phenobarbital has been researched along with 4p Deletion Syndrome in 2 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with phenobarbital and potassium bromide completely terminated the seizures within 10days." | 5.43 | Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide. ( Itakura, A; Maegaki, Y; Nishimura, Y; Ohno, K; Okazaki, T; Saito, Y; Sejima, H; Yamamoto, T, 2016) |
| "Seizures are present in over 90% of infants and children with Wolf-Hirschhorn syndrome (WHS)." | 1.48 | A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome. ( Battaglia, A; Carey, JC; Ho, KS; Lortz, A; Markham, LM; Newcomb, T; Olson, LM; Sheng, X; Twede, H; Wassman, ER; Weng, C, 2018) |
| "Treatment with phenobarbital and potassium bromide completely terminated the seizures within 10days." | 1.43 | Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide. ( Itakura, A; Maegaki, Y; Nishimura, Y; Ohno, K; Okazaki, T; Saito, Y; Sejima, H; Yamamoto, T, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ho, KS | 1 |
| Markham, LM | 1 |
| Twede, H | 1 |
| Lortz, A | 1 |
| Olson, LM | 1 |
| Sheng, X | 1 |
| Weng, C | 1 |
| Wassman, ER | 2 |
| Newcomb, T | 1 |
| Carey, JC | 1 |
| Battaglia, A | 1 |
| Itakura, A | 1 |
| Saito, Y | 1 |
| Nishimura, Y | 1 |
| Okazaki, T | 1 |
| Ohno, K | 1 |
| Sejima, H | 1 |
| Yamamoto, T | 1 |
| Maegaki, Y | 1 |
2 other studies available for phenobarbital and 4p Deletion Syndrome
| Article | Year |
|---|---|
A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clobazam; Female; Humans | 2018 |
Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide.
Topics: Anticonvulsants; Brain; Bromides; Chromosome Deletion; Chromosomes, Human, Pair 4; Comparative Genom | 2016 |