phenobarbital has been researched along with Alloxan Diabetes in 23 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the effects of phenobarbital, an inducer, on plasma glucose and serum immunoreactive insulin levels and on hepatic glucose and drug metabolism using an animal model of non-insulin dependent diabetes mellitus." | 3.67 | Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non-insulin dependent diabetes mellitus. ( Huupponen, R; Karvonen, I; Sotaniemi, EA; Stenbäck, FG; Stengård, JH, 1989) |
| " Chronic administration of PB reduced hepatic PEPCK mRNA in streptozotocin-induced diabetic and nondiabetic rats, and PB reduced blood glucose level in diabetic rats." | 1.42 | Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats. ( Kakinuma, A; Kimura, N; Oda, H; Okuda, Y; Yoshida, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oda, H | 2 |
| Okuda, Y | 1 |
| Yoshida, Y | 2 |
| Kimura, N | 2 |
| Kakinuma, A | 2 |
| DIXON, RL | 1 |
| HART, LG | 1 |
| ROGERS, LA | 1 |
| FOUTS, JR | 1 |
| Liu, H | 1 |
| Zhang, D | 1 |
| Xu, X | 1 |
| Liu, X | 1 |
| Wang, G | 1 |
| Xie, L | 1 |
| Pang, X | 1 |
| Liu, L | 1 |
| Rouer, E | 1 |
| Mahu, JL | 1 |
| Columelli, S | 1 |
| Dansette, P | 1 |
| Leroux, JP | 1 |
| Morrison, MH | 1 |
| Hawksworth, GM | 1 |
| Venkatesan, N | 1 |
| Davidson, MB | 1 |
| Simsolo, RB | 1 |
| Kern, PA | 1 |
| Varone, CL | 1 |
| Canepa, ET | 4 |
| Llambias, EB | 4 |
| Grinstein, M | 4 |
| da-Silva, CA | 1 |
| Gonçalves, AA | 1 |
| Komori, T | 1 |
| Nonaka, A | 1 |
| Maruyama, T | 1 |
| Otagiri, M | 1 |
| Ragnotti, G | 1 |
| Aletti, MG | 1 |
| Pereda, MP | 1 |
| Nedzhar, A | 1 |
| Boiadzhieva, N | 1 |
| Stoĭchev, Ts | 1 |
| Karvonen, I | 1 |
| Stengård, JH | 1 |
| Huupponen, R | 1 |
| Stenbäck, FG | 1 |
| Sotaniemi, EA | 1 |
| Galvagno, MA | 1 |
| Passeron, S | 1 |
| Zysset, T | 1 |
| Sommer, L | 1 |
| Danhof, M | 1 |
| Hisaoka, M | 1 |
| Levy, G | 1 |
| Wiśniewski, K | 1 |
| Schulze, HU | 1 |
| Staudinger, H | 1 |
| Stetten, MR | 1 |
| Ghosh, SB | 1 |
| Kato, R | 1 |
| Takahashi, A | 1 |
| Nelson, SR | 1 |
| Schulz, DW | 1 |
| Passonneau, JV | 1 |
| Lowry, OH | 1 |
23 other studies available for phenobarbital and Alloxan Diabetes
| Article | Year |
|---|---|
Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Down-Regulation; Gene Expression Profiling; | 2015 |
THE METABOLISM OF DRUGS BY LIVER MICROSOMES FROM ALLOXAN-DIABETIC RATS: LONG TERM DIABETES.
Topics: Alloxan; Aminopyrine; Aniline Compounds; Animals; Codeine; Diabetes Mellitus, Experimental; Hexobarb | 1963 |
Attenuated function and expression of P-glycoprotein at blood-brain barrier and increased brain distribution of phenobarbital in streptozotocin-induced diabetic mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain | 2007 |
Induction of drug metabolizing enzymes in the liver of diabetic mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Diabetes Mellitus, Experimental; Enzyme Induction; In Vitro T | 1982 |
Glucuronic acid conjugation by hepatic microsomal fractions isolated from streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Enzyme Induction; Female; Glucuronates; | 1984 |
Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat.
Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gluco | 1994 |
Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Culture Techniques; Cytochrome P-450 CYP2B1 | 1996 |
Glucose inhibits phenobarbital-induced delta-aminolevulinate synthase expression in normal but not in diabetic rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 5-Aminolevulinate Synthetase; Aden | 1996 |
Partial recovery of erythrocyte glycogen in diabetic rats treated with phenobarbital.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocytes; Glucuronosyltransferase; Glycogen; Hypnotics | 1997 |
Effect of clarithromycin on alpha1-acid glycoprotein levels in normal and diabetic rats.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Clarithromycin; Dexamethasone; Diabetes Me | 1998 |
Phenobarbitone-induced stimulation of protein synthesis in liver of diabetic rat.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Insulin; Liver; Male; NADPH-Ferrihemoprotein | 1978 |
Regulation of phenobarbital-induced ferrochelatase mRNA activity by dibutyryl cAMP and glucose in normal and diabetic rat hepatocytes.
Topics: Animals; Bucladesine; Diabetes Mellitus, Experimental; Enzyme Induction; Ferrochelatase; Gene Expres | 1992 |
[The mixed-function oxidase activity in male rats with a pancreatectomy].
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Diabetes Mellitus, Experimental; Enzyme Induction; Male | 1991 |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of insulin.
Topics: 5-Aminolevulinate Synthetase; Animals; Cyclic AMP; Cytochrome P-450 Enzyme System; Dexamethasone; Di | 1990 |
Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non-insulin dependent diabetes mellitus.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabete | 1989 |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats.
Topics: 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cyclic AMP; Cytochrome P-450 Enzyme System; Diab | 1985 |
Diabetes alters drug metabolism--in vivo studies in a streptozotozin-diabetic rat model.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; | 1986 |
Kinetics of drug action in disease states. VI. Effect of experimental diabetes on phenobarbital concentrations in rats at onset of loss of righting reflex.
Topics: Animals; Blood Proteins; Diabetes Mellitus, Experimental; Female; Kinetics; Phenobarbital; Postural | 1985 |
[The studies on "nonspecific transport effect" of insulin].
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Brain Chemistry; Cell Membrane Permeabilit | 1968 |
[Changes in the phospholipid content of liver microsomes following various pretreatments of rats and guinea pigs].
Topics: Animals; Cytochromes; Diabetes Mellitus, Experimental; Guinea Pigs; Methylcholanthrene; Microsomes, | 1970 |
Different properties of glucose-6-phosphatase and related enzymes in rough and smooth endoplasmic reticular membranes.
Topics: Animal Nutritional Physiological Phenomena; Animals; Bile Acids and Salts; Diabetes Mellitus, Experi | 1971 |
Effect of phenobarbital on the activities of drug-metabolizing enzymes and electron transport system of liver microsomes in alloxan diabetes and thyroxine treated rats.
Topics: Animals; Diabetes Mellitus, Experimental; Electron Transport; Female; Liver; Microsomes; Organ Size; | 1969 |
Control of glycogen levels in brain.
Topics: Animals; Blood Glucose; Body Temperature; Brain Chemistry; Diabetes Mellitus, Experimental; Glucose; | 1968 |