phenobarbital has been researched along with Abnormality, Heart in 13 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "To develop a population pharmacokinetic model for IV phenobarbital in neonates following cardiac surgery and perform simulations to identify optimal dosing regimens." | 1.56 | Population Pharmacokinetics of IV Phenobarbital in Neonates After Congenital Heart Surgery. ( Abend, NS; Massey, SL; Naim, MY; Thibault, C; Zuppa, AF, 2020) |
| "Chloral hydrate (100mg/kg) was given orally for the induction of moderate to deep sedation 15 minutes before OSC; then the operative field was infiltrated with 1% lidocaine." | 1.39 | Central venous cutdown in neonates: feasibility as a bedside procedure without general anesthesia. ( Hong, SM; Lee, HS; Moon, SB, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Thibault, C | 1 |
| Massey, SL | 1 |
| Naim, MY | 1 |
| Abend, NS | 1 |
| Zuppa, AF | 1 |
| Hong, SM | 1 |
| Lee, HS | 1 |
| Moon, SB | 1 |
| Okuda, H | 1 |
| Nagao, T | 1 |
| Domenici, R | 1 |
| Giovannucci Uzielli, ML | 1 |
| Castelli, S | 1 |
| Anderson, RC | 1 |
| Annegers, JF | 2 |
| Elveback, LR | 2 |
| Hauser, WA | 2 |
| Kurland, LT | 2 |
| Tanaka, H | 1 |
| Takeda, A | 1 |
| Izumi, M | 1 |
| Okada, H | 1 |
| Ishikawa, S | 1 |
| Nishikawa, T | 3 |
| Kajita, A | 1 |
| Ando, M | 1 |
| Takao, A | 1 |
| Bruyere, HJ | 3 |
| Gilbert, EF | 3 |
| Matsuoka, R | 2 |
| Fang, TT | 1 |
| Opitz, JM | 1 |
| Takagi, Y | 1 |
| Hay, JD | 1 |
13 other studies available for phenobarbital and Abnormality, Heart
| Article | Year |
|---|---|
Population Pharmacokinetics of IV Phenobarbital in Neonates After Congenital Heart Surgery.
Topics: Child; Extracorporeal Membrane Oxygenation; Heart Defects, Congenital; Humans; Infant, Newborn; Phen | 2020 |
Central venous cutdown in neonates: feasibility as a bedside procedure without general anesthesia.
Topics: Administration, Oral; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Chlora | 2013 |
Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats.
Topics: Abnormalities, Drug-Induced; Animals; Cardiovascular Abnormalities; Dose-Response Relationship, Drug | 2006 |
[Multiple-abnormalities syndrome with phenotypic characteristics falling within the lacrimo-auriculo-dento-digital syndrome].
Topics: Abnormalities, Drug-Induced; Ear, External; Female; Growth Disorders; Hand Deformities, Congenital; | 1984 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Potentiating effects of verapamil on cardiovascular teratogenicity of phenobarbital in the chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aorta; Calcium; Chick Embryo; Drug Synergism; Heart Defects, C | 1988 |
Experimentally induced cardiovascular malformations in the chick embryo. Part II. Teratogenic effect of Tedral (theophylline, ephedrine, and phenobarbital) on cardiac development in chick embryos.
Topics: Animals; Cardiovascular System; Chick Embryo; Dose-Response Relationship, Drug; Drug Combinations; D | 1987 |
Experimentally induced cardiovascular malformations in the chick embryo. Part III. The teratogenic effect of phenobarbital on the embryonic chick heart.
Topics: Animals; Cardiovascular System; Chick Embryo; Heart Defects, Congenital; Heart Rate; Phenobarbital; | 1987 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
The management and prognosis of congenital heart disease.
Topics: Digitalis Glycosides; Heart Defects, Congenital; Hemodynamics; Humans; Infant; Infant, Newborn; Orga | 1966 |