phenobarbital has been researched along with Abnormalities, Autosome in 38 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls." | 3.67 | Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin. ( Ambani, LM; Kulkarni, PS; Mondkar, VP; Sonawalla, AB, 1984) |
| "An increased number of chromosomal aberrations were observed after pre-treatment with PB." | 1.37 | N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Oliveira, I; Ribeiro Pinto, LF, 2011) |
| " The results of all these studies, when compared with controls, showed that PB has both genotoxic and cytotoxic potential in apparently increasing intensity at longer periods of chronic feeding in mice, which would warrant due consideration in its long-term use on human subjects." | 1.32 | Assessment of the genotoxic and cytotoxic potential of an anti-epileptic drug, phenobarbital, in mice: a time course study. ( Biswas, SJ; Khuda-Bukhsh, AR; Pathak, S, 2004) |
| " The use of a combined PB/beta NF induction regime using oral dosing is therefore considered to be a suitable substitute for Aroclor 1254." | 1.29 | Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays. ( Callander, RD; Clay, P; Elcombe, CR; Elliott, BM; Mackay, JM, 1995) |
| "Benign Familial Neonatal Seizures (BFNS) occur in normal newborns without perinatal neurological damage or metabolic abnormalities in the setting of a positive family history for neonatal seizures." | 1.28 | Benign Familial Neonatal Seizures. ( Dworsky, ME; Raispis, T, 1992) |
| "The rate of the cells with chromosomal aberrations in the bone marrow after combined action of PB and CP did not depend on the PB dose and was significantly higher as compared with CP action alone." | 1.27 | [Effect of phenobarbital on the cytogenetic activity of cyclophosphamide]. ( Burmantova, NP; Merkur'eva, RV; Votiakov, AV; Vyskubenko, IF; Zhurkov, VS, 1983) |
| "The rate of chromosomal aberrations induced by the 3 anticonvulsants was significantly increased from the first concentration analyzed, similar to half the therapeutic serum concentration." | 1.27 | Effect of anticonvulsants on human chromosomes. 2. In vitro studies. ( García Sagredo, JM, 1988) |
| "Phenobarbital pretreatment synergistically interacted with benzene exposure to further increase sister chromatid exchanges in female mice, induce greater inhibition of cellular proliferation in male mice, and induce a significant level of chromatid-type chromosomal aberrations in both sexes." | 1.26 | Cytogenetic effects of inhaled benzene in murine bone marrow: induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice. ( Costa, DL; Drew, RT; Tice, RR, 1980) |
| "In the treated series, the incidence of chromosome aberrations was significant at all dose levels." | 1.26 | Induction of chromosome aberrations by phenobarbitone in the germ cells of Swiss male mice. ( Nandan, SD; Rao, MS, 1982) |
| "Pretreatment with caffeine enhanced the effect of MMS at high but not at low doses, suggesting an error-free repair process operating at low doses and an error-prone and caffeine-sensitive repair at higher doses." | 1.26 | Factors affecting the induction of micronuclei at low doses of X-rays, MMS and dimethylnitrosamine in mouse erythroblasts. ( Jenssen, D; Ramel, C, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (65.79) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banerjee, A | 2 |
| Pathak, S | 3 |
| Biswas, SJ | 3 |
| Roy-Karmakar, S | 1 |
| Boujedaini, N | 1 |
| Belon, P | 1 |
| Khuda-Bukhsh, AR | 4 |
| Karmakar, SR | 2 |
| Aiub, CA | 1 |
| Gadermaier, G | 1 |
| Oliveira, I | 1 |
| Felzenszwalb, I | 1 |
| Ferreira, F | 1 |
| Ribeiro Pinto, LF | 1 |
| Eckl, P | 1 |
| Bhattacharjee, N | 1 |
| Das, JK | 1 |
| Choudhury, SC | 1 |
| Banerjee, P | 1 |
| Paul, S | 1 |
| Subramanyam, S | 2 |
| Murthy, DK | 2 |
| Riedel, L | 2 |
| Obe, G | 2 |
| Kulkarni, PS | 1 |
| Mondkar, VP | 1 |
| Sonawalla, AB | 1 |
| Ambani, LM | 1 |
| Devaki Nandan, S | 1 |
| Sanjeeva Rao, M | 1 |
| Ito, Y | 2 |
| Maeda, S | 2 |
| Fujihara, T | 1 |
| Ueda, N | 1 |
| Sugiyama, T | 1 |
| Zhurkov, VS | 5 |
| Merkur'eva, RV | 2 |
| Burmantova, NP | 4 |
| Votiakov, AV | 2 |
| Vyskubenko, IF | 2 |
| Tice, RR | 1 |
| Costa, DL | 1 |
| Drew, RT | 1 |
| Nandan, SD | 1 |
| Rao, MS | 1 |
| Sycheva, LP | 4 |
| Callander, RD | 1 |
| Mackay, JM | 1 |
| Clay, P | 1 |
| Elcombe, CR | 1 |
| Elliott, BM | 1 |
| Genton, P | 1 |
| Rodríguez Rivera, L | 1 |
| Flores García, R | 1 |
| Gutiérrez Calzado, C | 1 |
| Betancourt Rovira, A | 1 |
| Sánchez Castillo, A | 1 |
| Jenssen, D | 1 |
| Ramel, C | 1 |
| Revazova, IuA | 1 |
| Sidirov, VP | 1 |
| Radchenko, LU | 1 |
| Mutovin, GR | 1 |
| Akif'ev, AP | 1 |
| Nikonov, VP | 1 |
| Fujie, K | 1 |
| Raispis, T | 1 |
| Dworsky, ME | 1 |
| Meisner, LF | 1 |
| Roloff, B | 2 |
| Sargent, L | 1 |
| Pitot, H | 1 |
| Sargent, LM | 1 |
| Sattler, GL | 1 |
| Xu, YH | 1 |
| Sattler, CA | 1 |
| Meisner, L | 1 |
| Pitot, HC | 1 |
| Webb, R | 1 |
| Bobele, G | 1 |
| Kirkland, DJ | 1 |
| Marshall, RR | 1 |
| McEnaney, S | 1 |
| Bidgood, J | 1 |
| Rutter, A | 1 |
| Mullineux, S | 1 |
| Miyazaki, M | 1 |
| Handa, Y | 1 |
| Sato, J | 1 |
| García Sagredo, JM | 1 |
| Schwartz-Porsche, D | 1 |
| Barthel, A | 1 |
| Gad-el-Karim, MM | 1 |
| Ramanujam, VM | 1 |
| Ahmed, AE | 1 |
| Legator, MS | 1 |
| Foerst, D | 1 |
| Halbrecht, I | 1 |
| Komlos, L | 1 |
| Shabtay, F | 1 |
| Solomon, M | 1 |
| Böök, JA | 1 |
| Benedict, WF | 1 |
| Gielen, JE | 1 |
| Nebert, DW | 1 |
| Stenchever, MA | 1 |
| Jarvis, JA | 1 |
2 reviews available for phenobarbital and Abnormalities, Autosome
| Article | Year |
|---|---|
[Limitations of the concept of idiopathic generalized epilepsy].
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; | 1999 |
'Benign' familial neonatal convulsions.
Topics: Chromosome Aberrations; Chromosome Disorders; Female; Follow-Up Studies; Genes, Dominant; Humans; In | 1990 |
36 other studies available for phenobarbital and Abnormalities, Autosome
| Article | Year |
|---|---|
Chelidonium majus 30C and 200C in induced hepato-toxicity in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Hepatocellular; Chelidonium; Chromosome Ab | 2010 |
Anti-carcinogenic potentials of a plant extract (Hydrastis canadensis): I. Evidence from in vivo studies in mice (Mus musculus).
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Chromosome Aberrations; Female; Hydrastis; Lipid Pe | 2010 |
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Death; Cells, Cultured; Chromosome Aberrat | 2011 |
Assessment of the genotoxic and cytotoxic potential of an anti-epileptic drug, phenobarbital, in mice: a time course study.
Topics: Administration, Oral; Animals; Anticonvulsants; Bone Marrow Cells; Chromosome Aberrations; Humans; K | 2004 |
Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Carcinoma, Hepatocellular; Chr | 2007 |
Response of meiotic chromosomes of mice to phenobarbitone.
Topics: Animals; Chromosome Aberrations; Male; Meiosis; Mice; Phenobarbital; Testis | 1984 |
Mutagenicity of antiepileptic drugs. II. Phenytoin, primidone and phenobarbital.
Topics: Animals; Biotransformation; Cells, Cultured; Chromosome Aberrations; Cricetinae; Female; Mutation; O | 1984 |
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.
Topics: Adult; Animals; Chromosome Aberrations; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; M | 1984 |
Evaluation of the mutagenic effects of phenobarbital by dominant lethal assay in Swiss mice.
Topics: Animals; Chromosome Aberrations; Embryo Implantation; Female; Male; Mice; Mutagenicity Tests; Mutage | 1983 |
Suppression of 7,12-dimethylbenz[a]anthracene-induced chromosome aberrations in rat bone marrow cells after treatment with Sudan III and related azo dyes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Glands; Animals; Azo Compounds; Benz(a)Anthracenes; Bone M | 1982 |
[Effect of phenobarbital on the cytogenetic activity of cyclophosphamide].
Topics: Animals; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; En | 1983 |
Cytogenetic effects of inhaled benzene in murine bone marrow: induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice.
Topics: Animals; Benzene; Biotransformation; Bone Marrow; Bromodeoxyuridine; Cell Division; Chromosome Aberr | 1980 |
Induction of chromosome aberrations by phenobarbitone in the germ cells of Swiss male mice.
Topics: Animals; Chromosome Aberrations; Male; Mice; Phenobarbital; Sex Chromosomes; Spermatocytes; Spermato | 1982 |
[The role of the microsomal mono-oxygenase system in modifying the effect of mutagens].
Topics: Animals; Aziridines; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Dru | 1993 |
Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays.
Topics: Administration, Oral; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcino | 1995 |
[Chromosomal in study patients treated with anticonvulsant drugs].
Topics: Adolescent; Adult; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human | 1977 |
Factors affecting the induction of micronuclei at low doses of X-rays, MMS and dimethylnitrosamine in mouse erythroblasts.
Topics: Animals; Caffeine; Cell Cycle; Cell Nucleus; Chromosome Aberrations; Dimethylnitrosamine; Dose-Respo | 1978 |
Response of somatic chromosomes of mice to phenobarbitone.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Chromosomes; Mice; Phenobarbital | 1978 |
[Mutagenic activity of luminal and pyrazidol].
Topics: Animals; Antidepressive Agents; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; | 1977 |
[Chemical and radiation chromosomal mutagenesis in rat liver cells].
Topics: Animals; Antineoplastic Agents; Chromosome Aberrations; Enzyme Induction; Hepatectomy; Liver; Male; | 1975 |
Acute cytogenetic effect of benzene on rat bone marrow cells in vivo and the effect of inducers or inhibitors of drug-metabolizing enzymes.
Topics: Animals; Azo Compounds; Benzene; Benzoquinones; Bone Marrow; Bone Marrow Cells; Chi-Square Distribut | 1992 |
Benign Familial Neonatal Seizures.
Topics: Adult; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 20; Diagnosis, Differe | 1992 |
Interactive cytogenetic effects on rat bone-marrow due to chronic ingestion of 2,5,2',5' and 3,4,3',4' PCBs.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Female; Mitotic I | 1992 |
Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver.
Topics: Animals; Carcinogens; Cell Division; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorde | 1992 |
Aroclor-1254-induced rat-liver S9 causes chromosomal aberrations in CHO cells but not human lymphocytes: a role for active oxygen?
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Catalase; Cell Line; Chrom | 1989 |
[Modification of the mutagenic effect of cyclophosphamide after long-term induction of the microsomal monooxygenase system].
Topics: Animals; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Cytochrome b Group; Cytochrome P-450 | 1989 |
Effect of phenobarbital on adult rat liver cells treated with 3'-methyl-4-dimethylaminoazobenzene in primary culture.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; Dimethyl Sulfoxide; Dose-Response Relationship, Dr | 1985 |
[Modification of the effect of fotrin in phenobarbital-induced metabolic system].
Topics: Animals; Aziridines; Azirines; Bone Marrow; Chromosome Aberrations; Cytochrome P-450 Enzyme System; | 1988 |
Effect of anticonvulsants on human chromosomes. 2. In vitro studies.
Topics: Anticonvulsants; Chromosome Aberrations; Chromosomes, Human; Ethosuximide; Humans; In Vitro Techniqu | 1988 |
[Cytogenetic analysis of lymphocytes from epileptic dogs].
Topics: Animals; Anticonvulsants; Chromosome Aberrations; Dog Diseases; Dogs; Epilepsy; Lymphocytes; Phenoba | 1987 |
[Modified effect of the induction of the mixed function oxidase system on the cytogenetic action of cyclophosphamide].
Topics: Animals; Chromosome Aberrations; Cyclophosphamide; Cytochrome b Group; Cytochrome P-450 Enzyme Syste | 1985 |
Benzene myeloclastogenicity: a function of its metabolism.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Bone Marrow; Catechols; Chromosome Aberrations | 1985 |
[Chromosome studies on the effect of primidone (Mylepsinum) and its metabolites phenobarbital and phenylethylmalondiamide in vitro].
Topics: Amides; Cell Division; Cells, Cultured; Chromosome Aberrations; Chromosomes; Humans; In Vitro Techni | 1972 |
Triploidy 69, XXX in a stillborn girl.
Topics: Adult; Asthma; Chromatids; Chromosome Aberrations; Chromosomes, Human, 1-3; Chromosomes, Human, 13-1 | 1973 |
Polycyclic hydrocarbon-produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chromosome Ab | 1972 |
Effect of barbiturates on the chromosomes of human cells in vitro--a negative report.
Topics: Abnormalities, Drug-Induced; Adult; Cells, Cultured; Chromosome Aberrations; Chromosomes; Female; Fi | 1970 |