phenobarbital has been researched along with Aging in 218 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 7.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months." | 7.69 | The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. ( Breimer, DD; Groen, K; Jansen, EJ; van Bezooijen, CF, 1994) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Acute exposure to dieldrin (HEOD) causes hyperglycemia and death in the adult rat." | 7.67 | Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats. ( Fox, GR; Virgo, BB, 1986) |
| "Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients of both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA)." | 7.66 | PB:PRM ratio in patients with epilepsy treated with primidone. ( Altamura, AC; Bianchi, M; Canger, R; Cornaggia, CM; Polana, P; Pruneri, C, 1983) |
| "The influence of aging on hepatic microsomal monooxygenase induction by phenobarbital (PB) or beta-naphthoflavone (BNF) was investigated in male Fischer 344 rats maintained in a constant environment." | 7.66 | Differential effects of aging on hepatic microsomal monooxygenase induction by phenobarbital and beta-naphthoflavone. ( Notley, BA; Rikans, LE, 1982) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 7.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| "When phenobarbital was readministered 1 week later, the hamsters again exhibited severe dystonia." | 5.31 | Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model. ( Löscher, W; Richter, A, 2000) |
| "Phenobarbital treatment increased mRNA levels in both genders." | 5.28 | Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver. ( Callaerts, A; Coecke, S; Guillouzo, A; Morel, F; Rogiers, V; Van Bezooijen, CF; Vandenberghe, Y; Vercruysse, A; Verleye, G, 1991) |
| "Phenobarbital was injected intraperitoneally into male white NMRI mice aged 0." | 5.26 | Excessive reversible phenobarbital induced nuclear DNA-polyploidization in the growing mouse liver. ( Böhm, N; Noltemeyer, N, 1981) |
| "To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period." | 5.09 | Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999) |
| "The aim of the present study was to build population pharmacokinetic models for the clearance of carbamazepine (CBZ) in two separate populations of Serbian patients with epilepsy, children and adults." | 3.77 | Factors influencing carbamazepine pharmacokinetics in children and adults: population pharmacokinetic analysis. ( Jankovic, SM; Milovanovic, JR, 2011) |
| "To assess the influence of aging on the pharmacokinetics of phenobarbital (PB) at steady state in patients receiving long-term therapy." | 3.73 | Phenobarbital pharmacokinetics in old age: a case-matched evaluation based on therapeutic drug monitoring data. ( Battino, D; Croci, D; Mamoli, D; Messina, S; Perucca, E; Ratti, S, 2005) |
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 3.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "Naturally occurring basophilic foci (focal hepatocellular proliferative lesions) (FHPL) in the livers of aging female F344/NCr rats could not be promoted to grow or progress into tumors after phenobarbital (PB) exposure." | 3.68 | Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens. ( Henneman, JR; Ward, JM, 1990) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Barbiturates, such as phenobarbital (PHB), are often used during pregnancy and early neonatal life to prevent epileptic seizures, hyperbilirubinemia and the stressful effects of labor." | 3.67 | The influence of prenatal phenobarbital exposure on the growth of dendrites in the rat hippocampus. ( Antolick, LL; Jacobson, CD; Scholey, R; Uemura, E, 1988) |
| "Acute exposure to dieldrin (HEOD) causes hyperglycemia and death in the adult rat." | 3.67 | Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats. ( Fox, GR; Virgo, BB, 1986) |
| "Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients of both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA)." | 3.66 | PB:PRM ratio in patients with epilepsy treated with primidone. ( Altamura, AC; Bianchi, M; Canger, R; Cornaggia, CM; Polana, P; Pruneri, C, 1983) |
| "Phenobarbital pharmacokinetics after intravenous injection were studied in 8 neonates with seizures." | 3.66 | Phenobarbital pharmacokinetics in neonates. ( Painter, M; Pippenger, C; Pitlick, W, 1978) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 3.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "Epilepsy was confirmed in 58 cases." | 1.37 | [Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011) |
| " Application of the findings in this study to patient care may permit selection of an appropriate initial maintenance dosage to achieve target phenobarbital concentrations, thus enabling the clinician to achieve the desired therapeutic effect in neonates and infants." | 1.33 | Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants. ( Minemoto, M; Suematsu, F; Yukawa, E; Yukawa, M, 2005) |
| "Pretreatment with phenobarbital i." | 1.32 | Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004) |
| "When phenobarbital was readministered 1 week later, the hamsters again exhibited severe dystonia." | 1.31 | Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model. ( Löscher, W; Richter, A, 2000) |
| "Attacks of sustained dystonia of the limbs and trunk can be initiated by handling or mild environmental stimuli (e." | 1.29 | Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters. ( Löscher, W; Richter, A, 1993) |
| " Rats receiving phenobarbital had therapeutic concentrations during most of the 24-hour dosing period, but also experienced supratherapeutic peak concentrations." | 1.29 | Phenobarbital modifies seizure-related brain injury in the developing brain. ( Chronopoulos, A; Gatt, A; Holmes, GL; Hyde, P; Liu, Z; Mikati, MA; Stafstrom, CE; Thurber, S; Werner, S, 1994) |
| "When cimetidine was pre-administered in SD rats of three age groups, all rats exhibited lower serum theophylline concentration and higher pharmacokinetics parameters (P < 0." | 1.28 | Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. ( Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK, 1992) |
| "Routine clinical pharmacokinetic data collected from patients receiving phenobarbitone have been analysed to evaluate the role of patient characteristics for estimating dosing regimens." | 1.28 | Phenobarbitone population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens. ( Aoyama, T; Higuchi, S; Yukawa, E, 1992) |
| "Phenobarbital treatment increased mRNA levels in both genders." | 1.28 | Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver. ( Callaerts, A; Coecke, S; Guillouzo, A; Morel, F; Rogiers, V; Van Bezooijen, CF; Vandenberghe, Y; Vercruysse, A; Verleye, G, 1991) |
| "As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age." | 1.28 | Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats. ( Appenroth, D; Bräunlich, H; Friese, KH; Gambaryan, S, 1990) |
| "Phenobarbital (PhB) was administered to pregnant mice during days 9-18 of gestation." | 1.28 | Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors. ( Fares, F; Gavish, M; Pick, CG; Weizman, A; Yanai, J, 1990) |
| " These findings should therefore be considered when defining dosage regimens or interpreting serum drug concentrations." | 1.28 | Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid. ( Aoyama, T; Higuchi, S; Hirata, K; Ieiri, I; Yamada, H, 1990) |
| "phenobarbital dosing requirements and plasma clearance were examined for asphyxiated and nonasphyxiated neonates." | 1.27 | The influence of asphyxia on phenobarbital dosing requirements in neonates. ( Boer, HR; Erkan, NV; Gal, P; Toback, J, 1984) |
| " Chloramphenicol was administered by the intravenous, intramuscular or oral route and dosage ranged between 12 and 210 mg/kg/day." | 1.27 | The pharmacokinetics of chloramphenicol in the neonate and young infant. ( de Louvois, J; Hurley, R; Mulhall, A, 1983) |
| "Phenobarbital pretreatment did not alter the ICG elimination half lives in 10-, 20- and 110-day-old rats." | 1.27 | Hepatic elimination kinetics of organic anions in rats: developmental aspects and influence of phenobarbital. ( Barth, A; Hoppe, H; Klinger, W, 1986) |
| " The dose-response relationship was also determined in juvenile rats for a single and for up to 64 daily doses of 3 mg/kg DENA started on day 32 of age." | 1.27 | The effect of single versus split doses of diethylnitrosamine on the induction of gamma-glutamyltranspeptidase-foci in the livers of adult and juvenile rats. ( Herren-Freund, SL; Khoury, MM; Long, RE; Pereira, MA, 1986) |
| "Corticosterone metabolism was studied in the 10,000 X g supernatant fraction of the liver homogenate supplemented with cofactors (NADH, NADPH), or with the system participating in NADPH synthesis." | 1.27 | Regulation of corticosterone metabolism in liver cell fractions in young and adult rats: cofactor requirements, effects of stress and phenobarbital treatment. ( Kraus, M; Rehulka, J, 1987) |
| "The anticonvulsant effect of phenobarbital was examined in young (6 month old) and old (24 month old) BDF1 female mice consisting of three groups each (one control and two chronically dosed phenobarbital groups), using the abolition of the tonic hindlimb extensor component of maximal electroshock seizure as the index." | 1.27 | The effect of age on the adaptation of the brain to the anticonvulsant effect of phenobarbital in mice. ( Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y, 1986) |
| " sex, excess intracranial flow of metrizamide and myelographic blockage were not shown to have a significant influence on the adverse reactions." | 1.27 | Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography. ( du Boulay, GH; Paul, E; Yu, YL, 1986) |
| "Phenobarbital was slowly eliminated from the plasma at all ages and there was no indication of p-hydroxylated metabolite formation." | 1.27 | Drug disposition and biotransformation in the developing beagle dog. ( D'Ver, AS; Ecobichon, DJ; Ehrhart, W, 1988) |
| "Phenobarbital was injected intraperitoneally into male white NMRI mice aged 0." | 1.26 | Excessive reversible phenobarbital induced nuclear DNA-polyploidization in the growing mouse liver. ( Böhm, N; Noltemeyer, N, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 146 (66.97) | 18.7374 |
| 1990's | 58 (26.61) | 18.2507 |
| 2000's | 10 (4.59) | 29.6817 |
| 2010's | 4 (1.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, X | 1 |
| Kania-Korwel, I | 1 |
| Chen, H | 1 |
| Stamou, M | 1 |
| Dammanahalli, KJ | 1 |
| Duffel, M | 1 |
| Lein, PJ | 1 |
| Lehmler, HJ | 1 |
| Tien, YC | 1 |
| Piekos, SC | 1 |
| Pope, C | 1 |
| Zhong, XB | 1 |
| Lupp, A | 1 |
| Glöckner, R | 1 |
| Etzrodt, J | 1 |
| Müller, D | 1 |
| Yang, YH | 1 |
| Zheng, QS | 1 |
| Li, J | 1 |
| Shang, FJ | 1 |
| Liu, T | 1 |
| Wang, HT | 1 |
| Liu, XT | 1 |
| Liu, L | 1 |
| Milovanovic, JR | 1 |
| Jankovic, SM | 1 |
| Kotov, AS | 1 |
| Rudakova, IG | 1 |
| Agrawal, AK | 3 |
| Shapiro, BH | 3 |
| FROMMEL, E | 1 |
| KUNTZMAN, R | 1 |
| JACOBSON, M | 1 |
| SCHNEIDMAN, K | 1 |
| CONNEY, AH | 2 |
| KATO, R | 6 |
| CHIESARA, E | 1 |
| FRONTINO, G | 1 |
| de Oliveira, DL | 1 |
| Horn, JF | 1 |
| Rodrigues, JM | 1 |
| Frizzo, ME | 1 |
| Moriguchi, E | 1 |
| Souza, DO | 1 |
| Wofchuk, S | 1 |
| Messina, S | 1 |
| Battino, D | 1 |
| Croci, D | 1 |
| Mamoli, D | 1 |
| Ratti, S | 1 |
| Perucca, E | 2 |
| Yukawa, E | 3 |
| Suematsu, F | 1 |
| Yukawa, M | 1 |
| Minemoto, M | 1 |
| Silverman, DA | 1 |
| Talalay, P | 1 |
| Kitagawa, T | 1 |
| Imai, F | 1 |
| Sato, K | 1 |
| Law, FC | 1 |
| So, EM | 1 |
| Burley, FE | 1 |
| Bray, TM | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| Thomas, PE | 2 |
| Reik, LM | 1 |
| Ryan, DE | 1 |
| Levin, W | 1 |
| Ward, JM | 3 |
| Schmucker, DL | 4 |
| Wang, RK | 4 |
| Kleeberg, U | 1 |
| Klinger, W | 6 |
| Sitar, DS | 1 |
| Desai, CD | 1 |
| Chapman, JB | 1 |
| Cutler, MG | 1 |
| Chiang, JY | 1 |
| DiLella, AG | 1 |
| Steggles, AW | 1 |
| Donham, RS | 1 |
| DiPinto, MN | 1 |
| Stetson, MH | 1 |
| Kanai, K | 1 |
| Kanamura, S | 1 |
| Asada-Kubota, M | 1 |
| Watanabe, J | 1 |
| Oka, M | 1 |
| Watanabe, HK | 1 |
| Matsui, M | 1 |
| Keith, DA | 1 |
| Gundberg, CM | 1 |
| Japour, A | 1 |
| Aronoff, J | 1 |
| Alvarez, N | 1 |
| Gallop, PM | 1 |
| Robbi, M | 1 |
| Beaufay, H | 1 |
| Mulhall, A | 1 |
| de Louvois, J | 1 |
| Hurley, R | 1 |
| Gattermann, R | 1 |
| Fiedler, B | 1 |
| Kadiiska, M | 1 |
| Stoytchev, T | 1 |
| Jahn, F | 2 |
| Cornaggia, CM | 1 |
| Altamura, AC | 1 |
| Bianchi, M | 1 |
| Canger, R | 1 |
| Polana, P | 1 |
| Pruneri, C | 1 |
| Gal, P | 1 |
| Toback, J | 1 |
| Erkan, NV | 1 |
| Boer, HR | 1 |
| Schwab, GE | 1 |
| Norman, RL | 1 |
| Muller-Eberhard, U | 1 |
| Johnson, EF | 1 |
| Förlin, L | 1 |
| Morselli, PL | 2 |
| Franco-Morselli, R | 1 |
| Rikans, LE | 2 |
| Notley, BA | 2 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Agnoli, A | 1 |
| Raimondo, S | 1 |
| Fulle, D | 1 |
| Pastoris, O | 1 |
| Curti, D | 1 |
| Villa, RF | 1 |
| DiRenzo, AB | 1 |
| Gandolfi, AJ | 1 |
| Sipes, IG | 1 |
| McDougal, JN | 1 |
| Bar, S | 1 |
| Feller, N | 1 |
| Savir, H | 1 |
| Soliman, KF | 1 |
| Richardson, SD | 1 |
| Taburet, AM | 1 |
| Chamouard, C | 1 |
| Aymard, P | 1 |
| Chevalier, JY | 1 |
| Costil, J | 1 |
| Hawcroft, DM | 1 |
| Jones, TW | 1 |
| Martin, PA | 1 |
| Terranova, PF | 1 |
| Ascanio, LE | 1 |
| Yanai, J | 3 |
| Bergman, A | 1 |
| Pickett, CB | 1 |
| Jeter, RL | 1 |
| Morin, J | 1 |
| Lu, AY | 2 |
| Dixit, R | 1 |
| Mukhtar, H | 1 |
| Seth, PK | 1 |
| Murti, CR | 1 |
| Böhm, N | 1 |
| Noltemeyer, N | 1 |
| Iser, C | 1 |
| van Boxtel, CJ | 1 |
| Rane, A | 3 |
| Brown, RD | 1 |
| Wilson, JT | 4 |
| Gerken, DK | 1 |
| Yeary, RA | 1 |
| Murota, S | 2 |
| Morita, I | 2 |
| Kao, J | 1 |
| Hudson, P | 1 |
| Schaeffer, DJ | 1 |
| Janardan, KG | 1 |
| Somani, SM | 1 |
| Easton, D | 1 |
| Sherman, D | 1 |
| McMartin, DN | 1 |
| O'Connor, JA | 1 |
| Fasco, MJ | 1 |
| Kaminsky, LS | 1 |
| Heimann, G | 1 |
| Frolkis, VV | 2 |
| Kobzar, AL | 1 |
| Paramonova, GI | 2 |
| Pollard, M | 1 |
| Luckert, PH | 1 |
| Scheu, J | 1 |
| Zhu, BT | 1 |
| Suchar, LA | 2 |
| Gwynne, M | 1 |
| Huang, MT | 2 |
| Plewka, A | 6 |
| Plewka, D | 4 |
| Kamiński, M | 4 |
| Appenroth, D | 2 |
| Pampori, NA | 1 |
| Hammerl, R | 1 |
| Kirchner, T | 1 |
| Neumann, HG | 1 |
| Yoo, SD | 1 |
| Burgio, DE | 1 |
| McNamara, PJ | 1 |
| Coceani, F | 1 |
| Kelsey, L | 1 |
| Ackerley, C | 1 |
| Rabinovitch, M | 1 |
| Gelboin, H | 1 |
| Mikati, MA | 1 |
| Holmes, GL | 1 |
| Chronopoulos, A | 1 |
| Hyde, P | 1 |
| Thurber, S | 1 |
| Gatt, A | 1 |
| Liu, Z | 1 |
| Werner, S | 1 |
| Stafstrom, CE | 1 |
| Groen, K | 1 |
| Breimer, DD | 1 |
| Jansen, EJ | 1 |
| van Bezooijen, CF | 8 |
| Martini, R | 1 |
| Murray, M | 1 |
| Richter, A | 2 |
| Löscher, W | 2 |
| Zangar, RC | 1 |
| Springer, DL | 1 |
| Buhler, DR | 1 |
| Schilter, B | 1 |
| Turesky, RJ | 1 |
| Juillerat, M | 1 |
| Honegger, P | 1 |
| Guigoz, Y | 1 |
| Van Asten, JG | 3 |
| Te Koppele, JM | 1 |
| Horbach, GJ | 3 |
| Chang, RL | 1 |
| Rosen, RT | 1 |
| Lech, J | 1 |
| Wani, JH | 1 |
| Ono, T | 1 |
| Fueta, Y | 1 |
| Janjua, NA | 1 |
| Ohmori, O | 1 |
| Ohno, K | 1 |
| Murai, Y | 1 |
| Mita, T | 1 |
| Charpentier, KP | 1 |
| von Moltke, LL | 1 |
| Poku, JW | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 1 |
| Yokoyama, H | 1 |
| Onodera, K | 1 |
| Yagi, T | 1 |
| Iinuma, K | 1 |
| da Silva, LF | 1 |
| Pereira, P | 1 |
| Elisabetsky, E | 1 |
| Morita, K | 1 |
| Maeda, Y | 1 |
| Masuda, M | 1 |
| Kazusaka, A | 1 |
| Imaoka, S | 1 |
| Funae, Y | 1 |
| Fujita, S | 1 |
| Fukura, H | 1 |
| Kitani, Y | 1 |
| Komiya, Y | 1 |
| Igarashi, M | 1 |
| Koyama, H | 1 |
| Sugioka, N | 1 |
| Uno, A | 1 |
| Mori, S | 1 |
| Nakajima, K | 1 |
| Nowaczyk, G | 1 |
| Carrillo, MC | 1 |
| Favre, C | 1 |
| Carnovale, CE | 1 |
| Monti, JA | 1 |
| Alvarez, ML | 1 |
| Scapini, C | 1 |
| Pisani, GB | 1 |
| Lugano, MC | 1 |
| Kondziella, D | 1 |
| Bidar, A | 1 |
| Urfjell, B | 1 |
| Sletvold, O | 1 |
| Sonnewald, U | 1 |
| Iwasaki, K | 1 |
| Shiraga, T | 1 |
| Noguchi, N | 1 |
| Bräunlich, H | 3 |
| Bonow, A | 1 |
| Schröter, S | 1 |
| Narbonne, JF | 1 |
| Birnbaum, LS | 1 |
| Baird, MB | 2 |
| Bartoli, GM | 1 |
| Galeotti, T | 1 |
| Palombini, G | 1 |
| Parisi, G | 1 |
| Azzi, A | 1 |
| Fischer, E | 1 |
| Barth, A | 2 |
| Varga, F | 2 |
| Adelman, RC | 3 |
| Maugras, M | 1 |
| Reichart, E | 1 |
| West, SB | 1 |
| Miwa, GT | 1 |
| Seixas, FA | 1 |
| Garg, BD | 1 |
| Kourounakis, P | 1 |
| Tuchweber, B | 1 |
| Hassall, KA | 1 |
| Addala, SA | 1 |
| Lindell, TJ | 1 |
| Ellinger, R | 1 |
| Warren, JT | 1 |
| Sundheimer, D | 1 |
| O'Malley, AF | 1 |
| Pitlick, W | 1 |
| Painter, M | 1 |
| Pippenger, C | 1 |
| Kluwe, WM | 1 |
| McCormack, KM | 1 |
| Hook, JB | 1 |
| Shaywitz, BA | 1 |
| Pearson, DA | 1 |
| Fysh, JM | 1 |
| Okey, AB | 1 |
| Poole, TW | 1 |
| Parke, DV | 1 |
| Short, CR | 1 |
| Kinden, DA | 1 |
| Stith, R | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Nicolosi, RJ | 1 |
| Massie, HR | 1 |
| Samis, HV | 1 |
| Erdösová, R | 1 |
| Kraus, M | 2 |
| Rehulka, J | 2 |
| Emanuél', NM | 1 |
| Obukhnova, LK | 1 |
| Naĭdich, VI | 1 |
| Murza, LI | 1 |
| Bunto, TV | 1 |
| Miller, RR | 1 |
| Harbison, RD | 1 |
| Bender, AD | 1 |
| Post, A | 1 |
| Meier, JP | 1 |
| Higson, JE | 1 |
| Reichard, G | 1 |
| Klaassen, CD | 2 |
| Wiebel, FJ | 1 |
| Gelboin, HV | 2 |
| Hayes, MJ | 1 |
| Langman, MJ | 1 |
| Short, AH | 1 |
| Oesch, F | 1 |
| Powis, G | 1 |
| Drummond, AH | 1 |
| Macintyre, DE | 1 |
| Jondorf, WR | 1 |
| Stanková, L | 1 |
| Mares, P | 2 |
| Lin, SY | 1 |
| Hou, SJ | 1 |
| Perng, RI | 1 |
| Chen, SM | 1 |
| Young, TK | 1 |
| Bienioszek, M | 1 |
| Higuchi, S | 4 |
| Aoyama, T | 4 |
| Rietjens, IM | 1 |
| Kremers, P | 1 |
| Telhada, MB | 1 |
| Pereira, TM | 1 |
| Lechner, MC | 2 |
| Stijnen, AM | 2 |
| Danhof, M | 2 |
| Turski, W | 1 |
| Dziki, M | 1 |
| Parada, J | 1 |
| Kleinrok, Z | 1 |
| Cavalheiro, EA | 1 |
| Miyazaki, M | 1 |
| Bai, L | 1 |
| Tsuboi, S | 1 |
| Namba, M | 1 |
| Omiecinski, CJ | 1 |
| Redlich, CA | 1 |
| Costa, P | 1 |
| Suzuki, Y | 1 |
| Cox, S | 1 |
| Hayes, J | 1 |
| Walson, PD | 1 |
| Rogiers, V | 2 |
| Coecke, S | 2 |
| Vandenberghe, Y | 2 |
| Morel, F | 1 |
| Callaerts, A | 2 |
| Verleye, G | 2 |
| Guillouzo, A | 1 |
| Vercruysse, A | 2 |
| Hasegawa, R | 1 |
| Takahashi, S | 2 |
| Imaida, K | 1 |
| Yamaguchi, S | 1 |
| Shirai, T | 1 |
| Ito, N | 1 |
| Kraupp-Grasl, B | 2 |
| Huber, W | 1 |
| Taper, H | 1 |
| Schulte-Hermann, R | 2 |
| Fleck, C | 1 |
| Haake-McMillan, JM | 1 |
| Safe, SH | 1 |
| Nowaczyk-Dura, G | 1 |
| Czekaj, P | 1 |
| Gambaryan, S | 1 |
| Friese, KH | 1 |
| Fares, F | 1 |
| Weizman, A | 1 |
| Pick, CG | 1 |
| Gavish, M | 1 |
| Henneman, JR | 1 |
| Sonck, W | 1 |
| Ichikou, N | 1 |
| Ieiri, I | 2 |
| Hirata, K | 2 |
| Yamada, H | 2 |
| Martines, C | 1 |
| Gatti, G | 1 |
| Sasso, E | 1 |
| Calzetti, S | 1 |
| Chasserot-Golaz, S | 1 |
| Ribeiro, V | 1 |
| Genot, G | 1 |
| Beck, G | 1 |
| Pereira de Vasconcelos, A | 3 |
| Boyet, S | 1 |
| Nehlig, A | 3 |
| Karge, E | 2 |
| Hoppe, H | 1 |
| Sedowofia, SK | 1 |
| Innes, J | 1 |
| Peter, A | 1 |
| Alleva, E | 1 |
| Manning, A | 1 |
| Clayton, RM | 1 |
| Bursch, W | 1 |
| Gerbracht, U | 1 |
| Timmermann-Trosiener, I | 1 |
| Shimada, M | 2 |
| Nagata, K | 1 |
| Murayama, N | 2 |
| Yamazoe, Y | 2 |
| Velísek, L | 1 |
| Roztocilová, L | 1 |
| Kubová, H | 1 |
| Yamamoto, T | 1 |
| Nakaoko, H | 1 |
| Nakazato, M | 1 |
| Suda, M | 1 |
| Moriwaki, Y | 1 |
| Hada, T | 1 |
| Yanagisawa, M | 1 |
| Higashino, K | 1 |
| Henderson, DJ | 1 |
| Gregus, Z | 1 |
| Schmelás, A | 1 |
| Ohshima, M | 1 |
| Herren-Freund, SL | 1 |
| Pereira, MA | 2 |
| Long, RE | 1 |
| Khoury, MM | 1 |
| Tavoloni, N | 1 |
| Baughman, VL | 1 |
| Hoffman, WE | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 1 |
| Igarashi, T | 1 |
| Irokawa, N | 1 |
| Ono, S | 1 |
| Ohmori, S | 1 |
| Ueno, K | 1 |
| Kitagawa, H | 1 |
| Satoh, T | 1 |
| Rath, PC | 1 |
| Kanungo, MS | 1 |
| Ecobichon, DJ | 1 |
| D'Ver, AS | 1 |
| Ehrhart, W | 1 |
| Jacobson, CD | 1 |
| Antolick, LL | 1 |
| Scholey, R | 1 |
| Uemura, E | 1 |
| Kitani, K | 3 |
| Sato, Y | 3 |
| Kanai, S | 3 |
| Ohta, M | 3 |
| Nokubo, M | 3 |
| Masuda, Y | 3 |
| Pacifici, GM | 1 |
| Park, SS | 1 |
| Gelboin, HW | 1 |
| Wynne, H | 1 |
| Mutch, E | 1 |
| James, OF | 1 |
| Rawlins, MD | 1 |
| Woodhouse, KW | 1 |
| Klaunig, JE | 1 |
| Weghorst, CM | 1 |
| Schroeder, H | 1 |
| Clozel, M | 1 |
| Beharry, K | 1 |
| Aranda, JV | 1 |
| Sun, JQ | 1 |
| Lau, PP | 1 |
| Strobel, HW | 1 |
| Gulyaeva, LF | 1 |
| Mishin, VM | 1 |
| Lyakhovich, VV | 1 |
| Yu, YL | 1 |
| du Boulay, GH | 1 |
| Paul, E | 1 |
| Fox, GR | 1 |
| Virgo, BB | 1 |
| Sadana, A | 1 |
| Henley, JP | 1 |
| Gielen, JE | 1 |
| Goujon, FM | 1 |
| Nebert, DW | 2 |
| Freeman, C | 1 |
| Cohen, BS | 1 |
| Kuenzig, W | 1 |
| Kamm, JJ | 1 |
| Boublik, M | 1 |
| Jenkins, F | 1 |
| Burns, JJ | 1 |
| Yang, CS | 1 |
| Strickhart, FS | 1 |
| Illing, HP | 1 |
| Dutton, GJ | 2 |
| Burchell, B | 1 |
| Winsnes, A | 1 |
| Takanaka, A | 2 |
| Oesch, E | 1 |
| Jerina, DM | 1 |
| Daly, J | 1 |
| Dallner, G | 1 |
| Bergstrand, A | 1 |
| Nilsson, R | 1 |
| Hospador, MA | 1 |
| Grosso, LS | 1 |
| Manthei, RW | 1 |
| Schönharting, M | 1 |
| Mende, G | 1 |
| Siebert, G | 1 |
| Sato, T | 1 |
| Moroi, K | 1 |
| Funcke, AB | 1 |
| Timmerman, H | 1 |
| Blank, H | 1 |
| Petty, WC | 1 |
| Karler, R | 1 |
| Wong, KP | 1 |
| Ehrnebo, M | 1 |
| Agurell, S | 1 |
| Jalling, B | 1 |
| Boréus, LO | 1 |
| Fujii, T | 1 |
| Imai, M | 1 |
| Morohashi, C | 1 |
| Wakahara, E | 1 |
| Watanabe, M | 1 |
| Koyama, R | 1 |
| Trojaborg, W | 1 |
| Jaccarini, A | 1 |
| Jepson, JB | 1 |
| Tardiff, RG | 1 |
| Dubois, KP | 1 |
12 reviews available for phenobarbital and Aging
| Article | Year |
|---|---|
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
[Induced modifications of liver cytochrome P-450 levels as a function of age in rats].
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; L | 1994 |
[Induced modification of liver NADPH-cytochrome P-450 activity and II microsomal electron transport chain as a function of age in rats].
Topics: Aging; Animals; Benzoflavones; Dexamethasone; Electron Transport; Microsomes, Liver; NADPH-Ferrihemo | 1994 |
Disruptions in enzyme regulation during aging.
Topics: Aging; Animals; Corticosterone; Cytochrome Reductases; Enzyme Induction; Enzymes; Female; Genes; Glu | 1975 |
Fetal and neonatal development of the microsomal monooxygenase system.
Topics: Aging; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Animals, Newborn; Cytochrome P-450 E | 1976 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
[Effects of age and selected inductors of aromatic hydrocarbon hydroxylase (AHH) activity in the rat liver].
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Dexamethasone; En | 1990 |
Enzyme adaptation as a biochemical probe of development and aging.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Animals, Newborn; Blood Glucose; Diet; Dihydrolipoamide | 1972 |
Developmental pharmacology: a review of its application to clinical and basic science.
Topics: Aging; Androgens; Aniline Compounds; Animals; Estrogens; Ethanol; Female; Fetus; Fluorosis, Dental; | 1972 |
Age-dependent effects in enzyme induction--a biochemical expression of aging.
Topics: Adipose Tissue; Aging; Animals; Cell Division; Diet; Electron Transport Complex IV; Enzyme Induction | 1971 |
The actions and interactions of drugs: the therapeutic significance of enzyme induction.
Topics: Aging; Animals; Child; Chloral Hydrate; Dogs; Drug Antagonism; Drug Resistance, Microbial; Endoplasm | 1967 |
1 trial available for phenobarbital and Aging
| Article | Year |
|---|---|
Age-related alteration of carbamazepine-serum protein binding in man.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl | 1999 |
205 other studies available for phenobarbital and Aging
| Article | Year |
|---|---|
Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent.
Topics: Aging; Animals; Animals, Newborn; Cell Survival; Cytochrome P-450 Enzyme System; Dexamethasone; Fema | 2013 |
Phenobarbital Treatment at a Neonatal Age Results in Decreased Efficacy of Omeprazole in Adult Mice.
Topics: Aging; Animals; Animals, Newborn; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; | 2017 |
Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.
Topics: Aging; Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; C | 2008 |
Age-related changes in the atrial muscarinic type 2 receptor and their effects on atrial fibrillation vulnerability in rabbits.
Topics: Aging; Animals; Atrial Fibrillation; Atrial Function, Left; Atrial Function, Right; Blotting, Wester | 2009 |
Factors influencing carbamazepine pharmacokinetics in children and adults: population pharmacokinetic analysis.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressure Liquid; Drug Inte | 2011 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, | 2011 |
Constitutive and inducible hepatic cytochrome P450 isoforms in senescent male and female rats and response to low-dose phenobarbital.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; | 2003 |
[ON THE DURATION OF SLEEP INDUCED BY PHENOBARBITAL, MORPHINE, MEPROBAMATE, METAMINODIAZEPOXIDE AND CHLORPROMAZINE ACCORDING TO WEIGHT (AGE) IN THE GUINEA PIG].
Topics: Aging; Body Weight; Chlorpromazine; Guinea Pigs; Meprobamate; Morphine; Pharmacology; Phenobarbital; | 1963 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Mic | 1964 |
Induced increase of meprobamate metabolism in rats pretreated with phenobarbital or phenaglycodol in relation to age.
Topics: Aging; Animals; Butylene Glycols; Meprobamate; Phenobarbital; Rats | 1961 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2004 |
Phenobarbital pharmacokinetics in old age: a case-matched evaluation based on therapeutic drug monitoring data.
Topics: Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anticonvulsants; B | 2005 |
Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants.
Topics: Administration, Rectal; Aging; Biological Availability; Body Weight; Clinical Trials as Topic; Femal | 2005 |
Studies on the enzymic hydroxylation of 3,4-benzpyrene.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Enzyme Induction; Ethanol; Glycerol; Hydrogen-Ion Con | 1967 |
Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age.
Topics: Aging; Animals; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous | 1980 |
Induction studies of delta 1-tetrahydrocannabinol metabolism by rat and rabbit lungs.
Topics: Aging; Animals; Dronabinol; Enzyme Induction; Lung; Male; Methylcholanthrene; Mixed Function Oxygena | 1981 |
Effect of rumen development and pre-exposure to chemicals on the activity of the mixed function oxidase system in goats.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Goats; Lung; Microsomes; Microsome | 1983 |
Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Famil | 1981 |
Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms.
Topics: Adenoma; Aging; Animals; Carcinoma, Hepatocellular; Disease Susceptibility; Eosine Yellowish-(YS); g | 1983 |
Effects of animal age and phenobarbital on rat liver glucose-6-phosphatase activity.
Topics: Aging; Animals; Glucose-6-Phosphatase; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Pr | 1980 |
Glucose-6-phosphatase activities in the developing rat liver and kidney and after phenobarbital, 3-methylcholanthrene, and actinomycin D pretreatment.
Topics: Aging; Animals; Animals, Laboratory; Animals, Newborn; Dactinomycin; Glucose-6-Phosphatase; Kidney; | 1984 |
Effect of aging on response to induction and metabolizing activity of the hepatic mixed-function oxidase system of male Sprague-Dawley rats.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme Syst | 1983 |
Behavioural effects of phenobarbitone. 1. Effects in the offspring of laboratory mice.
Topics: Aging; Animals; Behavior, Animal; Female; Fertility; Male; Mice; Phenobarbital; Sex Factors; Social | 1983 |
Effect of inducers and aging on rabbit liver microsomal drug-metabolizing enzymes.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cholesterol; Cholestyramine Resin; Cytochrome b | 1983 |
Twenty four-hour rhythm of gonadotropin release induces cyclic progesterone secretion by the ovary of prepubertal and adult golden hamsters.
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Estrus; Female; Follicle Stimulating Hormone; Luteiniz | 1984 |
Quantitative analysis of smooth endoplasmic reticulum proliferation in hepatocytes of early postnatal and adult mice treated with phenobarbital.
Topics: Aging; Animals; Animals, Newborn; Endoplasmic Reticulum; Liver; Male; Mice; Mice, Inbred Strains; Ph | 1984 |
Rat liver sulfotransferases: effects of gonadal hormones and other factors on enzyme activities.
Topics: Aging; Androsterone; Animals; Body Weight; Corticosterone; Cytosol; Estradiol; Gonadal Steroid Hormo | 1984 |
Vitamin K-dependent proteins and anticonvulsant medication.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Calcium-Binding Proteins; Child; Child, Preschool; Drug I | 1983 |
Purification and characterization of various esterases from rat liver.
Topics: Aging; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Concanavalin A; Endoplasmic R | 1983 |
The pharmacokinetics of chloramphenicol in the neonate and young infant.
Topics: Administration, Oral; Aging; Chloramphenicol; Drug Interactions; Female; Humans; Infant; Infant, New | 1983 |
[Circadian and ontogenetic changes in sensitivity to sodium phenobarbital in the golden hamster].
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Female; Lethal Dose 50; Male; Mesocricetus; Phenobarbi | 1983 |
Effect of cadmium in vitro on benzphetamine-N-demethylation and ethoxyresorufin-O-deethylation in rats of different age.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cadmium; Cytochrome P-450 CYP1A1; Cytochrome P-4 | 1983 |
PB:PRM ratio in patients with epilepsy treated with primidone.
Topics: Adolescent; Adult; Aging; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Primido | 1983 |
The influence of asphyxia on phenobarbital dosing requirements in neonates.
Topics: Aging; Asphyxia Neonatorum; Drug Administration Schedule; Female; Humans; Infant, Newborn; Kinetics; | 1984 |
Identification of the form of cytochrome P-450 induced in neonatal rabbit liver microsomes by phenobarbital.
Topics: Aging; Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Microsom | 1980 |
Effects of clophen A50, 3-methylcholanthrene, pregnenolone-16 alpha-carbonitrile, and phenobarbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout, Salmo gairdneri, of different age and sex.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Female; Male; Methylcholant | 1980 |
Age-related changes in liver drug-metabolizing enzymes.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; | 1980 |
Age-related changes in liver drug-metabolizing enzymes.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; | 1980 |
Effects of aging and phenobarbital on the rat liver microsomal drug-metabolizing system.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Mixed Function Oxyge | 1981 |
Substrate specificity of age-related changes in the inducibility of hepatic microsomal monooxygenases in middle-aged rats.
Topics: Aging; Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Sys | 1981 |
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
Topics: Adenine Nucleotides; Aging; Animals; Dihydroergotoxine; Dogs; Female; Hypoxia; Lactates; Lactic Acid | 1982 |
Effect of senescence on the bioactivation of aliphatic halides.
Topics: Aflatoxin B1; Aflatoxins; Aging; Animals; Biotransformation; Enzyme Induction; Hydrocarbons, Halogen | 1982 |
Differential effects of aging on hepatic microsomal monooxygenase induction by phenobarbital and beta-naphthoflavone.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction | 1982 |
Presenile cataracts in phenytoin-treated epileptic patients.
Topics: Adult; Aging; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rodentia | 1983 |
Effect of prenatal exposure to phenobarbital on the development of monoamine oxidase and glucocorticoids.
Topics: Adrenal Cortex; Aging; Animals; Body Weight; Corticosterone; Female; Glucocorticoids; Growth; Liver; | 1983 |
Phenobarbital protein binding in neonates.
Topics: Adolescent; Aging; Blood Proteins; Child; Child, Preschool; Epilepsy; Humans; Infant; Infant, Newbor | 1982 |
Studies on age related changes in cytochrome P-450, cytochrome b-5 and mixed function oxidase activity in mouse liver microsomes, in relation to their phospholipid composition.
Topics: Aging; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Fatty Acids; Mal | 1982 |
Alterations of ovarian steroidogenesis induced by ovulatory delay in immature rats treated with pregnant mare serum gonadotropin.
Topics: Aging; Androstenedione; Animals; Estradiol; Female; Gonadotropins, Equine; Kinetics; Luteinizing Hor | 1982 |
Neuronal deficits after neonatal exposure to phenobarbital.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebellum; Mice; Mice, Inbred Strains; Neurons; Organ Spec | 1981 |
Electroimmunochemical quantitation of cytochrome P-450, cytochrome P-448, and epoxide hydrolase in rat liver microsomes.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Inducti | 1981 |
Conjugation of acrylamide with glutathione catalysed by glutathione-S-transferases of rat liver and brain.
Topics: Acrylamides; Aging; Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, Gel; Cytosol; Glu | 1981 |
Excessive reversible phenobarbital induced nuclear DNA-polyploidization in the growing mouse liver.
Topics: Aging; Animals; Cell Nucleus; DNA; Liver; Male; Mice; Phenobarbital; Polyploidy | 1981 |
Stereologic study of Purkinje cells in mice after early exposure to phenobarbital.
Topics: Aging; Animals; Animals, Newborn; Brain; Dendrites; Female; Fetus; Male; Mice; Organ Size; Phenobarb | 1981 |
The formation of carbamazepine epoxide by rat liver microsomes: an investigation of the biphasic kinetic profile.
Topics: Aging; Animals; Carbamazepine; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; | 1981 |
Effect of anticonvulsants on in vitro prothrombin synthesis in adult and fetal rat liver.
Topics: Aging; Animals; Anticonvulsants; Female; In Vitro Techniques; Liver; Male; Phenobarbital; Phenytoin; | 1981 |
Prostaglandin-synthesizing system in rat liver: changes with aging and various stimuli.
Topics: Aging; Animals; Arachidonic Acids; Carbon Tetrachloride; Cytosol; Liver; Liver Regeneration; Male; M | 1980 |
Effect of aging on the prostaglandin-synthesizing system in rat liver.
Topics: Aging; Animals; Arachidonic Acids; Chromatography, Thin Layer; Liver; Male; Microsomes, Liver; Pheno | 1980 |
Induction of the hepatic cytochrome P-450-dependent mono-oxygenase system in young and geriatric rats.
Topics: Aging; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; M | 1980 |
Multivariate statistical methods in toxicology: application to the analysis of outpatient clinical data for diphenylhydantoin and phenobarbital in the treatment of epilepsy.
Topics: Adolescent; Adult; Aging; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sex | 1980 |
Influence of aging and induction of rat liver and kidney microsomal mixed function oxidase systems.
Topics: Aging; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; I | 1980 |
Enteral absorption and bioavailability in children in relation to age.
Topics: Adolescent; Aging; Biological Availability; Child; Child, Preschool; Digoxin; Half-Life; Humans; Inf | 1980 |
Changes in the plasmatic membrane characteristics during microsomal monooxygenase induction in the liver of adult and old rats.
Topics: Aging; Animals; Cell Membrane; Liver; Male; Membrane Potentials; Microsomes; Phenobarbital; Rats; Ra | 1995 |
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Ne | 1995 |
Effect of age and sex on the inducibility of hepatic microsomal 4-nitrophenol UDP-glucuronyltransferase activity in rats.
Topics: Aging; Animals; Dexamethasone; Enzyme Induction; Female; Glucuronosyltransferase; Male; Methylcholan | 1995 |
Ontogenic changes in the nephrotoxicity of chromate correlate with the glutathione oxidoreduction system.
Topics: Acetylcysteine; Aging; Animals; Chromates; Female; Glutaredoxins; Glutathione; Kidney; Male; Oxidati | 1994 |
Neonatal phenobarbital-induced defects in age- and sex-specific growth hormone profiles regulating monooxygenases.
Topics: Aging; Animals; Animals, Newborn; Female; Growth Hormone; Hexobarbital; Male; Microsomes, Liver; Mix | 1995 |
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma | 1994 |
Phenobarbital disposition in adult and neonatal rabbits.
Topics: Aging; Animals; Animals, Newborn; Biological Availability; Chromatography, High Pressure Liquid; Fem | 1994 |
Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues.
Topics: Aging; Animals; Animals, Newborn; Aorta; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethas | 1994 |
Phenobarbital modifies seizure-related brain injury in the developing brain.
Topics: Aging; Analysis of Variance; Animals; Brain Diseases; Kainic Acid; Male; Phenobarbital; Rats; Rats, | 1994 |
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Longitud | 1994 |
Retinal dehydrogenation and retinoic acid 4-hydroxylation in rat hepatic microsomes: developmental studies and effect of foreign compounds on the activities.
Topics: Aging; Aldehyde Oxidoreductases; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzym | 1994 |
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
Topics: Aging; Aminooxyacetic Acid; Animals; Cricetinae; Diazepam; Dopamine Antagonists; Dystonia; Mesocrice | 1993 |
Alterations in cytochrome P-450 levels in adult rats following neonatal exposure to xenobiotics.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; | 1993 |
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Cells, Cultured; Dimethyl Sulfoxide; Drug Synergism; | 1993 |
The influence of aging on dimethylnitrosamine-demethylase enzyme kinetics in rat liver microsomes.
Topics: Aging; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione Transferase; Is | 1995 |
Effects of phenobarbital, dexamethasone, and 3-methylcholanthrene administration on the metabolism of 17 beta-estradiol by liver microsomes from female rats.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Estradiol; Female; | 1996 |
Neonatal phenobarbital-induced persistent alterations in plasma testosterone profiles and testicular function.
Topics: Aging; Androgens; Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Female; | 1996 |
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; E | 1997 |
Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction.
Topics: Aging; Alprazolam; Animals; Anti-Anxiety Agents; Biotransformation; Cytochrome P-450 Enzyme System; | 1997 |
Therapeutic doses of theophylline exert proconvulsant effects in developing mice.
Topics: Aging; Animals; Anticonvulsants; Bronchodilator Agents; Dose-Response Relationship, Drug; Electrosho | 1997 |
A neuropharmacological analysis of PTZ-induced kindling in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Diazepam; Glutamic Acid; Kindling, Neurologic; Male; M | 1998 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En | 1998 |
Effect of enzyme imprinting of liver microsomal monooxygenases upon lifespan of rats.
Topics: Aging; Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Female; Injections; Linear Models; | 1999 |
GABA(A) receptor in growth cones: the outline of GABA(A) receptor-dependent signaling in growth cones is applicable to a variety of alpha-subunit species.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chlorides; Diazepam; Fetus; gamma-Aminob | 1999 |
Glucose-6-phosphatase and age: biochemical and histochemical studies.
Topics: Aging; Animals; beta-Naphthoflavone; Dexamethasone; Enzyme Induction; Glucose-6-Phosphatase; Histocy | 2000 |
Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.
Topics: Aging; Animals; Area Under Curve; Behavior, Animal; Cricetinae; Disease Models, Animal; Dose-Respons | 2000 |
Involvement of mu class glutathione S-transferase subunit M2 (rGST M2) levels in the initiation and promotion of hepatocellular carcinogenesis in old rats.
Topics: Aflatoxin B1; Aging; Animals; Carcinogens; Glutathione Transferase; Immunohistochemistry; Liver Neop | 2001 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism.
Topics: Aging; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Epilepsy; Excita | 2002 |
Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Female; Kinetics; Liv | 1976 |
Age-dependence of renal tubular reabsorption of nitrofurantoin.
Topics: Absorption; Aging; Animals; Diuresis; Female; Hydrogen-Ion Concentration; Kidney Tubules; Nitrofuran | 1978 |
Effect of age and sex on liver response to phenoclor DP6, a polychlorinated biphenyl, in the rat.
Topics: Aging; Animals; Body Weight; Diet; Female; Liver; Male; Organ Size; Phenobarbital; Polychlorinated B | 1978 |
Induction of hepatic mixed function oxidases in senescent rodents.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Benzphetamine; Biotransformation; Cytochrome P-450 Enzyme S | 1978 |
Different contribution of rat liver microsomal pigments in the formation of superoxide anions and hydrogen peroxide during development.
Topics: Aging; Animals; Animals, Newborn; Cytochrome Reductases; Cytochromes; Female; Hydrogen Peroxide; Liv | 1977 |
Age dependence of hepatic transport in control and phenobarbital-pretreated rats.
Topics: Aging; Animals; Bile; Eosine Yellowish-(YS); Female; Liver; Organ Size; Phenobarbital; Rats | 1979 |
The hepatic cytochrome level in the cat (Felis catus): normal value and variations in relation to some biological parameters.
Topics: Aging; Animals; Body Weight; Cats; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Phenobar | 1979 |
A simple and rapid procedure for the purification of phenobarbital-inducible cytochrome P-450 from rat liver microsomes.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Inductio | 1979 |
Drug/alcohol interactions: avert potential dangers.
Topics: Aged; Aging; Alcohol Drinking; Alcoholism; Antidepressive Agents, Tricyclic; Aspirin; California; Di | 1979 |
Fine structural changes in the liver of young and old rats as influenced by microsomal enzyme inducers.
Topics: Aging; Animals; Dexamethasone; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Microsomes, Liv | 1979 |
Use of a dimethylated oxirane to characterise microsomal mono-oxygenases in rat liver.
Topics: Aging; Animals; Dieldrin; Enzyme Induction; Female; In Vitro Techniques; Male; Methylcholanthrene; M | 1979 |
The effect of acute and chronic phenobarbital treatment on the activity of rat liver deoxyribonucleic acid-dependent ribonucleic acid polymerases.
Topics: Adrenal Cortex Hormones; Aging; Animals; Cell Nucleus; Circadian Rhythm; DNA-Directed RNA Polymerase | 1977 |
Phenobarbital pharmacokinetics in neonates.
Topics: Aging; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kinetics; Models, Biol | 1978 |
Chemical induction of p-aminohippuric acid transport in renal cortical slices from adult and immature rabbits.
Topics: Aging; Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidn | 1978 |
Effect of phenobarbital on activity and learning in 6-hydroxydopamine treated rat pups.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain Chemistry; Catecholamines; Cognition; Habituati | 1978 |
Aryl hydrocarbon (benzo[a]pyrene) hydroxylase development in rat mammary tissue.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; Castration; D | 1978 |
Effects of age, inducing agents and carcinogens on the distribution of cytochrome P-450 in microsomal membranes from rat liver.
Topics: 2-Acetylaminofluorene; Aging; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Male; Methylchol | 1978 |
Microsomal mixed-function oxidase activity and senescence-I. Hexobarbital sleep time and induction of components of the hepatic microsomal enzyme system in rats of different ages.
Topics: Age Factors; Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Liver; | 1975 |
Influence of stress and phenobarbital on corticosterone metabolism during early postnatal life of rat.
Topics: Aging; Animals; Animals, Newborn; Corticosterone; Liver; Male; Organ Size; Phenobarbital; Rats; Stre | 1977 |
[Slowing aging by activating the microsomal oxidase system with phenobarbital].
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Mice; Mice, Inbred CBA; Mice, Inbr | 1977 |
Effects of smoking on drug action.
Topics: Adult; Aged; Aging; Alcohol Drinking; Dextropropoxyphene; Dose-Response Relationship, Drug; Female; | 1977 |
Clinical pharmacokinetics in infants and children.
Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid | 1976 |
Proceedings: Drug disposition during development.
Topics: Aging; Child Development; Child, Preschool; Diazepam; Half-Life; Humans; Infant; Infant, Newborn; Ph | 1974 |
Comparative toxicity of some selected pesticides in neonatal and adult rats.
Topics: Aging; Animals; Animals, Newborn; Drug Synergism; Female; Insecticides; Lethal Dose 50; Male; Parath | 1975 |
Plasma protein binding of drugs as a function of age in adult human subjects.
Topics: Adult; Aged; Aging; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood P | 1975 |
Biliary excretion of drugs: role of ligandin in newborn immaturity and in the action of microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Biotransformation; Carrier Proteins; Enzyme Induction; Gluta | 1975 |
Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone.
Topics: Aging; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Diet; Enzyme Induction; Female; Fla | 1975 |
Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.
Topics: Adult; Aged; Aging; Female; Humans; Male; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Protei | 1975 |
Differential control of rat microsomal "aryl hydrocarbon" monooxygenase and epoxide hydratase.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Epoxide Hydrolases; Female; Fetus; Hydro-Lyases; Live | 1976 |
Development of liver microsomal oxidations in the chick.
Topics: Aging; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chickens; Cytochrome P-450 Enzyme Sy | 1976 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang.
Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System; | 1992 |
[Effect of age and inductors on UDP-glucuronyltransferase activity].
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Dexamethasone; Glucuronosyltransferase; Male; Mi | 1992 |
[Effect of age and phenobarbital on liver activity of mixed function oxidase].
Topics: Aging; Animals; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar | 1992 |
Phenobarbitone population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens.
Topics: Adolescent; Aging; Anticonvulsants; Body Weight; Child; Drug Interactions; Female; Humans; Male; Mod | 1992 |
The effect of age on inducibility of various types of rat liver cytochrome P-450.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Li | 1992 |
Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development.
Topics: Aging; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Souther | 1992 |
Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug | 1992 |
Age and the pharmacokinetic-pharmacodynamic relationship of phenobarbital in rats: "pseudo"-longitudinal vs cross-sectional study design.
Topics: Aging; Animals; Brain; Cross-Sectional Studies; Half-Life; Longitudinal Studies; Male; Phenobarbital | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Infusions, Intravenous; Male; Phenobarbital; R | 1992 |
Effects of barbiturates with or without liver-tumor-promoting activity on survival and DNA synthesis of suckling and adult rat hepatocytes in serum-free primary culture.
Topics: Aging; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Cell Survival; Culture Media, Seru | 1992 |
Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
Topics: Aging; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cytochrome P-450 Enzyme Syste | 1990 |
Phenobarbital doses necessary to achieve 'therapeutic' concentrations in children.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug | 1991 |
Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver.
Topics: Aging; Animals; Body Weight; Cytosol; Female; Glutathione Transferase; Isoenzymes; Liver; Male; Orga | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously.
Topics: Aging; Animals; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Phenobarbital; P | 1991 |
Age dependent differences in stimulation and compensation of renal and biliary transport processes. Correlation to the physicochemical properties of the exerted substances.
Topics: Aging; Animals; Bile; Biological Transport, Active; Chemical Phenomena; Chemistry, Physical; Colorin | 1990 |
Neonatal modulation of adult rat hepatic microsomal benzo[a]pyrene hydroxylase activities by Aroclor 1254 or phenobarbital.
Topics: Aging; Animals; Animals, Newborn; Aroclors; Benzopyrene Hydroxylase; Chlorodiphenyl (54% Chlorine); | 1990 |
Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats.
Topics: Aging; Animals; Chromates; Chromium; Cromolyn Sodium; Female; Kidney; Kidney Diseases; Kidney Tubule | 1990 |
Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors.
Topics: Aging; Animals; Brain; Female; Flunitrazepam; Male; Mice; Muscimol; Phenobarbital; Pregnancy; Prenat | 1990 |
Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens.
Topics: Aging; Animals; Basophils; Eosinophils; Female; Glutathione Transferase; Immunoenzyme Techniques; Li | 1990 |
Hepatic cytosolic glutathione S-transferase activities in ageing brown Norway rats--importance of sex differences and phenobarbital treatment for studies of ageing.
Topics: Aging; Animals; Cytosol; Dinitrochlorobenzene; Enzyme Induction; Female; Glutathione Transferase; Li | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--carbamazepine.
Topics: Aging; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid.
Topics: Adolescent; Adult; Aging; Aspartate Aminotransferases; Body Weight; Carbamazepine; Dose-Response Rel | 1990 |
The disposition of primidone in elderly patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Chromatography, High Pressure | 1990 |
The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases.
Topics: Aging; Animals; Antibodies; Biotransformation; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male | 1990 |
Consequences of chronic phenobarbital treatment on local cerebral glucose utilization in the developing rat.
Topics: Aging; Animals; Blood Glucose; Brain; Deoxy Sugars; Deoxyglucose; Energy Metabolism; Female; Male; O | 1990 |
The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2.
Topics: Aging; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Liver; Ma | 1990 |
Influence of age, phenobarbital and beta-naphthoflavone on hepatic microsomal lipid peroxidation in rats.
Topics: Aging; Animals; Animals, Newborn; Benzoflavones; beta-Naphthoflavone; Flavonoids; Lipid Peroxidation | 1990 |
Hepatic elimination kinetics of organic anions in rats: developmental aspects and influence of phenobarbital.
Topics: Aging; Animals; Anions; Bile; Eosine Yellowish-(YS); Half-Life; Indocyanine Green; Kinetics; Liver; | 1986 |
Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Brain Chemistry; Cells, Cultured; Female; | 1989 |
Effects of non-genotoxic hepatocarcinogens phenobarbital and nafenopin on phenotype and growth of different populations of altered foci in rat liver.
Topics: Aging; Animals; Carcinogenicity Tests; Carcinogens; Cell Survival; Female; gamma-Glutamyltransferase | 1989 |
Role of growth hormone in modulating the constitutive and phenobarbital-induced levels of two P-450(6)beta (testosterone 6 beta-hydroxylase) mRNAs in rat livers.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Growth Hormone; Isoenzymes | 1989 |
Effects of carbamazepine and phenobarbital on kainic acid-induced model of psychomotor seizures during ontogenesis in the rat.
Topics: Aging; Animals; Carbamazepine; Dose-Response Relationship, Drug; Kainic Acid; Male; Phenobarbital; R | 1989 |
The effect of phenobarbital on human plasma lipids.
Topics: Adult; Aged; Aging; Apolipoproteins; Body Weight; Cholesterol; Epilepsy; Female; Humans; Lipids; Mid | 1989 |
The effect of age on antipyrine metabolism by liver microsomes isolated from phenobarbital-treated rats.
Topics: Aging; Animals; Antipyrine; Male; Microsomes, Liver; Phenobarbital; Rats | 1989 |
Age-development and inducibility of hepatic glutathione S-transferase activities in mice, rats, rabbits and guinea-pigs.
Topics: Aging; Animals; Enzyme Induction; Female; Glutathione Transferase; Guinea Pigs; Liver; Male; Mice; P | 1985 |
Evidence for lack of promotion of the growth of the common naturally occurring basophilic focal hepatocellular proliferative lesions in aged F344/NCr rats by phenobarbital.
Topics: Adenoma; Aging; Animals; Basophils; Cell Division; DNA; Female; gamma-Glutamyltransferase; Liver; Li | 1985 |
The effect of single versus split doses of diethylnitrosamine on the induction of gamma-glutamyltranspeptidase-foci in the livers of adult and juvenile rats.
Topics: Aging; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; gamma-Glutam | 1986 |
Regulation of corticosterone metabolism in liver cell fractions in young and adult rats: cofactor requirements, effects of stress and phenobarbital treatment.
Topics: Aging; Animals; Chemical Fractionation; Coenzymes; Corticosterone; Liver; Male; NAD; NADP; Phenobarb | 1987 |
Postnatal changes in hepatic microsomal enzyme activities in the puppy.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Cytochrome P-450 Enzyme System; Dogs; Female; Glucose | 1985 |
Effects of phenobarbital on cerebral blood flow and metabolism in young and aged rats.
Topics: Aging; Anesthesia, Inhalation; Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circu | 1986 |
Difference in the effects of phenobarbital and 3-methylcholanthrene treatment on subunit composition of hepatic glutathione S-transferase in male and female rats.
Topics: Aging; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Glutathione Transfera | 1987 |
Age-related changes in the expression of cytochrome P-450 (b+e) gene in the rat after phenobarbitone administration.
Topics: Aging; Animals; Brain; Cell Nucleus; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulat | 1988 |
Drug disposition and biotransformation in the developing beagle dog.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Blood Proteins; Dogs; Female; Half-Life; Male; Pha | 1988 |
The influence of prenatal phenobarbital exposure on the growth of dendrites in the rat hippocampus.
Topics: Aging; Animals; Body Weight; Dendrites; Female; Hippocampus; Phenobarbital; Pregnancy; Prenatal Expo | 1988 |
The neurotoxicity of phenobarbital and its effect in preventing pentylenetetrazole-induced maximal seizure in aging mice.
Topics: Administration, Oral; Aging; Animals; Drug Tolerance; Female; Injections, Intraperitoneal; Mice; Pen | 1988 |
Ontogenic development of 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylase in the rat and effect of monoclonal antibodies.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP1A1; Cyto | 1988 |
Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Syst | 1987 |
The effect of age on mono-oxygenase enzyme kinetics in rat liver microsomes.
Topics: Aging; Aldrin; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Kinet | 1987 |
Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level.
Topics: Age Factors; Aging; Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Coumarins; Cytochrome | 1987 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
Effects of early chronic phenobarbital treatment on the maturation of energy metabolism in the developing rat brain. I. Incorporation of glucose carbon into amino acids.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Blood Glucose; Brain; Carbon Radioisotopes; Energy Me | 1987 |
Effects of early chronic phenobarbital treatment on the maturation of energy metabolism in the developing rat brain. II. Incorporation of beta-hydroxybutyrate into amino acids.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Amino Acids; Animals; Animals, Newborn; Cerebellum; Cer | 1987 |
The effect of age on the adaptation of the brain to the anticonvulsant effect of phenobarbital in mice.
Topics: Adaptation, Physiological; Aging; Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; | 1986 |
Indomethacin metabolism in liver microsomes during postnatal development in the rat.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Ind | 1986 |
Aging modifies the expression of hepatic microsomal cytochromes P-450 after pretreatment of rats with beta-naphthoflavone or phenobarbital.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme Syste | 1986 |
Induction and catalytic activities of cytochromes P-450b/e and P-450c in the liver microsomes of neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Kinetics; Liver; Methylcholanthren | 1986 |
Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography.
Topics: Adult; Aged; Aging; Confusion; Dizziness; Headache; Humans; Metrizamide; Middle Aged; Myelography; N | 1986 |
Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats.
Topics: Administration, Oral; Aging; Animals; Animals, Suckling; Blood Glucose; Deoxyglucose; Dieldrin; Drug | 1986 |
A mathematical analysis of aging influences on enzyme deactivation/activation kinetics. Examples of the influence of regional brain development and drugs in rats.
Topics: 5-Aminolevulinate Synthetase; Aging; Animals; Brain; Carboxy-Lyases; Enzyme Activation; Female; Hexa | 1985 |
Increased anticonvulsant effect of phenobarbital with age in mice--a possible pharmacological index for brain aging.
Topics: Aging; Animals; Anticonvulsants; Brain; Female; Mice; Mice, Inbred Strains; Phenobarbital | 1985 |
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Crosses, Genetic; Cytochromes; Enzyme Induction; Fema | 1972 |
Perinatal drug metabolism and morphological changes in the hepatocytes of normal and phenobarbital-treated guinea pigs.
Topics: Aging; Aniline Compounds; Animals; Animals, Newborn; Benzopyrenes; Cytochrome P-450 Enzyme System; C | 1974 |
Inhibition of hepatic mixed function oxidase activity by propyl gallate.
Topics: Aging; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Benzphetamine; Cytochrome c Group; Cytochro | 1974 |
Some properties of the uridine diphosphate glucuronyltransferase activity synthesizing thio-beta-D-glucuronides.
Topics: Aging; Animals; Carbon Isotopes; Chick Embryo; Drug Stability; Enzyme Activation; Female; Glucosamin | 1973 |
Comparison of culture-induced, phenobarbital-induced and naturally-developing UDP-glucuronyltransferase.
Topics: Aging; Animals; Chick Embryo; Chickens; Enzyme Induction; Glucosamine; Glucuronosyltransferase; Hexo | 1974 |
Effect of phenobarbital on electron transport system, oxidation and reduction of drugs in liver microsomes of rats of different age.
Topics: Aging; Animals; Centrifugation; Electron Transport; Electron Transport Complex IV; Female; Liver; Mi | 1968 |
A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide.
Topics: Aging; Animals; Cell Fractionation; Centrifugation; Chemical Phenomena; Chemistry; Chromatography, T | 1971 |
Heterogeneity of rough-surfaced liver microsomal membranes of adult, phenobarbital-treated, and newborn rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Centrifugation, Density Gradient; Electron Transp | 1968 |
Influence of age and diet on the induction of microsomal enzymes in the mouse.
Topics: Aging; Animals; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Cytochromes; Dietary Proteins; | 1971 |
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Enzyme Induction; Liver; Methylcholanthrene; Microsomes, Liv | 1974 |
Metabolic transformation of colchicine, II. The metabolism of colchicine by mammalian liver microsomes.
Topics: Aging; Animals; Colchicine; Cricetinae; Glucuronates; Liver; Methylcholanthrene; Mice; Microsomes, L | 1974 |
Species differences in induction and inhibition of liver isocarboxazid hydrolase.
Topics: Aging; Animals; Animals, Newborn; Enzyme Induction; Female; Guinea Pigs; Hydrolases; In Vitro Techni | 1973 |
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.
Topics: Aging; Animals; Benzene Derivatives; Body Weight; Drug Tolerance; Enzyme Induction; Ethers; Ethylami | 1973 |
The influence of aging on the activity of anticonvulsant drugs.
Topics: Acetazolamide; Aging; Animals; Blood-Brain Barrier; Carbon Dioxide; Carbonic Anhydrases; Cerebral Co | 1965 |
Bilirubin glucosyl- and glucuronyltransferases. A comparative study and the effects of drugs.
Topics: Aging; Alkaloids; Animals; Bilirubin; Cats; China; Cricetinae; Female; Glucosyltransferases; Glucuro | 1972 |
Age differences in drug binding by plasma proteins: studies on human foetuses, neonates and adults.
Topics: Adult; Age Factors; Aging; Ampicillin; Azides; Bilirubin; Blood Proteins; Dialysis; Female; Fetus; F | 1971 |
Sex and age differences in the effects of barbiturates.
Topics: Aging; Animals; Female; Male; Pentobarbital; Phenobarbital; Rats; Sex | 1965 |
Focal spike discharges in children, a longitudinal study.
Topics: Adolescent; Aging; Central Nervous System Diseases; Cerebral Palsy; Cerebral Ventriculography; Child | 1966 |
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats.
Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecti | 1968 |
Alteration of normal development of drug metabolism by injection of growth hormone.
Topics: Aging; Aminopyrine; Animals; Growth Hormone; Injections; Liver; Morphine; Phenobarbital; Rats | 1970 |
Enzymic 6-hydroxylation of indolealkylamines and related compounds.
Topics: Aging; Amines; Animals; Buffers; Carbon Monoxide; Chemical Phenomena; Chemistry, Physical; Depressio | 1968 |
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction.
Topics: Aging; Animals; Benz(a)Anthracenes; Brain; Carbon Monoxide; Chick Embryo; Cricetinae; Culture Techni | 1968 |
Inhibition of hepatic microsomal enzymes by alkylating agents.
Topics: Aging; Aminopyrine; Animals; Cyclophosphamide; Drug Synergism; Enzyme Induction; Enzymes; Liver; Mal | 1969 |