phenobarbital has been researched along with Alcoholism in 82 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In severely jaundiced patients (serum bilirubin concentrations greater than 140 mumol/l) a markedly decreased or absent uptake of 99mTc-EHIDA was observed." | 3.66 | The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. ( Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ, 1983) |
| "The effect of phenobarbital (PB) pretreatment and of chronic alcoholism on blood ethanol elimination rate (BEER) was investigated in man." | 3.66 | Alcohol metabolism in man: effect of intravenous fructose infusion on blood ethanol elimination rate following stimulation by phenobarbital treatment or chronic alcohol consumption. ( Bode, C; Bode, JC; Thiele, D, 1979) |
| "Phenobarbital (PB) has been acknowledged among clinicians as a potential alternative to benzodiazepines (BZD) to decrease the need for hospital length of stay and complications associated with alcohol withdrawal syndrome (AWS)." | 3.01 | Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome. ( Choi, H; Colgan, B; Kistler, H; Mercado, F; Nishimura, Y, 2023) |
| "Secondary outcomes such as rates of seizures, hospital, and ICU length of stay (LOS), also were included." | 3.01 | Evaluation of phenobarbital based approach in treating patient with alcohol withdrawal syndrome: A systematic review and meta-analysis. ( AlRemeithi, R; Bronstein, D; Kartiko, S; Pourmand, A; Tran, QK, 2023) |
| "Propofol is a viable alternative for patients refractory to benzodiazepines; however, the role of other agents remains unclear." | 2.53 | Treatment of Severe Alcohol Withdrawal. ( Cadiz, M; Doshi, MR; Holzhausen, JM; Natavio, A; Schmidt, KJ; Winegardner, JE, 2016) |
| "The acquired immunodeficiency syndrome (AIDS) has recently emerged as a serious medical complication of parenteral substance abuse." | 2.37 | Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics. ( Novick, DM, 1984) |
| " Further research is needed to identify an optimal dosing strategy for TSCU patients at high risk for severe AWS." | 1.91 | Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Critically Ill, Surgical-Trauma Patients. ( Chau, T; Chuang, L; Goldenberg-Sandau, A; Igneri, L; Pham, C; Sensenig, R; Solomon, D, 2023) |
| "There was no incidence of delirium tremens or seizures and no difference in intubation rates ( p = 0." | 1.91 | Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients. ( Dorfman, JD; Forni, A; Kip, LM; Li, I, 2023) |
| "Treatment with phenobarbital, alone or in combination with benzodiazepines, was associated with significantly lower odds of a return ED visit within three days compared with benzodiazepines alone [AOR 0." | 1.72 | Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal. ( Lebin, JA; Mudan, A; Murphy, CE; Smollin, CG; Wang, RC, 2022) |
| " The purpose of this study was to compare the incidence of mechanical ventilation in patients with benzodiazepine-resistant alcohol withdrawal between front-loaded and low-intermittent phenobarbital dosing strategies." | 1.72 | Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome. ( Dodd, KW; Hanif, T; Rachid, M; Shah, P; Stegner-Smith, KL, 2022) |
| "Phenobarbital has been shown to be an effective adjunctive therapy for AWS, reducing benzodiazepine use, in the emergency department." | 1.56 | Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit. ( Lam, SW; Nguyen, TA, 2020) |
| "Phenobarbital treatment was associated with decreased mortality, which might be confounded by somatic comorbidity among patients receiving chlordiazepoxide." | 1.43 | Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality. ( Askgaard, G; Fink-Jensen, A; Hallas, J; Madsen, KG; Molander, AC; Pottegård, A, 2016) |
| "Pyrazole treatment produced an identical 3- to 4-fold increase in content and catalytic activity of P450 2E1 in the two lines." | 1.28 | The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. ( Cederbaum, AI; Winters, DK, 1992) |
| "The development of withdrawal seizures depended on repeated episodes of withdrawal, whereas repeated alcohol intoxication per se did not explain the development of seizures." | 1.28 | Convulsive behaviour during alcohol dependence: discrimination between the role of intoxication and withdrawal. ( Clemmesen, L; Hemmingsen, R; Ulrichsen, J, 1992) |
| "Baclofen was largely ineffective in reducing withdrawal-induced tremors, although it was capable of producing sedation of a different type than that produced by phenobarbitol and ethanol." | 1.26 | The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey. ( Tarika, JS; Winger, G, 1980) |
| "The effects of acute and chronic administration of D-Galactosamine (GalN), Ethanol and Phenobarbital were investigated on the activities of lysosomal enzymes, i." | 1.26 | [Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)]. ( Sato, R, 1978) |
| " The results do not support the hypothesis, at least not in the case of dopamine, that a postjunctional supersensitivity to neurotransmitters is important for withdrawal symptoms after chronic administration of drugs inducing physical dependence." | 1.26 | Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal. ( Kuschinsky, K; Seeber, U, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (59.76) | 18.7374 |
| 1990's | 12 (14.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (8.54) | 24.3611 |
| 2020's | 14 (17.07) | 2.80 |
| Authors | Studies |
|---|---|
| Lebin, JA | 1 |
| Mudan, A | 1 |
| Murphy, CE | 1 |
| Wang, RC | 1 |
| Smollin, CG | 1 |
| Staidle, A | 1 |
| Geier, C | 1 |
| Pistore, A | 1 |
| Penney, S | 1 |
| Bryce, R | 1 |
| Meyer, C | 1 |
| Bouchard, B | 1 |
| Shah, P | 1 |
| Stegner-Smith, KL | 1 |
| Rachid, M | 1 |
| Hanif, T | 1 |
| Dodd, KW | 1 |
| Bosch, NA | 2 |
| Law, AC | 1 |
| Walkey, AJ | 2 |
| Ware, LR | 1 |
| Schuler, BR | 1 |
| Goodberlet, MZ | 1 |
| Marino, KK | 1 |
| Lupi, KE | 1 |
| DeGrado, JR | 1 |
| Pham, C | 1 |
| Goldenberg-Sandau, A | 1 |
| Sensenig, R | 1 |
| Chau, T | 1 |
| Igneri, L | 1 |
| Solomon, D | 1 |
| Chuang, L | 1 |
| Nishimura, Y | 1 |
| Choi, H | 1 |
| Colgan, B | 1 |
| Kistler, H | 1 |
| Mercado, F | 1 |
| Terasaki, D | 1 |
| Kulick, B | 1 |
| Calcaterra, S | 1 |
| Ray, L | 1 |
| Pourmand, A | 1 |
| AlRemeithi, R | 1 |
| Kartiko, S | 1 |
| Bronstein, D | 1 |
| Tran, QK | 1 |
| Kip, LM | 1 |
| Forni, A | 1 |
| Dorfman, JD | 1 |
| Li, I | 1 |
| Murphy, JA | 1 |
| Curran, BM | 1 |
| Gibbons, WA | 1 |
| Harnica, HM | 1 |
| Crable, EL | 1 |
| Ackerbauer, KA | 1 |
| Clark, K | 1 |
| Drainoni, ML | 1 |
| Grim, V | 1 |
| Ieong, MH | 1 |
| Murphy, J | 1 |
| Nelson, AC | 1 |
| Kaucher, KA | 1 |
| Sankoff, J | 1 |
| Mintzer, D | 1 |
| Taub, J | 1 |
| Kehoe, J | 1 |
| Lee, JA | 1 |
| Duby, JJ | 1 |
| Cocanour, CS | 1 |
| Fenves, AZ | 1 |
| Mojtahed, A | 1 |
| Nisavic, M | 1 |
| Massoth, LR | 1 |
| Nguyen, TA | 1 |
| Lam, SW | 1 |
| Schmidt, KJ | 1 |
| Doshi, MR | 1 |
| Holzhausen, JM | 1 |
| Natavio, A | 1 |
| Cadiz, M | 1 |
| Winegardner, JE | 1 |
| Askgaard, G | 1 |
| Hallas, J | 1 |
| Fink-Jensen, A | 1 |
| Molander, AC | 1 |
| Madsen, KG | 1 |
| Pottegård, A | 1 |
| Riggan, MA | 1 |
| Hayman, K | 1 |
| Chen, BC | 1 |
| Hoffman, RS | 1 |
| Long, D | 1 |
| Long, B | 1 |
| Koyfman, A | 1 |
| JOYCE, CR | 1 |
| EDGECOMBE, PC | 1 |
| KENNARD, DA | 1 |
| WEATHERALL, M | 1 |
| WOODS, DP | 1 |
| WARIN, EM | 1 |
| LEVY, HA | 1 |
| BODI, T | 1 |
| SIEGLER, PE | 1 |
| SLAP, J | 1 |
| NODINE, JH | 1 |
| Olesen, OV | 1 |
| Ishii, H | 2 |
| Okuno, F | 1 |
| Shigeta, Y | 1 |
| Yasuraoka, S | 1 |
| Ebihara, Y | 1 |
| Takagi, T | 1 |
| Tsuchiya, M | 1 |
| Novick, DM | 1 |
| Ohnishi, K | 1 |
| Mishima, A | 1 |
| Hatano, H | 1 |
| Saito, M | 1 |
| Nakayama, T | 1 |
| Hiyama, Y | 1 |
| Tsuchiya, S | 1 |
| Nomura, F | 1 |
| Kono, K | 1 |
| Ohtsuki, T | 1 |
| Hirayama, C | 1 |
| Horie, Y | 1 |
| Tarika, JS | 1 |
| Winger, G | 1 |
| Coenegracht, JM | 1 |
| Oei, TL | 1 |
| van Breda Vriesman, PJ | 1 |
| Linder, M | 1 |
| Schwarz, E | 1 |
| Kielholz, P | 1 |
| Hobi, V | 1 |
| Goldberg, L | 2 |
| Hofstetter, M | 1 |
| Ladewig, D | 2 |
| Goldberg, DM | 1 |
| Cohen, MS | 1 |
| Mackenzie, TB | 1 |
| Collins, NM | 1 |
| Popkin, ME | 1 |
| Tampier, L | 1 |
| Quintanilla, ME | 1 |
| Mardones, J | 1 |
| Lau, CE | 1 |
| Tang, M | 1 |
| Falk, JL | 1 |
| Rodríguez-Martos, A | 1 |
| Binder, D | 1 |
| Jost, R | 1 |
| Flury, R | 1 |
| Salomon, F | 1 |
| Bhagwat, SV | 1 |
| Boyd, MR | 1 |
| Ravindranath, V | 1 |
| Rosenthal, RN | 1 |
| Perkel, C | 1 |
| Singh, P | 1 |
| Anand, O | 1 |
| Miner, CR | 1 |
| Joly, JG | 1 |
| Feinman, L | 1 |
| Lieber, CS | 4 |
| Rodgers, JE | 1 |
| Crouch, MA | 1 |
| Sato, R | 1 |
| Nambara, K | 1 |
| Bode, JC | 2 |
| Bode, C | 2 |
| Thiele, D | 2 |
| Seixas, FA | 1 |
| Yanaura, S | 1 |
| Suzuki, T | 1 |
| Teijeiro, J | 2 |
| Seeber, U | 1 |
| Kuschinsky, K | 1 |
| Rodin, EA | 1 |
| Lucas, D | 2 |
| Ménez, JF | 2 |
| Berthou, F | 2 |
| Cauvin, JM | 1 |
| Deitrich, RA | 2 |
| Piepho, R | 1 |
| Whelton, A | 1 |
| Mayor, G | 1 |
| Neu, H | 1 |
| Laddu, A | 1 |
| Winters, DK | 1 |
| Cederbaum, AI | 1 |
| Ulrichsen, J | 1 |
| Clemmesen, L | 1 |
| Hemmingsen, R | 1 |
| Stibler, H | 1 |
| Beaugé, F | 1 |
| Leguicher, A | 1 |
| Borg, S | 1 |
| Winston, GW | 1 |
| Narayan, S | 1 |
| Bounds, PL | 1 |
| Dreano, Y | 1 |
| Floch, HH | 1 |
| Schwarz-Ottersbach, E | 1 |
| Lé, CT | 1 |
| Igra, J | 1 |
| Rubin, E | 3 |
| Haschen, RJ | 1 |
| Wesson, DR | 1 |
| Smith, DE | 1 |
| Lerner, SE | 1 |
| Kettner, VR | 1 |
| De Matteis, F | 1 |
| Porta, EA | 1 |
| Koch, OR | 1 |
| Hartroft, WS | 1 |
| Altman, H | 1 |
| Evenson, RC | 1 |
| Sletten, IW | 1 |
| Cho, DW | 1 |
| Hepner, GW | 1 |
| Vesell, ES | 1 |
| Smith, SE | 1 |
| Freund, G | 1 |
| Miletto, G | 1 |
| Pelkonen, O | 1 |
| Jouppila, P | 1 |
| Kärki, NT | 1 |
| Carroll, BJ | 1 |
| Descloux, A | 1 |
| Knott, DH | 1 |
| Beard, JD | 1 |
| Bruncsák, A | 1 |
| Timár, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for phenobarbital and Alcoholism
| Article | Year |
|---|---|
Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Prospective Studies | 2023 |
Evaluation of phenobarbital based approach in treating patient with alcohol withdrawal syndrome: A systematic review and meta-analysis.
Topics: Adult; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Prospective Studies; Retrospective Studie | 2023 |
Adjunctive Phenobarbital for Alcohol Withdrawal Syndrome: A Focused Literature Review.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Substance W | 2021 |
Treatment of Severe Alcohol Withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dexmedetomidine; Drug Thera | 2016 |
The emergency medicine management of severe alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dose-Response Relationship, | 2017 |
Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics.
Topics: Acquired Immunodeficiency Syndrome; Alcoholism; Homosexuality; Humans; Hypnotics and Sedatives; Infe | 1984 |
[Disorders of calcium and phosphorus metabolism in biliary tract diseases].
Topics: Adrenal Cortex Hormones; Alcoholism; Biliary Tract Diseases; Calcium; Calcium Metabolism Disorders; | 1982 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
Drug abuse in pregnancy: fetal ad neonatal effects.
Topics: Alcoholism; Birth Weight; Chlorpromazine; Diazepam; Female; Fetus; Humans; Infant, Newborn; Infant, | 1982 |
Phenobarbital for alcohol withdrawal syndrome.
Topics: Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Substance Withdrawal Syndrome | 1999 |
Ethanol metabolism in the liver.
Topics: Alcohol Oxidoreductases; Alcoholism; Animals; Biological Transport; Catalase; Depression, Chemical; | 1972 |
[Progress in diagnostic enzymology].
Topics: Alcoholism; Aminopeptidases; Amylases; Aspartate Aminotransferases; Cholinesterases; Creatine Kinase | 1973 |
Toxic hepatic porphyrias.
Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc | 1968 |
Recent advances in molecular pathology: a review of the effects of alcohol on the liver.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Butyrates; Chemical and Drug Induced Liv | 1970 |
5 trials available for phenobarbital and Alcoholism
| Article | Year |
|---|---|
Changes in EEG, blood levels, mood scales and performance scores during long term treatment with diazepam, phenobarbital or placebo in patients.
Topics: Adult; Alcoholism; Arousal; Diazepam; Electroencephalography; Emotions; Humans; Middle Aged; Phenoba | 1982 |
A pilot open randomized trial of valproate and phenobarbital in the treatment of acute alcohol withdrawal.
Topics: Adult; Affect; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Dose-Response Relationship, | 1998 |
[A double blind comparative study of atrium 300 and heminiurine in chronic alcoholics].
Topics: Alcoholism; Barbiturates; Chlormethiazole; Chronic Disease; Clinical Trials as Topic; Drug Combinati | 1975 |
[A comparative double-blind study of atrium 300 and hemineurine in chronic alcoholics (author's transl)].
Topics: Alcoholism; Barbiturates; Chlormethiazole; Drug Combinations; Humans; Phenobarbital; Psychotropic Dr | 1976 |
Treatment- and task-induced changes in interhemispheric EEG.
Topics: Alcoholism; Brain; Diazepam; Electroencephalography; Functional Laterality; Humans; Male; Phenobarbi | 1989 |
63 other studies available for phenobarbital and Alcoholism
| Article | Year |
|---|---|
Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal.
Topics: Alcoholism; Benzodiazepines; Emergency Service, Hospital; Humans; Phenobarbital; Retrospective Studi | 2022 |
Phenobarbital and/or benzodiazepines for recurrent alcohol withdrawal: A self-controlled, retrospective cohort study.
Topics: Alcoholism; Benzodiazepines; Humans; Hypotension; Phenobarbital; Retrospective Studies; Substance Wi | 2022 |
A retrospective evaluation of phenobarbital versus benzodiazepines for treatment of alcohol withdrawal in a regional Canadian emergency department.
Topics: Adult; Alcoholism; Benzodiazepines; Canada; Emergency Service, Hospital; Humans; Length of Stay; Phe | 2022 |
Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Ethanol; Humans; Hypnotics and Sedatives; | 2022 |
Phenobarbital for Severe Alcohol Withdrawal Syndrome: A Multicenter Retrospective Cohort Study.
Topics: Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Retrospective Studies; Substance Withdra | 2022 |
Evaluation of Dexmedetomidine as an Adjunct to Phenobarbital for Alcohol Withdrawal in Critically Ill Patients.
Topics: Adult; Alcoholism; Benzodiazepines; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics a | 2023 |
Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Critically Ill, Surgical-Trauma Patients.
Topics: Alcoholism; Benzodiazepines; Critical Illness; Humans; Phenobarbital; Retrospective Studies; Substan | 2023 |
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.
Topics: Alcoholism; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opi | 2023 |
Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Retrospectiv | 2023 |
Implementation of a Phenobarbital-based Pathway for Severe Alcohol Withdrawal: A Mixed-Method Study.
Topics: Alcoholism; Humans; Length of Stay; Phenobarbital; Retrospective Studies; Substance Withdrawal Syndr | 2021 |
Incorporating phenobarbital into your symptom-based benzodiazepine alcohol withdrawal protocol in the emergency department.
Topics: Alcoholism; Benzodiazepines; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Phenoba | 2018 |
Effect of early and focused benzodiazepine therapy on length of stay in severe alcohol withdrawal syndrome.
Topics: Academic Medical Centers; Adult; Alcoholism; Benzodiazepines; Cohort Studies; Diazepam; Female; Huma | 2019 |
Case 13-2019: A 54-Year-Old Man with Alcohol Withdrawal and Altered Mental Status.
Topics: 2-Propanol; Acetone; Acid-Base Equilibrium; Acidosis; Alcohol Withdrawal Delirium; Alcoholism; Diagn | 2019 |
Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit.
Topics: Adult; Aged; Alcoholism; Central Nervous System Agents; Drug Therapy, Combination; Ethanol; Female; | 2020 |
Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality.
Topics: Adult; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort Studies; Ethanol; Female; GABA Modulato | 2016 |
Regarding "Phenobarbital for Acute Alcohol Withdrawal: A Prospective Randomized Double-Blind Placebo-Controlled Study".
Topics: Alcoholism; Double-Blind Method; Humans; Phenobarbital; Prospective Studies; Substance Withdrawal Sy | 2016 |
Potentiation by phenobarbitone of effects of ethyl alcohol on human behaviour.
Topics: Alcoholism; Behavior; Ethanol; Humans; Pharmacology; Phenobarbital | 1959 |
WERNICKE'S ENCEPHALOPATHY AND ALCOHOLISM. THE COURSE AND TREATMENT OF AN UNUSUAL CASE.
Topics: Alcoholism; Chlorpromazine; Humans; Korsakoff Syndrome; Nursing; Occupational Therapy; Penicillins; | 1963 |
CHLORPROTHIXENE: A NEW NON-PHENOTHIAZINE ATARACTIC AGENT: SPECTRUM IN THE OUTPATIENT THERAPY OF PSYCHONEUROSIS.
Topics: Alcoholism; Anxiety; Anxiety Disorders; Chlorprothixene; Fluphenazine; Humans; Neurotic Disorders; O | 1963 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Female; gamma-Glutamyltransferase; Humans; Memb | 1980 |
[Effect of chronic ethanol feeding on the amount of phenobarbital inducible form of cytochrome P-450 and its localization in the hepatic lobule of the rat].
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Histocytochemistry; Humans; Liver; Male; Phenob | 1983 |
The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey.
Topics: Alcoholism; Animals; Ataxia; Baclofen; Behavior, Animal; Drug Interactions; Ethanol; Humans; Macaca | 1980 |
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans.
Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Ph | 1983 |
[Epileptic seizures in chronic alcoholism].
Topics: Alcoholism; Epilepsy; Humans; Phenobarbital; Substance Withdrawal Syndrome | 1983 |
A case of fetal abuse?
Topics: Adult; Alcoholism; Child Abuse; Chlorthalidone; Female; Fetus; Humans; Maternal-Fetal Relations; Mor | 1982 |
Genetic differences in tolerance to ethanol: a study in UChA and UChB rats.
Topics: Alcoholism; Animals; Drug Tolerance; Ethanol; Female; Humans; Latency Period, Psychological; Male; P | 1981 |
Cross-tolerance to phenobarbital following chronic ethanol polydipsia.
Topics: Alcoholism; Animals; Discrimination Learning; Drug Tolerance; Ethanol; Humans; Male; Phenobarbital; | 1981 |
[The medical treatment of the alcoholic--it's value and importance, shown with Atrium (author's transl)].
Topics: Adult; Alcoholism; Ambulatory Care; Barbiturates; Drug Combinations; Female; Humans; Male; Middle Ag | 1980 |
[Anxiolytic agents in alcoholism].
Topics: Alcoholism; Anti-Anxiety Agents; Anxiety; Barbiturates; Drug Combinations; Humans; Phenobarbital; Ps | 1994 |
[Acute liver failure following tetrabamate].
Topics: Adult; Alcoholism; Barbiturates; Drug Combinations; Female; Humans; Liver; Liver Failure, Acute; Liv | 1995 |
Brain mitochondrial cytochromes P450: xenobiotic metabolism, presence of multiple forms and their selective inducibility.
Topics: 7-Alkoxycoumarin O-Dealkylase; Alcoholism; Aminopyrine N-Demethylase; Animals; Brain; Cytochrome P-4 | 1995 |
Effect of chronic ethanol feeding on hepatic microsomal glycerophosphate acyltransferase activity.
Topics: Alcoholism; Animals; Dietary Fats; Fatty Liver, Alcoholic; Female; Glycerol-3-Phosphate O-Acyltransf | 1973 |
[Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)].
Topics: Acetylglucosaminidase; Acid Phosphatase; Adenosine Triphosphatases; Alcoholism; Animals; Anticonvuls | 1978 |
[Clinical and experimental studies on the enzymes of liver, small intestinal mucosa and pancreas after chronic ethanol ingestion and anti-epileptic drugs (author's transl)].
Topics: Alcoholism; Animals; Glucaric Acid; Humans; Intestinal Mucosa; Intestine, Small; Liver; Male; NADPH- | 1979 |
Alcohol metabolism in man: effect of intravenous fructose infusion on blood ethanol elimination rate following stimulation by phenobarbital treatment or chronic alcohol consumption.
Topics: Adult; Aged; Alcoholism; Blood Glucose; Ethanol; Fructose; Humans; Infusions, Parenteral; Lactates; | 1979 |
Drug/alcohol interactions: avert potential dangers.
Topics: Aged; Aging; Alcohol Drinking; Alcoholism; Antidepressive Agents, Tricyclic; Aspirin; California; Di | 1979 |
Cross-dependence between phenobarbital and alcohol in rats.
Topics: Alcoholism; Animals; Body Weight; Humans; Male; Phenobarbital; Rats; Substance Withdrawal Syndrome; | 1977 |
Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Corpus Striatum; Dopamine; Humans; Male; Phenobarbital; Rats | 1976 |
Psychosocial management of patients with complex partial seizures.
Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E | 1975 |
Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Me | 1992 |
Grand mal status epilepticus.
Topics: Alcoholism; Anticonvulsants; Diazepam; Epilepsy, Tonic-Clonic; Ethanol; Humans; Lorazepam; Male; Mid | 1992 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; M | 1992 |
Convulsive behaviour during alcohol dependence: discrimination between the role of intoxication and withdrawal.
Topics: Alcoholism; Analysis of Variance; Animals; Behavior, Animal; Male; Phenobarbital; Rats; Rats, Inbred | 1992 |
Biophysical and biochemical alterations in erythrocyte membranes from chronic alcoholics.
Topics: Adult; Alcoholism; Biophysical Phenomena; Biophysics; Drug Tolerance; Erythrocyte Membrane; Ethanol; | 1991 |
Profiles of ethanol-induced microsomal alkoxyresorufin (alkoxyphenoxazone) O-dealkylation: comparison with phenobarbital- and Aroclor 1254-induced systems.
Topics: Alcoholism; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2B1; Cytochrome P- | 1990 |
Ethanol-inducible cytochrome P-450: assessment of substrates' specific chemical probes in rat liver microsomes.
Topics: Acetone; Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; | 1990 |
Shifting CNS symptoms in a chronic alcoholic.
Topics: Adult; Alcoholism; Central Nervous System Diseases; Cysticercosis; Dexamethasone; Humans; Male; Phen | 1985 |
Treatment of polydrug users in San Francisco.
Topics: Adult; Aftercare; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; California; Crisis Intervention; | 1974 |
Patterns of psychotropic drug prescription in four midwestern state hospitals.
Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Computers; Drug Utilization | 1972 |
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
Topics: Administration, Oral; Adult; Aged; Alcoholism; Aminopyrine; Breath Tests; Carbon Dioxide; Carbon Rad | 1974 |
[Changes in the speed of alcohol catabolism in man due to phenobarbital, chronic alcohol consumption and fasting].
Topics: Alcoholism; Chronic Disease; Ethanol; Fasting; Humans; Liver; Phenobarbital; Time Factors | 1974 |
Genetic basis of phenobarbital-induced increase in aldehyde dehydrogenase: implications for alcohol research.
Topics: Alcohol Drinking; Alcoholism; Aldehydes; Animals; Enzyme Induction; Genotype; Humans; Inbreeding; Li | 1972 |
Taste thresholds in drug addicts and alcoholics.
Topics: Adult; Alcoholism; Amphetamine; Female; Humans; Male; Nicotiana; Phenobarbital; Plants, Toxic; Quini | 1972 |
Alcohol, barbiturate, and bromide withdrawal syndromes in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Barbiturates; Body Weight; Bromides; Diet; Disease Models, An | 1973 |
[A very special drug in acute or chronic alcoholism].
Topics: Administration, Oral; Alcoholism; Barbiturates; Chronic Disease; Drug Combinations; Humans; Phenobar | 1972 |
Attempts to induce drug metabolism in human fetal liver and placenta by the administration of phenobarbital to mothers.
Topics: Adult; Alcoholism; Aniline Compounds; Benzoates; Benzopyrenes; Chlorpromazine; Female; Humans; Liver | 1973 |
Barbiturate overdosage: presentation with focal neurological signs.
Topics: Adult; Alcoholism; Amobarbital; Barbiturates; Basilar Artery; Bromides; Cerebral Hemorrhage; Coma; C | 1969 |
[Treatment of the psychosyndrome of alcoholic withdrawal using Atrium].
Topics: Aggression; Alcoholism; Anxiety; Barbiturates; Depression; Drug Combinations; Drug Evaluation; Human | 1971 |
Diagnosis and therapy of acute withdrawal from alcohol.
Topics: Acute Disease; Adult; Alcoholism; Anti-Bacterial Agents; Anticonvulsants; Carbohydrate Metabolism; C | 1970 |
Alcoholism, alcohol, and drugs.
Topics: Alcoholism; Animals; Calorimetry; Chemical and Drug Induced Liver Injury; Diet; Drug Antagonism; Dru | 1971 |
[On acute isoniazid poisoning on the basis of 2 successfully treated cases].
Topics: Adult; Alcoholism; Blood Transfusion; Brain; Brain Edema; Gastric Lavage; Glucose; Glutamates; Human | 1967 |
Alcohol, other drugs, and the liver.
Topics: Alcoholism; Animals; Central Nervous System; Chemical and Drug Induced Liver Injury; Ethanol; Humans | 1968 |