phenobarbital has been researched along with Acute Porphyria in 14 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Finally, a theoretical hemin effect was implemented to illustrate the applicability of the model to dosage optimization in drug therapies." | 1.51 | Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model. ( Fontanellas, A; Jericó, D; Parra-Guillén, ZP; Sampedro, A; Serrano-Mendioroz, I; Trocóniz, IF; Vera-Yunca, D, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Serrano-Mendioroz, I | 2 |
| Sampedro, A | 2 |
| Serna, N | 1 |
| de Salamanca, RE | 1 |
| Sanz-Parra, A | 1 |
| Corrales, F | 1 |
| Berraondo, P | 1 |
| Millet, O | 1 |
| Fontanellas, A | 2 |
| Yasuda, M | 3 |
| Gan, L | 3 |
| Chen, B | 2 |
| Yu, C | 1 |
| Zhang, J | 1 |
| Gama-Sosa, MA | 1 |
| Pollak, DD | 1 |
| Berger, S | 1 |
| Phillips, JD | 1 |
| Edelmann, W | 1 |
| Desnick, RJ | 3 |
| Vera-Yunca, D | 1 |
| Jericó, D | 1 |
| Trocóniz, IF | 1 |
| Parra-Guillén, ZP | 1 |
| Pulgar, VM | 1 |
| Bonkovsky, HL | 1 |
| Wang, M | 1 |
| Zhang, B | 1 |
| Homedan, C | 1 |
| Schmitt, C | 1 |
| Laafi, J | 1 |
| Gueguen, N | 1 |
| Desquiret-Dumas, V | 1 |
| Lenglet, H | 1 |
| Karim, Z | 1 |
| Gouya, L | 1 |
| Deybach, JC | 1 |
| Simard, G | 1 |
| Puy, H | 1 |
| Malthièry, Y | 1 |
| Reynier, P | 1 |
| TAKASAKI, H | 1 |
| SAKAKURA, T | 1 |
| ARAKI, T | 1 |
| TANAKA, A | 1 |
| IKEDA, N | 1 |
| SEKIUCHI, T | 1 |
| Johansson, A | 1 |
| Nowak, G | 1 |
| Möller, C | 1 |
| Blomberg, P | 1 |
| Harper, P | 1 |
| Kenny, JM | 1 |
| Chipolombwe, MJ | 1 |
| Molyneux, E | 1 |
| Lindberg, RL | 2 |
| Porcher, C | 1 |
| Grandchamp, B | 1 |
| Ledermann, B | 1 |
| Bürki, K | 1 |
| Brandner, S | 1 |
| Aguzzi, A | 1 |
| Meyer, UA | 2 |
| Tishler, PV | 1 |
| Sykes, RM | 1 |
| Schuurmans, MM | 1 |
| Hoffmann, F | 1 |
14 other studies available for phenobarbital and Acute Porphyria
| Article | Year |
|---|---|
Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria.
Topics: Animals; Computer Simulation; Disease Models, Animal; Genetic Therapy; Hydroxymethylbilane Synthase; | 2018 |
Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria.
Topics: Aminolevulinic Acid; Animals; Central Nervous System; Gene Knock-In Techniques; Genes, Dominant; Hom | 2019 |
Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
Topics: Aminolevulinic Acid; Animals; Computer Simulation; Disease Models, Animal; Male; Mice; Mice, Inbred | 2019 |
Sex differences in vascular reactivity in mesenteric arteries from a mouse model of acute intermittent porphyria.
Topics: Acetylcholine; Animals; Disease Models, Animal; Female; Heme; Hydroxymethylbilane Synthase; Male; Me | 2019 |
Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electron Transport; Gene Expression Profiling; Li | 2019 |
Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria.
Topics: Adenosine Triphosphate; Animals; Brain; Disease Models, Animal; Electron Transport Complex I; Electr | 2015 |
[Two cases of acute porphyria].
Topics: Humans; Phenobarbital; Porphyria, Acute Intermittent; Porphyrias; Vitamin A; Vitamin K; Vitamins | 1963 |
Adenoviral-mediated expression of porphobilinogen deaminase in liver restores the metabolic defect in a mouse model of acute intermittent porphyria.
Topics: Adenoviridae; Aminolevulinic Acid; Animals; Disease Models, Animal; Gene Expression; Genetic Therapy | 2004 |
A case of repeated coma in an 8-year-old boy.
Topics: Anticonvulsants; Child; Coma; Humans; Male; Phenobarbital; Porphyria, Acute Intermittent; Recurrence | 2007 |
[Case history--red urine].
Topics: Adult; Aminopyrine; Drug Combinations; Female; Humans; Phenobarbital; Porphyria, Acute Intermittent | 1995 |
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Atrophy; Axons; Base Sequence; Chimera; Disease Models, Animal; Female | 1996 |
The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria.
Topics: Animals; Chlorpromazine; Diazepam; Enzyme Activation; Erythrocytes; Humans; Hydroxymethylbilane Synt | 1999 |
Acute intermittent porphyria, seizures, and antiepileptic drugs: a report on a 3-year-old Nigerian boy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Epilepsy, Generalized; Humans; Male; Phenobarbital | 2001 |
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug C | 2001 |