
Hume, AS	1
Janocko, L	1
Mycek, MJ	1
Randich, A	1
Callahan, MF	1
Chen, CF	1
Shetty, SN	1
Himes, JA	1
Edds, GT	1
Klissiunis, N	1
Paradelis, A	1
Kato, R	4
Takanaka, A	4
Voukydis, PC	1
Petri, G	1
Pórszász, J	1
Pórszász-Gibiszer, K	1
Blake, DA	1
Mergner, GW	1
Katzin, DB	1
Rubinstein, EH	1
Sonnenschein, RR	1
Miranda, CL	1
Webb, RE	1
Nilsson, L	3
Busto, R	1
Pontén, U	1
Ratcheson, RA	1
Salford, LG	1
Sieg, JW	1
Robinson, JR	1
Graber, P	1
Laurent, G	1
Tanagho, EA	1
Granholm, L	1
Kaasik, AE	1
Borella, LE	1
Herr, F	1
Paulini, K	1
Gostomzyk, JG	1
Beneke, G	1
Ahnefeld, FW	1
Brown, DR	2
Murphy, SD	2
Passonneau, JV	2
Lowry, OH	2
Kaltiala, EH	1
Oshima, T	1
Onoda, K	1
Omori, Y	1
Rügheimer, E	1
Sharma, RP	1
Stowe, CM	1
Good, AL	1
Hahn, EW	1
Ward, WF	1
Ookawa, T	1
Dey, PK	1
Mukherjee, A	1
Nagasawa, K	1
Fukuda, H	1
Schulz, DW	1