phenobarbital has been researched along with Acute Liver Injury, Drug-Induced in 310 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 8.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| "Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model." | 7.67 | Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. ( Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR, 1988) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 7.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0." | 7.66 | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 7.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 7.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 5.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 5.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| "Phenobarbital pretreatment potentiated the hepatic necrosis produced by both thioacetamide and thioacetamide sulfine." | 5.26 | Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. ( Holscher, MA; Hunter, AL; Neal, RA, 1977) |
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 4.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| "The mechanism of prolongation of sleeping (anesthesia) time after phenobarbital (PB) treatment was assessed in mice with ethionine (ET)-induced liver disorders (ET-treated group)." | 3.69 | Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice. ( Kawai, Y; Noguchi, M, 1996) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 3.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model." | 3.67 | Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. ( Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR, 1988) |
| "We report the case of a 19-year-old Laotian patient affected by fulminant hepatitis during the third trimester of her pregnancy after a 1-month administration of quinidine phenylethylbarbiturate." | 3.67 | Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report. ( Benhamou, JP; Bernuau, J; Bourlière, M; Rueff, B, 1988) |
| "A rat model of enflurane-associated hepatotoxicity was compared with the halothane-hypoxia (HH) model (adult male rats, phenobarbital induction, 1% halothane, 14% O2, for 2 hr)." | 3.67 | Comparison of the requirements for hepatic injury with halothane and enflurane in rats. ( Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG, 1985) |
| "Multiple doses of beta-naphthoflavone to iron-loaded C57BL/10ScSn mice for 6 weeks caused inhibition of hepatic uroporphyrinogen decarboxylase and a porphyria indistinguishable from that previously only reported for polyhalogenated aromatic chemicals." | 3.67 | Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. ( Francis, JE; Smith, AG, 1987) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 3.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0." | 3.66 | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 3.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| " Halothane hepatotoxic was produced in all rat strains by exposing phenobarbital-pretreated rats to 1 per cent halothane under mild hypoxia (14 per cent oxygen, inspired) for 2 h." | 3.66 | Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains. ( Adams, JF; Cousins, MJ; Gourlay, GK; Hall, P, 1981) |
| "A prospective study was undertaken to determine the cause of the acute anemia previously observed in pigs manifesting acute liver necrosis after administration of acetaminophen in dosages in excess of the LD100." | 3.65 | Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia. ( Fiskerstrand, C; Miller, DJ; Pichanick, GG; Saunders, SJ, 1977) |
| "A single 6-hr exposure to vinyl chloride monomer (5%) produces extensive vacuolization of centrolobular liver parenchyma and focal midzonal necrosis in the hepatic lobuole in phenobarbital-pretreated rats." | 3.65 | Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats. ( Jaeger, RJ; Murphy, SD; Reynolds, ES, 1975) |
| "Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture." | 3.65 | Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977) |
| "Treatment of rats with phenobarbital, which stimulates the activity of the drug-metabolizing enzymes in the liver, potentiates hepatic necrosis elicited by bromobenzene and a number of other chemically inert halogenated aromatic hydrocarbons." | 3.65 | Possible mechanism of liver necrosis caused by aromatic organic compounds. ( Brodie, BB; Cho, AK; Gillette, JR; Krishna, G; Reid, WD; Sipes, G, 1971) |
| " Dose-response paradigms in which tissue repair response is measured as a parallel but opposing effect to toxic injury might be useful in more precise prediction of the ultimate outcome of toxic injury in risk assessment." | 2.39 | Toxicodynamics of low level toxicant interactions of biological significance: inhibition of tissue repair. ( Mehendale, HM, 1995) |
| "The toxicological relevance of effects observed at molecular stage, which occur at dose levels well below classical no-observed adverse effect levels is currently subject to controversial scientific debate." | 1.42 | Hepatotoxic effects of (tri)azole fungicides in a broad dose range. ( Haider, W; Heise, T; Knebel, C; Kneuer, C; Marx-Stoelting, P; Niemann, L; Pfeil, R; Rieke, S; Schmidt, F, 2015) |
| "On VPA 1000 mg/d, the seizure frequency decreased significantly." | 1.37 | Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011) |
| " For studies of toxic processes, 1H NMR spectroscopy of biofluids allows monitoring of endogenous metabolite profiles that alter characteristically in response to changes in physiological status." | 1.37 | A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. ( Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T, 2011) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Dicofol pretreatment at 25mg/kg increased CCl4-induced serum alanine aminotransferase activity by 4." | 1.35 | Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. ( Chan, PK; Chan, WH; Chou, CP; Liao, JW; Ueng, TH; Wei, CF, 2009) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 1.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| " Rats were pretreated with PB (75 mg/kg for 4 days) prior to itraconazole or fluconazole dosing (20 and 200 mg/kg for 4 days)." | 1.33 | Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats. ( Ahmad Bustamam, A; Hasiah, AH; Israf, DA; Khairi, HM; Somchit, N; Sulaiman, MR; Wong, CW; Zuraini, A, 2006) |
| "Phencyclidine (PCP) pretreatment did not increase either P450s 3A or 2B, yet it markedly enhanced cocaine- or norcocaine-induced serum ALT activity." | 1.30 | Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity. ( Bornheim, LM, 1998) |
| " Protein binding of PB was unchanged in ET-treated animals, but the extent of bioavailability of PB tended to increase." | 1.29 | Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury. ( Fukushima, T; Kawai, Y; Kuwamura, Y; Noguchi, M; Tanaka, K, 1993) |
| "Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice." | 1.29 | Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993) |
| " AMD activity at 48 hr after dosing of PB in the ET-treated rats was increased in the same degree as that in the control (normal)." | 1.29 | Effects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury. ( Fujitsuka, T; Honda, K; Kawai, Y; Noguchi, M, 1994) |
| "Phenobarbital pretreatment of the rats did not affect any of these kinetic parameters." | 1.28 | Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol. ( Dunbar, D; Fraser, JM; Kaminsky, LS; Seaman, M, 1992) |
| " In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion." | 1.28 | Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990) |
| " Other features of this adverse drug reaction were unremitting fever, leukocytosis with eosinophilia and atypical lymphocytosis, and proteinuria." | 1.28 | Phenobarbital hepatotoxicity in an 8-month-old infant. ( Goldbach, M; Phillips, MJ; Roberts, EA; Spielberg, SP, 1990) |
| " Since the normal human dosage of paracetamol is up to 4 g/day, which is equivalent to 1% of the diet, the possibility of induction of amino acid deficiency by chronic use of paracetamol in normal dosage is raised." | 1.28 | Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats. ( Armstrong, GR; Beales, D; McLean, AE, 1989) |
| "The laboratory findings revealed leukocytosis with atypical lymphocytes, eosinophilia and altered liver function." | 1.27 | [Hypersensitivity syndrome caused by phenytoins and phenobarbital]. ( Azulay, DR; Azulay, RD; Fonseca, JC; Rozembau, I, 1984) |
| "Isoflurane anesthesia was given for the placement of a catheter into the femoral artery." | 1.27 | Effects of halothane, isoflurane, enflurane, thiopental, and fentanyl on blood gas values in rats exposed to hypoxia. ( Eger, EI; Johnson, BH; Lurz, FW; Shingu, K; Taber, V, 1983) |
| " The different toxic effects were related to the structure and metabolism of the compounds." | 1.27 | The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids. ( Driver, HE; Mattocks, AR, 1984) |
| "Acetylhydrazine did not produce detectable lesions in organs other than the liver, despite the occurrence of covalent binding to protein in those organs." | 1.27 | Acetylhydrazine hepatotoxicity: the role of covalent binding. ( Timbrell, JA; Woodward, KN, 1984) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| " It was concluded that, at the dose ranges studied, pretreatment with PB or PCB did not significantly alter the toxic effects produced by TCB." | 1.27 | Effect of phenobarbital and polychlorinated biphenyls on the toxicity and disposition of 1,2,4,5-tetrachlorobenzene in the rat. ( Chu, I; Valli, VE; Villeneuve, DC; Yagminas, A, 1986) |
| "Phenobarbital pretreatment of females of the four inbred strains resulted in enhancement of the hepatotoxic response to cocaine in the C3H, DBA, and Balb mice." | 1.27 | Sex and strain differences in the hepatotoxic response to acute cocaine administration in the mouse. ( Boyer, CS; Petersen, DR; Ross, D, 1988) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 1.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| " The activities of NADPH-cytochrome P-450 reductase, AHH, and ECOD following treatment with HCB were similar to those found after dosing with PB." | 1.27 | A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. ( Buhler, DR; Carpenter, HM; Williams, DE, 1985) |
| "Pretreatment with phenobarbital (0." | 1.27 | Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats. ( Loeser, W; Siegers, CP, 1985) |
| "Particulate drug carriers have a pronounced tendency to localize in the mononuclear phagocyte system and chronic administration of such carriers can result in reticuloendothelial (RE) blockade." | 1.27 | Liver pathology accompanying chronic liposome administration in mouse. ( Allen, TM; Smuckler, EA, 1985) |
| " Liver and kidney samples were also taken at appropriate times after dosing and examined histologically for evidence of drug induced damage." | 1.26 | Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat. ( Clampitt, RB, 1978) |
| "Phenobarbital pretreatment increased and CoCl2 pretreatment decreased trichloroethylene hepatotoxicity." | 1.26 | Metabolic activation of trichloroethylene into a chemically reactive metabolite toxic to the liver. ( Allemand, H; Benhamou, JP; DeGott, C; Descatoire, V; Feldmann, G; Pessayre, D, 1978) |
| "Phenobarbital pretreatment reduced injurious effect of furylfuramide on the liver with preservation of the centrolobular region." | 1.26 | Furylfuramide-induced hepatic necrosis in mice and its modification by phenobarbital. ( Horiuchi, T; Ohtsubo, K; Saito, M, 1976) |
| "Phenobarbital pretreatment provided little or no protection." | 1.26 | Iodipamide hepatotoxicity in the rat. ( Barnhart, JL; Burk, RF, 1979) |
| "The effects of acute and chronic administration of D-Galactosamine (GalN), Ethanol and Phenobarbital were investigated on the activities of lysosomal enzymes, i." | 1.26 | [Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)]. ( Sato, R, 1978) |
| " A connection is suggested between the first-pass metabolism in male rats and the hepatotoxicity, which is possibly mediated through a metabolite or intermediate formed in toxic amount during the first passage of the liver." | 1.26 | Hepatotoxicity of citalopram in rats and first-pass metabolism. ( Fredricson Overø, K; Svendsen, O, 1978) |
| "Phenobarbital pretreatment potentiated the hepatic necrosis produced by both thioacetamide and thioacetamide sulfine." | 1.26 | Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. ( Holscher, MA; Hunter, AL; Neal, RA, 1977) |
| " Toxic doses of acetylisoniazid and acetylhydrazine, radiolabeled in the acetyl group, were found to bind covalently to liver protein in vivo." | 1.26 | Isoniazid hepatoxicity: the relationship between covalent binding and metabolism in vivo. ( Mitchell, JR; Nelson, SD; Snodgrass, WR; Timbrell, JA, 1980) |
| " Prior dosing with phenobarbitone augments CCl4 toxicity only in the adult and the newborn but the foetus continues to be resistant." | 1.25 | Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine. ( Chopra, P; Das, PK; Dhar, A; Nayak, NC, 1975) |
| "The influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (CCl4) was investigated in a group of rhesus monkeys." | 1.25 | Protein deficiency in carbon tetrachloride-induced hepatic lesions. ( Deo, MG; Ramalingaswami, V; Roy, H, 1975) |
| " Dose-response curves can be derived for the parameters used for assessing dysfunction." | 1.25 | Metabolic alterations in organ function. ( Plaa, GL, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 228 (73.55) | 18.7374 |
| 1990's | 41 (13.23) | 18.2507 |
| 2000's | 24 (7.74) | 29.6817 |
| 2010's | 16 (5.16) | 24.3611 |
| 2020's | 1 (0.32) | 2.80 |
| Authors | Studies |
|---|---|
| Yogeeswari, P | 1 |
| Sriram, D | 1 |
| Thirumurugan, R | 1 |
| Raghavendran, JV | 1 |
| Sudhan, K | 1 |
| Pavana, RK | 1 |
| Stables, J | 1 |
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 1 |
| Trauner, M | 1 |
| van Staden, CJ | 1 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 1 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 1 |
| Liu, Z | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Pathak, S | 1 |
| Catanzaro, R | 1 |
| Vasan, D | 1 |
| Marotta, F | 1 |
| Chabria, Y | 1 |
| Jothimani, G | 1 |
| Verma, RS | 1 |
| Ramachandran, M | 1 |
| Khuda-Bukhsh, AR | 1 |
| Banerjee, A | 1 |
| Cheng, LT | 1 |
| Yeh, MM | 1 |
| Lu, CC | 1 |
| Shaban, NZ | 2 |
| El-Kersh, MA | 2 |
| El-Rashidy, FH | 1 |
| Habashy, NH | 1 |
| Nishikawa, T | 1 |
| Bellance, N | 1 |
| Damm, A | 1 |
| Bing, H | 1 |
| Zhu, Z | 1 |
| Handa, K | 1 |
| Yovchev, MI | 1 |
| Sehgal, V | 1 |
| Moss, TJ | 1 |
| Oertel, M | 1 |
| Ram, PT | 1 |
| Pipinos, II | 1 |
| Soto-Gutierrez, A | 1 |
| Fox, IJ | 1 |
| Nagrath, D | 1 |
| Bader-Eldin, MM | 1 |
| Kato, SA | 1 |
| Hamoda, AF | 1 |
| Heise, T | 1 |
| Schmidt, F | 3 |
| Knebel, C | 2 |
| Rieke, S | 2 |
| Haider, W | 1 |
| Pfeil, R | 1 |
| Kneuer, C | 1 |
| Niemann, L | 1 |
| Marx-Stoelting, P | 2 |
| Bosseler, L | 1 |
| Cornelis, I | 1 |
| Defauw, P | 1 |
| Daminet, S | 1 |
| Ducatelle, R | 1 |
| Ganzenberg, K | 1 |
| Hammer, H | 1 |
| Pötz, O | 1 |
| Schwarz, M | 1 |
| Braeuning, A | 1 |
| Vorne, M | 1 |
| Arvela, P | 1 |
| Alavaikko, M | 1 |
| Das, BK | 1 |
| Bepary, S | 1 |
| Datta, BK | 1 |
| Chowdhury, AA | 1 |
| Ali, MS | 1 |
| Rouf, AS | 1 |
| Beilke, LD | 1 |
| Aleksunes, LM | 1 |
| Holland, RD | 1 |
| Besselsen, DG | 1 |
| Beger, RD | 1 |
| Klaassen, CD | 1 |
| Cherrington, NJ | 1 |
| Girish, C | 1 |
| Koner, BC | 1 |
| Jayanthi, S | 1 |
| Rao, KR | 1 |
| Rajesh, B | 1 |
| Pradhan, SC | 1 |
| Chan, WH | 1 |
| Liao, JW | 1 |
| Chou, CP | 1 |
| Chan, PK | 1 |
| Wei, CF | 1 |
| Ueng, TH | 1 |
| Bishayee, A | 1 |
| Barnes, KF | 1 |
| Bhatia, D | 1 |
| Darvesh, AS | 1 |
| Carroll, RT | 1 |
| Lee, SK | 1 |
| Kang, MJ | 1 |
| Jeon, TW | 1 |
| Ha, HW | 1 |
| Yoo, JW | 1 |
| Ko, GS | 1 |
| Kang, W | 1 |
| Jeong, HG | 1 |
| Lyoo, WS | 1 |
| Jeong, TC | 1 |
| Velizarova, R | 1 |
| Gelisse, P | 1 |
| Pageaux, GP | 1 |
| Genton, P | 1 |
| Crespel, A | 1 |
| Fukuhara, K | 1 |
| Ohno, A | 1 |
| Ando, Y | 1 |
| Yamoto, T | 1 |
| Okuda, H | 1 |
| López-Torres, E | 1 |
| Lucena, MI | 1 |
| Andrade, RJ | 1 |
| García Ruiz, E | 1 |
| Fernández, MC | 1 |
| Peláez, G | 1 |
| Soria de la Cruz, MJ | 1 |
| Pizarro, A | 1 |
| Lin, G | 1 |
| Cui, YY | 1 |
| Liu, XQ | 1 |
| Aitken, MM | 1 |
| Hall, E | 1 |
| Scott, L | 1 |
| Davot, JL | 1 |
| Allen, WM | 1 |
| Vetoshkina, TV | 1 |
| Fomina, TI | 1 |
| HERDSON, PB | 1 |
| GARVIN, PJ | 1 |
| JENNINGS, RB | 1 |
| Donald, S | 1 |
| Verschoyle, RD | 1 |
| Greaves, P | 1 |
| Orr, S | 1 |
| Jimeno, J | 1 |
| Gescher, AJ | 1 |
| Wang, AG | 1 |
| Xia, T | 1 |
| Yuan, J | 1 |
| Yu, RA | 1 |
| Yang, KD | 1 |
| Chen, XM | 1 |
| Qu, W | 1 |
| Waalkes, MP | 1 |
| Gaskill, CL | 1 |
| Miller, LM | 1 |
| Mattoon, JS | 1 |
| Hoffmann, WE | 1 |
| Burton, SA | 1 |
| Gelens, HC | 1 |
| Ihle, SL | 1 |
| Miller, JB | 1 |
| Shaw, DH | 1 |
| Cribb, AE | 1 |
| Amacher, DE | 1 |
| Adler, R | 1 |
| Herath, A | 1 |
| Townsend, RR | 1 |
| Ferencz, V | 1 |
| Horváth, C | 1 |
| Kári, B | 1 |
| Gaál, J | 1 |
| Mészáros, S | 1 |
| Wolf, Z | 1 |
| Hegedus, D | 1 |
| Horváth, A | 1 |
| Folhoffer, A | 1 |
| Szalay, F | 1 |
| Somchit, N | 1 |
| Wong, CW | 1 |
| Zuraini, A | 1 |
| Ahmad Bustamam, A | 1 |
| Hasiah, AH | 1 |
| Khairi, HM | 1 |
| Sulaiman, MR | 1 |
| Israf, DA | 1 |
| Chilakapati, J | 1 |
| Korrapati, MC | 1 |
| Shankar, K | 1 |
| Hill, RA | 1 |
| Warbritton, A | 1 |
| Latendresse, JR | 1 |
| Mehendale, HM | 6 |
| Di Mizio, G | 1 |
| Gambardella, A | 1 |
| Labate, A | 1 |
| Perna, A | 1 |
| Ricci, P | 1 |
| Quattrone, A | 1 |
| Seawright, AA | 4 |
| McLean, AE | 4 |
| Blake, DA | 1 |
| Rozman, RS | 1 |
| Cascorbi, HF | 2 |
| Krantz, JC | 1 |
| Jacobi, G | 1 |
| Thorbeck, R | 1 |
| Ritz, A | 1 |
| Janssen, W | 1 |
| Schmidts, HL | 1 |
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| Brown, BR | 5 |
| Mitchell, JR | 10 |
| Snodgrass, WR | 2 |
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| Piovesana, H | 1 |
| Polimeno, NC | 1 |
| Ferraz, JG | 1 |
| de Nucci, G | 1 |
| Pedrazzoli, J | 1 |
| Karas, M | 1 |
| Chakrabarti, SK | 1 |
| Ford, EJ | 3 |
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| Hobara, N | 1 |
| Nagashima, H | 1 |
| Kitagawa, Y | 1 |
| Kuroiwa, Y | 1 |
| McColl, KE | 1 |
| Fletcher, CD | 1 |
| Thomson, TJ | 1 |
| Tatematsu, M | 1 |
| Murasaki, G | 1 |
| Nakanishi, K | 3 |
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| Weisburst, M | 1 |
| Self, T | 1 |
| Peace, R | 1 |
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| Gopinath, C | 2 |
| Deo, MG | 1 |
| Roy, H | 1 |
| Ramalingaswami, V | 3 |
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| Ford, JH | 1 |
| Reynolds, ES | 7 |
| Moslen, MT | 4 |
| Jaeger, RJ | 3 |
| Frimmer, M | 1 |
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| Svendsen, O | 1 |
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| Magos, L | 8 |
| Butler, WH | 7 |
| Snowden, R | 1 |
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| Krishna, G | 7 |
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| Gillette, JR | 8 |
| Day, PA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Omega-5 Fatty Acid Supplement on Markers of Inflammation and Oxidative Stress in Patients With Severe Alcoholic Hepatitis Treated With Prednisone[NCT03732586] | 40 participants (Actual) | Interventional | 2018-09-30 | Completed | |||
| [NCT00799578] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00799578)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Number of Improved Subjects | 7 |
19 reviews available for phenobarbital and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Tetrabamate-induced hepatotoxicity. Report of seven cases and literature review].
Topics: Adult; Aged; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans | 2002 |
[Various problems in therapy and prognosis of drug-induced liver diseases].
Topics: Chemical and Drug Induced Liver Injury; Diet, Fat-Restricted; Drug-Related Side Effects and Adverse | 1995 |
Hepatotoxicity associated with pharmacologic agents in dogs and cats.
Topics: Animals; Anthelmintics; Benzimidazoles; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; | 1993 |
Toxicodynamics of low level toxicant interactions of biological significance: inhibition of tissue repair.
Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dr | 1995 |
The liver as a target for chemical-chemical interactions.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Drug Antagoni | 1997 |
The role of metabolism in the hepatotoxicity of isoniazid and iproniazid.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cobalt; Humans; Hydrazines; Iproniazid; Isoniazid; | 1979 |
The clinical and experimental aspects of carbon disulphide intoxication.
Topics: Animals; Basal Ganglia Diseases; Carbon Disulfide; Catecholamines; Chemical and Drug Induced Liver I | 1975 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Massive hepatic necrosis in a child after administration of phenobarbital.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Hypersensitivity; Humans; Liver Disea | 1989 |
Induction of drug-metabolizing enzymes: mechanisms and consequences.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Chemical and Drug Induced Li | 1986 |
Role of nutrition in the drug-metabolizing enzyme system.
Topics: Ascorbic Acid Deficiency; Calcium; Carbohydrates; Carcinogens; Catalysis; Chemical and Drug Induced | 1974 |
Toxic hepatic porphyrias.
Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc | 1968 |
Recent advances in molecular pathology: a review of the effects of alcohol on the liver.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Butyrates; Chemical and Drug Induced Liv | 1970 |
Halothane anesthesia and hepatitis in a high-risk population.
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Diazepam; Enzyme Induction; Halothane; Human | 1973 |
[Advances in the field of liver diseases].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Chronic Disease; Drug Synergism; Enzyme Induc | 1972 |
Medical therapy for gallstones.
Topics: Administration, Oral; Bile; Bile Acids and Salts; Bilirubin; Calcium; Chemical and Drug Induced Live | 1974 |
Phenobarbital in the perinatal period.
Topics: Animals; Animals, Newborn; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Antagonism; Drug | 1969 |
[Recent progress in the study of liver diseases].
Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Bilirubin; Biological Transport; Chemical and Drug | 1971 |
291 other studies available for phenobarbital and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver | 2005 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in
Topics: Animals; Biomarkers; Blood Glucose; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Catalase | 2020 |
Phenobarbital-Induced Liver Injury With Nodal Angiomatosis.
Topics: Adolescent; Angiomatosis; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; Humans; L | 2019 |
Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats.
Topics: Animals; Caspase 3; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; DNA Fragmentation; G | 2013 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Dr | 2014 |
Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats.
Topics: Animals; Beverages; Caspase 3; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Glutathio | 2014 |
Hepatotoxic effects of (tri)azole fungicides in a broad dose range.
Topics: Animals; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Cytochrome P-450 | 2015 |
Suspected phenobarbitone hypersensitivity with acute liver failure in a dog.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Drug Hypersens | 2017 |
Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Dose-Response Rel | 2017 |
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Am | 1981 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice.
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure | 2009 |
Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Mice; | 2009 |
Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Catalysis; Chemical and Drug Induced Liver Injury; | 2009 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Role of metabolism in 1-bromopropane-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2010 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H | 2011 |
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Inj | 2011 |
Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Chromatography, High | 2003 |
Liver-related biochemical changes in the serum of dogs being treated with phenobarbitone.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Chemical and Drug Induced Live | 2003 |
Effects of homeopathic preparations on the liver in rats with acute and chronic toxic hepatitis.
Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; Cholecystokinin; Dose-Response Relation | 2003 |
FINE STRUCTURAL CHANGES IN RAT LIVER INDUCED BY PHENOBARBITAL.
Topics: Chemical and Drug Induced Liver Injury; Electrons; Hepatitis; Liver; Microscopy; Microscopy, Electro | 1964 |
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotra | 2004 |
Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cell Separation; Ce | 2004 |
Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Chemical and Drug Induced Live | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tet | 2005 |
Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats.
Topics: Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; | 2006 |
Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Biotransf | 2007 |
Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients.
Topics: Adult; Anticonvulsants; Autopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Chromatography | 2007 |
Induced susceptibility of sheep to carbon tetrachloride intoxication.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1967 |
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; D | 1967 |
Fatal hepatotoxicity in child on phenobarbitone and sodium valproate.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy, Tonic-Clonic; Humans; Male; Phenobarbital; | 1980 |
[Protective effect of alpha-tocopherol on fluoroxene toxicity in mice (author's transl)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethers; Liver Diseases; Male; Mice; Phenobarbital; | 1980 |
Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatotoxicity.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Inter | 1980 |
Potentiation of CCl4 lethality by chlordecone.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Synergism; | 1982 |
[Hypersensitivity syndrome caused by phenytoins and phenobarbital].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; | 1984 |
Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein.
Topics: Acetaminophen; Animals; Catechin; Chemical and Drug Induced Liver Injury; Deanol; Dimethyl Sulfoxide | 1980 |
Superoxide anion: its involvement in carbon disulfide hepatotoxicity in phenobarbital-treated rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Hemeproteins; In Vitro Techniques | 1981 |
The damage of the hepatic mixed functional oxygenase system by CCl4: significance of incorporation of 14CCl4 metabolites in vivo.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Choleca | 1982 |
Influence of dithiocarb, (+)-catechin and silybine on halothane hepatotoxicity in the hypoxic rat model.
Topics: Animals; Benzopyrans; Catechin; Chemical and Drug Induced Liver Injury; Ditiocarb; Flavonoids; Fluor | 1983 |
Role of microsomal drug detoxifying enzyme systems in paracetamol induced liver injury in rats.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Glucose-6-Phosphat | 1983 |
Effects of halothane, isoflurane, enflurane, thiopental, and fentanyl on blood gas values in rats exposed to hypoxia.
Topics: Anesthetics; Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Enflurane; Fentanyl; H | 1983 |
Apparent potentiation of hepatotoxicity from small doses of acetaminophen by phenobarbital.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Humans; Middle Aged; | 1984 |
Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Cross Reactions; Drug Hypersensitivity; Female; | 1984 |
The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids.
Topics: Alkaloids; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 1984 |
Isoflurane does not prevent hepatic injury produced by halothane in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Isoflurane; Male; Meth | 1984 |
Cocaine-induced hepatotoxicity: lipid peroxidation as a possible mechanism.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enz | 1984 |
The effect of halothane, isoflurane, and blood loss on hepatotoxicity and hepatic oxygen availability in phenobarbital-pretreated hypoxic rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage; Isoflurane; Liver; Liver Cir | 1984 |
Changes induced in human liver by long-term anticonvulsant therapy. Functional and ultrastructural data.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endoplasm | 1984 |
Decreased hepatic vitamin A after drug administration in men and in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Humans; Kidney; Liver; Liver Diseases; Methylcholan | 1984 |
Potentiation of carbon-tetrachloride hepato-nephrotoxicity by phenobarbital in man, a case report.
Topics: Barbiturates; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Synergism | 1983 |
Hepatitis as a manifestation of phenobarbital hypersensitivity.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Hypersensitivity; Erythema Multiforme | 1984 |
Acetylhydrazine hepatotoxicity: the role of covalent binding.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Hydrazines; Liv | 1984 |
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat.
Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Ch | 1984 |
Factors influencing halothane hepatotoxicity in the rat hypoxic model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Interactions; | 1980 |
Isoniazid hepatoxicity: the relationship between covalent binding and metabolism in vivo.
Topics: Acetylation; Amidohydrolases; Animals; Biotransformation; Carbon Dioxide; Chemical and Drug Induced | 1980 |
Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.
Topics: 1-Propanol; Animals; Carbon Dioxide; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1981 |
Hepatic injury induced by anesthetic agents in rats.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Necrosis; Oxygen; Phenoba | 1983 |
Role of protein binding in cocaine-induced hepatic necrosis.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cricetinae; Esterase | 1983 |
Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Glutathione; Halothane; Hyperthyroidism; | 1983 |
Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fasting; Fluorides; Halothane; Hypoxia; Liver Disea | 1983 |
Hepatic Injury following halothane, enflurane, and isoflurane anesthesia in rats.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Enzyme Induction; Halothane | 1982 |
Limited hepatotoxic potential of acrylonitrile in rats.
Topics: Acrylonitrile; Alanine Transaminase; Alkaline Phosphatase; Animals; Aroclors; Chemical and Drug Indu | 1982 |
Cimetidine in pregnancy: apparent transient liver impairment in the newborn.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cimetidine; Fema | 1980 |
Drug-induced liver injury and microsomal arylamidase activity in needle biopsy of human liver.
Topics: Adult; Aged; Aminopeptidases; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Clinical Enzym | 1980 |
Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Enzyme I | 1981 |
Acetylhydrazine hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Hydrazines; Isoniaz | 1981 |
The effect of dibutyl sulphide on hepatocytes studied by means of the isolated rat liver perfusion after preceding exposure to tetrachloromethane and phenobarbital in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Perfus | 1981 |
Time-course of formation of volatile reductive metabolites of halothane in humans and an animal model.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Disease Models, Animal; | 1980 |
[Fulminating hepatitis caused by administration of isoniazid and rifampicin in a patient under chronic treatment with barbiturates].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Hepatic | 1980 |
Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.
Topics: Adult; Aged; Aged, 80 and over; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinati | 1994 |
Effects of ascorbic acid on iproniazid-induced hepatitis in phenobarbital-treated rats.
Topics: Alanine Transaminase; Aminopyrine; Animals; Ascorbic Acid; Aspartate Aminotransferases; Chemical and | 1994 |
[Severe hepatitis caused by phenobarbital].
Topics: Adult; Chemical and Drug Induced Liver Injury; Dyspepsia; Humans; Liver Function Tests; Male; Phenob | 1994 |
Effects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Enz | 1994 |
[Fatal fulminant hepatitis induced by nilutamide (Anandron)].
Topics: Adenocarcinoma; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Drug Interaction | 1993 |
Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury.
Topics: Animals; Biological Availability; Blood Proteins; Chemical and Drug Induced Liver Injury; Ethionine; | 1993 |
Effects of acute ethanol doses or dietary phenobarbitol with carbon tetrachloride exposure on vitamin A status of rats.
Topics: Alcoholic Intoxication; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Inj | 1993 |
[Severe acute hepatitis caused by Atrium].
Topics: Acute Disease; Adult; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; Human | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav | 1993 |
Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Free Radical | 1993 |
[Atrium 300 hepatitis. A new case].
Topics: Aged; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans; Pheno | 1995 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; C | 1996 |
Effects of phenobarbital on aniline metabolism in primary liver cell culture of rats with ethionine-induced liver disorder.
Topics: Acetaminophen; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Chemical and Drug Induced | 1996 |
[Acute hepatitis associated with microvesicular steatosis induced by Atrium].
Topics: Acute Disease; Adult; Barbiturates; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; | 1995 |
Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice.
Topics: Anesthesia; Anesthesia Recovery Period; Animals; Brain Chemistry; Carcinogens; Chemical and Drug Ind | 1996 |
Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Ester Hydrolases; Chemical and Drug Ind | 1998 |
Atrium and paroxetine-related severe hepatitis.
Topics: Adult; Anti-Anxiety Agents; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; | 1999 |
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; DNA-B | 2000 |
CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Topics: Aminolevulinic Acid; Animals; Antibodies; Blotting, Western; Chemical and Drug Induced Liver Injury; | 2000 |
Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication.
Topics: Acute Disease; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Excitatory Amino | 2000 |
Participation of CYP2A in cocaine-induced hepatotoxicity in female mice.
Topics: Alanine Transaminase; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cocaine; Cyt | 2000 |
Liver injury due to tetrabamate (Atrium): an analysis of 11 cases.
Topics: Adult; Aged; Aged, 80 and over; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinati | 2000 |
Development of an experimental model of liver cirrhosis in rabbits.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2000 |
Influence of caffeine on allyl alcohol-induced hepatotoxicity in rats. I. In vivo study.
Topics: Acrolein; Alanine Transaminase; Alcohol Dehydrogenase; Animals; Caffeine; Chemical and Drug Induced | 2001 |
The modification of the dehydromyodesmone-induced hepatic lesion in cattle by microsomal drug metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Bilirubin; Cattle; Chemical and Drug Induced Liver Injury; Enzym | 1978 |
[Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)].
Topics: Acetylglucosaminidase; Acid Phosphatase; Adenosine Triphosphatases; Alcoholism; Animals; Anticonvuls | 1978 |
[Biochemical and morphological study on hepato-toxicity of azathioprine in rat (author's transl)].
Topics: Alkaline Phosphatase; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; gamma-Glutamylt | 1979 |
Effect of phenobarbital and 3-methylcholanthrene on decrease in pH in liver induced by 3'-methyl-4-dimethylaminoazobenzene, of partial hepatectomy and hepatotoxic agents.
Topics: Animals; Chemical and Drug Induced Liver Injury; Hepatectomy; Hydrogen-Ion Concentration; In Vitro T | 1979 |
Hepatitis and anticonvulsant therapy.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Humans; | 1978 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Jaundice and rash associated with the use of phenobarbital and hydrochlorothiazide.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Drug Eruptions; Female; Humans; Hydrochlorothiaz | 1976 |
The effect of induced hepatic microsomal amidopyrine demethylase activity on the susceptibility of the liver of the calf and horse to carbon disulphide.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Aminopyrine N-Demethylase; Animals; Aspartate Amino | 1976 |
Protein deficiency in carbon tetrachloride-induced hepatic lesions.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Glucos | 1975 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1975 |
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT; | 1975 |
Vinyl chloride-induced deactivation of cytochrome P-450 and other components of the liver mixed function oxidase system: an in vivo study.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Animals; Aroclors; Aspartate Aminotransferases; Che | 1975 |
[Inhibition by diethyldithiocarbamate (DEDTC) of acute hepatotoxic effects induced by polyhalogenated hydrocarbons (PHHC)].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Ditioca | 1976 |
[Effect of phenobarbital stimulation on morphological and cytoenzymatic changes in the liver of benzene intoxicated rats (author's transl)].
Topics: Adenosine Triphosphatases; Animals; Benzene; Chemical and Drug Induced Liver Injury; Endoplasmic Ret | 1976 |
Letter: Fluroxene in rat and man.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethers; Hum | 1975 |
Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Evaluation Studies | 1978 |
Hepatotoxicity of citalopram in rats and first-pass metabolism.
Topics: Administration, Oral; Animals; Benzofurans; Chemical and Drug Induced Liver Injury; Female; Injectio | 1978 |
Extrahepatic tissue distribution, covalent binding, and toxicity of halothane in control and phenobarbital-pretreated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Lung; Male; Necrosis; Phe | 1978 |
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li | 1977 |
Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats.
Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Disulfiram; Ethanol; Male; Maleates; Phen | 1977 |
The effects of phenobarbital and 3,4-benzypyrene on microsomal cytochrome P-450 and NADPH-cytochrome C reductase in regenerating rat liver after partial hepatectomy or chemical injury.
Topics: Animals; Benzopyrenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytoc | 1977 |
Halothane hepatotoxicity and fluoride production in mice and rats.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fluorides; | 1979 |
Iodipamide hepatotoxicity in the rat.
Topics: Age Factors; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dos | 1979 |
The effect of size and timing of a pretreatment dose of phenobarbitone on the liver lesion caused by ngaione in the mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relat | 1979 |
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc | 1979 |
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys | 1979 |
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine | 1979 |
The effect of dichloralphenazone pretreatment on paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Cytochr | 1979 |
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver | 1978 |
Influence of aliphatic alcohols on the hepatic response to halogenated olefins.
Topics: Alcohols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Drug Sy | 1977 |
Induction of cytochrome P-450 in a selective subpopulation of hepatocytes.
Topics: Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Endo | 1978 |
Metabolic activation of trichloroethylene into a chemically reactive metabolite toxic to the liver.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cobalt; Glutathione; In Vitro Te | 1978 |
The hepatotoxicity of 3-amino-1,2,4-triazole and carbon disulphide in phenobarbitone-treated starved rats.
Topics: Alanine Transaminase; Amitrole; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; L | 1978 |
Deuterium isotope effect in bioactivation and hepatotoxicity of chloroform.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cysteine; Cytochr | 1978 |
Substituent effects on the hepatotoxicity of thiobenzamide derivatives in the rat.
Topics: Alanine Transaminase; Animals; Benzamides; Bilirubin; Chemical and Drug Induced Liver Injury; Dose-R | 1978 |
Responses of rats and nonhuman primates to 2,5,2',5'-tetrachlorobiphenyl.
Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Drug Antagonism; Drug Synergism; Female; | 1975 |
Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system.
Topics: Acetamides; Aminopyrine; Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Drug In | 1977 |
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy | 1977 |
Long-term studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene.
Topics: Animals; Butylated Hydroxytoluene; Chemical and Drug Induced Liver Injury; Cresols; Diet; Enzyme Ind | 1977 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytoc | 1977 |
Portal venous infusion of paracetamol and antipyrine in the rat.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Injections, I | 1977 |
Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia.
Topics: Acetaminophen; Acute Disease; Anemia; Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; | 1977 |
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp | 1976 |
Furylfuramide-induced hepatic necrosis in mice and its modification by phenobarbital.
Topics: Acrylamides; Animals; Chemical and Drug Induced Liver Injury; Food Additives; Lethal Dose 50; Liver; | 1976 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estra | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr | 1976 |
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto | 1975 |
Metabolic alterations in organ function.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Dose-Response Relationship | 1975 |
"Ground-glass" hepatocytes.
Topics: Adult; Biopsy; Carrier State; Chemical and Drug Induced Liver Injury; Female; Hepatitis B; Hepatitis | 1975 |
Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Environmental Exposure; Live | 1975 |
Effects of vinyl chloride exposures to rats pretreated with phenobarbital.
Topics: Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; C | 1975 |
Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Temperature; | 1975 |
Inhibition, by drugs, of galactosamine induced hepatitis in the rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced | 1975 |
Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Halothane; Hypoxia; Lipid Metabolism; Li | 1976 |
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Cell Size; Chemical and Drug Induced Liver Injury; C | 1992 |
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Cy | 1992 |
Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol.
Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Biotransformation; Chemical and Drug Induced Liver In | 1992 |
[Atrium-induced hepatitis with autoimmune pattern].
Topics: Aged; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Male; Phenoba | 1992 |
A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; D | 1992 |
Immunocytochemical detection of the 72-kDa heat shock protein in halothane--induced hepatotoxicity in rats.
Topics: Animals; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Halothane; Heat-Shock Prote | 1992 |
Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.
Topics: Adolescent; Animals; Autoantibodies; Carbamazepine; Cell Death; Chemical and Drug Induced Liver Inju | 1992 |
[Atrium-related hepatitis. Report of four cases].
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Alcohol Withdrawal Delirium; Aspartate Aminotransfera | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Hepatotoxicity of phenobarbital in dogs: 18 cases (1985-1989).
Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Female; Liver; Liver Diseases; | 1991 |
An ultrastructural study of spontaneous and phenobarbitone-induced nodules in the mouse liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Liver Neoplasms, Experimenta | 1991 |
Liver damage in long-term anticonvulsant therapy: a serological and histological study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Combinatio | 1991 |
The response of the rat liver in situ to bromobenzene--in vivo proton magnetic resonance imaging and 31P magnetic resonance spectroscopy studies.
Topics: Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 Enzyme Sy | 1991 |
Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine.
Topics: Alanine Transaminase; Animals; Antimetabolites; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfo | 1991 |
Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon Tetrachloride; Chemical and Drug Ind | 1990 |
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Gl | 1990 |
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li | 1990 |
Phenobarbital hepatotoxicity in an 8-month-old infant.
Topics: Carbamazepine; Cell Survival; Chemical and Drug Induced Liver Injury; Humans; Infant; Lymphocytes; M | 1990 |
Liver pathology accompanying chronic liposome administration in mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Kinetics; Liposomes; Liver; Mice; Mice, Inb | 1985 |
The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Nucleus; Chemical and Drug Induced | 1989 |
Hepatic lesions in Danish epileptics after long-term exposure to anticonvulsant drugs including phenobarbitone.
Topics: Adult; Aged; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Denmark; Epilepsy; Hu | 1989 |
Electron transport and protection of liver slices in the late stage of paracetamol injury of the liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; In Vitro Techniq | 1989 |
Halothane associated hepatitis and phenobarbitone.
Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halo | 1989 |
Interactive toxicity of cocaine with phenobarbital, morphine and ethanol in organ cultured human and rat liver slices.
Topics: Animals; Calcium; Chemical and Drug Induced Liver Injury; Cocaine; Drug Interactions; Ethanol; Human | 1989 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Growth; Methi | 1989 |
Medroxyprogesterone acetate and phenobarbital induce NADPH producing enzyme activities in rats with a chemical liver injury.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; | 1985 |
Hepatic effects of phenobarbitone in female mice fed sublethal levels of dietary cyanide.
Topics: Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Cyanides; Drug Interactions; F | 1986 |
Effect of phenobarbital and polychlorinated biphenyls on the toxicity and disposition of 1,2,4,5-tetrachlorobenzene in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Drug Interactions; Glutathione; Liv | 1986 |
Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Chemical and Drug Induced Liver In | 1987 |
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Lipid Meta | 1988 |
A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Hydrocarbons, Fluorinated; Liver; L | 1988 |
Sex and strain differences in the hepatotoxic response to acute cocaine administration in the mouse.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enz | 1988 |
[Protective effect of phenobarbital in toxic liver damage by kerosine hydrocarbons in rats].
Topics: Animals; Chemical and Drug Induced Liver Injury; Hydrocarbons; Kerosene; Liver; Male; Petroleum; Phe | 1988 |
Effect of the antioxidant N,N1-diphenyl-p-phenylenediamine (DPPD) on bromobenzene metabolism and toxicity in isolated hepatocytes.
Topics: Animals; Antioxidants; Bromobenzenes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Gluta | 1988 |
Effects of treatment with phenobarbitone or isoniazid on hepatotoxicity due to prolonged subanaesthetic halothane inhalation.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Halothane; Isoniazid; Liver; Male; Org | 1988 |
Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Halothane; Hypoxia; In Vitro Techniq | 1988 |
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits.
Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; | 1988 |
Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans; Phenobarbital; Pre | 1988 |
Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice.
Topics: Animals; Biotransformation; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Cyclohexane Mo | 1987 |
Halogenated anesthetics increase oxygen consumption in isolated hepatocytes from phenobarbital-treated rats.
Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 1987 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Che | 1987 |
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and | 1987 |
Halothane hepatotoxicity--again?
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Humans; | 1986 |
[Severe hypersensitivity to phenobarbital with erythema multiforme, cholestatic hepatitis and aplastic anemia].
Topics: Anemia, Aplastic; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Drug Hypersensitivity; | 1986 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co | 1986 |
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 1985 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Ch | 1985 |
Nitrous oxide does not hinder the repair of halothane-induced hepatic injury in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bretylium Compounds; Chemical an | 1985 |
Sex differences in halothane metabolism and hepatotoxicity in a rat model.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Biotransformation; Breath Tests; Chemical and | 1985 |
Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochro | 1985 |
Comparison of the requirements for hepatic injury with halothane and enflurane in rats.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical | 1985 |
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.
Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1985 |
Effect of the production of experimental cirrhosis in rats on serum protein levels.
Topics: Alpha-Globulins; Animals; Blood Proteins; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1973 |
Effect of phenobarbital on acute toxicity and liver damage induced by cerium chloride in male mice.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Chlorides; Depression, Chemical; Liver; Mal | 1973 |
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
Massive lethal hepatic necrosis in rats anesthetized with fluroxene, after microsomal enzyme induction.
Topics: Anesthesia, Inhalation; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 1973 |
Diphenylhydantoin--induced hepatic necrosis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female | 1974 |
Toxicity of halogenated oxyquinolines in dogs. A clinical study. II. History, symptoms, laboratory findings, therapy, and follow-up.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dehydration; Dog Diseases; Dogs; Electrocardiograph | 1974 |
Barbiturate jaundice. Report of a case due to a barbital-containing drug, with positive rechallenge to phenobarbital.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Barbiturates; Chemic | 1969 |
[Toxicity and enzyme-inducing activity of clotrimazole].
Topics: Animals; Antifungal Agents; Benzene Derivatives; Chemical and Drug Induced Liver Injury; Enzyme Indu | 1970 |
Protective effect of phenobarbitone against fulvine-induced hepatic damage and hypertensive pulmonary vascular disease in the rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Chemical and Drug Induced Liver Injury; Female; Heart Ventric | 1973 |
Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities.
Topics: Alanine Transaminase; Amides; Animals; Anticholesteremic Agents; Barbiturates; Body Weight; Butyrate | 1967 |
The role of liver cell endoplasmic reticulum and microsomal enzymes in carbon tetrachloride toxicity: an in vivo study.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietary Proteins; E | 1970 |
Hepatocytic alterations induced by phenobarbitone--an ultrastructural study and histochemical assessment of glucose-6-phosphatase and lipid in the rat and rhesus monkey.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Glucose-6-Phosphatase; Haplo | 1971 |
Effect of phenobarbital and 3-methylcholanthrene pretreatment on the hepatotoxicity of 1,1,1-trichloroethane and 1,1,2-trichloroethane.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1973 |
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome | 1974 |
Enhancement of the hepatotoxicity of trichloroethylene by inducers of drug metabolism.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1974 |
Histochemical studies of hydropic degeneration of the rat liver induced by carbon disulphide.
Topics: Acid Phosphatase; Adenosine Triphosphatases; Animals; Carbon Disulfide; Cell Membrane; Chemical and | 1974 |
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Topics: Animals; Autoradiography; Benzene Derivatives; Carbon Isotopes; Chemical and Drug Induced Liver Inju | 1971 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; | 1971 |
Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction?
Topics: Aged; Anesthesia, Inhalation; Anesthetics; Autopsy; Chemical and Drug Induced Liver Injury; Drug Int | 1972 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 1972 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; | 1974 |
The effects of phenobarbital and carbon tetrachloride on the rate of decline of body burdens of hexachlorobenzene in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Body Burden; Carbon Tetrachloride; Chemical a | 1974 |
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione.
Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and D | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl | 1974 |
Biochemical effects of halothane.
Topics: Adult; Animals; Autoantibodies; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Dr | 1972 |
Autoimmune response in experimental halothan-induced liver injury.
Topics: Animals; Antibody Formation; Autoantibodies; Chemical and Drug Induced Liver Injury; Dose-Response R | 1973 |
[Drugs and the liver].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Humans; Liver; Liver Di | 1972 |
Toxicity of carbon disulphide.
Topics: Adrenal Glands; Animals; Brain Chemistry; Carbon Disulfide; Chemical and Drug Induced Liver Injury; | 1972 |
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glu | 1973 |
Hepatotoxicity of CS 2 in rats: relation to postexposure liver weight and pre-exposure cytochrome P-450 level.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; F | 1973 |
Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis.
Topics: Animals; Autoradiography; Bromine; Bronchial Diseases; Carbon Isotopes; Chemical and Drug Induced Li | 1973 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
Effect of experimental hepatic injury on the clearance of phenobarbital and paraldehyde.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Carbon | 1973 |
[Therapeutic hyperosmolarity].
Topics: Adult; Bicarbonates; Blood Transfusion; Brain Diseases; Chemical and Drug Induced Liver Injury; Diaz | 1973 |
Effect of pretreatment with phenobarbitone and CS2 on lesions caused in the mouse by 3-hydroxymethyl furan (N,N-diethyl)-carbamate.
Topics: Acute Kidney Injury; Animals; Carbamates; Carbon Disulfide; Chemical and Drug Induced Liver Injury; | 1973 |
Further observation on the effects of 3-methylcholanthrene and phenobarbital on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cell Sur | 1973 |
Potentiation of CCl4-induced hepatotoxicity in the dog by chronic exposure to phenobarbital.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, | 1973 |
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver | 1973 |
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; | 1973 |
Phenobarbital and organic solvent toxicity.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1973 |
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1973 |
The effect of phenobarbitone pretreatment on paracetamol toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1973 |
Liver injury following halothane anesthesia in phenobarbital-pretreated rats.
Topics: Alkadienes; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 1974 |
Effect of barbiturates on the liver of rats exposed to carbon disulphide vapour.
Topics: Animals; Barbiturates; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Environmental Expos | 1974 |
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
Topics: Animals; Benzene Derivatives; Biotransformation; Carbon Radioisotopes; Chemical and Drug Induced Liv | 1974 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |
An ultrastructural study of carbon disulphide induced liver injury in the rat.
Topics: Animals; Carbon Disulfide; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cytoplasm; Endoplas | 1974 |
[Relation of glutathione peroxidase and catalase activities during phenobarbital-induced liver hyperplasia].
Topics: Animals; Catalase; Chemical and Drug Induced Liver Injury; Glutathione; Male; Peroxidases; Phenobarb | 1974 |
Effect of drug pretreatment on CBrCl3-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver | 1974 |
Effects of phenobarbital and SKF 525A pretreatment, sex, liver injury, and vehicle on delta9-tetrahydrocannabinol toxicity.
Topics: Animals; Brain Chemistry; Cannabis; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Chemical a | 1974 |
[Histological, histochemical and electron microscopical findings in foreign substance induced liver hypertrophy in white mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum; Halothane; Hyper | 1967 |
Modifying effect of 3-amino-1,2,4-triazole on phenobarbital-induced changes in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrom | 1972 |
Enhanced hepatotoxicity of fluroxene.
Topics: Chemical and Drug Induced Liver Injury; Drug Synergism; Ethers; Fluorine; Humans; Liver; Phenobarbit | 1972 |
Effect of phenobarbitone and starvation on hepatotoxicity in rats exposed to carbon disulphide vapour.
Topics: Air Pollution; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Diet; Dietary Fats | 1972 |
Liver parenchymal cell injury. IX. Phenobarbital potentiation of endoplasmic reticulum denaturation following carbon tetrachloride.
Topics: Animals; Autoradiography; Calcium; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical and Dru | 1972 |
The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Mice; Microsomes, Li | 1972 |
Effects of phenobarbital pretreatment on the response of rat liver to halothane administration.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzyme Induction; | 1972 |
Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Lethal Dose 50; Liver; Male; Microsomes, Li | 1972 |
Factors affecting neurotoxicity by p-bromophenylacetylurea in rats.
Topics: Acetylcholinesterase; Age Factors; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Chemi | 1971 |
The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats.
Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical | 1971 |
Factors affecting the chronic hepatotoxicity of pyrrolizidine alkaloids.
Topics: Age Factors; Alkaloids; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chronic | 1971 |
Bromobenzene metabolism and hepatic necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Chemical and Drug Induced Li | 1971 |
On the use of drug rechallenge to substantiate drug-induced hepatic injury.
Topics: Chemical and Drug Induced Liver Injury; Ethics, Medical; Female; Humans; Phenobarbital | 1969 |
[Hepatoprotective activity in the rat of 2,4-monofurfurylidene-tetra-O-methyl-sorbitol (MSF). II. Influence of phenobarbital on sleep in animals with carbon tetrachloride poisoning].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Furans; Phenobarbit | 1969 |
[Late cutaneous porphyria with sclerodermic syndrome revealed by taking estrogens, barbiturates and estro-progestational hormones].
Topics: Adult; Amenorrhea; Chemical and Drug Induced Liver Injury; Female; Humans; Lynestrenol; Mestranol; P | 1969 |
Effect of drug pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver microsomal lipids.
Topics: Animals; Carbon Tetrachloride Poisoning; Centrifugation; Chemical and Drug Induced Liver Injury; Lip | 1970 |
Modification of the effects of chloroform on the rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Disulfiram; Enzyme Induction; Microsome | 1970 |
[Stimulation and depression of toxicity of chloroform for the liver by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1970 |
Liver damage and excretion of bivalent sulphur after exposure to carbon disulphide in fed and fasted rats with and without phenobarbitone pretreatment.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Liver; Male; Phenobarbital; Rats; | 1970 |
[Studies on a possibility of induction of lysosomal enzymes of the rat liver by phenobarbital. 2. (10): Cathepsin and acidic carboxypeptidase].
Topics: Animals; Carboxypeptidases; Cathepsins; Chemical and Drug Induced Liver Injury; Enzyme Induction; Le | 1970 |
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul | 1971 |
Toxicity of carbon tetrachloride and other fasciocidal drugs in sheep and chickens.
Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Anthelmintics; Aspartate Aminotransferases; | 1971 |
Alcoholism, alcohol, and drugs.
Topics: Alcoholism; Animals; Calorimetry; Chemical and Drug Induced Liver Injury; Diet; Drug Antagonism; Dru | 1971 |
Regeneration of the mammalian liver. VI. Retention of phenobarbital-induced cytoplasmic alterations in dividing hepatocytes.
Topics: Animals; Blood Proteins; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Femoral Vein | 1968 |
Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration.
Topics: Age Factors; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytoch | 1968 |
Alcohol, other drugs, and the liver.
Topics: Alcoholism; Animals; Central Nervous System; Chemical and Drug Induced Liver Injury; Ethanol; Humans | 1968 |
Increased bilirubin formation from nonhemoglobin sources in rats with disorders of the liver.
Topics: Animals; Bilirubin; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Erythrop | 1969 |
Developments in jaundice.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Enzyme Induction; Female; | 1969 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |