phenobarbital has been researched along with Alcohol Withdrawal Associated Autonomic Hyperactivity in 27 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital (PB) has been acknowledged among clinicians as a potential alternative to benzodiazepines (BZD) to decrease the need for hospital length of stay and complications associated with alcohol withdrawal syndrome (AWS)." | 3.01 | Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome. ( Choi, H; Colgan, B; Kistler, H; Mercado, F; Nishimura, Y, 2023) |
| "Propofol is a viable alternative for patients refractory to benzodiazepines; however, the role of other agents remains unclear." | 2.53 | Treatment of Severe Alcohol Withdrawal. ( Cadiz, M; Doshi, MR; Holzhausen, JM; Natavio, A; Schmidt, KJ; Winegardner, JE, 2016) |
| "There was no incidence of delirium tremens or seizures and no difference in intubation rates ( p = 0." | 1.91 | Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients. ( Dorfman, JD; Forni, A; Kip, LM; Li, I, 2023) |
| " The purpose of this study was to compare the incidence of mechanical ventilation in patients with benzodiazepine-resistant alcohol withdrawal between front-loaded and low-intermittent phenobarbital dosing strategies." | 1.72 | Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome. ( Dodd, KW; Hanif, T; Rachid, M; Shah, P; Stegner-Smith, KL, 2022) |
| "Phenobarbital has similar pharmacokinetics to select benzodiazepines frequently used for alcohol withdrawal." | 1.51 | Benzodiazepines vs barbiturates for alcohol withdrawal: Analysis of 3 different treatment protocols. ( Kaucher, KA; Kehoe, J; Mintzer, D; Nelson, AC; Sankoff, J; Taub, J, 2019) |
| "Phenobarbital is a safe alternative to diazepam in the treatment of DT." | 1.36 | Phenobarbital versus diazepam for delirium tremens--a retrospective study. ( Allerup, P; Anderson, JE; Fink-Jensen, A; Hjermø, I; Ulrichsen, J, 2010) |
| "The manifestations of delirium tremens persisted with titration of a lorazepam infusion in excess of 40 mg/hour." | 1.35 | Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome. ( Bolton, PJ; Hayner, CE; Wuestefeld, NL, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 4 (14.81) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, P | 1 |
| Stegner-Smith, KL | 1 |
| Rachid, M | 1 |
| Hanif, T | 1 |
| Dodd, KW | 1 |
| Nishimura, Y | 1 |
| Choi, H | 1 |
| Colgan, B | 1 |
| Kistler, H | 1 |
| Mercado, F | 1 |
| Kip, LM | 1 |
| Forni, A | 1 |
| Dorfman, JD | 1 |
| Li, I | 1 |
| Murphy, JA | 1 |
| Curran, BM | 1 |
| Gibbons, WA | 1 |
| Harnica, HM | 1 |
| Tidwell, WP | 1 |
| Thomas, TL | 1 |
| Pouliot, JD | 1 |
| Canonico, AE | 1 |
| Webber, AJ | 1 |
| Sullivan, SM | 1 |
| Dewey, BN | 1 |
| Jarrell, DH | 1 |
| Vadiei, N | 1 |
| Patanwala, AE | 1 |
| Nelson, AC | 1 |
| Kehoe, J | 1 |
| Sankoff, J | 1 |
| Mintzer, D | 1 |
| Taub, J | 1 |
| Kaucher, KA | 1 |
| Fenves, AZ | 1 |
| Mojtahed, A | 1 |
| Nisavic, M | 1 |
| Massoth, LR | 1 |
| Schmidt, KJ | 1 |
| Doshi, MR | 1 |
| Holzhausen, JM | 1 |
| Natavio, A | 1 |
| Cadiz, M | 1 |
| Winegardner, JE | 1 |
| Askgaard, G | 1 |
| Pottegård, A | 1 |
| Fink-Jensen, A | 2 |
| Long, D | 1 |
| Long, B | 1 |
| Koyfman, A | 1 |
| Lützen, L | 1 |
| Poulsen, LM | 1 |
| Ulrichsen, J | 2 |
| Becker, U | 1 |
| Meyer, CN | 1 |
| Benjaminsen, SE | 1 |
| Ruha, AM | 1 |
| Brooks, DE | 1 |
| Curry, SC | 1 |
| Hayner, CE | 1 |
| Wuestefeld, NL | 1 |
| Bolton, PJ | 1 |
| Hjermø, I | 1 |
| Anderson, JE | 1 |
| Allerup, P | 1 |
| Gold, JA | 1 |
| Rimal, B | 1 |
| Nolan, A | 1 |
| Nelson, LS | 1 |
| Skrobik, Y | 1 |
| Hayanga, A | 1 |
| Weiss, E | 1 |
| Rosenthal, RN | 1 |
| Perkel, C | 1 |
| Singh, P | 1 |
| Anand, O | 1 |
| Miner, CR | 1 |
| Prater, CD | 1 |
| Miller, KE | 1 |
| Zylstra, RG | 1 |
| Horsmans, Y | 1 |
| Larrey, D | 1 |
| Pessayre, D | 1 |
| Rueff, B | 1 |
| Degott, C | 1 |
| Benhamou, JP | 1 |
| Crabbe, JC | 1 |
| Young, ER | 1 |
| Tam, B | 1 |
| Kosobud, A | 1 |
| Belknap, JK | 1 |
| Laursen, SE | 1 |
| Young, GP | 1 |
| Rores, C | 1 |
| Murphy, C | 1 |
| Dailey, RH | 1 |
| Flügel, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for phenobarbital and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Prospective Studies | 2023 |
Adjunctive Phenobarbital for Alcohol Withdrawal Syndrome: A Focused Literature Review.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Humans; Hypnotics and Sedatives; Phenobarbital; Substance W | 2021 |
Treatment of Severe Alcohol Withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dexmedetomidine; Drug Thera | 2016 |
[Benzodiazepines should still be first-line treatment for alcohol withdrawal].
Topics: Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Barbiturates; Benzodiazepines; Chlordiazep | 2017 |
The emergency medicine management of severe alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dose-Response Relationship, | 2017 |
Outpatient detoxification of the addicted or alcoholic patient.
Topics: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Ambulatory Care; Anti-Anxiety Agents; Chlordiaz | 1999 |
1 trial available for phenobarbital and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
A pilot open randomized trial of valproate and phenobarbital in the treatment of acute alcohol withdrawal.
Topics: Adult; Affect; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Dose-Response Relationship, | 1998 |
20 other studies available for phenobarbital and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Ethanol; Humans; Hypnotics and Sedatives; | 2022 |
Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Retrospectiv | 2023 |
Treatment of Alcohol Withdrawal Syndrome: Phenobarbital vs CIWA-Ar Protocol.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Benzodiazepines; Clinical Protocols; Drug Therapy, Combina | 2018 |
Comparison of phenobarbital-adjunct versus benzodiazepine-only approach for alcohol withdrawal syndrome in the ED.
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Emergency Service, Hospital; Female; Hospitalization; | 2019 |
Benzodiazepines vs barbiturates for alcohol withdrawal: Analysis of 3 different treatment protocols.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Benzodiazepines; Clinical Protocols; Colorado; Drug Therap | 2019 |
Case 13-2019: A 54-Year-Old Man with Alcohol Withdrawal and Altered Mental Status.
Topics: 2-Propanol; Acetone; Acid-Base Equilibrium; Acidosis; Alcohol Withdrawal Delirium; Alcoholism; Diagn | 2019 |
[Respiratory depression in delirium tremens patients treated with phenobarbital. A retrospective study].
Topics: Adult; Alcohol Withdrawal Delirium; Anticonvulsants; Female; Humans; Hypnotics and Sedatives; Male; | 2008 |
[Is the Earth round or flat as a pancake?].
Topics: Alcohol Withdrawal Delirium; Anticonvulsants; Humans; Hypnotics and Sedatives; Phenobarbital; Respir | 2008 |
[Phenobarbital and delirium tremens].
Topics: Alcohol Withdrawal Delirium; Anticonvulsants; Humans; Hypnotics and Sedatives; Phenobarbital; Respir | 2008 |
[Phenemal and alcoholic ketoacidosis].
Topics: Alcohol Withdrawal Delirium; Anticonvulsants; Cause of Death; Humans; Hypnotics and Sedatives; Ketos | 2008 |
Letters on "Predictors of mortality in patients with delerium tremens".
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Drug Resistance; Ethanol; GABA Modulators; GABA-A Rece | 2009 |
Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome.
Topics: Adult; Alcohol Withdrawal Delirium; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hypno | 2009 |
Phenobarbital versus diazepam for delirium tremens--a retrospective study.
Topics: Alcohol Withdrawal Delirium; Diazepam; Female; Humans; Hypnotics and Sedatives; Male; Phenobarbital; | 2010 |
A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens.
Topics: Adult; Alcohol Withdrawal Delirium; Cohort Studies; Cross Infection; Diazepam; Dose-Response Relatio | 2007 |
Protocols, practice, and patients--the case of alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Conscious Sedation; Diazepam; Dose-Response Relationship, Drug; Drug Th | 2007 |
A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens.
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Drug Therapy, Combination; Humans; Hypnotics and Sedat | 2007 |
[Atrium-related hepatitis. Report of four cases].
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Alcohol Withdrawal Delirium; Aspartate Aminotransfera | 1991 |
Genetic differences in anticonvulsant sensitivity in mouse lines selectively bred for ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcohols; Animals; Anticonvulsants; Diazepam; Disease Susceptibility; E | 1986 |
Intravenous phenobarbital for alcohol withdrawal and convulsions.
Topics: Acute Disease; Adult; Alcohol Withdrawal Delirium; Drug Evaluation; Ethanol; Female; Follow-Up Studi | 1987 |
[Treatment of acute emotional disturbances].
Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Chlorpromazine; Chlorprothixene; Diazepam; Family Char | 1974 |