Page last updated: 2024-11-02

phenobarbital and Adenoma, Hepatocellular

phenobarbital has been researched along with Adenoma, Hepatocellular in 6 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

ExcerptRelevanceReference
" The authors discuss the possible development of adenomas of the liver as a result of long-term use of phenobarbital."1.32[Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital]. ( Bedrna, J; Ferko, A; Nozicka, J, 2003)
"The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0."1.31Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Klaunig, JE2
Gehen, SC1
Wang, Z1
Klein, PJ1
Billington, R1
Cerminara, C1
Bagnolo, V1
De Leonardis, F1
Coniglio, A1
Roberto, D1
Compagnone, E1
Curatolo, P1
Ferko, A1
Bedrna, J1
Nozicka, J1
Weghorst, CM1
Devor, DE1
Henneman, JR1
Ward, JM1
Watanabe, T1
Sugie, S1
Okamoto, K1
Rahman, KM1
Ushida, J1
Mori, H1

Other Studies

6 other studies available for phenobarbital and Adenoma, Hepatocellular

ArticleYear
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Adenoma, Liver Cell; Allyl Compounds; Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transform

2015
Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012, Volume: 28, Issue:6

    Topics: Adenoma, Liver Cell; Adolescent; Anticonvulsants; Epilepsy; Female; Humans; Intracranial Arterioveno

2012
[Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital].
    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 2003, Volume: 82, Issue:4

    Topics: Adenoma, Liver Cell; Adult; Anticonvulsants; Female; Humans; Liver Neoplasms; Phenobarbital; Pigment

2003
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
    Environmental health perspectives, 1993, Volume: 101 Suppl 5

    Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop

1993
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1994, Volume: 45, Issue:7

    Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Fe

1994
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:6

    Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce

2001