phenindione has been researched along with Drug-Related Side Effects and Adverse Reactions in 6 studies
Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No data are available on the efficacy and safety of a combination of fondaparinux and thrombolysis in the setting of high to intermediate risk pulmonary embolism (PE)." | 9.14 | Safety and efficacy of fondaparinux as an adjunctive treatment to thrombolysis in patients with high and intermediate risk pulmonary embolism. ( Bassand, JP; Bernard, Y; Chopard, R; Descotes-Genon, V; Dutheil, J; Janin, S; Mahemuti, A; Meneveau, N; Schiele, F; Seronde, MF, 2009) |
| "No data are available on the efficacy and safety of a combination of fondaparinux and thrombolysis in the setting of high to intermediate risk pulmonary embolism (PE)." | 5.14 | Safety and efficacy of fondaparinux as an adjunctive treatment to thrombolysis in patients with high and intermediate risk pulmonary embolism. ( Bassand, JP; Bernard, Y; Chopard, R; Descotes-Genon, V; Dutheil, J; Janin, S; Mahemuti, A; Meneveau, N; Schiele, F; Seronde, MF, 2009) |
| "(1) Renal failure, either pre-existing or induced by a nephrotoxic drug, increases the risk of adverse effects in patients taking colchicine; (2) Combining colchicines with a macrolide (except for spiramycin) carries a risk of life-threatening pancytopenia; (3) Ciclosporin co-administration can aggravate the neuromuscular adverse effects of colchicine; (4) Combining colchicine with lipid-lowering drugs (statins and fibrates) can cause myopathy; (5) Several mechanisms have been implicated: competition for cytochrome P450 or P-glycoprotein, additive adverse effects (especially on muscle), and colchicine accumulation due to a reduction in its renal excretion; (6) Patients with gout should use colchicine only after failure of symptomatic treatment: ice application, paracetamol, and possibly ibuprofen, a nonsteroidal antiinflammatory drug with well-documented adverse effects; (7) If colchicine is nevertheless used, it should be at the minimum effective dose." | 3.74 | Colchicine: serious interactions. ( , 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Béné, J | 1 |
| Rousselin, C | 1 |
| Bagheri, H | 1 |
| Vial, T | 1 |
| Gautier, S | 1 |
| Lambert, M | 1 |
| Janin, S | 1 |
| Meneveau, N | 1 |
| Mahemuti, A | 1 |
| Descotes-Genon, V | 1 |
| Dutheil, J | 1 |
| Chopard, R | 1 |
| Seronde, MF | 1 |
| Schiele, F | 1 |
| Bernard, Y | 1 |
| Bassand, JP | 1 |
| BAIRD, IM | 1 |
| ROSS, JB | 1 |
| Tubert, P | 1 |
| Bégaud, B | 1 |
| Haramburu, F | 1 |
| Péré, JC | 1 |
1 trial available for phenindione and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Safety and efficacy of fondaparinux as an adjunctive treatment to thrombolysis in patients with high and intermediate risk pulmonary embolism.
Topics: Aged; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug-Related Side Effects and Adverse React | 2009 |
5 other studies available for phenindione and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Nonhemorrhagic joint disorders and vitamin K antagonists: an under-recognized adverse drug reaction?
Topics: Acenocoumarol; Aged; Anticoagulants; Drug-Related Side Effects and Adverse Reactions; Female; Humans | 2018 |
Colchicine: serious interactions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Clofibric Acid; Colchicine; Cycl | 2008 |
Side-effect of phenindione.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Iatrogenic Disease; Phenindione; Pigmentati | 1963 |
Side-effect of phenindione.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Iatrogenic Disease; Phenindione; Pigmentati | 1963 |
Spontaneous reporting: how many cases are required to trigger a warning?
Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Phe | 1991 |