phenobarbital has been researched along with Abnormalities, Drug-Induced in 124 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a stillborn, GA/LMP = 37 weeks, delivered by an epileptic woman, who received in the first four months of pregnancy phenobarbital (PH) 0." | 7.79 | Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy. ( Brailoiu, CG; Cernea, N; Tica, AA; Tica, OS; Tica, VI, 2013) |
| " We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i." | 7.74 | Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. ( Christensen, J; Czeizel, AE; Horvath-Puhó, E; Kjaer, D; Olsen, J; Sørensen, HT; Vestergaard, M, 2007) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 5.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 5.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| "We report a stillborn, GA/LMP = 37 weeks, delivered by an epileptic woman, who received in the first four months of pregnancy phenobarbital (PH) 0." | 3.79 | Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy. ( Brailoiu, CG; Cernea, N; Tica, AA; Tica, OS; Tica, VI, 2013) |
| "To study the effect of large doses of phenobarbital used for a suicide attempt during pregnancy for fetuses to estimate the teratogenic potential of phenobarbital." | 3.75 | Congenital abnormalities of 88 children born to mothers who attempted suicide with phenobarbital during pregnany: the use of a disaster epidemiological model for the evaluation of drug teratogenicity. ( Acs, N; Bánhidy, F; Czeizel, AE; Timmermann, G, 2009) |
| " We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i." | 3.74 | Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. ( Christensen, J; Czeizel, AE; Horvath-Puhó, E; Kjaer, D; Olsen, J; Sørensen, HT; Vestergaard, M, 2007) |
| "Children exposed during pregnancy to the anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine as monotherapy and polytherapy have an increased frequency of midface and digit hypoplasia." | 3.73 | The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs. ( Coull, BA; Dorfman, J; Holmes, LB; Rosenberger, PB, 2005) |
| "To determine whether exposure during pregnancy to anticonvulsant drugs as monotherapy, and phenobarbital in particular, is associated with an increased risk of major malformations in comparison with unexposed controls." | 3.72 | The AED (antiepileptic drug) pregnancy registry: a 6-year experience. ( Holmes, LB; Lieberman, E; Wyszynski, DF, 2004) |
| "A full-term baby was born to an epileptic mother treated with two anti-epileptic drugs, sodium valproate and phenobarbital, throughout the pregnancy." | 3.70 | [A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord]. ( Adachi, M; Ai, Y; Maeda, E, 1999) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "Time-mated Swiss-Webster mice were pretreated in separate experiments with phenobarbital (60 mg/kg X d sc on d 7-10 of pregnancy), SKF-525A (40 mg/kg ip on d 12 of pregnancy) or 3-methylcholanthrene (20 mg/kg X d on d 10-12 of pregnancy)." | 3.67 | Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence. ( Khera, KS, 1984) |
| "Two cases concerning newborn infants whose mothers used phencyclidine (PCP) during pregnancy are described." | 3.66 | Neonatal manifestations of maternal phencyclidine (PCP) abuse. ( Bosu, SK; Modaniou, HD; Strauss, AA, 1981) |
| "Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities." | 3.66 | Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| ", raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself." | 3.65 | Anticonvulsants and parental epilepsy in the development of birth defects. ( Hartz, SC; Heinonen, OP; Mitchell, AA; Monson, RR; Rosenberg, L; Shapiro, S; Siskind, V; Slone, D, 1976) |
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| "05), compared with mice dosed with CBZ alone (1,000 mg/kg/day)." | 1.29 | Effect of treatment with phenobarbital and stiripentol on carbamazepine-induced teratogenicity and reactive metabolite formation. ( Amore, BM; Bajpai, M; Bennett, GD; Finnell, RH; Levy, RH; Slattery, JT, 1995) |
| "Thanatophoric dwarfism is not as rare as once thought." | 1.28 | Thanatophoric dwarfism; drugs and antenatal diagnosis; a case report. ( Meehan, FP; Rafla, NM, 1991) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 1.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 1.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| "To study the effects of SKF-525A, an inhibitor of cytochrome P-450, and of sodium phenobarbital (PB), a drug-metabolizing enzyme inducer, on the teratogenicity of thiabendazole (TBZ), pregnant mice were given ip either a single dose of 40 mg SKF-525A/kg 1 hr before oral dosing with 250 or 500 mg TBZ/kg or a dose of 75 mg PB/kg/day on three consecutive days before oral administration of a dose of 500 or 1000 mg TBZ/kg." | 1.27 | Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice. ( Imamichi, T; Ogata, A; Sasaki, M; Suzuki, K; Yoneyama, M, 1987) |
| "Phenobarbital was found to have a significant teratogenic potential in mice, resulting in skeletal, cardiac, renal, neural, and urogenital defects in a dose-related fashion." | 1.27 | Strain differences in phenobarbital-induced teratogenesis in mice. ( Chernoff, GF; Finnell, RH; Shields, HE; Taylor, SM, 1987) |
| "Phenobarbital was observed to produce cardiovascular malformations in embryonic chicks." | 1.27 | The teratogenic effect of phenobarbital on the embryonic chick heart. ( Bruyere, HJ; Gilbert, EF; Matsuoka, R; Nishikawa, T; Takagi, Y, 1986) |
| "This case of bilateral clinical anophthalmia presents a host of interrelated drug reactions and potential teratogenic factors." | 1.26 | Bilateral clinical anophthalmia: drugs as potential factors. ( Golden, SM; Perman, KI, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 91 (73.39) | 18.7374 |
| 1990's | 16 (12.90) | 18.2507 |
| 2000's | 13 (10.48) | 29.6817 |
| 2010's | 4 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tomson, T | 2 |
| Battino, D | 2 |
| Bonizzoni, E | 2 |
| Craig, J | 2 |
| Lindhout, D | 4 |
| Perucca, E | 2 |
| Sabers, A | 2 |
| Thomas, SV | 1 |
| Vajda, F | 2 |
| Tica, OS | 1 |
| Tica, AA | 1 |
| Brailoiu, CG | 1 |
| Cernea, N | 1 |
| Tica, VI | 1 |
| Ashtarinezhad, A | 1 |
| Panahyab, A | 1 |
| Shaterzadeh-Oskouei, S | 1 |
| Khoshniat, H | 1 |
| Mohamadzadehasl, B | 1 |
| Shirazi, FH | 1 |
| Timmermann, G | 1 |
| Acs, N | 1 |
| Bánhidy, F | 1 |
| Czeizel, AE | 2 |
| Bokhari, A | 3 |
| Coull, BA | 5 |
| Holmes, LB | 6 |
| Connolly, S | 1 |
| Harvey, EA | 3 |
| WINBERG, J | 1 |
| Yaris, F | 1 |
| Kadioglu, M | 1 |
| Kesim, M | 1 |
| Ulku, C | 1 |
| Yaris, E | 1 |
| Kalyoncu, NI | 1 |
| Wyszynski, DF | 1 |
| Lieberman, E | 1 |
| Dorfman, J | 1 |
| Rosenberger, PB | 1 |
| Okuda, H | 1 |
| Nagao, T | 1 |
| Kjaer, D | 1 |
| Horvath-Puhó, E | 1 |
| Christensen, J | 1 |
| Vestergaard, M | 1 |
| Sørensen, HT | 1 |
| Olsen, J | 1 |
| Eadie, MJ | 1 |
| McColl, JD | 3 |
| Robinson, S | 1 |
| Globus, M | 1 |
| Vorhees, CV | 1 |
| Fukuda, T | 1 |
| Fukushima, Y | 1 |
| Kuroki, Y | 1 |
| Iivanainen, M | 1 |
| Savolainen, H | 1 |
| Khera, KS | 1 |
| Pearl, KN | 1 |
| Dickens, S | 1 |
| Latham, P | 1 |
| Domenici, R | 1 |
| Giovannucci Uzielli, ML | 1 |
| Castelli, S | 1 |
| Todorov, S | 1 |
| Nomura, T | 3 |
| Isa, Y | 2 |
| Kurokawa, N | 1 |
| Kanzaki, T | 1 |
| Tanaka, H | 2 |
| Tada, E | 1 |
| Sakamoto, Y | 1 |
| Philbert, A | 1 |
| Dam, M | 1 |
| Krzelj, F | 1 |
| Rumboldt, Z | 1 |
| Jurica, A | 1 |
| Besker, M | 1 |
| Poskitt, EM | 1 |
| Hensey, OJ | 1 |
| Smith, CS | 1 |
| Zenk, KE | 1 |
| Greenaway, JC | 2 |
| Fantel, AG | 2 |
| Shepard, TH | 3 |
| Juchau, MR | 2 |
| Strauss, AA | 1 |
| Modaniou, HD | 1 |
| Bosu, SK | 1 |
| Golden, SM | 1 |
| Perman, KI | 1 |
| Yerby, MS | 2 |
| Yuschak, MM | 1 |
| Gautieri, RF | 1 |
| Finnell, RH | 3 |
| Bennett, GD | 1 |
| Slattery, JT | 1 |
| Amore, BM | 1 |
| Bajpai, M | 1 |
| Levy, RH | 1 |
| Azarbayjani, F | 1 |
| Danielsson, BR | 1 |
| Winn, LM | 1 |
| Kim, PM | 1 |
| Wells, PG | 1 |
| Adachi, M | 1 |
| Ai, Y | 1 |
| Maeda, E | 1 |
| Huntington, KB | 1 |
| Khoshbin, S | 1 |
| Hayes, AM | 1 |
| Ryan, LM | 1 |
| Fort, DJ | 2 |
| Rogers, RL | 2 |
| Stover, EL | 2 |
| Finch, RA | 2 |
| Paul, RR | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 2 |
| Smith, DW | 1 |
| Shapiro, S | 1 |
| Hartz, SC | 1 |
| Siskind, V | 1 |
| Mitchell, AA | 1 |
| Slone, D | 1 |
| Rosenberg, L | 1 |
| Monson, RR | 1 |
| Heinonen, OP | 1 |
| Visner, GH | 1 |
| Huisjes, HJ | 2 |
| Elshove, J | 2 |
| Livingston, S | 2 |
| Pruce, I | 1 |
| Pauli, LL | 1 |
| Gaetti, MT | 1 |
| Carotti, G | 1 |
| Vianelli, P | 1 |
| Pellegrini, L | 1 |
| Bini, PL | 1 |
| Scalseggi, V | 1 |
| Ghodse, AH | 1 |
| Reed, JL | 1 |
| Mack, JW | 1 |
| Conomy, JP | 1 |
| Redmond, GP | 1 |
| Montouris, GD | 1 |
| Fenichel, GM | 1 |
| McLain, LW | 1 |
| Swanson, PD | 1 |
| Berkowitz, FE | 1 |
| Salem, H | 1 |
| Loux, JJ | 1 |
| Smith, S | 1 |
| Nichols, CW | 1 |
| Bustamante, SA | 1 |
| Stumpff, LC | 1 |
| Goodman, RM | 1 |
| Katznelson, MB | 1 |
| Hertz, M | 1 |
| Katznelson, D | 1 |
| Rotem, Y | 1 |
| Seip, M | 1 |
| Sullivan, FM | 1 |
| McElhatton, PR | 1 |
| Anderson, RC | 1 |
| Waziri, M | 1 |
| Ionasescu, V | 1 |
| Zellweger, H | 1 |
| Vargas, GC | 1 |
| Pildes, RS | 1 |
| Vidyasagar, D | 1 |
| Keith, LG | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Preache, MM | 1 |
| Gibson, JE | 3 |
| Mackler, B | 1 |
| Grace, R | 1 |
| Tippit, DF | 1 |
| Lemire, RJ | 1 |
| Kelley, VC | 1 |
| Annegers, JF | 2 |
| Elveback, LR | 2 |
| Hauser, WA | 2 |
| Kurland, LT | 2 |
| Kondo, S | 1 |
| Leavitt, A | 1 |
| Erickson, DM | 1 |
| McCormick, KB | 1 |
| Loewenson, RB | 1 |
| Sells, CJ | 1 |
| Benedetti, TJ | 1 |
| Dravet, C | 1 |
| Julian, C | 1 |
| Legras, C | 1 |
| Magaudda, A | 1 |
| Guerrini, R | 1 |
| Genton, P | 1 |
| Soulayrol, S | 1 |
| Giraud, N | 1 |
| Mesdjian, E | 1 |
| Trentin, G | 1 |
| Meinardi, H | 1 |
| Meijer, JW | 1 |
| Nau, H | 1 |
| Kattner, E | 1 |
| Takeda, A | 1 |
| Izumi, M | 1 |
| Okada, H | 1 |
| Ishikawa, S | 1 |
| Kamath, SA | 1 |
| Phadke, V | 1 |
| Anand, AJ | 1 |
| Patel, RB | 1 |
| Deshpande, DV | 1 |
| van der Pol, MC | 1 |
| Hadders-Algra, M | 1 |
| Touwen, BC | 1 |
| Rafla, NM | 1 |
| Meehan, FP | 1 |
| Thakker, JC | 1 |
| Kothari, SS | 1 |
| Deshmukh, CT | 1 |
| Deshpande, PG | 1 |
| Dalwai, WM | 1 |
| Joshi, MK | 1 |
| Kandoth, PW | 1 |
| Holder, M | 1 |
| Majewski, F | 1 |
| Lenard, HG | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Pellock, JM | 1 |
| Shields, HE | 2 |
| Chernoff, GF | 2 |
| Bertollini, R | 1 |
| Källen, B | 1 |
| Mastroiacovo, P | 1 |
| Robert, E | 1 |
| Wladimiroff, JW | 1 |
| Stewart, PA | 1 |
| Reuss, A | 1 |
| van Swaay, E | 1 |
| Sachs, ES | 1 |
| Nishikawa, T | 2 |
| Kajita, A | 1 |
| Ando, M | 1 |
| Takao, A | 1 |
| Bruyere, HJ | 2 |
| Gilbert, EF | 3 |
| Ogata, A | 1 |
| Yoneyama, M | 1 |
| Sasaki, M | 1 |
| Suzuki, K | 1 |
| Imamichi, T | 1 |
| Taylor, SM | 1 |
| Takagi, Y | 1 |
| Matsuoka, R | 2 |
| Bruyers, H | 1 |
| Optiz, JM | 1 |
| Trice, JE | 1 |
| Ambler, M | 1 |
| Akintonwa, DA | 1 |
| Stumpf, DA | 1 |
| Giachelli, CM | 1 |
| Faustman-Watts, EM | 1 |
| Lowe, CR | 1 |
| King, CT | 1 |
| Horigan, E | 1 |
| Wilk, AL | 1 |
| Barr, M | 1 |
| Poznanski, AK | 1 |
| Schmickel, RD | 1 |
| Watson, JD | 1 |
| Spellacy, WN | 1 |
| Waddell, WJ | 1 |
| Wynnne, WP | 1 |
| Milkovich, L | 1 |
| van den Berg, BJ | 1 |
| Ho, NK | 1 |
| Loo, DS | 1 |
| Kutt, H | 1 |
| Louis, S | 1 |
| Bus, JS | 1 |
| Short, RD | 1 |
| Fedrick, J | 1 |
| Meyer, JG | 1 |
| Gastol-Lewińska, L | 1 |
| Goldman, AS | 1 |
| Loiseau, P | 1 |
| Henry, TP | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Aase, JM | 1 |
| Rothstein, P | 1 |
| Gould, JB | 1 |
| Becker, BA | 3 |
| Super, M | 1 |
| Muller, A | 1 |
| McMullin, GP | 1 |
| Harbison, RD | 2 |
| Fahim, MS | 1 |
| Hall, DG | 1 |
| Jones, TM | 1 |
| Fahim, Z | 1 |
| Whitt, FD | 1 |
| Stenchever, MA | 1 |
| Jarvis, JA | 1 |
| Pritchard, JA | 1 |
| Scott, DE | 1 |
| Whalley, PJ | 1 |
| van Eck, JH | 1 |
| Gleiss, J | 2 |
| Sinclair, JG | 1 |
| Abreu, BE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for phenobarbital and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
An overview of perinatal clinical pharmacology.
Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo | 1981 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
[Dysmorphisms and psychomotor retardation in infants of mothers treated with anticonvulsants in pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Fetus; Humans; | 1979 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
Effect of drugs on intrauterine growth.
Topics: Abnormalities, Drug-Induced; Animals; Ethanol; Female; Fetal Growth Retardation; Fetus; Growth; Huma | 1979 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Efficacy and adverse effects of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 1989 |
Anticonvulsant drugs. II. Clinical pharmacological and therapeutic aspects.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Cerebellum; Drug Interact | 1972 |
112 other studies available for phenobarbital and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Ectromelia; Epilepsy; Fatal Outcome; Female; Humans; Phe | 2013 |
Teratogenic study of phenobarbital and levamisole on mouse fetus liver tissue using biospectroscopy.
Topics: Abnormalities, Drug-Induced; Animals; Anthelmintics; Anticonvulsants; Drug Interactions; Female; Fet | 2016 |
Congenital abnormalities of 88 children born to mothers who attempted suicide with phenobarbital during pregnany: the use of a disaster epidemiological model for the evaluation of drug teratogenicity.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Case-Control Studies; Cohort Studies; Dose-Response | 2009 |
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epile | 2011 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Effects on toes from prenatal exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Epiphyses; Female; Fingers; | 2002 |
Anticonvulsant teratogenesis 5: observer bias in a cohort study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Boston; Cohort Studies | 2003 |
[ANALYSIS OF THE POSSIBLE RELATION OF FETAL DAMAGE AND DRUGS. V. PRELIMINARY STUDY ON THE INFLUENCE OF 4 ANTIEMETICS ON FETAL DEVELOPMENT].
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Antiemetics; Birth Weight; Ca | 1964 |
Barbexaclone use in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Phen | 2004 |
The AED (antiepileptic drug) pregnancy registry: a 6-year experience.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Maternal Exposure; Phenobarb | 2004 |
The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Face; Facie | 2005 |
Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats.
Topics: Abnormalities, Drug-Induced; Animals; Cardiovascular Abnormalities; Dose-Response Relationship, Drug | 2006 |
Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Case-Control Studies; Cross-Over Studies; Diaze | 2007 |
Effect of some therapeutic agents on the rabbit fetus.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Dimenhydrinate; Female; Fetus; Glut | 1967 |
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Developmental Disabilities; Dose-Response Re | 1983 |
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbit | 1983 |
Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Syst | 1983 |
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot | 1984 |
Functional palatal incompetence in the fetal anticonvulsant syndrome.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy; Female; Humans; Male; Maternal-Fetal Exchan | 1984 |
[Multiple-abnormalities syndrome with phenotypic characteristics falling within the lacrimo-auriculo-dento-digital syndrome].
Topics: Abnormalities, Drug-Induced; Ear, External; Female; Growth Disorders; Hand Deformities, Congenital; | 1984 |
[Relationship between the placental-fetal index (PFI) and the toxic and teratogenic effect in the fetuses of mothers treated with sedalgin during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Codeine; Drug Combinations; Female; Fetus; | 1983 |
Enhancement effects of barbital on the teratogenicity of aminopyrine.
Topics: Abnormalities, Drug-Induced; Aminopyrine; Animals; Barbital; Barbiturates; Cleft Palate; Dose-Respon | 1984 |
[Teratogenic effects of anticonvulsants with the development of multiple congenital anomalies - report on 3 patients].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child, Preschool; Female; Hum | 1983 |
Alcohol, other drugs and the fetus.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Dextropropoxyphene; Diazepam; Drug Synergism; Female; Fe | 1982 |
The in vitro teratogenicity of cyclophosphamide in rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aroclors; Brain; Chlorodiphenyl (54% Chlorine); Culture Techni | 1982 |
[Enhancement effects of barbital and phenobarbital on aminopyrine-initiated teratogenesis in mice].
Topics: Abnormalities, Drug-Induced; Aminopyrine; Animals; Barbital; Barbiturates; Drug Synergism; Female; F | 1981 |
Neonatal manifestations of maternal phencyclidine (PCP) abuse.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Mater | 1981 |
Bilateral clinical anophthalmia: drugs as potential factors.
Topics: Abnormalities, Drug-Induced; Adult; Amitriptyline; Anophthalmos; Dicyclomine; Drug Combinations; Dru | 1980 |
Teratogenicity of 13-cis retinoic acid and phenobarbital sodium in CF-1 mice.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Animals, Newborn; Body Weight; Bone and | 1993 |
Effect of treatment with phenobarbital and stiripentol on carbamazepine-induced teratogenicity and reactive metabolite formation.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Diethylcarbam | 1995 |
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 1998 |
Investigation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone for in vivo and iIn vitro murine embryopathy and embryonic ras mutations.
Topics: Abnormalities, Drug-Induced; Animals; Carcinogens; Embryo, Mammalian; Female; Fetus; Genes, ras; Mic | 1998 |
[A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Fatal Outcome; Female; Humans; Infant; Infant, | 1999 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; | 2001 |
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
Topics: Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; | 2001 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
Anticonvulsants and parental epilepsy in the development of birth defects.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Epilepsy; Female; Finland; Follow-Up Studies; | 1976 |
Letter: Anticonvulsants and fetal malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pr | 1976 |
The medical treatment of epilepsy: antiepileptic drug interactions and teratogenicity.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Carbamazepine; Child; Dicumarol; Digit | 1979 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
Anticonvulsant therapy. Approaches to some common clinical problems.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Eth | 1979 |
Fetal malformation due to phenobarbitone. A case report.
Topics: Abnormalities, Drug-Induced; Face; Fingers; Humans; Infant; Male; Phenobarbital | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Evaluation of the toxicologic and teratogenic potentials of sodium fluorescein in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fluoresceins; Litter Size; Maternal-Fetal Exchange; Ph | 1979 |
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder | 1978 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
Growth retardation, dysmorphic facies and minor malformations following massive exposure to phenobarbitone in utero.
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Epilepsy, Tonic-Clonic; Face; Female; Fingers; | 1976 |
A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Fema | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Teratogenic effect of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child, | 1976 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Effect of food deprivation, phenobarbital, and SKF-525A on teratogenicity induced by 2-sec-butyl-4,6-dinitrophenol (dinoseb) and on disposition of [14C]dinoseb in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Water; Body Weight; Bone and Bones; Dinitrophenols; Femal | 1975 |
Studies of the development of congenital anomalies in rats. III. Effects of inhibition of mitochondrial energy systems on embryonic development.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chloramphenicol; Diet; Embryo Implantation; En | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
The enhancement effect of phenobarbital on toxicity of furylfuramide in mouse embryo.
Topics: Abnormalities, Drug-Induced; Acrylamides; Animals; Female; Food Additives; Mice; Mice, Inbred ICR; M | 1976 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Epilepsy and craniofacial abnormalities.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Epilepsy, Tonic-Clonic; Female; Humans; | 1991 |
Antiepileptic medication in pregnancy: late effects on the children's central nervous system development.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Central Nervous System; Child; Child De | 1991 |
Thanatophoric dwarfism; drugs and antenatal diagnosis; a case report.
Topics: Abnormalities, Drug-Induced; Amitriptyline; Female; Humans; Infant, Newborn; Male; Phenobarbital; Ph | 1991 |
Hypoplasia of nails and phalanges: a teratogenic manifestation of phenobarbitone.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fingers; Humans; Microcephaly; | 1991 |
[Hypoplasia of the nails and end phalanges as a sequela of prenatal barbiturate exposure].
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Fingers; Humans; Male | 1990 |
Variable patterns in anticonvulsant drug-induced malformations in mice: comparisons of phenytoin and phenobarbital.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Growth Retardation; Mice; Mice, Inbred Strains; | 1987 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
The role of ultrasound in the early diagnosis of fetal structural defects following maternal anticonvulsant therapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Diazepam; Female; Humans; Infant, Newbo | 1988 |
Potentiating effects of verapamil on cardiovascular teratogenicity of phenobarbital in the chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aorta; Calcium; Chick Embryo; Drug Synergism; Heart Defects, C | 1988 |
Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Female; Fetal Resorption; Male; M | 1987 |
Strain differences in phenobarbital-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Dose-Response Relationship, Drug; Embryo | 1987 |
The teratogenic effect of phenobarbital on the embryonic chick heart.
Topics: Abnormalities, Drug-Induced; Animals; Arrhythmias, Cardiac; Chick Embryo; Dose-Response Relationship | 1986 |
An aborted human fetus with truncus arteriosus communis--possible teratogenic effect of Tedral.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Drug Combinations; Embryo, Mammalian; Eph | 1985 |
Multiple cerebral defects in an infant exposed in utero to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Cerebral Ventricles; E | 1985 |
High-pressure liquid chromatography separation of phenobarbitone, thiourea, and thioacetamide of toxicological interest.
Topics: Abnormalities, Drug-Induced; Acetamides; Animals; Chromatography, High Pressure Liquid; Mice; Mutage | 1985 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Biotransformation; Cyclophosphamide; Em | 1985 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
Fetal outcome from prolonged versus acute drug administration in the pregnant rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cleft Palate; Collagen; Demyelinating Dise | 1972 |
Digital hypoplasia and anticonvulsants during gestation: a teratogenic syndrome?
Topics: Abnormalities, Drug-Induced; Epilepsy, Tonic-Clonic; Female; Fingers; Hand; Humans; Infant, Newborn; | 1974 |
Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Blood Coagulation Disorders; Epilepsy; Female; Human | 1971 |
The effect of pretreatment with phenobarbital on the teratogenic action of chorcyclizine in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Dealkylation; Drug Antagonism; Embryo Implantati | 1971 |
Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development.
Topics: Abnormalities, Drug-Induced; Aluminum; Anxiety; Child, Preschool; Chlordiazepoxide; Embryo, Mammalia | 1974 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
Sympodia.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile | 1974 |
Effect of phenobarbital and SKF 525A on the toxicity, elimination and metabolism of cyclophosphamide in newborn mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Carbon Isotopes; Cyclophosphamide; Drug Synergism | 1973 |
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Evaluation of the toxicity and teratogenecity of drugs.
Topics: Abnormalities, Drug-Induced; Animals; Barbiturates; Chick Embryo; Gestational Age; Insulin; Methotre | 1973 |
Developmental defects: a final common pathway of teratogenicity?
Topics: Abnormalities, Drug-Induced; Animals; Autonomic Nervous System; Bicarbonates; Chlorpromazine; Embryo | 1973 |
[Letter: Teratogenic hazards in antiepileptic therapy].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg | 1974 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Letter: Anticonvulsant drugs and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Fingers; Humans; Infant; Nail | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Drug toxicity in the animal fetus.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cats; Cricetinae; Dogs; Embryo, Mammalian; Female; Fe | 1967 |
Effect of phenobarbital and SKF 525-A on the teratogenicity of cyclophosphamide in mice.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Cyclophosphamide; Eye Abnormalities; Female; Hydro | 1968 |
Phocomelia.
Topics: Abnormalities, Drug-Induced; Ectromelia; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; P | 1972 |
Teratogenic effects of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Disorders of Sex Development; Female; Humans; Infant, Newborn; Male; Ph | 1971 |
Effects of phenobarbital or SKF 525A pretreatment on diphenylhydantoin disposition in pregnant mice.
Topics: Abnormalities, Drug-Induced; Adipose Tissue; Amniotic Fluid; Animals; Brain Chemistry; Carbon Isotop | 1971 |
Drug-steroid interaction in the pregnant rat, fetus, and neonate.
Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Animals, Newborn; Ascorbic Acid; Body Weigh | 1970 |
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fet | 1970 |
Effect of barbiturates on the chromosomes of human cells in vitro--a negative report.
Topics: Abnormalities, Drug-Induced; Adult; Cells, Cultured; Chromosome Aberrations; Chromosomes; Female; Fi | 1970 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, | 1971 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
[Reflections on the teratogenicity of hypnotics].
Topics: Abnormalities, Drug-Induced; Female; Humans; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Me | 1968 |
Teratogenicity of soporific drugs.
Topics: Abnormalities, Drug-Induced; Female; Glutethimide; Humans; Lysergic Acid Diethylamide; Mescaline; Ph | 1969 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |
Teratogenicity studies.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Phenobarbital; Rabbits; Rats; Thalidomide | 1966 |