phenindione has been researched along with Renal Insufficiency in 5 studies
Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "(1) Renal failure, either pre-existing or induced by a nephrotoxic drug, increases the risk of adverse effects in patients taking colchicine; (2) Combining colchicines with a macrolide (except for spiramycin) carries a risk of life-threatening pancytopenia; (3) Ciclosporin co-administration can aggravate the neuromuscular adverse effects of colchicine; (4) Combining colchicine with lipid-lowering drugs (statins and fibrates) can cause myopathy; (5) Several mechanisms have been implicated: competition for cytochrome P450 or P-glycoprotein, additive adverse effects (especially on muscle), and colchicine accumulation due to a reduction in its renal excretion; (6) Patients with gout should use colchicine only after failure of symptomatic treatment: ice application, paracetamol, and possibly ibuprofen, a nonsteroidal antiinflammatory drug with well-documented adverse effects; (7) If colchicine is nevertheless used, it should be at the minimum effective dose." | 3.74 | Colchicine: serious interactions. ( , 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ROSCOE, MH | 1 |
| LEE, HA | 1 |
| HOLDEN, CE | 1 |
| FOLLETT, SA | 1 |
| SMITH, K | 1 |
5 other studies available for phenindione and Renal Insufficiency
| Article | Year |
|---|---|
Colchicine: serious interactions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Clofibric Acid; Colchicine; Cycl | 2008 |
URINE IN ACUTE AND CHRONIC RENAL FAILURE.
Topics: Acute Kidney Injury; Blood Chemical Analysis; Female; Kidney Diseases; Kidney Failure, Chronic; Osmo | 1964 |
PHENINDIONE NEPHROPATHY WITH RECOVERY: STUDIES OF MORPHOLOGY AND RENAL FUNCTION.
Topics: Acute Kidney Injury; Biopsy; Dermatitis, Exfoliative; Dialysis; Fracture Fixation; Humans; Kidney Di | 1964 |
OLIGURIA DUE TO A HYPERSENSITIVITY REACTION TO PHENINDIONE.
Topics: Acute Kidney Injury; Anuria; Drug Hypersensitivity; Fibula; Fractures, Bone; Kidney; Kidneys, Artifi | 1964 |
ACUTE RENAL FAILURE IN PHENINDIONE SENSITIVITY.
Topics: Acute Kidney Injury; Biopsy; Drug Eruptions; Drug Therapy; Myocardial Infarction; Pathology; Phenind | 1965 |