phenobarbital has been researched along with Adenoma in 34 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Adenoma: A benign epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat." | 7.68 | Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. ( Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW, 1991) |
| " sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype." | 7.67 | Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986) |
| " Following chronic treatment, altered hepatic foci and adenomas were classified as: small-cell, heterogeneous basophilic lesions (spontaneous or tetrachlorodibenzo-p-dioxin-induced); large-cell, homogeneous basophilic lesions (WY-14,643-induced); acidophilic lesions (phenobarbital- or chlordane-induced)." | 3.70 | Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice. ( Anderson, SP; Cattley, RC; Christensen, JG; Corton, JC; Fox, TR; Goldsworthy, TL; Gonzales, AJ; Healy, LN; Malarkey, DE; Romach, EH, 1999) |
| "The ability of diethylnitrosamine (DENA) to initiate and phenobarbital to promote altered-hepatocyte foci and hepatocellular carcinomas in C3H and C3B6F1 (C3H x C57BL/6) mice was compared to the extent of cell proliferation." | 3.68 | Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation. ( Pereira, MA, 1993) |
| "Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice." | 3.68 | Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice. ( Bazare, JJ; Harmon, JR; Law, MG; Leakey, JE; Webb, PJ; Wolff, GL, 1991) |
| "Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat." | 3.68 | Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. ( Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW, 1991) |
| "Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens." | 3.68 | Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. ( Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S, 1991) |
| " sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype." | 3.67 | Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986) |
| " Overall, while chronic administration of the model CAR activator NaPB results in both hepatocellular adenoma and carcinoma in the low spontaneous liver tumour incidence C57BL/10J mouse strain, only 40 % of the liver tumours evaluated in this study had β-catenin mutations." | 1.56 | Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. ( Foster, A; Jones, HB; Kalaitzi, K; Lake, BG; Orton, TC; Sidaway, JE, 2020) |
| "The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment." | 1.27 | Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988) |
| "Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil." | 1.27 | The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. ( Herren-Freund, SL; Khoury, MD; Olson, G; Pereira, MA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (52.94) | 18.7374 |
| 1990's | 13 (38.24) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Sidaway, JE | 1 |
| Orton, TC | 1 |
| Kalaitzi, K | 1 |
| Jones, HB | 1 |
| Foster, A | 1 |
| Lake, BG | 1 |
| Kakehashi, A | 1 |
| Ishii, N | 1 |
| Okuno, T | 1 |
| Fujioka, M | 1 |
| Gi, M | 1 |
| Fukushima, S | 1 |
| Wanibuchi, H | 1 |
| Rossmanith, W | 1 |
| Chabicovsky, M | 1 |
| Grasl-Kraupp, B | 2 |
| Peter, B | 1 |
| Schausberger, E | 1 |
| Schulte-Hermann, R | 2 |
| Ward, JM | 7 |
| Diwan, BA | 5 |
| Rice, JM | 6 |
| Ohshima, M | 4 |
| Lynch, PH | 1 |
| Creasia, D | 1 |
| Lynch, P | 1 |
| Riggs, C | 1 |
| Pollard, M | 1 |
| Luckert, PH | 1 |
| Scheu, J | 1 |
| Williams, GM | 1 |
| Gebhardt, R | 1 |
| Sirma, H | 1 |
| Stenbäck, F | 1 |
| Waldhör, T | 1 |
| Huber, W | 1 |
| Pereira, MA | 5 |
| Lee, GH | 1 |
| Ooasa, T | 1 |
| Osanai, M | 1 |
| Christensen, JG | 1 |
| Romach, EH | 1 |
| Healy, LN | 1 |
| Gonzales, AJ | 1 |
| Anderson, SP | 1 |
| Malarkey, DE | 1 |
| Corton, JC | 1 |
| Fox, TR | 1 |
| Cattley, RC | 1 |
| Goldsworthy, TL | 1 |
| Yoshida, M | 1 |
| Miyajima, K | 1 |
| Shiraki, K | 1 |
| Ando, J | 1 |
| Kudoh, K | 1 |
| Nakae, D | 1 |
| Takahashi, M | 1 |
| Maekawa, A | 1 |
| Uchida, E | 1 |
| Hirono, I | 1 |
| Balanski, RM | 1 |
| Dzhioev, FK | 1 |
| Lee, YS | 1 |
| Seo, JS | 1 |
| Chung, HT | 1 |
| Cho, KJ | 1 |
| Jan, JJ | 1 |
| Lijinsky, W | 1 |
| Kovatch, RM | 1 |
| Thomas, BJ | 1 |
| Wolff, GL | 3 |
| Leakey, JE | 1 |
| Bazare, JJ | 1 |
| Harmon, JR | 1 |
| Webb, PJ | 1 |
| Law, MG | 1 |
| Smith, PF | 1 |
| Grossman, SJ | 1 |
| Gerson, RJ | 1 |
| Gordon, LR | 1 |
| Deluca, JG | 1 |
| Majka, JA | 1 |
| Wang, RW | 1 |
| Germershausen, JI | 1 |
| MacDonald, JS | 1 |
| Sell, S | 1 |
| Hunt, JM | 1 |
| Dunsford, HA | 1 |
| Chisari, FV | 1 |
| Lubet, RA | 1 |
| Nims, RW | 1 |
| Klaunig, JE | 4 |
| Weghorst, CM | 3 |
| Henneman, JR | 1 |
| Shirai, T | 1 |
| Masuda, A | 1 |
| Imaida, K | 1 |
| Ogiso, T | 1 |
| Ito, N | 1 |
| Ruch, RJ | 2 |
| Herren-Freund, SL | 2 |
| Khoury, MD | 1 |
| Olson, G | 1 |
| Hu, H | 1 |
| Schuller, HM | 1 |
| Morrissey, RL | 2 |
| Chen, JJ | 2 |
| Dragani, TA | 1 |
| Manenti, G | 1 |
| Galliani, G | 1 |
| Della Porta, G | 1 |
| Adenis, L | 1 |
| Vlaeminck, MN | 1 |
| Driessens, J | 1 |
1 review available for phenobarbital and Adenoma
| Article | Year |
|---|---|
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; F | 1990 |
33 other studies available for phenobarbital and Adenoma
| Article | Year |
|---|---|
Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.
Topics: Adenoma; Animals; beta Catenin; Carcinoma, Hepatocellular; Constitutive Androstane Receptor; Female; | 2020 |
Progression of Hepatic Adenoma to Carcinoma in
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Apoptosis; Cell Proliferation; Deoxyguanosine; Diseas | 2017 |
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell | 2002 |
Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms.
Topics: Adenoma; Aging; Animals; Carcinoma, Hepatocellular; Disease Susceptibility; Eosine Yellowish-(YS); g | 1983 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp | 1984 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Ne | 1995 |
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; D | 1993 |
Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital.
Topics: Adenoma; Aflatoxin B1; Animals; Carcinogens; Female; Glutathione Transferase; Isoenzymes; Liver; Liv | 1993 |
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver | 1993 |
Mechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.
Topics: Adenoma; Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Divi | 1998 |
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Topics: Adenoma; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinogens; Carcinoma; Carr | 1999 |
Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Anti-Infective Agents; Carcinogenicity Tests; Cell Di | 1999 |
Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.
Topics: Adenoma; Animals; Animals, Newborn; Dimethylnitrosamine; Drug Synergism; Liver Neoplasms; Lung Neopl | 1979 |
[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Barbital; Chlorpromazine; | 1976 |
Lung adenoma development and NK activity in mice treated with multiple carcinogens.
Topics: Adenoma; Animals; Diethylnitrosamine; Female; Killer Cells, Natural; Lung Neoplasms; Methylnitrosour | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Carcinogens; Cytoch | 1991 |
Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat.
Topics: Adenoma; Animals; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Liver; Lovast | 1991 |
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression | 1991 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; | 1989 |
Evidence for lack of promotion of the growth of the common naturally occurring basophilic focal hepatocellular proliferative lesions in aged F344/NCr rats by phenobarbital.
Topics: Adenoma; Aging; Animals; Basophils; Cell Division; DNA; Female; gamma-Glutamyltransferase; Liver; Li | 1985 |
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell | 1989 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship | 1988 |
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Ma | 1986 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
Topics: Acetates; Adenoma; Animals; Body Weight; Dichloroacetic Acid; Drug Synergism; Ethylnitrosourea; Live | 1987 |
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh | 1986 |
Amplified response to phenobarbital promotion of hepatotumorigenesis in obese yellow Avy/A (C3H x VY) F-1 hybrid mice.
Topics: Adenoma; Animals; Body Weight; Hybridization, Genetic; Liver; Liver Neoplasms, Experimental; Male; M | 1986 |
Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital.
Topics: Adenoma; Animals; Body Weight; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Mu | 1986 |
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; | 1985 |
[Pulmonary adenoma in Swiss mice receiving urethane. 8. Action of phenobarbital].
Topics: Adenoma; Animals; Drug Antagonism; Female; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Phen | 1970 |