phenobarbital has been researched along with Alcohol Abuse, Nervous System in 2 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital 200 mg was administered orally every 30 or 60 minutes in response to the observed symptoms." | 1.36 | Linear correlation between phenobarbital dose and concentration in alcohol withdrawal patients. ( Allerup, P; Nielsen, MK; Tangmose, K; Ulrichsen, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tangmose, K | 1 |
| Nielsen, MK | 1 |
| Allerup, P | 1 |
| Ulrichsen, J | 1 |
| Rosenson, J | 1 |
| Clements, C | 1 |
| Simon, B | 1 |
| Vieaux, J | 1 |
| Graffman, S | 1 |
| Vahidnia, F | 1 |
| Cisse, B | 1 |
| Lam, J | 1 |
| Alter, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phenobarbital and Alcohol Abuse, Nervous System
| Article | Year |
|---|---|
Phenobarbital for acute alcohol withdrawal: a prospective randomized double-blind placebo-controlled study.
Topics: Adult; Alcohol-Induced Disorders, Nervous System; Anticonvulsants; Double-Blind Method; Female; Hosp | 2013 |
1 other study available for phenobarbital and Alcohol Abuse, Nervous System
| Article | Year |
|---|---|
Linear correlation between phenobarbital dose and concentration in alcohol withdrawal patients.
Topics: Adult; Alcohol-Induced Disorders, Nervous System; Emergency Service, Hospital; Female; Hospitals, Ps | 2010 |