phenindione and Acute Liver Injury, Drug-Induced studies

phenindione and Acute Liver Injury, Drug-Induced

Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)

Research Excerpts

Excerpt	Relevance	Reference
"Fluindione (Previscan) is an oral anti-vitamin K anticoagulant, widely prescribed in France."	6.42	[Fluindione-induced acute exanthematous pustulosis with renal involvement]. ( Beani, JC; Bourrain, JL; Pinel, N; Reymond, JL; Thurot, C, 2003)
"Fluindione (Previscan) is an oral anti-vitamin K anticoagulant, widely prescribed in France."	2.42	[Fluindione-induced acute exanthematous pustulosis with renal involvement]. ( Beani, JC; Bourrain, JL; Pinel, N; Reymond, JL; Thurot, C, 2003)
" In 7-day feeding trials, similar toxic effects were observed in owls fed diets containing 2."	1.38	Assessment of toxicity and potential risk of the anticoagulant rodenticide diphacinone using Eastern screech-owls (Megascops asio). ( Campton, CM; Eisemann, JD; Eisenreich, KM; Horak, KE; Johnston, JJ; Lazarus, RS; Meteyer, CU; Rattner, BA; Volker, SF, 2012)

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (52.94)	18.7374
1990's	4 (23.53)	18.2507
2000's	2 (11.76)	29.6817
2010's	2 (11.76)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

9 (52.94)

18.7374

1990's

4 (23.53)

18.2507

2000's

2 (11.76)

29.6817

2010's

2 (11.76)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Marchandot, B	1
Messas, N	1
Jesel, L	1
Trinh, A	1
Kibler, M	1
Reydel, A	1
Ohlmann, P	1
Morel, O	1
Cadranel, JF	1
Demontis, R	1
Seddik, M	1
Ramdani, S	1
Belloula, D	1
Biour, M	2
Rattner, BA	1
Horak, KE	1
Lazarus, RS	1
Eisenreich, KM	1
Meteyer, CU	1
Volker, SF	1
Campton, CM	1
Eisemann, JD	1
Johnston, JJ	1
BERTHELOT, P	1
OUDEA, P	1
BENHAMOU, JP	1
FAUVERT, R	1
Thurot, C	1
Reymond, JL	1
Bourrain, JL	1
Pinel, N	1
Beani, JC	1
Cristau, P	1
Merlin, P	1
Larroque, P	1
Roue, R	1
Saliou, P	1
Leleu, JP	1
Andant, C	1
Aguettant, L	1
Soule, JC	1
Penot, JP	1
Fontenelle, P	1
Dorleac, D	1
McMenamin, RA	1
Davies, LM	1
Craswell, PW	1
Tubert, P	1
Bégaud, B	1
Haramburu, F	1
Péré, JC	1
Davy, JM	1
Poynard, T	1
Lévy, VG	1
Skovgaard, N	1
Sehested, M	1
Copeman, PW	1
Manigand, G	1
Auzépy, P	1
Lardy, C	1
Opolon, P	1
Cartron, J	1
Chicot, D	1
Caroli, J	1
Gupta, MC	1
Kumar, S	1
Tyagi, SP	1
Srivastava, SS	1
Mohamed, SD	1

Studies

Marchandot, B

Messas, N

Jesel, L

Trinh, A

Kibler, M

Reydel, A

Ohlmann, P

Morel, O

Cadranel, JF

Demontis, R

Seddik, M

Ramdani, S

Belloula, D

Biour, M

Rattner, BA

Horak, KE

Lazarus, RS

Eisenreich, KM

Meteyer, CU

Volker, SF

Campton, CM

Eisemann, JD

Johnston, JJ

BERTHELOT, P

OUDEA, P

BENHAMOU, JP

FAUVERT, R

Thurot, C

Reymond, JL

Bourrain, JL

Pinel, N

Beani, JC

Cristau, P

Merlin, P

Larroque, P

Roue, R

Saliou, P

Leleu, JP

Andant, C

Aguettant, L

Soule, JC

Penot, JP

Fontenelle, P

Dorleac, D

McMenamin, RA

Davies, LM

Craswell, PW

Tubert, P

Bégaud, B

Haramburu, F

Péré, JC

Davy, JM

Poynard, T

Lévy, VG

Skovgaard, N

Sehested, M

Copeman, PW

Manigand, G

Auzépy, P

Lardy, C

Opolon, P

Cartron, J

Chicot, D

Caroli, J

Gupta, MC

Kumar, S

Tyagi, SP

Srivastava, SS

Mohamed, SD

Reviews

2 reviews available for phenindione and Acute Liver Injury, Drug-Induced

Article	Year
Unexpected Problems of Antithrombotic Therapy with An Unusual Side Effect of Vitamin K Antagonists after Mitral Valve Replacement. The Journal of heart valve disease, 2017, Volume: 26, Issue:3 Topics: Anticoagulants; Chemical and Drug Induced Liver Injury; Drug Substitution; Female; Fibrinolytic Agen	2017
[Fluindione-induced acute exanthematous pustulosis with renal involvement]. Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:12 Pt 1 Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Drug Eruptions; Exanthema; Humans; Male	2003

Article

Year

Unexpected Problems of Antithrombotic Therapy with An Unusual Side Effect of Vitamin K Antagonists after Mitral Valve Replacement.

The Journal of heart valve disease, 2017, Volume: 26, Issue:3

Topics: Anticoagulants; Chemical and Drug Induced Liver Injury; Drug Substitution; Female; Fibrinolytic Agen

2017

[Fluindione-induced acute exanthematous pustulosis with renal involvement].

Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:12 Pt 1

Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Drug Eruptions; Exanthema; Humans; Male

2003

Other Studies

15 other studies available for phenindione and Acute Liver Injury, Drug-Induced

Article	Year
[Hepatic and renal toxicity to fluindione (Previscan)]. Gastroenterologie clinique et biologique, 2008, Volume: 32, Issue:10 Topics: Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Diseases; Male	2008
Assessment of toxicity and potential risk of the anticoagulant rodenticide diphacinone using Eastern screech-owls (Megascops asio). Ecotoxicology (London, England), 2012, Volume: 21, Issue:3 Topics: Administration, Oral; Animals; Anticoagulants; Chemical and Drug Induced Liver Injury; Cost-Benefit	2012
[CHOLESTATIC HEPATITIS DUE TO PHENYL-INDANE-DIONE (PINDIONE)]. Revue internationale d'hepatologie, 1964, Volume: 14 Topics: Alkaline Phosphatase; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestyramine Resin; Drug	1964
[Does chronic hepatitis due to phenindione really exist?]. Medecine & chirurgie digestives, 1980, Volume: 9, Issue:8 Topics: Antibodies; Chemical and Drug Induced Liver Injury; Chronic Disease; DNA; Hepatitis; Humans; Male; M	1980
[Cytolytic hepatitis of immuno-allergic mechanism caused by fluindione]. Gastroenterologie clinique et biologique, 1997, Volume: 21, Issue:3 Topics: Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Humans; Male; Phenindione	1997
[Asymptomatic acute cytolytic hepatitis due to fluindione and associated with resistance to treatment: a case report and review of the literature]. Archives des maladies du coeur et des vaisseaux, 1998, Volume: 91, Issue:2 Topics: Acute Disease; Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Humans; Male; Phenindi	1998
Drug induced interstitial nephritis, hepatitis and exfoliative dermatitis. Australian and New Zealand journal of medicine, 1976, Volume: 6, Issue:6 Topics: Acute Disease; Adolescent; Adult; Allopurinol; Chemical and Drug Induced Liver Injury; Dermatitis, E	1976
Spontaneous reporting: how many cases are required to trigger a warning? British journal of clinical pharmacology, 1991, Volume: 32, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Phe	1991
[Is fluindione hepatotoxic?]. Gastroenterologie clinique et biologique, 1990, Volume: 14, Issue:10 Topics: Adult; Aged; Anticoagulants; Chemical and Drug Induced Liver Injury; Female; Humans; Phenindione	1990
[Acute drug-induced interstitial nephritis, granulomatous hepatitis and lymphadenitis, stomatitis and exanthema]. Ugeskrift for laeger, 1987, Mar-23, Volume: 149, Issue:13 Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Exanthema; Female; Humans; Liver; L	1987
Side-effects of phenindione. British medical journal, 1968, Aug-31, Volume: 3, Issue:5617 Topics: Anuria; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Eczema; Female; Humans; Mid	1968
[A case of serious intolerance during treatment by phenindione: preventive measures to be taken]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Dec-14, Volume: 44, Issue:52 Topics: Acute Kidney Injury; Agranulocytosis; Anuria; Bone Marrow; Chemical and Drug Induced Liver Injury; D	1968
[Application of the lymphoblastic transformation test (LTT) to the diagnosis of drug-induced hepatitis]. La Presse medicale, 1969, Dec-20, Volume: 77, Issue:54 Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans;	1969
Stomatitis, agranulocytosis and hepatits due to phenindione sensitivity. Journal of the Indian Medical Association, 1974, Nov-16, Volume: 63, Issue:10 Topics: Adult; Agranulocytosis; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Male;	1974
Sensitivity reaction to phenindione with urticaria, hepatitis, and pancytopenia. British medical journal, 1965, Dec-18, Volume: 2, Issue:5476 Topics: Agranulocytosis; Anemia, Aplastic; Angioedema; Chemical and Drug Induced Liver Injury; Drug Hypersen	1965

Article

Year

[Hepatic and renal toxicity to fluindione (Previscan)].

Gastroenterologie clinique et biologique, 2008, Volume: 32, Issue:10

Topics: Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Diseases; Male

2008

Assessment of toxicity and potential risk of the anticoagulant rodenticide diphacinone using Eastern screech-owls (Megascops asio).

Ecotoxicology (London, England), 2012, Volume: 21, Issue:3

Topics: Administration, Oral; Animals; Anticoagulants; Chemical and Drug Induced Liver Injury; Cost-Benefit

2012

[CHOLESTATIC HEPATITIS DUE TO PHENYL-INDANE-DIONE (PINDIONE)].

Revue internationale d'hepatologie, 1964, Volume: 14

Topics: Alkaline Phosphatase; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestyramine Resin; Drug

1964

[Does chronic hepatitis due to phenindione really exist?].

Medecine & chirurgie digestives, 1980, Volume: 9, Issue:8

Topics: Antibodies; Chemical and Drug Induced Liver Injury; Chronic Disease; DNA; Hepatitis; Humans; Male; M

1980

[Cytolytic hepatitis of immuno-allergic mechanism caused by fluindione].

Gastroenterologie clinique et biologique, 1997, Volume: 21, Issue:3

Topics: Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Humans; Male; Phenindione

1997

[Asymptomatic acute cytolytic hepatitis due to fluindione and associated with resistance to treatment: a case report and review of the literature].

Archives des maladies du coeur et des vaisseaux, 1998, Volume: 91, Issue:2

Topics: Acute Disease; Adult; Anticoagulants; Chemical and Drug Induced Liver Injury; Humans; Male; Phenindi

1998

Drug induced interstitial nephritis, hepatitis and exfoliative dermatitis.

Australian and New Zealand journal of medicine, 1976, Volume: 6, Issue:6

Topics: Acute Disease; Adolescent; Adult; Allopurinol; Chemical and Drug Induced Liver Injury; Dermatitis, E

1976

Spontaneous reporting: how many cases are required to trigger a warning?

British journal of clinical pharmacology, 1991, Volume: 32, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Phe

1991

[Is fluindione hepatotoxic?].

Gastroenterologie clinique et biologique, 1990, Volume: 14, Issue:10

Topics: Adult; Aged; Anticoagulants; Chemical and Drug Induced Liver Injury; Female; Humans; Phenindione

1990

[Acute drug-induced interstitial nephritis, granulomatous hepatitis and lymphadenitis, stomatitis and exanthema].

Ugeskrift for laeger, 1987, Mar-23, Volume: 149, Issue:13

Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Exanthema; Female; Humans; Liver; L

1987

Side-effects of phenindione.

British medical journal, 1968, Aug-31, Volume: 3, Issue:5617

Topics: Anuria; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Eczema; Female; Humans; Mid

1968

[A case of serious intolerance during treatment by phenindione: preventive measures to be taken].

La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Dec-14, Volume: 44, Issue:52

Topics: Acute Kidney Injury; Agranulocytosis; Anuria; Bone Marrow; Chemical and Drug Induced Liver Injury; D

1968

[Application of the lymphoblastic transformation test (LTT) to the diagnosis of drug-induced hepatitis].

La Presse medicale, 1969, Dec-20, Volume: 77, Issue:54

Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans;

1969

Stomatitis, agranulocytosis and hepatits due to phenindione sensitivity.

Journal of the Indian Medical Association, 1974, Nov-16, Volume: 63, Issue:10

Topics: Adult; Agranulocytosis; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Male;

1974

Sensitivity reaction to phenindione with urticaria, hepatitis, and pancytopenia.

British medical journal, 1965, Dec-18, Volume: 2, Issue:5476

Topics: Agranulocytosis; Anemia, Aplastic; Angioedema; Chemical and Drug Induced Liver Injury; Drug Hypersen

1965