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phenobarbital and Adenoma

phenobarbital has been researched along with Adenoma in 34 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Adenoma: A benign epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat."7.68Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. ( Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW, 1991)
" sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype."7.67Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986)
" Following chronic treatment, altered hepatic foci and adenomas were classified as: small-cell, heterogeneous basophilic lesions (spontaneous or tetrachlorodibenzo-p-dioxin-induced); large-cell, homogeneous basophilic lesions (WY-14,643-induced); acidophilic lesions (phenobarbital- or chlordane-induced)."3.70Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice. ( Anderson, SP; Cattley, RC; Christensen, JG; Corton, JC; Fox, TR; Goldsworthy, TL; Gonzales, AJ; Healy, LN; Malarkey, DE; Romach, EH, 1999)
"The ability of diethylnitrosamine (DENA) to initiate and phenobarbital to promote altered-hepatocyte foci and hepatocellular carcinomas in C3H and C3B6F1 (C3H x C57BL/6) mice was compared to the extent of cell proliferation."3.68Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation. ( Pereira, MA, 1993)
"Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice."3.68Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice. ( Bazare, JJ; Harmon, JR; Law, MG; Leakey, JE; Webb, PJ; Wolff, GL, 1991)
"Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat."3.68Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. ( Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW, 1991)
"Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens."3.68Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. ( Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S, 1991)
" sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype."3.67Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986)
" Overall, while chronic administration of the model CAR activator NaPB results in both hepatocellular adenoma and carcinoma in the low spontaneous liver tumour incidence C57BL/10J mouse strain, only 40 % of the liver tumours evaluated in this study had β-catenin mutations."1.56Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. ( Foster, A; Jones, HB; Kalaitzi, K; Lake, BG; Orton, TC; Sidaway, JE, 2020)
"The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment."1.27Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988)
"Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil."1.27The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. ( Herren-Freund, SL; Khoury, MD; Olson, G; Pereira, MA, 1987)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199018 (52.94)18.7374
1990's13 (38.24)18.2507
2000's1 (2.94)29.6817
2010's1 (2.94)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Sidaway, JE1
Orton, TC1
Kalaitzi, K1
Jones, HB1
Foster, A1
Lake, BG1
Kakehashi, A1
Ishii, N1
Okuno, T1
Fujioka, M1
Gi, M1
Fukushima, S1
Wanibuchi, H1
Rossmanith, W1
Chabicovsky, M1
Grasl-Kraupp, B2
Peter, B1
Schausberger, E1
Schulte-Hermann, R2
Ward, JM7
Diwan, BA5
Rice, JM6
Ohshima, M4
Lynch, PH1
Creasia, D1
Lynch, P1
Riggs, C1
Pollard, M1
Luckert, PH1
Scheu, J1
Williams, GM1
Gebhardt, R1
Sirma, H1
Stenbäck, F1
Waldhör, T1
Huber, W1
Pereira, MA5
Lee, GH1
Ooasa, T1
Osanai, M1
Christensen, JG1
Romach, EH1
Healy, LN1
Gonzales, AJ1
Anderson, SP1
Malarkey, DE1
Corton, JC1
Fox, TR1
Cattley, RC1
Goldsworthy, TL1
Yoshida, M1
Miyajima, K1
Shiraki, K1
Ando, J1
Kudoh, K1
Nakae, D1
Takahashi, M1
Maekawa, A1
Uchida, E1
Hirono, I1
Balanski, RM1
Dzhioev, FK1
Lee, YS1
Seo, JS1
Chung, HT1
Cho, KJ1
Jan, JJ1
Lijinsky, W1
Kovatch, RM1
Thomas, BJ1
Wolff, GL3
Leakey, JE1
Bazare, JJ1
Harmon, JR1
Webb, PJ1
Law, MG1
Smith, PF1
Grossman, SJ1
Gerson, RJ1
Gordon, LR1
Deluca, JG1
Majka, JA1
Wang, RW1
Germershausen, JI1
MacDonald, JS1
Sell, S1
Hunt, JM1
Dunsford, HA1
Chisari, FV1
Lubet, RA1
Nims, RW1
Klaunig, JE4
Weghorst, CM3
Henneman, JR1
Shirai, T1
Masuda, A1
Imaida, K1
Ogiso, T1
Ito, N1
Ruch, RJ2
Herren-Freund, SL2
Khoury, MD1
Olson, G1
Hu, H1
Schuller, HM1
Morrissey, RL2
Chen, JJ2
Dragani, TA1
Manenti, G1
Galliani, G1
Della Porta, G1
Adenis, L1
Vlaeminck, MN1
Driessens, J1

Reviews

1 review available for phenobarbital and Adenoma

ArticleYear
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
    Progress in clinical and biological research, 1990, Volume: 331

    Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; F

1990

Other Studies

33 other studies available for phenobarbital and Adenoma

ArticleYear
Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.
    Toxicology, 2020, 01-30, Volume: 430

    Topics: Adenoma; Animals; beta Catenin; Carcinoma, Hepatocellular; Constitutive Androstane Receptor; Female;

2020
Progression of Hepatic Adenoma to Carcinoma in
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Apoptosis; Cell Proliferation; Deoxyguanosine; Diseas

2017
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
    Molecular carcinogenesis, 2002, Volume: 35, Issue:1

    Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell

2002
Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:4

    Topics: Adenoma; Aging; Animals; Carcinoma, Hepatocellular; Disease Susceptibility; Eosine Yellowish-(YS); g

1983
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
    Cancer letters, 1984, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp

1984
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
    Carcinogenesis, 1983, Volume: 4, Issue:8

    Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas

1983
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Ne

1995
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; D

1993
Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Adenoma; Aflatoxin B1; Animals; Carcinogens; Female; Glutathione Transferase; Isoenzymes; Liver; Liv

1993
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
    Carcinogenesis, 1993, Volume: 14, Issue:2

    Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver

1993
Mechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.
    Cancer research, 1998, Apr-15, Volume: 58, Issue:8

    Topics: Adenoma; Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Divi

1998
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
    Carcinogenesis, 1999, Volume: 20, Issue:8

    Topics: Adenoma; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinogens; Carcinoma; Carr

1999
Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice.
    Cancer letters, 1999, Jul-01, Volume: 141, Issue:1-2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Anti-Infective Agents; Carcinogenicity Tests; Cell Di

1999
Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.
    Gan, 1979, Volume: 70, Issue:5

    Topics: Adenoma; Animals; Animals, Newborn; Dimethylnitrosamine; Drug Synergism; Liver Neoplasms; Lung Neopl

1979
[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice].
    Voprosy onkologii, 1976, Volume: 22, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Barbital; Chlorpromazine;

1976
Lung adenoma development and NK activity in mice treated with multiple carcinogens.
    Journal of Korean medical science, 1992, Volume: 7, Issue:1

    Topics: Adenoma; Animals; Diethylnitrosamine; Female; Killer Cells, Natural; Lung Neoplasms; Methylnitrosour

1992
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
    Carcinogenesis, 1992, Volume: 13, Issue:7

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy

1992
Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice.
    Carcinogenesis, 1991, Volume: 12, Issue:5

    Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Carcinogens; Cytoch

1991
Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat.
    Toxicologic pathology, 1991, Volume: 19, Issue:3

    Topics: Adenoma; Animals; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Liver; Lovast

1991
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression

1991
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
    Carcinogenesis, 1989, Volume: 10, Issue:9

    Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam;

1989
Evidence for lack of promotion of the growth of the common naturally occurring basophilic focal hepatocellular proliferative lesions in aged F344/NCr rats by phenobarbital.
    Carcinogenesis, 1985, Volume: 6, Issue:9

    Topics: Adenoma; Aging; Animals; Basophils; Cell Division; DNA; Female; gamma-Glutamyltransferase; Liver; Li

1985
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell

1989
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
    Japanese journal of cancer research : Gann, 1988, Volume: 79, Issue:4

    Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop

1988
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
    Toxicologic pathology, 1988, Volume: 16, Issue:3

    Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship

1988
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:2

    Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Ma

1986
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
    Toxicology and applied pharmacology, 1987, Volume: 90, Issue:1

    Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In

1987
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
    Toxicology and applied pharmacology, 1987, Sep-15, Volume: 90, Issue:2

    Topics: Acetates; Adenoma; Animals; Body Weight; Dichloroacetic Acid; Drug Synergism; Ethylnitrosourea; Live

1987
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
    Environmental health perspectives, 1986, Volume: 65

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh

1986
Amplified response to phenobarbital promotion of hepatotumorigenesis in obese yellow Avy/A (C3H x VY) F-1 hybrid mice.
    Carcinogenesis, 1986, Volume: 7, Issue:11

    Topics: Adenoma; Animals; Body Weight; Hybridization, Genetic; Liver; Liver Neoplasms, Experimental; Male; M

1986
Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital.
    Carcinogenesis, 1986, Volume: 7, Issue:11

    Topics: Adenoma; Animals; Body Weight; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Mu

1986
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
    Carcinogenesis, 1985, Volume: 6, Issue:2

    Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental;

1985
[Pulmonary adenoma in Swiss mice receiving urethane. 8. Action of phenobarbital].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1970, Volume: 164, Issue:3

    Topics: Adenoma; Animals; Drug Antagonism; Female; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Phen

1970