phenindione has been researched along with Drug Overdose in 5 studies
Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "(1) Renal failure, either pre-existing or induced by a nephrotoxic drug, increases the risk of adverse effects in patients taking colchicine; (2) Combining colchicines with a macrolide (except for spiramycin) carries a risk of life-threatening pancytopenia; (3) Ciclosporin co-administration can aggravate the neuromuscular adverse effects of colchicine; (4) Combining colchicine with lipid-lowering drugs (statins and fibrates) can cause myopathy; (5) Several mechanisms have been implicated: competition for cytochrome P450 or P-glycoprotein, additive adverse effects (especially on muscle), and colchicine accumulation due to a reduction in its renal excretion; (6) Patients with gout should use colchicine only after failure of symptomatic treatment: ice application, paracetamol, and possibly ibuprofen, a nonsteroidal antiinflammatory drug with well-documented adverse effects; (7) If colchicine is nevertheless used, it should be at the minimum effective dose." | 3.74 | Colchicine: serious interactions. ( , 2008) |
| " We report here the case of a woman treated with VKA in whom massive absorption of grapefruit juice entailed an excessive VKA dosage and a severe haemorrhage." | 1.35 | [Severe overdose in vitamin K antagonist secondary to grapefruit juice absorption]. ( Desmard, M; Hellmann, R; Mentec, H; Plantefève, G, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grondin, C | 1 |
| Pascal, ML | 1 |
| Bourdon, H | 1 |
| Vu, Q | 1 |
| Beaujeux, P | 1 |
| Koch, E | 1 |
| Strobbe, G | 1 |
| Pannier, D | 1 |
| Villain, A | 1 |
| Feutry, F | 1 |
| Marliot, G | 1 |
| Tranchard, F | 1 |
| Hein, C | 1 |
| Lacombe, J | 1 |
| Villars, H | 1 |
| Montastruc, JL | 1 |
| Despas, F | 1 |
| Desmard, M | 1 |
| Hellmann, R | 1 |
| Plantefève, G | 1 |
| Mentec, H | 1 |
5 other studies available for phenindione and Drug Overdose
| Article | Year |
|---|---|
[Submacular hemorrhage with retinal detachment due to an overdose of anticoagulant during age-related macular degeneration].
Topics: 4-Hydroxycoumarins; Aged, 80 and over; Allopurinol; Anticoagulants; Drug Interactions; Drug Overdose | 2019 |
First-time prescription of enzalutamide in a patient treated with fluindione and digoxin: serial drug interactions.
Topics: Aged; Atrial Fibrillation; Benzamides; Digoxin; Drug Interactions; Drug Overdose; Drug Substitution; | 2019 |
Medication errors and look-alike tablets: the splitting issue.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged, 80 and over; Anticoagulants; Discrimination, Psycholog | 2016 |
Colchicine: serious interactions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Clofibric Acid; Colchicine; Cycl | 2008 |
[Severe overdose in vitamin K antagonist secondary to grapefruit juice absorption].
Topics: Absorption; Anticoagulants; Beverages; Citrus paradisi; Drug Overdose; Female; Food-Drug Interaction | 2009 |