phenobarbital has been researched along with Abdominal Epilepsy in 116 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 9.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the effects of phenobarbitone compared to phenytoin when used as monotherapy in patients with partial onset seizures or generalized tonic-clonic seizures with or without other generalized seizure types." | 8.81 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Taylor, S; Tudur Smith, C; Williamson, PR, 2001) |
| "To assess pharmacokinetics, efficacy, and tolerability of oral levetiracetam administered as an adjunct to phenobarbital treatment in cats with poorly controlled suspected idiopathic epilepsy." | 7.74 | Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy. ( Bailey, KS; Barone, G; Boothe, DM; Dewey, CW; Kortz, GD, 2008) |
| " Seizures in three patients were stopped after high-dose lidocaine infusion (6-8 mg/kg/h) in the acute stage and three patients were stopped after high dose phenobarbital (serum level 60-80 ug/mL) combined with high-dose oral topiramate (15-20 mg/kg/day)." | 5.35 | Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures. ( Hsia, SH; Lin, JJ; Lin, KL; Wang, HS; Wu, CT, 2009) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 5.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 5.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| "Randomised controlled trials comparing monotherapy with either carbamazepine or phenobarbitone in children or adults with focal onset seizures or generalised onset tonic-clonic seizures." | 4.98 | Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C, 2018) |
| "RCTs in children or adults with partial onset seizures or generalised onset tonic-clonic seizures with a comparison of carbamazepine monotherapy versus phenobarbitone monotherapy." | 4.93 | Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the effects of phenobarbitone compared to phenytoin when used as monotherapy in patients with partial onset seizures or generalized tonic-clonic seizures with or without other generalized seizure types." | 4.81 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Taylor, S; Tudur Smith, C; Williamson, PR, 2001) |
| "High-dose phenobarbital (PB) therapy is effective for refractory status epilepticus." | 3.77 | Effectiveness and safety of non-intravenous high-dose phenobarbital therapy for intractable epilepsy during childhood. ( Hamano, S; Ida, H; Kikuchi, K; Koichihara, R; Minamitani, M; Oritsu, T; Tanaka, M, 2011) |
| "To assess pharmacokinetics, efficacy, and tolerability of oral levetiracetam administered as an adjunct to phenobarbital treatment in cats with poorly controlled suspected idiopathic epilepsy." | 3.74 | Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy. ( Bailey, KS; Barone, G; Boothe, DM; Dewey, CW; Kortz, GD, 2008) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "The penetration of phenobarbital (PB) into cerebral tissue was determined in cats rendered epileptic by parenteral penicillin and in cats with focal penicillin-induced epilepsy." | 3.66 | The penetration of phenobarbital in generalized and focal penicillin-induced epileptic brain of the cat. ( Frassetto, M; Monaco, F; Mutani, R; Piredda, S; Russo, A; Sechi, GP; Zoroddu, GF, 1983) |
| "We report on the effect that pretreating patients with phenobarbital has on averting adverse events when primidone is introduced." | 2.69 | The "forgotten" cross-tolerance between phenobarbital and primidone: it can prevent acute primidone-related toxicity. ( Frey, M; Kanner, AM; Parra, J, 2000) |
| "Gabapentin was started at 400 mg/day and was individually titrated to effective tolerable dose up to 2400 mg/day." | 2.69 | Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice. ( Bruni, J, 1998) |
| "Children with simple febrile convulsions were randomly allocated to receive either phenobarbitone or placebo." | 2.67 | Role of phenobarbitone in preventing recurrence of febrile convulsions. ( Ahamed, S; Banu, K; Kamala, KG; Krishnamurthy, PV; Thilothammal, N, 1993) |
| "Decreased libido and impotence were more common in patients given primidone." | 2.66 | Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. ( Browne, TR; Collins, JF; Cramer, JA; Delgado-Escueta, AV; Mattson, RH; McCutchen, CB; McNamara, JO; Smith, DB; Treiman, DM; Williamson, PD, 1985) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Carbamazepine is a current first-line treatment for partial onset seizures in the USA and Europe." | 2.52 | Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2015) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Treatment of focal motor and complex partial status epilepticus is similar to that of tonic-clonic status epilepticus, but i." | 2.36 | Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978) |
| "Perampanel (PER) is a new antiepileptic drug (AED) with a novel mechanism of action." | 1.51 | Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. ( Ishikawa, N; Kobayashi, M; Kobayashi, Y; Tani, H; Tateishi, Y, 2019) |
| "Among those with Idiopathic Generalized Epilepsy (46%), generalized tonic clonic seizure was encountered in 74% and absence seizure was observed in 13%." | 1.39 | Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital. ( Chowdhury, AH; Chowdhury, RN; Ghose, SK; Habib, M; Haque, B; Hasan, AT; Hoque, A; Khan, SU; Mohammad, QD; Mondal, BA; Rahman, KM, 2013) |
| "Epilepsy was confirmed in 58 cases." | 1.37 | [Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011) |
| "All patients suffered from seizures during wakefulness." | 1.36 | Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy? ( Caraballo, R; Cersósimo, R; Flesler, S; Sakr, D, 2010) |
| " Seizures in three patients were stopped after high-dose lidocaine infusion (6-8 mg/kg/h) in the acute stage and three patients were stopped after high dose phenobarbital (serum level 60-80 ug/mL) combined with high-dose oral topiramate (15-20 mg/kg/day)." | 1.35 | Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures. ( Hsia, SH; Lin, JJ; Lin, KL; Wang, HS; Wu, CT, 2009) |
| "The aggravation of habitual seizures and interictal discharges indicate ENM." | 1.35 | A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 1.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| "As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up." | 1.33 | Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? ( Bianchi, MC; Crisanti, AF; Del Giudice, E; Imperati, F; Romano, A; Titomanlio, L; Tosetti, M; Varrone, A, 2006) |
| "Epilepsy is a relatively common problem in children, adults and the elderly." | 1.30 | Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998) |
| "Idiopathic generalized epilepsy (IGE) was diagnosed in 12 cases and partial epilepsy (PE) in 23 cases." | 1.29 | Sex hormones, gonadotropins and prolactin in male epileptic subjects in remission: role of the epileptic syndrome and of antiepileptic drugs. ( Costelli, P; Fonzi, S; Galimberti, CA; Manni, R; Murialdo, G; Parodi, C; Polleri, A; Solinas, GP; Tartara, A; Torre, F, 1994) |
| "Treatment of phenytoin responders and nonresponders with other primary antiepileptic drugs showed that valproate and phenobarbital induced much smaller increases in focal seizure threshold in phenytoin nonresponders than in responders, whereas carbamazepine induced about the same threshold increase in both groups." | 1.29 | Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. ( Hönack, D; Löscher, W; Rundfeldt, C, 1993) |
| "Treatment with phenobarbital was effective in 5 of 7 dogs." | 1.29 | Behavioral changes associated with suspected complex partial seizures in bull terriers. ( Dodman, NH; Keen, CL; Knowles, KE; Moon-Fanelli, AA; Shuster, L; Tidwell, AS, 1996) |
| "The paper describes the case of a depressive syndrome induced in a nine-year-old boy, with complex localised attacks and secondary generalisation, which completely receded on treatment with Convulsofin." | 1.28 | [A barbiturate derivative-induced depressive syndrome in a 9-year-old boy with complex focal seizures and secondary generalization--a case report]. ( Hässler, F, 1989) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety." | 1.27 | Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983) |
| "The optimal dosage of phenytoin can be accurately determined by a pharmacokinetic method." | 1.26 | Rapid metabolism of phenytoin: a method of calculating proper dosage. ( Allen, JP; Hawkins, DW; Hoffman, SF; Ludden, TM, 1979) |
| "Carbamazepine levels were also slightly greater in white matter." | 1.26 | Distribution of anticonvulsant drugs in gray and white matter of human brain. ( Harvey, CD; Sherwin, AL; Van Der Kleijn, E, 1977) |
| "Benign focal epilepsy of childhood is an entity that includes characteristic clinical and electroencephalographic manifestations." | 1.25 | Benign focal epilepsy of childhood. A follow-up study of 100 recovered patients. ( Kivity, S; Lerman, P, 1975) |
| " (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity." | 1.25 | Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (58.62) | 18.7374 |
| 1990's | 16 (13.79) | 18.2507 |
| 2000's | 17 (14.66) | 29.6817 |
| 2010's | 14 (12.07) | 24.3611 |
| 2020's | 1 (0.86) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 1 |
| Li, J | 1 |
| Zhao, D | 1 |
| Lin, W | 1 |
| Nevitt, SJ | 3 |
| Sudell, M | 2 |
| Weston, J | 4 |
| Tudur Smith, C | 8 |
| Marson, AG | 8 |
| Ishikawa, N | 1 |
| Tateishi, Y | 1 |
| Tani, H | 1 |
| Kobayashi, Y | 1 |
| Kobayashi, M | 1 |
| Chin, EM | 1 |
| Cohen, JS | 1 |
| Harris, J | 1 |
| Nolan, SJ | 3 |
| Pulman, J | 1 |
| Imataka, G | 1 |
| Noguchi, M | 1 |
| Tsukada, K | 1 |
| Takahashi, T | 1 |
| Yamanouchi, H | 1 |
| Arisaka, O | 1 |
| Habib, M | 1 |
| Khan, SU | 1 |
| Hoque, A | 1 |
| Mondal, BA | 1 |
| Hasan, AT | 1 |
| Chowdhury, RN | 1 |
| Haque, B | 1 |
| Rahman, KM | 1 |
| Chowdhury, AH | 1 |
| Ghose, SK | 1 |
| Mohammad, QD | 1 |
| Yang, Z | 1 |
| Liu, X | 1 |
| Qin, J | 1 |
| Zhang, Y | 1 |
| Bao, X | 1 |
| Chang, X | 1 |
| Wang, S | 1 |
| Wu, Y | 1 |
| Xiong, H | 1 |
| Lin, JJ | 1 |
| Lin, KL | 1 |
| Wang, HS | 1 |
| Hsia, SH | 1 |
| Wu, CT | 1 |
| Kikuchi, K | 1 |
| Hamano, S | 1 |
| Oritsu, T | 1 |
| Koichihara, R | 1 |
| Tanaka, M | 1 |
| Minamitani, M | 1 |
| Ida, H | 1 |
| Flesler, S | 1 |
| Sakr, D | 1 |
| Cersósimo, R | 1 |
| Caraballo, R | 1 |
| Sivkova, SN | 1 |
| Mukhin, KIu | 1 |
| Zaĭkova, FM | 1 |
| Kotov, AS | 1 |
| Rudakova, IG | 1 |
| Gilbert, TH | 2 |
| Corley, SM | 1 |
| Teskey, GC | 2 |
| Bozkurt, MF | 1 |
| Saygi, S | 1 |
| Erbas, B | 1 |
| Williamson, PR | 2 |
| PRESTON, DN | 1 |
| ATACK, EA | 1 |
| Dodman, NH | 2 |
| Cottam, N | 1 |
| Oka, E | 1 |
| Murakami, N | 1 |
| Ogino, T | 1 |
| Kobayashi, K | 1 |
| Ohmori, I | 1 |
| Akiyama, T | 1 |
| Ito, M | 1 |
| Del Giudice, E | 1 |
| Bianchi, MC | 1 |
| Tosetti, M | 1 |
| Varrone, A | 1 |
| Romano, A | 1 |
| Crisanti, AF | 1 |
| Titomanlio, L | 1 |
| Imperati, F | 1 |
| Di Mizio, G | 1 |
| Gambardella, A | 1 |
| Labate, A | 1 |
| Perna, A | 1 |
| Ricci, P | 1 |
| Quattrone, A | 1 |
| Bailey, KS | 1 |
| Dewey, CW | 1 |
| Boothe, DM | 1 |
| Barone, G | 1 |
| Kortz, GD | 1 |
| Wilensky, AJ | 2 |
| Ojemann, LM | 1 |
| Temkin, NR | 1 |
| Troupin, AS | 2 |
| Dodrill, CB | 1 |
| Rowan, AJ | 1 |
| Dreifuss, FE | 1 |
| Berendes, K | 1 |
| Mattes, W | 1 |
| Dörstelmann, D | 1 |
| McGowan, ME | 1 |
| Monaco, F | 1 |
| Sechi, GP | 1 |
| Piredda, S | 1 |
| Frassetto, M | 1 |
| Zoroddu, GF | 1 |
| Russo, A | 1 |
| Mutani, R | 1 |
| Schmidt, D | 1 |
| Wolf, P | 1 |
| Röder-Wanner, UU | 1 |
| Brede, M | 1 |
| Pratt, JA | 1 |
| Jenner, P | 1 |
| Johnson, AL | 4 |
| Shorvon, SD | 1 |
| Reynolds, EH | 4 |
| Davies, SM | 1 |
| Rothner, AD | 1 |
| Erenberg, G | 1 |
| Petrone, F | 1 |
| Cavalcanti, S | 1 |
| Turchiaro, GG | 1 |
| Rolando, G | 1 |
| Browne, TR | 3 |
| Heller, AJ | 1 |
| Chesterman, P | 1 |
| Elwes, RD | 1 |
| Crawford, P | 1 |
| Chadwick, D | 1 |
| Murialdo, G | 1 |
| Galimberti, CA | 1 |
| Fonzi, S | 1 |
| Manni, R | 1 |
| Costelli, P | 1 |
| Parodi, C | 1 |
| Torre, F | 1 |
| Solinas, GP | 1 |
| Polleri, A | 1 |
| Tartara, A | 1 |
| Karpova, MN | 1 |
| Pankov, OIu | 1 |
| Germane, SK | 1 |
| Klusha, VE | 1 |
| Duburs, G | 1 |
| Löscher, W | 1 |
| Rundfeldt, C | 1 |
| Hönack, D | 1 |
| Thilothammal, N | 1 |
| Krishnamurthy, PV | 1 |
| Kamala, KG | 1 |
| Ahamed, S | 1 |
| Banu, K | 1 |
| Eriksson, K | 1 |
| Baer, M | 1 |
| Kilpinen, P | 1 |
| Koivikko, M | 1 |
| Riley, RJ | 1 |
| Smith, G | 1 |
| Wolf, CR | 1 |
| Cook, VA | 1 |
| Leeder, JS | 1 |
| de Silva, M | 1 |
| MacArdle, B | 1 |
| McGowan, M | 1 |
| Hughes, E | 1 |
| Stewart, J | 1 |
| Neville, BG | 2 |
| Knowles, KE | 1 |
| Shuster, L | 1 |
| Moon-Fanelli, AA | 1 |
| Tidwell, AS | 1 |
| Keen, CL | 1 |
| Pal, DK | 1 |
| Das, T | 1 |
| Chaudhury, G | 1 |
| Kennedy, BT | 1 |
| Haller, JS | 1 |
| Bruni, J | 2 |
| Contin, M | 1 |
| Riva, R | 1 |
| Albani, F | 1 |
| Baruzzi, AA | 1 |
| Brückner, C | 1 |
| Heinemann, U | 1 |
| Husain, AM | 1 |
| Carwile, ST | 1 |
| Miller, PP | 1 |
| Radtke, RA | 1 |
| McBride, MC | 1 |
| Laroia, N | 1 |
| Guillet, R | 1 |
| Kanner, AM | 1 |
| Parra, J | 1 |
| Frey, M | 1 |
| Bauer, J | 1 |
| Burr, W | 1 |
| Taylor, S | 1 |
| Friel, P | 1 |
| Morretti-Ojemann, L | 1 |
| Levy, RH | 1 |
| Feigl, P | 1 |
| Hawkins, DW | 1 |
| Ludden, TM | 1 |
| Hoffman, SF | 1 |
| Allen, JP | 1 |
| Wilder, BJ | 1 |
| Harvey, CD | 1 |
| Sherwin, AL | 2 |
| Van Der Kleijn, E | 1 |
| Ito, T | 1 |
| Hori, M | 1 |
| Yoshida, K | 1 |
| Shimizu, M | 1 |
| Hosokawa, K | 1 |
| Kugoh, T | 1 |
| Otsuki, S | 1 |
| Nanda, RN | 1 |
| Johnson, RH | 1 |
| Keogh, HJ | 1 |
| Lambie, DG | 1 |
| Melville, ID | 1 |
| McNaughton, FL | 1 |
| Rasmussen, T | 1 |
| Lerman, P | 1 |
| Kivity, S | 1 |
| Mikkelsen, B | 1 |
| Birket-Smith, E | 1 |
| Holm, P | 1 |
| Lund, M | 1 |
| Vestermark, S | 1 |
| Olsen, PZ | 1 |
| Gibberd, FB | 2 |
| Sutton, G | 1 |
| Kupferberg, HJ | 1 |
| Dekaban, AS | 1 |
| Lehman, EJ | 1 |
| Mygind, KI | 1 |
| Dam, M | 1 |
| Christiansen, J | 1 |
| Hougaard, K | 1 |
| Oikawa, T | 2 |
| Sveinsdottir, E | 1 |
| Skinoj, E | 1 |
| Ingvar, DH | 1 |
| Lassen, NA | 1 |
| Hassan, MN | 1 |
| Laljee, HC | 1 |
| Parsonage, MJ | 1 |
| Thomas, JA | 1 |
| Knotts, GR | 1 |
| Vigevano, F | 1 |
| Di Capua, M | 1 |
| Fusco, L | 1 |
| Ricci, S | 1 |
| Sebastianelli, R | 1 |
| Lucchini, P | 1 |
| Duchowny, M | 1 |
| Herkes, GK | 1 |
| Eadie, MJ | 1 |
| Hara, H | 1 |
| Fukuyama, Y | 1 |
| Hässler, F | 1 |
| Pigatto, PD | 1 |
| Morelli, M | 1 |
| Polenghi, MM | 1 |
| Mozzanica, N | 1 |
| Altomare, GF | 1 |
| Cornaggia, CM | 1 |
| Canevini, MP | 1 |
| Giuccioli, D | 1 |
| Pruneri, C | 1 |
| Canger, R | 1 |
| Bova, VE | 1 |
| Parish, RA | 1 |
| Brownstein, D | 1 |
| Frost, JD | 1 |
| Kellaway, P | 1 |
| Hrachovy, RA | 1 |
| Glaze, DG | 1 |
| Mizrahi, EM | 1 |
| Faingold, CL | 1 |
| Browning, RA | 1 |
| Rozza, L | 1 |
| Marcolla, A | 1 |
| Ferrari, G | 1 |
| Medaglini, S | 1 |
| Filippi, M | 1 |
| Smirne, S | 1 |
| Ferini-Strambi, L | 1 |
| Giusti, MC | 1 |
| Poggi, A | 1 |
| Comi, G | 1 |
| Coulter, DL | 1 |
| Mattson, RH | 2 |
| Cramer, JA | 2 |
| Collins, JF | 2 |
| Mulroy, JJ | 1 |
| Mickell, JJ | 1 |
| Tong, TK | 1 |
| Pellock, JM | 1 |
| Smith, DB | 1 |
| Delgado-Escueta, AV | 1 |
| Williamson, PD | 1 |
| Treiman, DM | 1 |
| McNamara, JO | 1 |
| McCutchen, CB | 1 |
| Vining, EP | 2 |
| Freeman, JM | 2 |
| Sibley, WA | 1 |
| Wisen, AA | 1 |
| Sokolowski, CD | 1 |
| Billinghurst, JR | 1 |
| German, GA | 1 |
| Orley, JH | 1 |
| Cereghino, JJ | 1 |
| Brock, JT | 1 |
| Van Meter, JC | 1 |
| Penry, JK | 1 |
| Smith, LD | 1 |
| Fisher, P | 1 |
| Ellenberg, J | 1 |
| Arseni, C | 1 |
| Marinescu, V | 1 |
| Edmonds, HL | 1 |
| Stark, LG | 1 |
| Hollinger, MA | 1 |
| Pickering, JG | 1 |
| Degen, R | 1 |
| Helling, R | 1 |
| Kutt, H | 2 |
| Louis, S | 2 |
| van Duijn, H | 1 |
| Visser, SL | 1 |
| Dvilansky, A | 1 |
| Lehman, E | 1 |
| Bell, DS | 1 |
| Littler, WA | 1 |
| Dumon-Radermecker, M | 1 |
| Huber, Z | 1 |
| Spalona, M | 1 |
| Borkowska, Z | 1 |
| Mazurkowa, K | 1 |
| Wojakowski, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073] | Phase 2 | 2 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418] | Phase 4 | 122 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to Insufficient enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12
| Intervention | Abscence seizures (Number) |
|---|---|
| Week 8 Baseline | 165 |
| Week 12 Verapamil 4mg/kg/Day | 101 |
The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12
| Intervention | General tonic-clonic seizures (Number) |
|---|---|
| Week 8 Baseline | 39 |
| Week 12 Verapamil 4mg/kg/Day | 14 |
The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12
| Intervention | Myoclonic seizures (Number) |
|---|---|
| Week 8 Baseline | 116 |
| Week 12 Verapamil 4mg/kg/Day | 175 |
Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months
| Intervention | Units on a scale (Mean) |
|---|---|
| VNS Therapy | -6.0 |
| Best Medical Practice | -3.2 |
The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -2.2 |
| Best Medical Practice | 0.5 |
The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -1.0 |
| Best Medical Practice | -0.2 |
Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months
| Intervention | Number of AEDs Taken (Median) |
|---|---|
| VNS Therapy | 0 |
| Best Medical Practice | 0 |
The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -0.8 |
| Best Medical Practice | -0.3 |
Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months
| Intervention | Percent Change (Mean) |
|---|---|
| VNS Therapy | -19.1 |
| Best Medical Practice | -1.0 |
QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| VNS Therapy | 5.5 |
| Best Medical Practice | 1.2 |
Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months
| Intervention | participants (Number) |
|---|---|
| VNS Therapy | 10 |
| Best Medical Practice | 7 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score < 40 | 3.3 | 0.5 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | Units on a Scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score >= 40 | 3.3 | 0.7 |
17 reviews available for phenobarbital and Abdominal Epilepsy
| Article | Year |
|---|---|
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2018 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; I | 2013 |
Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2015 |
Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2016 |
Carbamazepine versus phenobarbitone monotherapy for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Humans; Ph | 2003 |
Diagnosis and treatment of epilepsy.
Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; E | 1983 |
Final adult height of patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Body Height; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; | 1983 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenobarbital; Phenytoin; Rando | 2001 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
Drug therapy reviews: drug therapy of status epilepticus.
Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil | 1978 |
Mechanisms of anticonvulsant drug action. I. Drugs primarily used for generalized tonic-clonic and partial epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Kinetics; Phenobarbital; Phen | 1987 |
Seizures which are not epilepsy.
Topics: Child, Preschool; Epilepsies, Partial; Fever; Humans; Hypocalcemia; Hypoglycemia; Infant; Infant, Ne | 1985 |
Anticonvulsants, folic acid, and epilepsy.
Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep | 1973 |
Diagnosis and treatment of epilepsy: overview and general principles.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; | 1974 |
Anticonvulsant drugs. II. Clinical pharmacological and therapeutic aspects.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Cerebellum; Drug Interact | 1972 |
17 trials available for phenobarbital and Abdominal Epilepsy
| Article | Year |
|---|---|
[Efficacy of treatment of focal forms of epilepsy in children with antiepileptic drugs of different generations].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; F | 2011 |
Clorazepate and phenobarbital as antiepileptic drugs: a double-blind study.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Clinical Trials as Topic; Clorazepate Dipotassium; Doub | 1981 |
Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy.
Topics: Adolescent; Adult; Aged; Drug Interactions; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Mid | 1984 |
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.
Topics: Adolescent; Adult; Aged; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; | 1995 |
Role of phenobarbitone in preventing recurrence of febrile convulsions.
Topics: Child; Child, Preschool; Double-Blind Method; Drug Tolerance; Epilepsies, Partial; Epilepsy, Tonic-C | 1993 |
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 1996 |
Randomised controlled trial to assess acceptability of phenobarbital for childhood epilepsy in rural India.
Topics: Adolescent; Anticonvulsants; Child; Child Behavior Disorders; Child, Preschool; Developing Countries | 1998 |
Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice.
Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anti-Anxiety Agents; Anticonvulsants; | 1998 |
Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Chil | 1999 |
Electrographic seizures in neonates correlate with poor neurodevelopmental outcome.
Topics: Anticonvulsants; Asphyxia Neonatorum; Demography; Developmental Disabilities; Electroencephalography | 2000 |
The "forgotten" cross-tolerance between phenobarbital and primidone: it can prevent acute primidone-related toxicity.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Child, Preschool; Dizziness; Dose-Response Relation | 2000 |
Evaluation of clorazepate (Tranxene) as an anticonvulsant--a pilot study.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clorazepate Dipotassium; Dose-Resp | 1979 |
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
Topics: Adolescent; Adult; Ambulatory Care; Benzodiazepinones; Brain; Child; Clinical Trials as Topic; Clona | 1977 |
A controlled trial on clonazepam INN (Ro 5-4023, Rivotril (R)) in the treatment of focal epilepsy and secondary generalized grand mal epilepsy.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clona | 1975 |
Aspects of compliance: taking drugs and keeping clinic appointments.
Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Clinical Trials as To | 1988 |
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P | 1985 |
Evaluation of albutoin as an antiepileptic drug.
Topics: Adolescent; Adult; Allyl Compounds; Analysis of Variance; Anticonvulsants; Appetite; Biopharmaceutic | 1974 |
82 other studies available for phenobarbital and Abdominal Epilepsy
| Article | Year |
|---|---|
Efficacy of phenobarbital in treating elderly epilepsy patients in rural northeast China: A community-based intervention trial.
Topics: Aged; Anticonvulsants; Carbamazepine; China; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; H | 2021 |
Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dizziness; Drug Resistant Epile | 2019 |
Vigabatrin as a Targeted Treatment of GABA
Topics: Animals; Anticonvulsants; Chromosomes, Human, Pair 9; Drug Substitution; Electroencephalography; Epi | 2019 |
Partial epilepsy and developmental delay in infant with ring chromosome 14.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Chromosome Disorders; Chromosomes, Human, Pair 1 | 2013 |
Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital.
Topics: Adolescent; Adult; Anticonvulsants; Bangladesh; Carbamazepine; Child; Drug Combinations; Epilepsies, | 2013 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; | 2009 |
Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography | 2009 |
Effectiveness and safety of non-intravenous high-dose phenobarbital therapy for intractable epilepsy during childhood.
Topics: Child; Child, Preschool; Epilepsies, Partial; Female; Humans; Infant; Male; Phenobarbital; Retrospec | 2011 |
Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy?
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child, Preschool; Drug Therapy, Combination; Electroen | 2010 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, | 2011 |
Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Part | 2002 |
SPECT in a patient with postictal PLEDs: is hyperperfusion evidence of electrical seizure?
Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Electroencephalography; Epilepsies, Partia | 2002 |
TEMPORAL LOBE EPILEPSY: A CLINICAL STUDY OF 47 CASES.
Topics: Adolescent; Biomedical Research; Birth Injuries; Depression; Depressive Disorder; Diagnosis, Differe | 1964 |
Animal behavior case of the month. Two dogs were evaluated for episodic bouts of bizarre behavior.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diagnosis, Differential; Dog Diseases; Dogs; Epilepsies, | 2004 |
Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 2004 |
Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
Topics: Adolescent; Anticonvulsants; Attention; Brain; Carbamazepine; Cerebral Cortex; Cognition; Epilepsies | 2006 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; | 2007 |
Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients.
Topics: Adult; Anticonvulsants; Autopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Chromatography | 2007 |
Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Drug Therapy, Combination; Epilepsies, Partial; Epilep | 2008 |
Treatment of the nonconvulsive epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi | 1983 |
[Drug treatment of reading epilepsy].
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Etho | 1983 |
The penetration of phenobarbital in generalized and focal penicillin-induced epileptic brain of the cat.
Topics: Absorption; Animals; Brain; Cats; Epilepsies, Partial; Epilepsy; Penicillins; Phenobarbital | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Anticonvulsant drugs alter plasma tryptophan concentrations in epileptic patients: implications for antiepileptic action and mental function.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsies, Myoclon | 1984 |
Epilepsy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalogr | 1984 |
Status epilepticus.
Topics: Anesthesia, General; Child; Child, Preschool; Diazepam; Epilepsies, Myoclonic; Epilepsies, Partial; | 1980 |
[Polytherapy and monotherapy in the treatment of patients with epilepsy].
Topics: Adult; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, | 1981 |
Therapy of status epilepticus.
Topics: Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Paraldehy | 1982 |
Sex hormones, gonadotropins and prolactin in male epileptic subjects in remission: role of the epileptic syndrome and of antiepileptic drugs.
Topics: Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dihydrotestosterone; Epilepsies, Partial; Ep | 1994 |
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Ther | 1993 |
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Anim | 1993 |
Effects of long barbiturate anaesthesia on eight children with severe epilepsy.
Topics: Anesthesia, General; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsies | 1993 |
Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Topics: Adult; Animals; Anticonvulsants; Autoantibodies; Autoantigens; Carbamazepine; Cell Line; Cross React | 1993 |
Behavioral changes associated with suspected complex partial seizures in bull terriers.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Breeding; Dog Diseases; Dogs; Electroencephalogra | 1996 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep | 1998 |
Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamazepine; Entorhinal Cortex; Epilepsies, Partial; Fe | 2000 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
Course of chronic focal epilepsy resistant to anticonvulsant treatment.
Topics: Adult; Anticonvulsants; Carbamazepine; Cluster Analysis; Disease Progression; Documentation; Drug Ad | 2001 |
Rapid metabolism of phenytoin: a method of calculating proper dosage.
Topics: Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Tonic-Cl | 1979 |
Distribution of anticonvulsant drugs in gray and white matter of human brain.
Topics: Anticonvulsants; Brain; Carbamazepine; Epilepsies, Partial; Humans; Mesencephalon; Nervous System; P | 1977 |
Effect of anticonvulsants on cortical focal seizure in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps | 1977 |
[Clinical study of serum level of dipropylacetic acid sodium (Depakene) by gaschromatography (author's transl)].
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Gas; Drug Therapy, Combination; Epilepsi | 1977 |
Criteria for selection of patients for neurosurgical treatment.
Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy; | 1975 |
Benign focal epilepsy of childhood. A follow-up study of 100 recovered patients.
Topics: Adolescent; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Female; F | 1975 |
Diseases of the central nervous system: Epilepsy.
Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth | 1975 |
Isoniazid as an inhibitor of primidone metabolism.
Topics: Depression, Chemical; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Isoniazid; Mid | 1975 |
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep | 1975 |
Phenytoin and phenobarbitone plasma clearance during pregnancy.
Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human | 1976 |
Regional cerebral blood flow in focal cortical epilepsy.
Topics: Adult; Aged; Brain Neoplasms; Cerebral Cortex; Cerebrovascular Circulation; Diazepam; Electroencepha | 1976 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Epilepsy and other seizure disorders in children: drug management.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1976 |
[Cerebral blood flow in focal cortical epilepsy, with special reference to the pathophysiology of epileptic foci during functional tests].
Topics: Adult; Aged; Angiotensin II; Cerebrovascular Circulation; Diazepam; Electroencephalography; Epilepsi | 1976 |
Sixth-month benign familial convulsions.
Topics: Electroencephalography; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Infant; Male; Phenob | 1992 |
The syndrome of partial seizures in infancy.
Topics: Brain; Carbamazepine; Child, Preschool; Electroencephalography; Epilepsies, Partial; Female; Humans; | 1992 |
Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Menstrua | 1990 |
Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention.
Topics: Anticonvulsants; Attention; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial; Ep | 1989 |
[A barbiturate derivative-induced depressive syndrome in a 9-year-old boy with complex focal seizures and secondary generalization--a case report].
Topics: Anticonvulsants; Child; Depressive Disorder; Drug Combinations; Drug Therapy, Combination; Epilepsie | 1989 |
Phenobarbital-induced allergic dermatitis.
Topics: Adolescent; Drug Eruptions; Eczema; Epilepsies, Partial; Female; Humans; Phenobarbital | 1987 |
Carbamazepine, phenytoin and phenobarbital in drug-resistant partial epilepsies.
Topics: Adolescent; Adult; Carbamazepine; Drug Evaluation; Drug Resistance; Epilepsies, Partial; Epilepsy, T | 1986 |
[Treatment of epileptic patients with Jacksonian seizures].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Epilep | 1986 |
Emergency department management of children with acute isoniazid poisoning.
Topics: Adolescent; Child; Diazepam; Emergencies; Epilepsies, Partial; Epilepsy, Temporal Lobe; Epilepsy, To | 1986 |
Changes in epileptic spike configuration associated with attainment of seizure control.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epi | 1986 |
Endocrine function changes in young males during long-term antiepileptic therapy with phenobarbitone and carbamazepine.
Topics: Adult; Carbamazepine; Drug Therapy, Combination; Endocrine Glands; Epilepsies, Partial; Epilepsy, Te | 1987 |
Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials.
Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Carbamazepine; Child; Epilepsies, Partial; Evoked Po | 1988 |
Withdrawal of barbiturate anticonvulsant drugs: prospective controlled study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Partial; Epi | 1988 |
Postictal pulmonary edema in children.
Topics: Carbamazepine; Child; Epilepsies, Partial; Furosemide; Humans; Intubation, Intratracheal; Male; Oxyg | 1985 |
Where, why, and what type of therapy.
Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum | 1985 |
Anticonvulsant drugs in human epileptogenic brain. Correlation of phenobarbital and diphenylhydantoin levels with plasma.
Topics: Adolescent; Adult; Aged; Animals; Biopsy; Cerebral Cortex; Child; Electroencephalography; Epilepsies | 1973 |
The pattern of epilepsy in Uganda.
Topics: Adolescent; Adult; Age Factors; Black People; Child; Child, Preschool; Electroencephalography; Epile | 1973 |
Epilepsy in cerebral hydatidosis.
Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Dominance, Cerebral; Echinococcosis; Ele | 1974 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence | 1974 |
Partial unilateral lentiginosis with associated developmental abnormalities.
Topics: Angiography; Blood Vessels; Carotid Arteries; Cerebral Arteries; Deafness; Electroencephalography; E | 1973 |
[The treatment of epiletic seizures in childhood].
Topics: Adrenocorticotropic Hormone; Ambulatory Care; Anticonvulsants; Barbiturates; Child; Child, Preschool | 1968 |
Epilepsy.
Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T | 1969 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.
Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography; | 1972 |
Megaloblastic anemia after anticonvulsive therapy.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Epilepsies, Partial; Humans; Male; Phenobarbital; Phenyt | 1972 |
Dangers of treatment of status epilepticus with diazepam.
Topics: Adolescent; Adult; Aged; Cheyne-Stokes Respiration; Child; Diazepam; Drug Antagonism; Epilepsies, Pa | 1969 |
Successful pregnancy in a patient with Ebstein's anomaly.
Topics: Adult; Cardiac Catheterization; Ebstein Anomaly; Electrocardiography; Epilepsies, Partial; Female; H | 1970 |
[Results obtained with Depakine in epilepsy resistant to other therapies. Preliminary note].
Topics: Acetates; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epile | 1969 |
[Effect of hydantoin together with small doses of phenobarbital in various forms of epileptic seizures].
Topics: Adolescent; Adult; Age Factors; Aged; Brain; Child; Drug Synergism; Electroencephalography; Epilepsi | 1971 |
[Results of treatment of epilepsy in children up to 14 years of age].
Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc | 1971 |