Page last updated: 2024-08-18

phenformin and Neoplasms

phenformin has been researched along with Neoplasms in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19905 (23.81)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's9 (42.86)24.3611
2020's5 (23.81)2.80

Authors

AuthorsStudies
Chen, S; Chen, Y; Fu, L; He, G; Liu, B1
Altinoz, MA; Ozpinar, A1
Agostinelli, E; Battistini, L; Cairoli, S; Canettieri, G; Capalbo, C; Coni, S; De Smaele, E; Di Magno, L; Di Marcotullio, L; Di Pastena, F; Giannini, G; Goffredo, BM; Infante, P; Iorio, E; Macone, A; Manni, S; Maroder, M; Moretti, M; Nicoletti, C; Petroni, M; Sambucci, M1
Jang, H; Kang, JH; Kim, HY; Kim, SY; Lee, H; Lee, JS; Lee, SH; Park, JB; Song, J; Woo, SM1
Bollag, WB; Jung, J1
Ando, A; Baba, Y; Ebara, S; Hara, T; Kitazawa, S; Satomi, Y; Soga, T1
Antonia, RJ; Baldwin, AS1
A Marchal, J; Boulaiz, H; Carrillo, E; Domínguez-Martín, A; García Rubiño, ME; Ruiz Alcalá, G1
Bayraktar, EC; Birsoy, K; Chen, WW; Clish, CB; Lorbeer, FK; Possemato, R; Sabatini, DM; Thiru, P; Wang, T; Yucel, B1
Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B1
Birman, E; Blouin, MJ; Gravel, SP; Hulea, L; Pollak, M; St-Pierre, J; Toban, N; Topisirovic, I; Zakikhani, M; Zhao, Y1
Choi, EK; Jang, SJ; Jo, SY; Jung, CL; Lee, C; Mun, H; Oh, JH; Suh, YA1
Gan, B; Liu, X1
Furuno, A; Park, HR; Saito, S; Sakamoto, A; Sakurai, J; Shin-Ya, K; Tomida, A; Tsuruo, T1
Berstein, LM1
Anisimov, VN; Semenchenko, AV; Yashin, AI1
Kreisberg, RA1
Bastl, CP; Narins, RG; Rudnick, MR1
Dilman, VM1
Harken, AH1
Bershteĭn, LM; Bobrov, IuF; Dil'man, VM; Kovaleva, IG; Tsyrlina, EV1

Reviews

6 review(s) available for phenformin and Neoplasms

ArticleYear
Targeting Extracellular Signal-Regulated Protein Kinase 1/2 (ERK1/2) in Cancer: An Update on Pharmacological Small-Molecule Inhibitors.
    Journal of medicinal chemistry, 2022, 10-27, Volume: 65, Issue:20

    Topics: Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neoplasms; Protein Kinase Inhibitors; Signal Transduction

2022
Oxamate targeting aggressive cancers with special emphasis to brain tumors.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 147

    Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Glycolysis; Humans; L-Lactate Dehydrogenase; Mitochondria; Neoplasms; Oxamic Acid; Phenformin; Radiation Tolerance; Reactive Oxygen Species; Temozolomide

2022
Phenformin as an Anticancer Agent: Challenges and Prospects.
    International journal of molecular sciences, 2019, Jul-05, Volume: 20, Issue:13

    Topics: Animals; Antineoplastic Agents; Diabetes Mellitus, Type 2; Humans; Models, Biological; Neoplasms; Phenformin; Risk Factors

2019
Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond.
    Future oncology (London, England), 2010, Volume: 6, Issue:8

    Topics: Diet Therapy; Exercise Therapy; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Phenformin

2010
Lactate homeostasis and lactic acidosis.
    Annals of internal medicine, 1980, Volume: 92, Issue:2 Pt 1

    Topics: Acidosis; Animals; Diabetic Ketoacidosis; Dichloroacetic Acid; Ethanol; Homeostasis; Humans; Hypoglycemia; Kidney; Lactates; Liver; Liver Diseases; Neoplasms; Phenformin; Renal Dialysis; Salicylates; Seizures; Vasodilator Agents

1980
Lactic acidosis.
    Surgery, gynecology & obstetrics, 1976, Volume: 142, Issue:4

    Topics: Acid-Base Equilibrium; Acidosis; Catecholamines; Diabetic Ketoacidosis; Energy Metabolism; Ethanol; Humans; Lactates; Neoplasms; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Phenformin; Pyruvates; Shock; Thiamine Deficiency

1976

Other Studies

15 other study(ies) available for phenformin and Neoplasms

ArticleYear
Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.
    Cell reports, 2020, 02-11, Volume: 30, Issue:6

    Topics: Animals; Antineoplastic Agents; Co-Repressor Proteins; Hedgehog Proteins; Humans; Hypoglycemic Agents; Mice; Neoplasms; Phenformin

2020
Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling.
    Cells, 2020, 09-01, Volume: 9, Issue:9

    Topics: Aldehyde Dehydrogenase; Animals; Antineoplastic Agents; Autophagy; Drug Resistance, Neoplasm; Drug Synergism; Electron Transport Complex I; Gossypol; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Oxidative Phosphorylation; Phenformin; Xenograft Model Antitumor Assays

2020
Phenformin: AMP(K)ed for Potential Repurposing.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:1

    Topics: Adenosine Monophosphate; Drug Repositioning; Humans; Hypoglycemic Agents; Neoplasms; Phenformin

2021
Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors.
    Oncotarget, 2017, Apr-25, Volume: 8, Issue:17

    Topics: Antineoplastic Agents; Azepines; Benzodiazepines; Citric Acid Cycle; CRISPR-Cas Systems; Dehydroepiandrosterone; Fumarates; Gene Knockout Techniques; Glucosephosphate Dehydrogenase; Glycolysis; HCT116 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Metabolomics; Mitochondria; Mutation; Neoplasms; Oxygen Consumption; Phenformin; Phosphoglycerate Dehydrogenase; Proto-Oncogene Proteins c-myc; RNA Interference; RNA, Small Interfering; Succinate Dehydrogenase; Succinic Acid; Triazoles

2017
IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells.
    Science signaling, 2018, 07-10, Volume: 11, Issue:538

    Topics: A549 Cells; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Apoptosis; Cells, Cultured; Cytokines; HeLa Cells; Humans; I-kappa B Kinase; Mice, Knockout; Neoplasms; Phenformin; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Threonine

2018
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.
    Nature, 2014, Apr-03, Volume: 508, Issue:7494

    Topics: Adenosine Triphosphate; Animals; Biguanides; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Culture Media; DNA, Mitochondrial; Electron Transport Complex I; Glucose; Humans; Hypoglycemic Agents; Male; Mice; Mitochondria; Molecular Typing; Mutation; Neoplasm Transplantation; Neoplasms; Oxidative Phosphorylation; Phenformin; RNA Interference; Saccharomyces cerevisiae Proteins; Xenograft Model Antitumor Assays

2014
Differential effects of AMPK agonists on cell growth and metabolism.
    Oncogene, 2015, Volume: 34, Issue:28

    Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes

2015
Serine deprivation enhances antineoplastic activity of biguanides.
    Cancer research, 2014, Dec-15, Volume: 74, Issue:24

    Topics: Animals; Biguanides; Cell Line, Tumor; Glycolysis; Humans; Metformin; Mice; Neoplasms; Oxidative Phosphorylation; Phenformin; Serine; Xenograft Model Antitumor Assays

2014
Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo.
    Oncotarget, 2016, Nov-22, Volume: 7, Issue:47

    Topics: A549 Cells; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Deoxyglucose; Gene Expression Regulation, Neoplastic; Gene Knock-In Techniques; Humans; MAP Kinase Signaling System; Mice; Mutation; Neoplasm Metastasis; Neoplasms; Phenformin; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2016
lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1.
    Cell cycle (Georgetown, Tex.), 2016, Dec-16, Volume: 15, Issue:24

    Topics: AMP-Activated Protein Kinases; Cell Death; Cell Line, Tumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; HEK293 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neoplasms; Phenformin; RNA, Long Noncoding; Subcellular Fractions; TOR Serine-Threonine Kinases; Transcription Factors

2016
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.
    Cancer research, 2009, May-15, Volume: 69, Issue:10

    Topics: Activating Transcription Factor 4; Cell Death; Cell Survival; DNA-Binding Proteins; Gene Expression Profiling; Genes, Reporter; Genomics; Glucose; Humans; Hypoglycemic Agents; Macrolides; Neoplasms; Oligosaccharides; Phenformin; Plasmids; Protein Denaturation; Protein Folding; Regulatory Factor X Transcription Factors; Transcription Factors; Transfection; X-Box Binding Protein 1

2009
Insulin and longevity: antidiabetic biguanides as geroprotectors.
    Biogerontology, 2003, Volume: 4, Issue:5

    Topics: Aging; Animals; Buformin; Female; Humans; Hypoglycemic Agents; Insulin; Longevity; Mice; Neoplasms; Phenformin; Rats; Survival Rate

2003
The kidney in health and disease: XVIII: lactic acidosis and the elevated anion gap (II).
    Hospital practice, 1980, Volume: 15, Issue:6

    Topics: Acidosis; Bicarbonates; Blood Chemical Analysis; Diabetes Mellitus; Hemodynamics; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactates; Neoplasms; Phenformin; Pyruvate Dehydrogenase Complex; Water-Electrolyte Imbalance

1980
Ageing, metabolic immunodepression and carcinogenesis.
    Mechanisms of ageing and development, 1978, Volume: 8, Issue:3

    Topics: Adult; Aged; Aging; Cell Transformation, Neoplastic; Cholesterol; Clofibrate; Coronary Disease; Diabetes Mellitus; Energy Metabolism; Fatty Acids, Nonesterified; Female; Humans; Hypothalamo-Hypophyseal System; Immunity, Cellular; Immunologic Deficiency Syndromes; Insulin; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Neoplasms; Phenformin; Pregnancy; Triglycerides

1978
[Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin].
    Voprosy onkologii, 1975, Volume: 21, Issue:11

    Topics: Adrenal Cortex Hormones; Aged; Biguanides; Blood Glucose; Body Weight; Breast Neoplasms; Buformin; Cholesterol; Clofibrate; Colonic Neoplasms; Endocrine System Diseases; Fatty Acids; Female; Growth Hormone; Humans; Insulin; Lipoproteins; Lung Neoplasms; Middle Aged; Neoplasms; Phenformin; Phenytoin; Phospholipids; Triglycerides; Uric Acid; Uterine Neoplasms

1975