phenobarbital has been researched along with Alagille Syndrome in 1 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Alagille Syndrome: A multisystem disorder that is characterized by aplasia of intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC), and malformations in the cardiovascular system, the eyes, the vertebral column, and the facies. Major clinical features include JAUNDICE, and congenital heart disease with peripheral PULMONARY STENOSIS. Alagille syndrome may result from heterogeneous gene mutations, including mutations in JAG1 on CHROMOSOME 20 (Type 1) and NOTCH2 on CHROMOSOME 1 (Type 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been stated that arteriohepatic dysplasia is a form of biliary paucity with a good prognosis." | 1.28 | Long-term complications of arteriohepatic dysplasia. ( Freese, D; Grothe, RM; Schwarzenberg, SJ; Sharp, HL; Snover, DC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwarzenberg, SJ | 1 |
| Grothe, RM | 1 |
| Sharp, HL | 1 |
| Snover, DC | 1 |
| Freese, D | 1 |
1 other study available for phenobarbital and Alagille Syndrome
| Article | Year |
|---|---|
Long-term complications of arteriohepatic dysplasia.
Topics: Adolescent; Adult; Alagille Syndrome; Child; Child, Preschool; Cholestyramine Resin; Drug Therapy, C | 1992 |