phenobarbital has been researched along with Abnormalities, Multiple in 18 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An 11-month-old boy with multiple surface anomalies and respiratory distress due to upper airway narrowing developed generalized tonic seizures coinciding with apnea." | 7.73 | [High-dose phenobarbital therapy is effective for the control of intractable tonic seizure with apnea in a case of multiple anomalies syndrome]. ( Hayashi, T; Horio, K; Kubota, M; Mimaki, M; Tomita, S, 2006) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "An 11-month-old boy with multiple surface anomalies and respiratory distress due to upper airway narrowing developed generalized tonic seizures coinciding with apnea." | 3.73 | [High-dose phenobarbital therapy is effective for the control of intractable tonic seizure with apnea in a case of multiple anomalies syndrome]. ( Hayashi, T; Horio, K; Kubota, M; Mimaki, M; Tomita, S, 2006) |
| "Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities." | 3.66 | Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (77.78) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toomes, M | 1 |
| Maleck, WH | 1 |
| Koetter, KP | 1 |
| Petroianu, GA | 1 |
| Harvey, EA | 1 |
| Coull, BA | 1 |
| Holmes, LB | 1 |
| Hayashi, T | 1 |
| Kubota, M | 1 |
| Mimaki, M | 1 |
| Tomita, S | 1 |
| Horio, K | 1 |
| Krzelj, F | 1 |
| Rumboldt, Z | 1 |
| Jurica, A | 1 |
| Besker, M | 1 |
| García Nieto, V | 1 |
| López Mendoza, S | 1 |
| Ortigosa, L | 1 |
| Rodríguez, I | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 2 |
| Smith, DW | 1 |
| Brun, A | 1 |
| Gilboa, M | 1 |
| Meeuwisse, GW | 1 |
| Nordgren, H | 1 |
| Bustamante, SA | 1 |
| Stumpff, LC | 1 |
| Goodman, RM | 1 |
| Katznelson, MB | 1 |
| Hertz, M | 1 |
| Katznelson, D | 1 |
| Rotem, Y | 1 |
| Waziri, M | 1 |
| Ionasescu, V | 1 |
| Zellweger, H | 1 |
| Vargas, GC | 1 |
| Pildes, RS | 1 |
| Vidyasagar, D | 1 |
| Keith, LG | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Thakker, JC | 1 |
| Kothari, SS | 1 |
| Deshmukh, CT | 1 |
| Deshpande, PG | 1 |
| Dalwai, WM | 1 |
| Joshi, MK | 1 |
| Kandoth, PW | 1 |
| Trice, JE | 1 |
| Ambler, M | 1 |
| Ho, NK | 1 |
| Loo, DS | 1 |
| Tilz, GP | 1 |
| Elshove, J | 1 |
| van Eck, JH | 1 |
18 other studies available for phenobarbital and Abnormalities, Multiple
| Article | Year |
|---|---|
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai | 2003 |
Anticonvulsant teratogenesis 5: observer bias in a cohort study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Boston; Cohort Studies | 2003 |
[High-dose phenobarbital therapy is effective for the control of intractable tonic seizure with apnea in a case of multiple anomalies syndrome].
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Cough; Humans; Infant, Newborn; Male; Phenobarbital | 2006 |
[Teratogenic effects of anticonvulsants with the development of multiple congenital anomalies - report on 3 patients].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child, Preschool; Female; Hum | 1983 |
[Absence of hypoplasia of fingernails and toenails and terminal phalanges of hands and feet (author's transl)].
Topics: Abnormalities, Multiple; Animals; Brain Diseases; Carbamazepine; Cats; Child, Preschool; Cysts; Deaf | 1980 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
The Zellweger syndrome: subcellular pathology, neuropathology, and the demonstration of pneumocystis carinii pneumonitis in two siblings.
Topics: Abnormalities, Multiple; Autopsy; Brain; Endoplasmic Reticulum; Female; Humans; Infant; Infant, Newb | 1978 |
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder | 1978 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
Teratogenic effect of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child, | 1976 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Hypoplasia of nails and phalanges: a teratogenic manifestation of phenobarbitone.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fingers; Humans; Microcephaly; | 1991 |
Multiple cerebral defects in an infant exposed in utero to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Cerebral Ventricles; E | 1985 |
Sympodia.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile | 1974 |
[Enzyme induction in hereditary spherocytosis using barbiturate].
Topics: Abnormalities, Multiple; Anemia, Hemolytic, Congenital Nonspherocytic; Enzyme Induction; Female; Fol | 1972 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |