phenobarbital has been researched along with Action Tremor in 40 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind cross-over trial, primidone was superior to both placebo and phenobarbital in reducing essential tremor in 13 patients." | 9.06 | Double-blind comparison of primidone and phenobarbital in essential tremor. ( Calzetti, S; Perucca, E; Sasso, E, 1988) |
| "Primidone, 50 to 1,000 mg/d, reduced the amplitude of essential tremor in both untreated and propranolol-treated patients." | 9.06 | Efficacy of primidone in essential tremor. ( Koller, WC; Royse, VL, 1986) |
| "The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions." | 7.69 | Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994) |
| "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions." | 7.68 | Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. ( Calzetti, S; Fava, R; Perucca, E; Sasso, E, 1990) |
| "To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested." | 7.67 | Primidone and essential tremor. ( Holl, G; Honé, A; Seyfert, S, 1988) |
| "Primidone given to a patient for epilepsy produced an unexpected reduction in benign familial tremor." | 7.66 | Benign familial tremor treated with primidone. ( O'Brien, MD; Toseland, PA; Upton, AR, 1981) |
| "The tremor affected the legs while standing and had a frequency of 14-16 Hz." | 5.28 | Orthostatic tremor: successful treatment with phenobarbital. ( Ayuso-Peralta, L; Cabrera-Valdivia, F; García Albea, E; Jiménez-Jiménez, FJ; Tejeiro-Martínez, J; Vaquero Ruipérez, JA, 1991) |
| "The tremorolytic effects of primidone and phenobarbital in essential tremor of hands and head were compared in a double-blind, placebo-controlled trial." | 5.07 | Quantitative comparison of barbiturates in essential hand and head tremor. ( Calzetti, S; Fava, R; Perucca, E; Sasso, E, 1991) |
| "In a double-blind cross-over trial, primidone was superior to both placebo and phenobarbital in reducing essential tremor in 13 patients." | 5.06 | Double-blind comparison of primidone and phenobarbital in essential tremor. ( Calzetti, S; Perucca, E; Sasso, E, 1988) |
| "Primidone, 50 to 1,000 mg/d, reduced the amplitude of essential tremor in both untreated and propranolol-treated patients." | 5.06 | Efficacy of primidone in essential tremor. ( Koller, WC; Royse, VL, 1986) |
| "The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions." | 3.69 | Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994) |
| "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions." | 3.68 | Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. ( Calzetti, S; Fava, R; Perucca, E; Sasso, E, 1990) |
| "To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested." | 3.67 | Primidone and essential tremor. ( Holl, G; Honé, A; Seyfert, S, 1988) |
| "Primidone given to a patient for epilepsy produced an unexpected reduction in benign familial tremor." | 3.66 | Benign familial tremor treated with primidone. ( O'Brien, MD; Toseland, PA; Upton, AR, 1981) |
| "Orthostatic tremor is an unusual kind of potentially disabiling tremor appearing immediately when standing." | 1.30 | ["Primary" orthostatic tremor. 10 clinical electrophysiologic observations]. ( Cassim, F; Destée, A; Guieu, JD; Mastain, B, 1998) |
| "The tremor affected the legs while standing and had a frequency of 14-16 Hz." | 1.28 | Orthostatic tremor: successful treatment with phenobarbital. ( Ayuso-Peralta, L; Cabrera-Valdivia, F; García Albea, E; Jiménez-Jiménez, FJ; Tejeiro-Martínez, J; Vaquero Ruipérez, JA, 1991) |
| "Essential tremor is a common disorder whose aetiology is unknown." | 1.27 | Essential tremor. ( Findley, LJ, 1986) |
| "Baclofen was largely ineffective in reducing withdrawal-induced tremors, although it was capable of producing sedation of a different type than that produced by phenobarbitol and ethanol." | 1.26 | The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey. ( Tarika, JS; Winger, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (60.00) | 18.7374 |
| 1990's | 10 (25.00) | 18.2507 |
| 2000's | 3 (7.50) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kees, M | 1 |
| Beckel, N | 1 |
| Sharp, C | 1 |
| Kailainathan, R | 1 |
| Wong, A | 1 |
| Greene, S | 1 |
| Koutsogiannis, Z | 1 |
| Lees, M | 1 |
| Regier, L | 1 |
| Jensen, B | 1 |
| Dayal, M | 1 |
| Parmar, D | 1 |
| Dhawan, A | 1 |
| Ali, M | 1 |
| Dwivedi, UN | 1 |
| Seth, PK | 1 |
| MARSH, DO | 1 |
| SCHNIEDEN, H | 1 |
| MARSHALL, J | 1 |
| Da Silva, AM | 1 |
| Rocha, N | 1 |
| Pinto, M | 1 |
| Alves, V | 1 |
| Farinha, F | 1 |
| Correia, AP | 1 |
| Coelho, T | 1 |
| Magalhães, M | 1 |
| Platt, SR | 1 |
| De Stefani, A | 1 |
| Wieczorek, L | 1 |
| Walther, H | 1 |
| Spoerlein, MT | 1 |
| VanderWende, C | 1 |
| Baruzzi, A | 2 |
| Procaccianti, G | 2 |
| Martinelli, P | 2 |
| Riva, R | 1 |
| Denoth, F | 1 |
| Montanaro, N | 1 |
| Lugaresi, E | 1 |
| Tarika, JS | 1 |
| Winger, G | 1 |
| O'Brien, MD | 1 |
| Upton, AR | 1 |
| Toseland, PA | 1 |
| Pazzaglia, P | 1 |
| Lugarezi, E | 1 |
| Koguchi, Y | 1 |
| Nakajima, M | 1 |
| Kawamura, M | 1 |
| Hirayama, K | 1 |
| Metzer, WS | 1 |
| Hoffman, A | 1 |
| Alfon, J | 1 |
| Siegal, T | 2 |
| Marchand, L | 1 |
| Mastain, B | 1 |
| Cassim, F | 1 |
| Guieu, JD | 1 |
| Destée, A | 1 |
| Boldyrev, AI | 1 |
| Fleĭs, EP | 1 |
| Vaĭntrub, MIa | 1 |
| Freund, G | 1 |
| Madden, JD | 1 |
| Chadwick, D | 1 |
| Reynolds, EH | 1 |
| Marsden, CD | 1 |
| Pariente, EA | 1 |
| Mineur, D | 1 |
| Cabrera-Valdivia, F | 1 |
| Jiménez-Jiménez, FJ | 1 |
| García Albea, E | 1 |
| Tejeiro-Martínez, J | 1 |
| Vaquero Ruipérez, JA | 1 |
| Ayuso-Peralta, L | 1 |
| Sasso, E | 4 |
| Perucca, E | 4 |
| Fava, R | 2 |
| Calzetti, S | 4 |
| Martines, C | 1 |
| Gatti, G | 1 |
| Findley, LJ | 3 |
| Seyfert, S | 1 |
| Honé, A | 1 |
| Holl, G | 1 |
| Cleeves, L | 1 |
| Koller, WC | 1 |
| Royse, VL | 1 |
| Trubnikov, BM | 1 |
| Brenton, DP | 1 |
| Cusworth, DC | 1 |
| Hartley, S | 1 |
| Lumley, S | 1 |
| Kuzemko, JA | 1 |
| Smith, RP | 1 |
| Birkett, DP | 1 |
| Boltuch, B | 1 |
| Zaroslinski, JF | 1 |
| Browne, RK | 1 |
| Possley, LH | 1 |
| Porot, M | 1 |
| Petit, G | 1 |
| Couadau, A | 1 |
| Bosson, P | 1 |
| Meyer, HJ | 1 |
| Dierstein, M | 1 |
2 reviews available for phenobarbital and Action Tremor
| Article | Year |
|---|---|
Essential tremor: an overview.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Diagnosis, Differ | 1994 |
The pharmacological management of essential tremor.
Topics: Adrenergic beta-Antagonists; Ethanol; Humans; Phenobarbital; Primidone; Propranolol; Tremor | 1986 |
7 trials available for phenobarbital and Action Tremor
| Article | Year |
|---|---|
Phenobarbital and propranolol in essential tremor: a double-blind controlled clinical trial.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle | 1983 |
Benign familial tremor treated with primidone.
Topics: Female; Humans; Male; Phenobarbital; Primidone; Tremor | 1981 |
Quantitative comparison of barbiturates in essential hand and head tremor.
Topics: Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hand; Head; Humans; Ma | 1991 |
Double-blind comparison of primidone and phenobarbital in essential tremor.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Phenobarbital; Primidone; Tremor | 1988 |
Phenobarbitone in essential tremor.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Pheno | 1985 |
Efficacy of primidone in essential tremor.
Topics: Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Phenobarbital; Primidone; Propranolol; | 1986 |
Chlorpromazine in geriatric psychiatry.
Topics: Aged; Chloral Hydrate; Chlorpromazine; Constipation; Dementia; Drug Synergism; Humans; Intracranial | 1972 |
31 other studies available for phenobarbital and Action Tremor
| Article | Year |
|---|---|
Successful treatment of Solanum dulcamara intoxication in a Labrador retriever puppy.
Topics: Animals; Dog Diseases; Dogs; Hypnotics and Sedatives; Male; Methocarbamol; Muscle Relaxants, Central | 2015 |
Recognition of gamma-hydroxybutyric acid withdrawal: Rapid progression and prolonged symptomatology.
Topics: Adult; Anti-Bacterial Agents; Australia; Baclofen; Benzodiazepines; Diazepam; Humans; Hydroxybutyrat | 2017 |
Pharmacologic management of essential tremor.
Topics: Adrenergic beta-Antagonists; Aged; Anticonvulsants; Ethanol; Humans; Male; Phenobarbital; Primidone; | 2010 |
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inductio | 2003 |
A CONTROLLED CLINICAL TRIAL OF ALPHA METHYL DOPA IN PARKINSONIAN TREMOR.
Topics: Depression; Depressive Disorder; Hypnotics and Sedatives; Methyldopa; Parasympatholytics; Parkinsoni | 1963 |
Tremor as the first neurological manifestation of Sneddon's syndrome.
Topics: Anticonvulsants; Brain; Clonazepam; Electroencephalography; Female; Humans; Lateral Ventricles; Magn | 2005 |
Primary orthostatic tremor in a Scottish deerhound.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dog Diseases; Dogs; Electromyography; Excitatory Amino | 2006 |
[Pharmacologic studies of the strychnine tremor in infantile mice].
Topics: Animals; Animals, Newborn; Anticonvulsants; Atropine; Benactyzine; Diphenhydramine; Electromyography | 1967 |
Nature of the tremors induced by p-methoxydopamine.
Topics: Animals; Chlorpromazine; Dopamine; Male; Methylation; Mice; Movement; Parasympatholytics; Phenobarbi | 1967 |
The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey.
Topics: Alcoholism; Animals; Ataxia; Baclofen; Behavior, Animal; Drug Interactions; Ethanol; Humans; Macaca | 1980 |
Benign familial tremor treated with primidone.
Topics: Adolescent; Adult; Aged; Humans; Male; Middle Aged; Phenobarbital; Phenylethylmalonamide; Primidone; | 1981 |
[Clinical subtypes of essential tremor and their electrophysiological and pharmacological differences].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Electrophysiology; Female; Humans; Male; Middle Aged; Phen | 1995 |
Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression.
Topics: Anesthesia; Animals; Histiocytoma, Benign Fibrous; Male; Paraplegia; Pentylenetetrazole; Phenobarbit | 1994 |
[Treatment of essential tremor].
Topics: Anti-Anxiety Agents; Anti-Dyskinesia Agents; Botulinum Toxins; Humans; Hypnotics and Sedatives; Meth | 1995 |
["Primary" orthostatic tremor. 10 clinical electrophysiologic observations].
Topics: Adult; Aged; Anti-Anxiety Agents; Arm; Clonazepam; Diazepam; Electromyography; Female; Humans; Leg; | 1998 |
[Neurologic complications following medical treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey | 1979 |
Prevention of ethanol withdrawal seizures in mice by local anesthetics and dextro-propranolol.
Topics: Anesthetics, Local; Animals; Ataxia; Behavior, Animal; Ethanol; Female; Humans; Mice; Mice, Inbred C | 1977 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P | 1978 |
Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cerebellar Diseases; Chorea; Dyskinesia, Dr | 1976 |
[Atrium-induced hepatitis with autoimmune pattern].
Topics: Aged; Barbiturates; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Male; Phenoba | 1992 |
Orthostatic tremor: successful treatment with phenobarbital.
Topics: Aged; Female; Humans; Leg; Phenobarbital; Posture; Tremor | 1991 |
The disposition of primidone in elderly patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Chromatography, High Pressure | 1990 |
Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis.
Topics: Aged; Anxiety; Computers; Female; Humans; Male; Middle Aged; Phenobarbital; Primidone; Prospective S | 1990 |
Primidone and essential tremor.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Phenobarbital; Phenylethylmalonamide; Primidone; Tre | 1988 |
Essential tremor.
Topics: Diagnosis, Differential; Humans; Parkinson Disease; Phenobarbital; Phenylethylmalonamide; Primidone; | 1986 |
[Disability and rehabilitation expertise regarding patients with diencephalic autonomic-vascular paroxysms].
Topics: Adolescent; Adult; Ambulatory Care; Angina Pectoris; Anti-Bacterial Agents; Atropa belladonna; Blood | 1974 |
Argininosuccinicaciduria: clinical, metabolic and dietary study.
Topics: Affective Symptoms; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginase; Arginine; Ataxia; Child | 1974 |
Cyanate and thiocyanate: acute toxicity.
Topics: Amphetamine; Animals; Antidotes; Arginine; Cyanates; Female; Methemoglobin; Mice; Morphine; Oxyhemog | 1973 |
Propylene glycol as a drug solvent in pharmacologic studies.
Topics: Animals; Anticonvulsants; Drug Interactions; Hexobarbital; Mice; Motor Activity; Phenobarbital; Prop | 1971 |
[Clinical tests of C.E. 10010 in tremor and abnormal movements].
Topics: Adult; Aged; Humans; Middle Aged; Movement Disorders; Parkinson Disease; Phenobarbital; Tremor | 1968 |
[On the antagonistic effect of pyrone compounds of the kava rhizome (Piper methysticum Forst) against 1,4-dipyrrolidino-2-butyne].
Topics: Alkynes; Animals; Atropine; Chlorpromazine; Drug Antagonism; Drug Synergism; Hypothermia; Male; Mice | 1965 |