phenobarbital has been researched along with Acute Disease in 78 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression." | 9.30 | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. ( Abdel Baki, SG; Birbeck, GL; Capparelli, EV; Dzinjalamala, FK; Gardiner, JC; Herman, ST; Mallewa, M; Postels, DG; Seydel, KB; Taylor, TE; Toto, NM, 2019) |
| "To clarify the effect of levetiracetam (LEV) for acute and chronic seizure control in acute encephalitis with refractory, repetitive partial seizures (AERRPS)." | 7.81 | Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase. ( Imamura, A; Maegaki, Y; Maruta, K; Matsunami, K; Narita, A; Nishimura, Y; Ohno, K; Saiki, Y; Saito, Y; Sokota, T; Sugihara, S; Tamasaki, A; Ueda, R, 2015) |
| "Acute intermittent porphyria (AIP) is a rare metabolic disorder of heme biosynthesis characterized by enzymatic defect of porphobiligen desaminase with accumulation and increased excretion of porphyrins and their precursors." | 7.75 | [Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment]. ( Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I, 2009) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "Pharmacokinetics of methohexital were studied in patients with acute hepatitis and after a treatment period either with "essential phospholipids" or phenobarbital." | 7.66 | [Methohexital clearance in patients with acute hepatitis (author's transl)]. ( Breimer, DD; Gallenkamp, H; Heusler, H; Richter, E; Zilly, W, 1979) |
| "3 mg Atropinmethylnitrat, without phenobarbital) was given in a dosis of 3 and 6 tablets in patients with acute myocardial infarction." | 7.65 | [The effect of nitroglycerin in patients with acute myocardial infarction. IV. Myocardon in patients with and without left ventricular failure (author's transl)]. ( Bussmann, WD; Kaltenbach, M; Löhner, J, 1976) |
| "After treatment, convulsions were suppressed and daily life continued, but intellectual impairment and high-level dysfunction remained." | 5.43 | High-dose phenobarbital with intermittent short-acting barbiturates for acute encephalitis with refractory, repetitive partial seizures. ( Endo, W; Haginoya, K; Kitamura, T; Nishio, T; Numata, Y; Ohura, T; Takayanagi, M; Uchida, T, 2016) |
| "Phenobarbital (PB) was administrated at a very high daily dose up to 80 mg/kg, reaching serum trough level of 250 μg/ml, which was markedly effective to the treatment." | 5.40 | [A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy]. ( Aiba, H; Okumura, Y; Watanabe, S, 2014) |
| " Seizures in three patients were stopped after high-dose lidocaine infusion (6-8 mg/kg/h) in the acute stage and three patients were stopped after high dose phenobarbital (serum level 60-80 ug/mL) combined with high-dose oral topiramate (15-20 mg/kg/day)." | 5.35 | Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures. ( Hsia, SH; Lin, JJ; Lin, KL; Wang, HS; Wu, CT, 2009) |
| "Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression." | 5.30 | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. ( Abdel Baki, SG; Birbeck, GL; Capparelli, EV; Dzinjalamala, FK; Gardiner, JC; Herman, ST; Mallewa, M; Postels, DG; Seydel, KB; Taylor, TE; Toto, NM, 2019) |
| " PROSPECTIVE CONTROLLED CLINICAL TRIALS: Two of the 94 publications were prospective controlled studies (only one stated that allocation was via blinded randomisation), and both assessed the effect of multiple-dose activated charcoal for acute phenobarbital poisoning." | 4.87 | Enhanced elimination in acute barbiturate poisoning - a systematic review. ( Buckley, NA; Roberts, DM, 2011) |
| "To clarify the effect of levetiracetam (LEV) for acute and chronic seizure control in acute encephalitis with refractory, repetitive partial seizures (AERRPS)." | 3.81 | Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase. ( Imamura, A; Maegaki, Y; Maruta, K; Matsunami, K; Narita, A; Nishimura, Y; Ohno, K; Saiki, Y; Saito, Y; Sokota, T; Sugihara, S; Tamasaki, A; Ueda, R, 2015) |
| "Acute intermittent porphyria (AIP) is a rare metabolic disorder of heme biosynthesis characterized by enzymatic defect of porphobiligen desaminase with accumulation and increased excretion of porphyrins and their precursors." | 3.75 | [Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment]. ( Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I, 2009) |
| "Rats in experiment 1 received 1% creatine or cyclocreatine chow from age (P) 21-65 days, underwent kainate induced status epilepticus on P35 and were compared, as adults, to kainate alone rats and to normal controls." | 3.72 | Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. ( Abu Rialy, S; Farhat, F; Francis, E; Geha, G; Kurdit, RM; Lteif, L; Maraashli, W; Mikati, MA; Rahmeh, AA, 2004) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "Assay of the clinical course of poisoning with acetic acid, dichloroethane, carbophos, chlorophos, phenobarbital and sodium etaminal in 2538 patients made it possible to define, with the use of the probit analysis, the 25, 50, 75 and 95% concentration thresholds of the lethality in acute poisonings with acetic acid, carbophos and dichloroethane." | 3.67 | [Age-related aspects of intensive therapy of acute poisoning of chemical etiology]. ( Dagaev, VN; Gorin, EE; Kostomarova, LG; Luzhnikov, EA, 1985) |
| "Pharmacokinetics of methohexital were studied in patients with acute hepatitis and after a treatment period either with "essential phospholipids" or phenobarbital." | 3.66 | [Methohexital clearance in patients with acute hepatitis (author's transl)]. ( Breimer, DD; Gallenkamp, H; Heusler, H; Richter, E; Zilly, W, 1979) |
| "Serum squalene levels did not change in patients with acute hepatitis, chronic active hepatitis and liver cirrhosis, but were significantly reduced in patients with intra- and extrahepatic cholestasis." | 3.66 | Serum squalene levels in hepatobiliary diseases. ( Hirayama, C; Ikawa, S; Yamanishi, Y, 1978) |
| "3 mg Atropinmethylnitrat, without phenobarbital) was given in a dosis of 3 and 6 tablets in patients with acute myocardial infarction." | 3.65 | [The effect of nitroglycerin in patients with acute myocardial infarction. IV. Myocardon in patients with and without left ventricular failure (author's transl)]. ( Bussmann, WD; Kaltenbach, M; Löhner, J, 1976) |
| "A prospective study was undertaken to determine the cause of the acute anemia previously observed in pigs manifesting acute liver necrosis after administration of acetaminophen in dosages in excess of the LD100." | 3.65 | Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia. ( Fiskerstrand, C; Miller, DJ; Pichanick, GG; Saunders, SJ, 1977) |
| "The urinary excretion of D-glucaric acid and the plasma clearance of antipyrine were estimated during the acute phase of viral hepatitis and again during recovery." | 3.65 | Paradoxical urinary excretion of D-glucaric acid in acute viral hepatitis. ( Barak, AJ; Burnett, DA; Sorrell, MF; Tuma, DJ, 1976) |
| " Further studies are required to establish its role and the optimal dosage regimen of charcoal to be administered." | 2.40 | Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. ( , 1999) |
| "After treatment, convulsions were suppressed and daily life continued, but intellectual impairment and high-level dysfunction remained." | 1.43 | High-dose phenobarbital with intermittent short-acting barbiturates for acute encephalitis with refractory, repetitive partial seizures. ( Endo, W; Haginoya, K; Kitamura, T; Nishio, T; Numata, Y; Ohura, T; Takayanagi, M; Uchida, T, 2016) |
| "Phenobarbital (PB) was administrated at a very high daily dose up to 80 mg/kg, reaching serum trough level of 250 μg/ml, which was markedly effective to the treatment." | 1.40 | [A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy]. ( Aiba, H; Okumura, Y; Watanabe, S, 2014) |
| "Abdominal CT was performed again and bezoars formation was suspected." | 1.38 | [Aggressive endoscopic removal of bezoars effective for the treatment of acute poisoning]. ( Aruga, T; Dohi, K; Minemura, A; Miyake, Y; Miyamoto, K; Nakamura, S; Watanabe, M, 2012) |
| " Seizures in three patients were stopped after high-dose lidocaine infusion (6-8 mg/kg/h) in the acute stage and three patients were stopped after high dose phenobarbital (serum level 60-80 ug/mL) combined with high-dose oral topiramate (15-20 mg/kg/day)." | 1.35 | Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures. ( Hsia, SH; Lin, JJ; Lin, KL; Wang, HS; Wu, CT, 2009) |
| "Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia." | 1.35 | Translocation-positive acute myeloid leukemia associated with valproic acid therapy. ( Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC, 2008) |
| "Complex febrile seizures, affecting an estimated 5000 children in Illinois, were treated with phenobarbital by 90% of respondents, and therapy was continued for an average of 2 years." | 1.28 | Management of febrile seizures: current concepts and recommendations for phenobarbital and the electroencephalogram. ( Millichap, JG, 1991) |
| " The LD50 were determined by the method of moving averages." | 1.27 | Acute hepatotoxicity and lethality of CCl4 in chlordecone-pretreated rats. ( Klingensmith, JS; Lockard, V; Mehendale, HM, 1983) |
| " Aspirin, ibuprofen, indomethacin, ketoprofen, flurbiprofen, phenylbutazone, naproxen, prednisolone, and penicillamine did not increase ALA synthase activity and should be safe in porphyria." | 1.27 | Studies in laboratory animals to assess the safety of anti-inflammatory agents in acute porphyria. ( McColl, KE; Moore, MR; Thompson, GG, 1987) |
| "Bicyclic phosphorus esters (BCP) originating from the combustion of fire-retardant polyurethane foam containing phosphorus are highly toxic compounds and potent antagonists of GABA-ergic receptors." | 1.27 | [Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters]. ( Emilianowicz, J; Smok, W, 1986) |
| "Phenobarbital treatment significantly reduced the level of unconjugated serum bilirubin in patients with acute hepatitis or Gilbert's syndrome, but without any difference within these two groups of patients." | 1.26 | Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests. ( Hardt, F; Juhl, E; Thomsen, HF, 1981) |
| "During this treatment a severe mainly motor polyneuropathy occurred acutely which was more pronounced in the distal parts of the legs, and cerebellar symptoms were noted at the same time." | 1.25 | [Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)]. ( Bajc, O; Meienberg, O, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (53.85) | 18.7374 |
| 1990's | 13 (16.67) | 18.2507 |
| 2000's | 11 (14.10) | 29.6817 |
| 2010's | 11 (14.10) | 24.3611 |
| 2020's | 1 (1.28) | 2.80 |
| Authors | Studies |
|---|---|
| Birbeck, GL | 1 |
| Herman, ST | 1 |
| Capparelli, EV | 1 |
| Dzinjalamala, FK | 1 |
| Abdel Baki, SG | 1 |
| Mallewa, M | 1 |
| Toto, NM | 1 |
| Postels, DG | 1 |
| Gardiner, JC | 1 |
| Taylor, TE | 1 |
| Seydel, KB | 1 |
| Ramírez-Zamora, M | 1 |
| Veliz-Martínez, V | 1 |
| Barahona, GE | 1 |
| Mena, ID | 1 |
| Ortez, CI | 1 |
| Nolasco-Tovar, GA | 1 |
| Tominaga, A | 1 |
| Iseki, K | 1 |
| Hayashida, M | 1 |
| Shinosaki, K | 1 |
| Toyokuchi, S | 1 |
| Shiroishi, T | 1 |
| Ueda, R | 1 |
| Saito, Y | 1 |
| Ohno, K | 1 |
| Maruta, K | 1 |
| Matsunami, K | 1 |
| Saiki, Y | 1 |
| Sokota, T | 1 |
| Sugihara, S | 1 |
| Nishimura, Y | 1 |
| Tamasaki, A | 1 |
| Narita, A | 1 |
| Imamura, A | 1 |
| Maegaki, Y | 1 |
| Watanabe, S | 1 |
| Okumura, Y | 1 |
| Aiba, H | 1 |
| Matsumoto, H | 2 |
| Umakoshi, K | 1 |
| Kikuchi, S | 2 |
| Takeba, J | 1 |
| Aibiki, M | 1 |
| Simerdova, V | 1 |
| Hajek, I | 1 |
| Schanilec, P | 1 |
| Uchida, T | 1 |
| Takayanagi, M | 1 |
| Kitamura, T | 1 |
| Nishio, T | 1 |
| Numata, Y | 1 |
| Endo, W | 1 |
| Haginoya, K | 1 |
| Ohura, T | 1 |
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Lin, JJ | 1 |
| Lin, KL | 1 |
| Wang, HS | 1 |
| Hsia, SH | 1 |
| Wu, CT | 1 |
| Akopova-Larbi, R | 1 |
| Ben Youssef, TI | 1 |
| Gargouri, A | 1 |
| Kraoua, I | 1 |
| Gouider, R | 1 |
| Gouider-Khouja, N | 1 |
| Desalew, M | 1 |
| Aklilu, A | 1 |
| Amanuel, A | 1 |
| Addisu, M | 1 |
| Ethiopia, T | 1 |
| Roberts, DM | 1 |
| Buckley, NA | 1 |
| Takei, T | 1 |
| Fukushima, H | 1 |
| Hatakeyama, J | 1 |
| Fujisawa, M | 1 |
| Ito, T | 1 |
| Miyamoto, K | 1 |
| Minemura, A | 1 |
| Watanabe, M | 1 |
| Nakamura, S | 1 |
| Dohi, K | 1 |
| Miyake, Y | 1 |
| Aruga, T | 1 |
| Rahman, TM | 1 |
| Selden, AC | 1 |
| Hodgson, HJ | 1 |
| Mikati, MA | 1 |
| Kurdit, RM | 1 |
| Rahmeh, AA | 1 |
| Farhat, F | 1 |
| Abu Rialy, S | 1 |
| Lteif, L | 1 |
| Francis, E | 1 |
| Geha, G | 1 |
| Maraashli, W | 1 |
| Kobayashi, A | 1 |
| Yoshita, T | 1 |
| Sugiyama, K | 1 |
| Miyashita, K | 1 |
| Niida, Y | 1 |
| Koizumi, S | 1 |
| Tseng, SC | 1 |
| Williams, DC | 1 |
| Massey, GV | 1 |
| Russell, EC | 1 |
| Riley, RS | 1 |
| Ben-Ezra, J | 1 |
| Goulding, R | 1 |
| Klingensmith, JS | 1 |
| Lockard, V | 1 |
| Mehendale, HM | 1 |
| Kravchenko, LV | 1 |
| Avren'eva, LI | 1 |
| Tutel'ian, VA | 1 |
| Pisani, F | 1 |
| Perucca, E | 1 |
| Primerano, G | 1 |
| D'Agostino, AA | 1 |
| Petrelli, RM | 1 |
| Fazio, A | 1 |
| Oteri, G | 1 |
| Di Perri, R | 1 |
| Kuo, TL | 1 |
| Chen, WY | 1 |
| Fong, JM | 1 |
| How, SW | 1 |
| Clark, JD | 1 |
| Hatch, RC | 1 |
| Jain, AV | 1 |
| Weiss, R | 1 |
| Tessore, V | 1 |
| Luboz, MP | 1 |
| Denti, E | 1 |
| Thomsen, HF | 1 |
| Hardt, F | 1 |
| Juhl, E | 1 |
| Lin, JL | 1 |
| Jeng, LB | 1 |
| Angelov, EP | 1 |
| Zakharova, MV | 1 |
| Shkurupiĭ, VA | 1 |
| Grek, OR | 1 |
| Brocheriou, I | 1 |
| Zafrani, ES | 1 |
| Mavier, P | 1 |
| Schneider, S | 1 |
| Charles, F | 1 |
| Chichmanian, RM | 1 |
| Montoya, ML | 1 |
| Rampal, P | 1 |
| Vezzani, A | 1 |
| Ravizza, T | 1 |
| Moneta, D | 1 |
| Conti, M | 1 |
| Borroni, A | 1 |
| Rizzi, M | 1 |
| Samanin, R | 1 |
| Maj, R | 1 |
| McLaughlin, GE | 1 |
| Rossique-Gonzalez, M | 1 |
| Gelman, B | 1 |
| Kato, T | 1 |
| Videla, LA | 1 |
| Arisi, AC | 1 |
| Fuzaro, AP | 1 |
| Koch, OR | 2 |
| Junqueira, VB | 1 |
| Schuurmans, MM | 1 |
| Hoffmann, F | 1 |
| Lindberg, RL | 1 |
| Meyer, UA | 1 |
| Corda, D | 1 |
| Gelisse, P | 1 |
| Genton, P | 1 |
| Dravet, C | 1 |
| Baldy-Moulinier, M | 1 |
| McColl, KE | 2 |
| Fletcher, CD | 1 |
| Thomson, TJ | 1 |
| Heipertz, R | 1 |
| Guthoff, A | 1 |
| Bernhardt, W | 1 |
| Meienberg, O | 1 |
| Bajc, O | 1 |
| Plaa, GL | 1 |
| Richter, E | 1 |
| Gallenkamp, H | 1 |
| Heusler, H | 1 |
| Zilly, W | 1 |
| Breimer, DD | 1 |
| Carrella, M | 1 |
| D'Arienzo, A | 1 |
| Manzillo, G | 1 |
| De Ritis, F | 1 |
| Yamanishi, Y | 1 |
| Ikawa, S | 1 |
| Hirayama, C | 1 |
| Bruya, MA | 1 |
| Bolin, RH | 1 |
| Bussmann, WD | 1 |
| Löhner, J | 1 |
| Kaltenbach, M | 1 |
| Miller, DJ | 1 |
| Pichanick, GG | 1 |
| Fiskerstrand, C | 1 |
| Saunders, SJ | 1 |
| Sorrell, MF | 1 |
| Burnett, DA | 1 |
| Tuma, DJ | 1 |
| Barak, AJ | 1 |
| Rosenberg, M | 1 |
| Sharpe, J | 1 |
| Hoyt, WF | 1 |
| Aoki, N | 1 |
| Mayhew, LA | 1 |
| Hanzel, TE | 1 |
| Ferron, FR | 1 |
| Kalachnik, JE | 1 |
| Harder, SR | 1 |
| Levy, FE | 1 |
| Chauvelot-Moachon, L | 1 |
| Florentin, I | 1 |
| Forest, M | 1 |
| Poüs, C | 1 |
| Fournier, C | 1 |
| Giroud, JP | 1 |
| Schoenfeld, N | 1 |
| Mamet, R | 1 |
| Mevasser, R | 1 |
| Atsmon, A | 1 |
| Millichap, JG | 1 |
| Ishida, C | 1 |
| Kakehashi, H | 1 |
| Kusunoki, Y | 1 |
| Sakata, H | 1 |
| Takimoto, M | 1 |
| Yoshioka, H | 1 |
| Maes, V | 1 |
| Huyghens, L | 1 |
| Dekeyser, J | 1 |
| Sevens, C | 1 |
| Klockowski, PM | 1 |
| Levy, G | 1 |
| Young, GP | 1 |
| Rores, C | 1 |
| Murphy, C | 1 |
| Dailey, RH | 1 |
| Thompson, GG | 1 |
| Moore, MR | 1 |
| Smok, W | 1 |
| Emilianowicz, J | 1 |
| Khubenova, A | 1 |
| Popov, A | 1 |
| Makaveeva, V | 1 |
| Ito, M | 1 |
| Yachi, A | 1 |
| Bonitenko, IuIu | 1 |
| Buchko, VM | 1 |
| Kalmanson, ML | 1 |
| Luzhnikov, EA | 1 |
| Dagaev, VN | 1 |
| Kostomarova, LG | 1 |
| Gorin, EE | 1 |
| Frantzen, E | 1 |
| Lennox-Buchthal, M | 1 |
| Nygaard, A | 1 |
| Neĭkoya, M | 1 |
| Kennedy, AC | 1 |
| Briggs, JD | 1 |
| Young, N | 1 |
| Lindsay, RM | 1 |
| Luke, RG | 1 |
| Campbell, D | 1 |
| St Jean, A | 1 |
| Sterlin, C | 1 |
| Noe, W | 1 |
| Ban, TA | 1 |
| Porta, EA | 1 |
| Hartroft, WS | 1 |
| Brown, BR | 1 |
| Sipes, IG | 1 |
| Sagalyn, AM | 1 |
| Strohmeyer, G | 1 |
| Chédru, F | 1 |
| Geschwind, N | 1 |
| Tamphaichitr, P | 1 |
| Toochinda, P | 1 |
| Kashemsant, C | 1 |
| Yatzidis, H | 1 |
| Lagos, JC | 1 |
| Knott, DH | 1 |
| Beard, JD | 1 |
| McCue, CM | 1 |
| Robertson, LW | 1 |
| Eldredge, WJ | 1 |
| Noble, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Safety and Feasibility Study of Enteral Levetiracetam vs. Phenobarbital for Seizure Control in Pediatric Cerebral Malaria[NCT01982812] | Phase 2 | 44 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| A Dose-Escalation, Safety And Feasibility Study Of Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria[NCT01660672] | Phase 1/Phase 2 | 7 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The mean time in hours from admission until the subject reaches Blantyre Coma Scale of greater than or equal to 4. Participants who died are excluded from this analysis.~The Blantyre Coma Score has ranges from 0-5 based upon the a sum of the following 3 domains- Eye movement~1 - Watches or follows 0 - Fails to watch or follow~Best motor response 2 - Localizes painful stimulus 1 - Withdraws limb from painful stimulus 0 - No response or inappropriate response~Best verbal response 2 - Cries appropriately with pain, or, if verbal, speaks~1 - Moan or abnormal cry with pain 0 - No vocal response to pain" (NCT01982812)
Timeframe: 7 days
| Intervention | hours of coma from admission (Mean) |
|---|---|
| Oral Levetiracetam | 35.4 |
| Comparison Group | 34.6 |
Comparing LVT to standard AED the number of minutes spent in seizure per cEEG in the 72 hours after treatment allocation. (NCT01982812)
Timeframe: 72 hours
| Intervention | minutes with seizure (Mean) |
|---|---|
| Oral Levetiracetam | 165.2 |
| Comparison Group | 464.8 |
Additional AEDs required (including for breakthrough seizures in LVT group) during admission for seizure control (yes/no) (NCT01982812)
Timeframe: 7 days
| Intervention | Participants requiring additional AEDs (Number) |
|---|---|
| Oral Levetiracetam | 18 |
| Comparison Group | 18 |
"Neurologic outcome in 3 categories--~Neurologically intact at discharge~Neurologic sequelae at discharge--specifically new sensory or motor deficits, ongoing seizures, or behavioral abnormalities based upon a physician examination at discharge~Died during admission, never discharged" (NCT01982812)
Timeframe: 7 days
| Intervention | participants (Number) | ||
|---|---|---|---|
| Neurologically intact at discharge | Neurologic sequelae at discharge | Died during admission | |
| Comparison Group | 14 | 2 | 5 |
| Oral Levetiracetam | 19 | 3 | 1 |
Number of subjects free of seizure at 24 hours after initiation of treatment (NCT01660672)
Timeframe: 24 hours
| Intervention | individuals (Number) |
|---|---|
| LEVETIRACETAM | 7 |
Mean time from admission to a BCS score greater than or equal to 4. The BCS (Blantyre Coma Scale) is a 0-5 scale measuring motor response, verbal response and eye movement assessing the severity of coma in children with cerebral malaria. Lower scores correspond to more profound coma. (NCT01660672)
Timeframe: 7 days
| Intervention | hours (Mean) |
|---|---|
| LEVETIRACETAM | 35.3 |
Number of participants who required AEDS during admission(including for breakthrough seizures in the LVT group) during admission. (NCT01660672)
Timeframe: 7 days
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 6 |
Number of participants with neurologic sequelae at discharge (NCT01660672)
Timeframe: day 7
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 2 |
Pre-enrollment exposure to phenobarbitone may impact LVT efficacy, and analysis base on this characteristic will be evaluated. (NCT01660672)
Timeframe: 0 hour
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 3 |
Retinopathy status may impact LVT efficacy and subject status will be analyzed based on this characteristic. (NCT01660672)
Timeframe: Upon admission
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 4 |
Range of plasma LVT concentrations will be determined through HPLC method at eight timepoints post administration to evaluate LVT absorption and elimination in pediatric CM. (NCT01660672)
Timeframe: 72 hours
| Intervention | mcg/ml (Mean) |
|---|---|
| LEVETIRACETAM | 35 |
Toxicity including vomiting, aspiration, complications related to the NGT, laboratory parameters at 24 hours and 1 week post LVT administration, and an overall acute case fatality rate significantly above the consistent historical ward average for CM. Pk studies to evaluate LVT absorption and elimination in pediatric CM. (NCT01660672)
Timeframe: 1 week
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 0 |
5 reviews available for phenobarbital and Acute Disease
| Article | Year |
|---|---|
Enhanced elimination in acute barbiturate poisoning - a systematic review.
Topics: Acute Disease; Adult; Barbiturates; Clinical Trials as Topic; Female; Humans; Pentobarbital; Phenoba | 2011 |
Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.
Topics: Acute Disease; Animals; Carbamazepine; Cathartics; Charcoal; Dapsone; Drug Therapy, Combination; Hum | 1999 |
Acute toxicity of antiepileptic drugs.
Topics: Acute Disease; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dogs; | 1975 |
Recent advances in molecular pathology: a review of the effects of alcohol on the liver.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Butyrates; Chemical and Drug Induced Liv | 1970 |
[Advances in the field of liver diseases].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Chronic Disease; Drug Synergism; Enzyme Induc | 1972 |
2 trials available for phenobarbital and Acute Disease
| Article | Year |
|---|---|
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
71 other studies available for phenobarbital and Acute Disease
| Article | Year |
|---|---|
[Hemicerebellitis due to chikungunya associated with refractory status epilepticus in the paediatric age].
Topics: Acute Disease; Antibodies, Viral; Anticonvulsants; Attention Deficit and Disruptive Behavior Disorde | 2020 |
[Case of phenobarbital intoxication taken to hospital three days after overdose].
Topics: Acute Disease; Anticonvulsants; Charcoal; Drug Overdose; Female; Fluid Therapy; Hospitalization; Hum | 2013 |
Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Bromides; Child; Chronic Disease; Encephalitis; F | 2015 |
[A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy].
Topics: Acute Disease; Child; Encephalitis; Humans; Male; Phenobarbital; Seizures; Status Epilepticus; Treat | 2014 |
[BIS values were useful on the evaluation of consciousness recovery in acute Vegetamin-A poisoning: report of a case].
Topics: Acute Disease; Adult; Charcoal; Chlorpromazine; Coma; Consciousness Monitors; Drug Combinations; Ene | 2014 |
Addisonian crisis in a dog treated with phenobarbitone.
Topics: Acute Disease; Addison Disease; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy, Generalized; | 2015 |
High-dose phenobarbital with intermittent short-acting barbiturates for acute encephalitis with refractory, repetitive partial seizures.
Topics: Acute Disease; Anticonvulsants; Barbiturates; Child; Dose-Response Relationship, Drug; Drug Administ | 2016 |
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography | 2009 |
[Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment].
Topics: Acute Disease; Adolescent; Arginine; Electromyography; Famotidine; Female; Heme; Heme Oxygenase (Dec | 2009 |
Pattern of acute adult poisoning at Tikur Anbessa specialized teaching hospital, a retrospective study, Ethiopia.
Topics: Acute Disease; Adolescent; Adult; Ethiopia; Female; Hospitals, Teaching; Household Products; Humans; | 2011 |
Acute amiodarone poisoning occurring twice in the same subject.
Topics: Acute Disease; Aged; Amiodarone; Antidotes; Charcoal; Humans; Male; Phenobarbital; Suicide, Attempte | 2011 |
[Aggressive endoscopic removal of bezoars effective for the treatment of acute poisoning].
Topics: Acute Disease; Adult; Bezoars; Chlorpromazine; Consciousness Disorders; Endoscopy, Gastrointestinal; | 2012 |
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.
Topics: Acute Disease; Aggression; Animals; Anticonvulsants; Creatine; Creatinine; Dietary Supplements; Emot | 2004 |
Amniotic membrane transplantation in acute phase of toxic epidermal necrolysis with severe corneal involvement.
Topics: Acute Disease; Amnion; Cell Count; Child; Conjunctival Diseases; Corneal Diseases; Cryopreservation; | 2006 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, | 2008 |
The treatment of acute poisoning.
Topics: Acute Disease; Antidotes; Atropine; Barbiturates; Carbon Monoxide Poisoning; Chlorpromazine; Deferox | 1967 |
Acute hepatotoxicity and lethality of CCl4 in chlordecone-pretreated rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chl | 1983 |
[Mechanism of the protective effect of modifiers of the liver enzyme systems metabolyzing xenobiotics in acute T-2 mycotoxicosis].
Topics: Acute Disease; Animals; Cobalt; Drug Evaluation, Preclinical; Enzyme Induction; Inactivation, Metabo | 1984 |
Single-dose kinetics of primidone in acute viral hepatitis.
Topics: Acute Disease; Adult; Biotransformation; Female; Hepatitis, Viral, Human; Humans; Kinetics; Male; Mi | 1984 |
Studies on serum barbiturate levels of acute intoxication.
Topics: Acute Disease; Adolescent; Adult; Aged; Barbiturates; Female; Humans; Male; Middle Aged; Phenobarbit | 1984 |
Effect of enzyme inducers and inhibitors and glutathione precursor and depleter on induced acute aflatoxicosis in rabbits.
Topics: Acute Disease; Aflatoxin B1; Aflatoxins; Animals; Benzoflavones; Carcinogens; Chlorides; Cobalt; Cys | 1982 |
Use of uncoated activated carbon hemoperfusion in acute poisoning: in vitro studies.
Topics: Acute Disease; Adsorption; Animals; Blood Glucose; Blood Urea Nitrogen; Carbon; Creatinine; Hemoperf | 1982 |
Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests.
Topics: Acute Disease; Adolescent; Adult; Bilirubin; Diagnosis, Differential; Energy Intake; Fasting; Female | 1981 |
Critical, acutely poisoned patients treated with continuous arteriovenous hemoperfusion in the emergency department.
Topics: Acute Disease; Adult; Aged; Emergencies; Emergency Service, Hospital; Hemoperfusion; Humans; Male; M | 1995 |
[A selective decrease in cytochrome P450 in the liver microsomes of male rats following phenobarbital and 3-methylcholanthrene induction and acute tetrachloromethane poisoning].
Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Cytochromes | 1993 |
[Effect of preliminary phenobarbital and ziksorin administration on reparative processes in the liver parenchyma after ischemic damage].
Topics: Acute Disease; Animals; Benzhydryl Compounds; Ischemia; Liver; Liver Regeneration; Male; Microscopy, | 1994 |
[Severe acute hepatitis caused by Atrium].
Topics: Acute Disease; Adult; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; Human | 1993 |
[Acute hepatitis associated with microvesicular steatosis induced by Atrium].
Topics: Acute Disease; Adult; Barbiturates; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; | 1995 |
Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y.
Topics: Acute Disease; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Colchicine; Elect | 1999 |
Use of phenobarbital in the management of acute tacrolimus toxicity: a case report.
Topics: Acute Disease; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Infant; Liver Transplantatio | 2000 |
Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication.
Topics: Acute Disease; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Excitatory Amino | 2000 |
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug C | 2001 |
Incidence of drug-induced aggravation in benign epilepsy with centrotemporal spikes.
Topics: Acute Disease; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administrat | 2001 |
Hepatitis and anticonvulsant therapy.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Humans; | 1978 |
Primidone metabolism in renal insufficiency and acute intoxication.
Topics: Acute Disease; Adult; Aged; Biotransformation; Female; Humans; Kidney Failure, Chronic; Phenobarbita | 1979 |
[Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)].
Topics: Acute Disease; Adult; Cerebellar Diseases; Epilepsy, Tonic-Clonic; Humans; Male; Peripheral Nervous | 1975 |
[Methohexital clearance in patients with acute hepatitis (author's transl)].
Topics: Acute Disease; Adolescent; Adult; Aged; Female; Hepatitis; Humans; Infusions, Parenteral; Male; Meth | 1979 |
An evaluation of urinary D-glucaric acid excretion during acute hepatitis in man.
Topics: Acute Disease; Adult; Bilirubin; Child; Glucaric Acid; Glucuronates; Hepatitis, Viral, Human; Humans | 1978 |
Serum squalene levels in hepatobiliary diseases.
Topics: Acute Disease; Adult; Azathioprine; Biliary Tract Diseases; Cholestasis; Cholesterol; Cholestyramine | 1978 |
Epilepsy: a controllable disease. Part 2. Drug therapy and nursing care.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Epilepsy; Ethosuximide; Gingival Hyperplasia; Hum | 1976 |
[The effect of nitroglycerin in patients with acute myocardial infarction. IV. Myocardon in patients with and without left ventricular failure (author's transl)].
Topics: Acute Disease; Adult; Aged; Atropine; Blood Pressure; Cardiac Output; Drug Combinations; Female; Hea | 1976 |
Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia.
Topics: Acetaminophen; Acute Disease; Anemia; Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; | 1977 |
Paradoxical urinary excretion of D-glucaric acid in acute viral hepatitis.
Topics: Acute Disease; Antipyrine; Female; Glucaric Acid; Hepatitis A; Humans; Male; Phenobarbital; Sugar Ac | 1976 |
Absent vestibulo-ocular reflexes and acute supratentorial lesions.
Topics: Acute Disease; Adult; Amobarbital; Anticonvulsants; Brain Stem; Cerebral Arteries; Child; Cranial Si | 1975 |
Infantile acute encephalopathy with combined symmetrical hypodensities in the thalami and the putamen on computed tomography.
Topics: Acute Disease; Brain Diseases; Coma; Follow-Up Studies; Glycerol; Humans; Infant; Male; Necrosis; Ph | 1992 |
Phenobarbital exacerbation of self-injurious behavior.
Topics: Acute Disease; Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hu | 1992 |
Modification of inflammatory processes by phenobarbital in rats.
Topics: Acute Disease; Animals; Arthritis, Experimental; Chronic Disease; Edema; Inflammation; Macrophages; | 1991 |
Experimental latent and acute porphyria in the non-fasted rat; preventive effect of propranolol.
Topics: Acute Disease; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Coproporphyrins; Dicarbethoxyd | 1991 |
Management of febrile seizures: current concepts and recommendations for phenobarbital and the electroencephalogram.
Topics: Acute Disease; Child, Preschool; Drug Utilization; Electroencephalography; Family Practice; Humans; | 1991 |
Acute phenobarbital intoxication in an infant.
Topics: Acute Disease; Humans; Inappropriate ADH Syndrome; Infant; Male; Phenobarbital | 1990 |
Acute and chronic intoxication with carbromal preparations.
Topics: Acute Disease; Bromides; Chlorides; Chromatography, High Pressure Liquid; Chromatography, Thin Layer | 1985 |
Kinetics of drug action in disease states. XXIII: Effect of acute hypovolemia on the pharmacodynamics of phenobarbital in rats.
Topics: Acute Disease; Animals; Chromatography, High Pressure Liquid; Male; Phenobarbital; Rats; Rats, Inbre | 1988 |
Intravenous phenobarbital for alcohol withdrawal and convulsions.
Topics: Acute Disease; Adult; Alcohol Withdrawal Delirium; Drug Evaluation; Ethanol; Female; Follow-Up Studi | 1987 |
Studies in laboratory animals to assess the safety of anti-inflammatory agents in acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Animals; Anti-Inflammatory Agents; Liver; Male; Phenoba | 1987 |
[Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters].
Topics: Acute Disease; Animals; Diazepam; Esters; Male; Organophosphorus Compounds; Phenobarbital; Rats; Rat | 1986 |
[Acute poisoning and pregnancy].
Topics: Acute Disease; Adolescent; Adult; Female; Humans; Mushroom Poisoning; Nitrazepam; Phenobarbital; Pre | 1986 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co | 1986 |
[Use of levomycetin in acute 1,2-dichloroethane poisonings].
Topics: Acute Disease; Animals; Chloramphenicol; Drug Evaluation; Drug Evaluation, Preclinical; Ethylene Dic | 1985 |
[Age-related aspects of intensive therapy of acute poisoning of chemical etiology].
Topics: Acetates; Acetic Acid; Acute Disease; Adult; Age Factors; Critical Care; Ethylene Dichlorides; Hemop | 1985 |
Longitudinal EEG and clinical study of children with febrile convulsions.
Topics: Acute Disease; Age Factors; Blood Chemical Analysis; Cerebral Cortex; Child, Preschool; Electroencep | 1968 |
[Treatment of acute schizophrenia with antibiotics, gamma-globulin and vitamins].
Topics: Acute Disease; Adolescent; Adult; Amobarbital; Anti-Bacterial Agents; Antimalarials; Ascorbic Acid; | 1966 |
Successful treatment of three cases of very severe barbiturate poisoning.
Topics: Acute Disease; Adolescent; Adult; Barbiturates; Diuresis; Female; Humans; Peritoneal Dialysis; Pheno | 1969 |
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione.
Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and D | 1974 |
Disorders of higher cortical functions in acute confusional states.
Topics: Acute Disease; Adult; Affect; Anesthesia, General; Art; Attention; Cognition Disorders; Electronarco | 1972 |
An analysis of acute glomerulonephritis in children treated conventionally in comparison to intravenous furosemide.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Female; Furosemide; Glomerulonephritis; Humans; | 1973 |
Bullous lesions in acute barbiturate poisoning.
Topics: Acute Disease; Adult; Barbiturates; Blister; Conjunctiva; Humans; Male; Phenobarbital; Poisoning; Ti | 1971 |
Febrile seizures: to treat or not to treat.
Topics: Acute Disease; Age Factors; Anticonvulsants; Child; Child, Preschool; Fever; Humans; Infant; Phenoba | 1970 |
Diagnosis and therapy of acute withdrawal from alcohol.
Topics: Acute Disease; Adult; Alcoholism; Anti-Bacterial Agents; Anticonvulsants; Carbohydrate Metabolism; C | 1970 |
Acute rheumatic fever in Virginia--has it changed in the last 20 years?
Topics: Acute Disease; Adult; Aspirin; Child; Demography; Digoxin; Female; Hospitalization; Humans; Male; Pe | 1970 |