phenobarbital has been researched along with Adenoma, Hepatocellular in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors discuss the possible development of adenomas of the liver as a result of long-term use of phenobarbital." | 1.32 | [Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital]. ( Bedrna, J; Ferko, A; Nozicka, J, 2003) |
| "The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klaunig, JE | 2 |
| Gehen, SC | 1 |
| Wang, Z | 1 |
| Klein, PJ | 1 |
| Billington, R | 1 |
| Cerminara, C | 1 |
| Bagnolo, V | 1 |
| De Leonardis, F | 1 |
| Coniglio, A | 1 |
| Roberto, D | 1 |
| Compagnone, E | 1 |
| Curatolo, P | 1 |
| Ferko, A | 1 |
| Bedrna, J | 1 |
| Nozicka, J | 1 |
| Weghorst, CM | 1 |
| Devor, DE | 1 |
| Henneman, JR | 1 |
| Ward, JM | 1 |
| Watanabe, T | 1 |
| Sugie, S | 1 |
| Okamoto, K | 1 |
| Rahman, KM | 1 |
| Ushida, J | 1 |
| Mori, H | 1 |
6 other studies available for phenobarbital and Adenoma, Hepatocellular
| Article | Year |
|---|---|
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
Topics: Adenoma, Liver Cell; Allyl Compounds; Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transform | 2015 |
Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report.
Topics: Adenoma, Liver Cell; Adolescent; Anticonvulsants; Epilepsy; Female; Humans; Intracranial Arterioveno | 2012 |
[Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital].
Topics: Adenoma, Liver Cell; Adult; Anticonvulsants; Female; Humans; Liver Neoplasms; Phenobarbital; Pigment | 2003 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Fe | 1994 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |