phenobarbital and Adverse Drug Event studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

Excerpt	Relevance	Reference
"The multiple drug interactions in which CAIs are involved should be carefully considered when such drugs are used in combination with the drug classes mentioned above, as the risks of developing toxicity and serious side effects if the dosages are not adjusted are high."	2.53	Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. ( Supuran, CT, 2016)
"Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids."	1.38	In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012)
"Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal."	1.38	The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. ( Borland, S; Ewart, L; Kirk, S; Lainée, P; Marks, L; Philp, K; Skinner, M; Valentin, JP, 2012)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."	1.37	FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (66.67)	18.7374
1990's	3 (8.33)	18.2507
2000's	1 (2.78)	29.6817
2010's	8 (22.22)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Pedersen, JM	1
Matsson, P	1
Bergström, CA	1
Norinder, U	1
Hoogstraate, J	1
Artursson, P	1
Chen, M	1
Vijay, V	1
Shi, Q	1
Liu, Z	1
Fang, H	1
Tong, W	1
Fischer, H	1
Atzpodien, EA	1
Csato, M	1
Doessegger, L	1
Lenz, B	1
Schmitt, G	1
Singer, T	1
Sakatis, MZ	1
Reese, MJ	1
Harrell, AW	1
Taylor, MA	1
Baines, IA	1
Chen, L	1
Bloomer, JC	1
Yang, EY	1
Ellens, HM	1
Ambroso, JL	1
Lovatt, CA	1
Ayrton, AD	1
Clarke, SE	1
Witcher, RH	1
Ramirez, MM	1
Gillinder, L	1
Lehn, A	1
Brown, H	1
Dionisio, S	1
Hosohata, K	1
Inada, A	1
Oyama, S	1
Niinomi, I	1
Wakabayashi, T	1
Iwanaga, K	1
Supuran, CT	1
Marks, L	1
Borland, S	1
Philp, K	1
Ewart, L	1
Lainée, P	1
Skinner, M	1
Kirk, S	1
Valentin, JP	1
WINNIK, H	1
FINKELSTEIN, J	1
VANDAM, LD	1
COLLINS, WL	1
RAJTAR-LEONTIEW, Z	1
ZALEWSKI, T	1
BURNS, JJ	1
CUCINELL, SA	1
KOSTER, R	1
CONNEY, AH	1
Dimitrova, K	1
Ivanov, V	1
Bogoeva, M	1
Golovinsky, E	1
Markov, K	1
Smith, MT	1
Wills, ED	1
Yaffe, SJ	1
Kawasaki, H	1
Murawaki, Y	1
Hanzlick, R	1
Sauer, JM	1
Stine, ER	1
Gunawardhana, L	1
Hill, DA	1
Sipes, IG	1
Hammond, KB	1
Windorfer, A	1
Stünkel, S	1
Vaisman, SL	1
Gartner, LM	1
Annau, Z	1
Maier, P	1
Okey, AB	1
Roberts, EA	1
Harper, PA	1
Denison, MS	1
Daniel, DG	1
Rabin, PL	1
Parsonage, M	1
Kellaway, GS	1
McCrae, E	1
Pochedly, C	1
Ente, G	1
Jacobs, HD	1
Shakun, NP	1
Oleinik, AN	1
de Matteis, F	1
Kaeser, HE	1
Weingärtner, L	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018]	Phase 1/Phase 2	30 participants (Anticipated)	Interventional	2019-01-10	Recruiting
Evidence-based Assessment of Medication Sensitivity in Acute Hepatic Porphyria[NCT03906214]		60 participants (Actual)	Observational	2019-04-03	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert opinion on drug metabolism & toxicology, 2016, Volume: 12, Issue:4 Topics: Acetazolamide; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Antibodies, Monoclonal;	2016
[Various problems in therapy and prognosis of drug-induced liver diseases]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1995, Feb-10, Volume: 84, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Diet, Fat-Restricted; Drug-Related Side Effects and Adverse	1995
The liver as a target for chemical-chemical interactions. Advances in pharmacology (San Diego, Calif.), 1997, Volume: 43 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Drug Antagoni	1997
Drugs and children: methods for therapeutic monitoring. Clinical toxicology, 1977, Volume: 10, Issue:2 Topics: Carbamazepine; Child; Child, Preschool; Chloramphenicol; Chromatography, Gas; Colorimetry; Drug Ther	1977
Pharmacologic treatment of neonatal hyperbilirubinemia. Clinics in perinatology, 1975, Volume: 2, Issue:1 Topics: Adolescent; Animals; Aspartic Acid; Bilirubin; DDT; Diazepam; Drug Therapy, Combination; Drug-Relate	1975
Induction of drug-metabolizing enzymes: mechanisms and consequences. Clinical biochemistry, 1986, Volume: 19, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Chemical and Drug Induced Li	1986
Adverse hematologic effects of drugs. Pediatric clinics of North America, 1972, Volume: 19, Issue:4 Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents	1972
Disturbances of liver porphyrin metabolism caused by drugs. Pharmacological reviews, 1967, Volume: 19, Issue:4 Topics: Animals; Chlorpropamide; Drug-Related Side Effects and Adverse Reactions; Estrogens; Griseofulvin; H	1967

Article	Year
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi	2008
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des	2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme	2012
Successful Phenobarbital Desensitization After DRESS Reaction in the Management of Refractory Status Epilepticus. Journal of pharmacy practice, 2019, Volume: 32, Issue:2 Topics: Anticonvulsants; Child, Preschool; Desensitization, Immunologic; Drug Hypersensitivity; Drug-Related	2019
Treatment outcomes after the introduction of a new seizure management protocol. Internal medicine journal, 2018, Volume: 48, Issue:7 Topics: Adult; Anticonvulsants; Clinical Protocols; Drug-Related Side Effects and Adverse Reactions; Emergen	2018
Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database. Clinical drug investigation, 2019, Volume: 39, Issue:4 Topics: Anticonvulsants; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Exanthema; Fem	2019
The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. Toxicology and applied pharmacology, 2012, Sep-01, Volume: 263, Issue:2 Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Drug E	2012
[Double poisoning with atropine and phenobarbital]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1953, Feb-28, Volume: 29, Issue:15 Topics: Atropine; Barbiturates; Drug-Related Side Effects and Adverse Reactions; Humans; Penicillins; Phenob	1953
Recovery from acute phenobarbital intoxication after prolonged coma. JAMA, 1963, Apr-20, Volume: 184 Topics: Barbiturates; Coma; Drug-Related Side Effects and Adverse Reactions; Phenobarbital; Psychoses, Subst	1963
[ACCIDENTAL INH POISONING IN A 2-YEAR-OLD GIRL]. Pediatria polska, 1964, Volume: 39 Topics: Drug-Related Side Effects and Adverse Reactions; Infant; Isoniazid; Phenobarbital; Seizures; Toxicol	1964
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES. Annals of the New York Academy of Sciences, 1965, Mar-12, Volume: 123 Topics: Aspirin; Blood; Chromatography; Dicumarol; Diphenhydramine; Dogs; Drug-Related Side Effects and Adve	1965
A study on the mutagenic effect of some Bulgarian drugs using the Salmonella/microsome test. Acta physiologica et pharmacologica Bulgarica, 1983, Volume: 9, Issue:4 Topics: Animals; Biotransformation; Bulgaria; Drug-Related Side Effects and Adverse Reactions; Enzyme Induct	1983
The mechanism of phenobarbitone potentiation of centrilobular hepatic necrosis. Advances in experimental medicine and biology, 1981, Volume: 136 Pt A Topics: Animals; Cytochrome P-450 Enzyme System; Drug Synergism; Drug-Related Side Effects and Adverse React	1981
Clinical implications of perinatal pharmacology. European journal of clinical pharmacology, 1980, Volume: 18, Issue:1 Topics: Drug-Related Side Effects and Adverse Reactions; Female; Fetus; Humans; Infant, Newborn; Infant, New	1980
National Association of Medical Examiners Pediatric Toxicology (PedTox) Registry Report 3. Case submission summary and data for acetaminophen, benzene, carboxyhemoglobin, dextromethorphan, ethanol, phenobarbital, and pseudoephedrine. The American journal of forensic medicine and pathology, 1995, Volume: 16, Issue:4 Topics: Acetaminophen; Benzene; Carboxyhemoglobin; Child, Preschool; Coroners and Medical Examiners; Dextrom	1995
[Significance of pharmacogenic liver reactions for metabolism of endogenous and exogenous substances]. Monatsschrift fur Kinderheilkunde, 1979, Volume: 127, Issue:3 Topics: Carbamazepine; Diazepam; Drug-Related Side Effects and Adverse Reactions; Female; Fenoterol; Humans;	1979
[Medicines in young children]. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1978, Sep-23, Volume: 54, Issue:13 Topics: Aspirin; Child; Digoxin; Drug-Related Side Effects and Adverse Reactions; Humans; Iron; Penicillins;	1978
The use of pharmacological challenges in behavioral toxicology. Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. Serie B, Umwelthygiene, Krankenhaushygiene, Arbeitshygiene, praventive Medizin, 1987, Volume: 185, Issue:1-2 Topics: Animals; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Drug-Related Side Ef	1987
Development of in vitro toxicity tests with cultures of freshly isolated rat hepatocytes. Experientia, 1988, Oct-15, Volume: 44, Issue:10 Topics: Animals; Cells, Cultured; Dimethyl Sulfoxide; DNA; Drug-Related Side Effects and Adverse Reactions;	1988
Disguises of delirium. Southern medical journal, 1985, Volume: 78, Issue:6 Topics: Adult; Aged; Brain Diseases; Delirium; Diagnosis, Differential; Drug-Related Side Effects and Advers	1985
Psychiatric side effects of nonpsychiatric drugs. Seminars in psychiatry, 1971, Volume: 3, Issue:4 Topics: Aminophylline; Analgesics; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics;	1971
Epilepsy. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec	1974
Intensive monitoring for adverse drug effects in patients discharged from acute medical wards. The New Zealand medical journal, 1973, Dec-26, Volume: 78, Issue:505 Topics: Adolescent; Adult; Age Factors; Aged; Drug Interactions; Drug Therapy, Combination; Drug-Related Sid	1973
[Effect of drugs on bilirubin metabolism in the treatment of jaundice]. Vrachebnoe delo, 1973, Volume: 11 Topics: Bilirubin; Drug Evaluation; Drug-Related Side Effects and Adverse Reactions; Humans; Hyperbilirubine	1973
[Neurotoxicity of drugs]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1972, Sep-26, Volume: 61, Issue:39 Topics: Arsenic; Drug-Related Side Effects and Adverse Reactions; Humans; Nervous System Diseases; Nitrofura	1972
[Special pharmacological problems of the neonatal period from the clinical point of view]. Zeitschrift fur arztliche Fortbildung, 1969, Jul-15, Volume: 63, Issue:14 Topics: Ampicillin; Animals; Chloramphenicol; Drug Therapy; Drug-Related Side Effects and Adverse Reactions;	1969

phenobarbital and Adverse Drug Event

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