Page last updated: 2024-11-02

phenobarbital and Ache

phenobarbital has been researched along with Ache in 37 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

ExcerptRelevanceReference
"A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain."9.07Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993)
"The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline."7.68Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993)
"Deafferentation pain has been related to abnormal electrical hyperactivity in the neurons of the sensory relays in the central nervous system."5.28Antinociceptive effects of phenobarbital in "tail-flick" test and deafferentation pain. ( González-Darder, JM; Ortega-Alvaro, A; Ruz-Franzi, I; Segura-Pastor, D, 1992)
"A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain."5.07Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993)
"The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice."3.77Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011)
"The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline."3.68Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993)
"Heart rate, cardiac output, mean arterial blood pressure (MABP), and cerebral blood flow (CBF) were measured in 12 newborn piglets (6 controls and 6 pretreated with 20 mg/kg phenobarbital), under two different stresses: pain stimulation and intravenous injection of 2."3.67Effect of phenobarbital on cerebral blood flow in the newborn piglet under stress. ( Aranda, JV; Beharry, K; Chemtob, S; Laudignon, N; Rex, J, 1986)
" Pharmacokinetic parameters of nicorandil and its isomers, as well as the plasma concentrations of the corresponding denitrated metabolites and also nicotinamide and nitrite were determined."1.40Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers. ( Almeida, MO; Araujo, DP; César, IC; Coelho, MM; de Fátima, A; Dutra, MM; Godin, AM; Machado, RR; Menezes, RR; Oliveira, FC; Pianetti, GA; Santos, DA; Santos, JR, 2014)
"Deafferentation pain has been related to abnormal electrical hyperactivity in the neurons of the sensory relays in the central nervous system."1.28Antinociceptive effects of phenobarbital in "tail-flick" test and deafferentation pain. ( González-Darder, JM; Ortega-Alvaro, A; Ruz-Franzi, I; Segura-Pastor, D, 1992)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199023 (62.16)18.7374
1990's5 (13.51)18.2507
2000's3 (8.11)29.6817
2010's5 (13.51)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Salomé, C1
Salomé-Grosjean, E1
Stables, JP1
Kohn, H1
César, IC1
Godin, AM1
Araujo, DP1
Oliveira, FC1
Menezes, RR1
Santos, JR1
Almeida, MO1
Dutra, MM1
Santos, DA1
Machado, RR1
Pianetti, GA1
Coelho, MM1
de Fátima, A1
Stróżyk, A1
Paraskevas, T1
Romantsik, O1
Calevo, MG1
Banzi, R1
Ley, D1
Bruschettini, M1
Patel, C1
Kleinig, P1
Bakker, M1
Tait, P1
Braun, B1
Reber, M1
Park, HJ1
Cha, DS1
Jeon, H1
KRAUSE, HJ2
STOLL, P1
KRUGER, EH1
FROMMEL, E2
FLEURY, C1
LEDEBUR, IV1
BEGUIN, M1
FAMILY, S1
Dodman, NH1
Billingham, EA1
Moon-Fanelli, AA1
Savica, R1
Beghi, E1
Mazzaglia, G1
Innocenti, F1
Brignoli, O1
Cricelli, C1
Caputi, AP1
Musolino, R1
Spina, E1
Trifirò, G1
Perlík, F1
Doi, T1
Jurna, I1
Goldman, SI1
Krings, MS1
Sullivan, M1
Toshima, M1
Lynn, P1
Roy-Byrne, P1
Hoffman, A1
Levy, G1
Salvolini, U1
Bonetti, MG1
Ciritella, P1
Rovetta, G1
Baratto, L1
Farinelli, G1
Monteforte, P1
González-Darder, JM1
Ortega-Alvaro, A1
Ruz-Franzi, I1
Segura-Pastor, D1
Buckley, PF1
Sizemore, WA1
Charlton, EJ1
Laudignon, N1
Chemtob, S1
Beharry, K1
Rex, J1
Aranda, JV1
Flügel, KA1
Moggian, G2
Cervellati, I2
Tamburini, E2
Riethe, P1
Wilske, E1
Christiansen, J1
Dam, M1
Haase, J1
Jepsen, BV1
Bech, H1
Langeback, E1
Puri, SK1
Lal, H1
Hunter, J1
Thompson, RP1
Rake, MO1
Williams, R1
Filipescu, A1
Spirescu, J1
Seydoux, J1
von Ledebur, I1
Chmouliovsky, M1
Prasad, CR1
Schnell, U1
Solc, J1
Sauerová, Z1
Qaqundah, BY1
Taylor, WF1
Klittscher, K1
Paalzow, L1

Reviews

2 reviews available for phenobarbital and Ache

ArticleYear
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.
    The Cochrane database of systematic reviews, 2023, 08-11, Volume: 8

    Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, N

2023
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
    Australian journal of general practice, 2019, Volume: 48, Issue:12

    Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed

2019

Trials

6 trials available for phenobarbital and Ache

ArticleYear
[Clinical evaluation of analgesics].
    Casopis lekaru ceskych, 1984, Jan-20, Volume: 123, Issue:3

    Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Comb

1984
Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1993, Volume: 5, Issue:2

    Topics: Adult; Anxiety Disorders; Chronic Disease; Clonazepam; Double-Blind Method; Female; Hospitalization;

1993
[Critical study of the post-partum pain by means of a clinical pharmacology experiment].
    Bollettino chimico farmaceutico, 1972, Volume: 111, Issue:8

    Topics: Adult; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenobarbital; Plac

1972
[Comparative study of a psychostimulating drug in the treatment of post-partum pain].
    Minerva ginecologica, 1973, Volume: 25, Issue:6

    Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenoba

1973
[Analgetic effects on the stimulus threshold of the human tooth].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:4

    Topics: Administration, Oral; Amides; Analgesics; Analysis of Variance; Aspirin; Caffeine; Clinical Trials a

1974
Controlled trial of phetharbital, a non-hypnotic barbiturate, in unconugated hyperbilirubinaemia.
    British medical journal, 1971, May-29, Volume: 2, Issue:5760

    Topics: Abdomen; Barbiturates; Bilirubin; Clinical Trials as Topic; Female; Humans; Hyperbilirubinemia, Here

1971

Other Studies

29 other studies available for phenobarbital and Ache

ArticleYear
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Acetamides; Alanine; Amides; Amino Acids; Animals; Anticonvulsants; Benzylamines; Drug Evaluation, P

2010
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
    Bioorganic & medicinal chemistry, 2014, May-01, Volume: 22, Issue:9

    Topics: Analgesics; Animals; Disease Models, Animal; Female; Half-Life; Isomerism; Mice; Nicorandil; Pain

2014
[Pain perception and pain therapy in premature infants].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2010, Volume: 29, Issue:5

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Infant;

2010
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
    Journal of ethnopharmacology, 2011, Oct-11, Volume: 137, Issue:3

    Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F

2011
[Lowering of pain and shortening of the birth process with causat].
    Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;

1956
[Lowering of pain and shortening of the birth process with causat].
    Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;

1956
[Lowering of pain and shortening of the birth process with causat].
    Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;

1956
[Lowering of pain and shortening of the birth process with causat].
    Munchener medizinische Wochenschrift (1950), 1956, Sep-07, Volume: 98, Issue:36

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin;

1956
[The treatment of painful conditions in the true pelvis of the female with ichthobellol compositum].
    Medizinische Klinik, 1957, Oct-11, Volume: 52, Issue:41

    Topics: Aminopyrine; Belladonna Alkaloids; Disease; Female; Humans; Lesser Pelvis; Pain; Papaverine; Pelvis;

1957
[Labor relief in obstetrical practice].
    Medizinische Klinik, 1958, Oct-24, Volume: 53, Issue:43

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Humans; Niacin; Nicotinic Acids; Pain; Pa

1958
THE PLACE OF ACETYLSALICYLIC ACID IN PSYCHOPHARMACOLOGY. AN EXPERIMENTAL STUDY.
    Arzneimittel-Forschung, 1963, Volume: 13

    Topics: Amphetamine; Amphetamines; Animals; Aspirin; Body Temperature Regulation; Chlordiazepoxide; Chlorpro

1963
Animal behavior case of the month. Behavioral seizures.
    Journal of the American Veterinary Medical Association, 2005, Jul-15, Volume: 227, Issue:2

    Topics: Aggression; Analgesics, Opioid; Animals; Anticonvulsants; Behavior, Animal; Butorphanol; Cat Disease

2005
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
    European journal of neurology, 2007, Volume: 14, Issue:12

    Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H

2007
Intrathecal pentobarbital prevents naloxone-induced facilitation of the tail-flick response in the rat.
    Neuroscience letters, 1982, Sep-20, Volume: 32, Issue:1

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Naloxone; Pain; Phenobarbital;

1982
Phenobarbital-induced fibromyalgia as the cause of bilateral shoulder pain.
    The Journal of the American Osteopathic Association, 1995, Volume: 95, Issue:8

    Topics: Chronic Disease; Female; Fibromyalgia; Humans; Middle Aged; Pain; Phenobarbital; Shoulder Joint

1995
Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Adrenalectomy; Animals; Blood Proteins; Corticosterone; Male; Pain; Pain Threshold; Phenobarbital; R

1993
Accidental intrathecal injection of ionic water-soluble contrast medium: report of a case, including treatment.
    Neuroradiology, 1996, Volume: 38, Issue:4

    Topics: Aged; Analgesia, Epidural; Bone Neoplasms; Consciousness Disorders; Contrast Media; Critical Care; D

1996
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
    International journal of tissue reactions, 2001, Volume: 23, Issue:1

    Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid

2001
Antinociceptive effects of phenobarbital in "tail-flick" test and deafferentation pain.
    Anesthesia and analgesia, 1992, Volume: 75, Issue:1

    Topics: Afferent Pathways; Animals; Behavior, Animal; Male; Pain; Phenobarbital; Rats; Rats, Inbred Strains;

1992
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
    Pain, 1986, Volume: 26, Issue:2

    Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone;

1986
Effect of phenobarbital on cerebral blood flow in the newborn piglet under stress.
    Biology of the neonate, 1986, Volume: 50, Issue:5

    Topics: Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Cerebrovascular Circulation; Heart Rate;

1986
[Treatment of acute emotional disturbances].
    Deutsche medizinische Wochenschrift (1946), 1974, Oct-18, Volume: 99, Issue:42

    Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Chlorpromazine; Chlorprothixene; Diazepam; Family Char

1974
Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy.
    Acta neurologica Scandinavica, 1973, Volume: 49, Issue:4

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Depression, Chemical; Drug Therapy, Combination; Epil

1973
Spinal fracture following radiculography using meglumine iothalamate (Conray).
    Neuroradiology, 1973, Volume: 6, Issue:2

    Topics: Adipates; Adult; Contrast Media; Diazepam; Female; Fractures, Bone; Humans; Hypesthesia; Iothalamic

1973
Reduced threshold to pain induced aggression specifically related to morphine dependence.
    Psychopharmacologia, 1974, Feb-27, Volume: 35, Issue:3

    Topics: Aggression; Animals; Dextroamphetamine; Drug Synergism; Electroshock; Ethanol; Humans; Male; Morphin

1974
[The pain syndrome of the edentulous alveolar crest and its treatment].
    Revue de stomatologie et de chirurgie maxillo-faciale, 1969, Volume: 70, Issue:2

    Topics: Administration, Topical; Alveolar Process; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Caffeine;

1969
Neuropharmacological study of central reactions to intense muscular exertion, sensorial fatigue, sexual excitation, hunger, and thirst.
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1966, Volume: 14

    Topics: Amphetamine; Animals; Brain; Electric Stimulation; Electroshock; Fatigue; Female; Guinea Pigs; Hunge

1966
[Dolo-Eupaco as an analgesic in gynecology].
    Die Medizinische Welt, 1970, Jan-31, Volume: 5

    Topics: Adult; Aminopyrine; Analgesics; Benzilates; Codeine; Esters; Female; Genital Diseases, Female; Genit

1970
[Reserpine therapy of periodic vomiting and abdominal pain in children].
    Ceskoslovenska pediatrie, 1970, Volume: 25, Issue:4

    Topics: Abdomen; Age Factors; Child; Humans; Pain; Phenobarbital; Reserpine; Vomiting

1970
Recurrent right middle lobe syndrome in an asthmatic child. Case report and serial vectorcardiographic study.
    Clinical pediatrics, 1970, Volume: 9, Issue:11

    Topics: Asthma; Child; Cough; Ephedrine; Female; Humans; Middle Lobe Syndrome; Pain; Phenobarbital; Predniso

1970
[Control of pain with target therapy with "Spasmo-Dolviran"].
    Hippokrates, 1967, Apr-15, Volume: 38, Issue:7

    Topics: Analgesics; Aspirin; Codeine; Female; Headache; Humans; Menopause; Neuralgia; Pain; Phenacetin; Phen

1967
Studies of analgesic and anticonvulsant activity in mice by high-frequency electrical stimulation.
    Acta pharmaceutica Suecica, 1969, Volume: 6, Issue:2

    Topics: Age Factors; Analgesics; Animals; Anticonvulsants; Aspirin; Body Weight; Electric Stimulation; Elect

1969