phenformin has been researched along with Diabetes Mellitus, Type 2 in 47 studies
*Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (23.40) | 18.7374 |
| 1990's | 23 (48.94) | 18.2507 |
| 2000's | 6 (12.77) | 29.6817 |
| 2010's | 3 (6.38) | 24.3611 |
| 2020's | 4 (8.51) | 2.80 |
| Authors | Studies |
|---|---|
| Jirkovsky, I; McCaleb, ML; Nowicki, JW; Zask, A | 1 |
| Jayabal, D; Jayanthi, S; Shimu, MSS; Thirumalaisamy, R | 1 |
| Fraser-Spears, R; Kim, SS; La-Viola, B; Ramsinghani, S; Sikazwe, D; Witte, AP; Yendapally, R | 1 |
| Davis, R; Ding, D; Hillel, AT; Lina, I; Motz, KM; Tsai, HW | 1 |
| Ansari, IH; Longacre, MJ; MacDonald, MJ; Stoker, SW | 1 |
| A Marchal, J; Boulaiz, H; Carrillo, E; Domínguez-Martín, A; García Rubiño, ME; Ruiz Alcalá, G | 1 |
| Bazelier, MT; de Vries, F; Dittrich, ST; Henry, RM; Knapen, LM; Neef, C; Starup-Linde, J; Stolk, LM; Vestergaard, P | 1 |
| de Courten, B; Drew, BG; Duffy, SJ; Febbraio, MA; Forbes, JM; Formosa, MF; Henstridge, DC; Kaye, DM; Kemp, BE; Kingwell, BA; Mukhamedova, N; Natoli, AK; Penfold, SA; Steinberg, GR; Sviridov, D; Thomas, WG; van Hall, G; Yap, FY | 1 |
| Birnbaum, MJ; Chu, Q; Foretz, M; Miller, RA; Viollet, B; Xie, J | 1 |
| Kuroda, A; Yamasaki, Y | 1 |
| Kalakunja, A; Kumar, A; Nugent, K; Pirtle, F | 1 |
| LAMBERT, TH | 1 |
| Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR | 1 |
| Tattersall, RB | 1 |
| Talwalkar, PG | 1 |
| Draghi, E; Tolfo, L; Zogno, MG | 1 |
| Braghetto, L; Crepaldi, G; Fedele, D; Lapolla, A; Manzato, E; Zambon, A; Zambon, S | 1 |
| Melander, A | 2 |
| Halvatsiotis, PG; Raptis, AE; Raptis, SA; Tountas, NB; Yalouris, AG | 1 |
| Lorber, DL; Lu, HC; Parikh, PP | 1 |
| Cheah, JS; Lee, KO; Yeoh, KG | 1 |
| Capra, L; Cavalli, PL; Curto, V; Goia, F; Lanza, G; Mariano, F; Vincenti, R | 1 |
| Lopez-Liuchi, JV; Meier, CA | 1 |
| Jedynasty, K; Kasperska-Czyzykowa, T; Nowaczyk, R; Stepień, K | 1 |
| Bethel, MA; Feinglos, MN | 1 |
| Lalau, JD; Race, JM | 2 |
| Amin, BM; Patel, JC; Sawant, MS | 1 |
| Balasubramaniam, J | 1 |
| Bianco, A; Ghirlanda, G; Greco, AV | 1 |
| Madhavan, R; Sankaran, JR; Seshasaianam, C; Seshiah, V; Shanker, R; Sundaram, A; Venkataraman, S | 1 |
| Aguilar, C; García, JE; Reza, A; Rull, JA | 1 |
| Caffau, C; Cernigoi, AM; Velussi, M; Viezzoli, L | 1 |
| Anfossi, G; Burzacca, S; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, E; Trovati, M | 1 |
| Allison, NL; Bland, PS; Ilson, BE; Jorkasky, DK; Stote, RM | 1 |
| Chandalia, HB; Rangnath, M | 1 |
| Gill, G | 1 |
| Conget, JI; Esmatjes, E; Goday, A; Vendrell, J | 1 |
| Bartosiewicz, W; Czyzyk, A; Lao, B; Orłowska, K; Szczepanik, Z | 1 |
| Dembe, K; Janeczko, E; Koneczna, A; Pacuła, P; Stryjek-Kamińska, D; Tomaszczyk, M; Trusiewicz, D | 1 |
| Aluffi, E; Bruno, A; Carta, Q; Cavallo-Perin, P; Estivi, P; Lenti, G; Pagano, G | 1 |
| Alexander, L; Fletcher, P; Hirji, MR; Kuhn, S; Mucklow, JC | 1 |
| Benzi, L; Boni, C; Cecchetti, P; Ciccarone, AM; Ciociaro, D; Di Cianni, G; Giannarelli, R; Marchetti, P; Navalesi, R; Zappella, A | 1 |
| Kilo, C; Williamson, JR | 1 |
| Schernthaner, G | 1 |
| Liang, JZ; Luo, ZT; Yang, DP | 1 |
10 review(s) available for phenformin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
A review of phenformin, metformin, and imeglimin.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Phenformin; Triazines | 2020 |
Phenformin as an Anticancer Agent: Challenges and Prospects.
Topics: Animals; Antineoplastic Agents; Diabetes Mellitus, Type 2; Humans; Models, Biological; Neoplasms; Phenformin; Risk Factors | 2019 |
[Adverse effect of biguanides].
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Gastrointestinal Diseases; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Phenformin; Vitamin B 12 Deficiency | 2002 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Phenformin; Risk Assessment | 2003 |
[25 years of diabetic treatment by oral hypoglycemic agents: successes and failures].
Topics: Aged; Aging; Blood Glucose; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diet, Reducing; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Phenformin; Sulfonylurea Compounds; Tolbutamide | 1984 |
Review of previous impaired glucose tolerance intervention studies.
Topics: Diabetes Mellitus, Type 2; Dietary Carbohydrates; Exercise; Follow-Up Studies; Glucose Intolerance; Humans; Hypoglycemic Agents; Incidence; Phenformin; Tolbutamide | 1996 |
Pharmacological intervention: the antidiabetic approach.
Topics: Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diet, Diabetic; Exercise; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Male; Middle Aged; Phenformin; Tolbutamide | 1998 |
Therapy for type 2 diabetes: where do we stand after the UK prospective diabetes study?
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diet Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Prospective Studies; Randomized Controlled Trials as Topic; Tolbutamide | 1999 |
Metformin and lactic acidosis in diabetic humans.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Hypoglycemic Agents; Metformin; Phenformin; Prognosis | 2000 |
Practical management of diabetes in the tropics.
Topics: Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Metformin; Phenformin; Pregnancy | 1990 |
8 trial(s) available for phenformin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.
Topics: AMP-Activated Protein Kinases; Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids; Female; Glucose; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Mice; Middle Aged; Muscle Cells; Muscle, Skeletal; Phenformin; Signal Transduction | 2009 |
Therapeutic effect of glibenclamide in a fixed combination with metformin or phenformin in NIDDM patients.
Topics: Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipids; Male; Metformin; Middle Aged; Phenformin; Prospective Studies | 1996 |
[Short-term intensive insulin therapy as a method of overcoming secondary failure of sulfonylureas in patients with type 2 diabetes (non-insulin-dependent)].
Topics: Aged; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Phenformin; Sulfonylurea Compounds; Treatment Failure | 1998 |
Therapy of type 2 diabetes, cardiovascular death, and the UGDP.
Topics: Angioplasty, Balloon, Coronary; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Phenformin; Prospective Studies; Risk Factors; Survival Rate; Tolbutamide; Treatment Outcome; Universities | 1999 |
Levels of lactic acid, normal level & its relation to food, glucose, cholesterol, raised blood urea and phenformin therapy.
Topics: Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypercholesterolemia; Hyperglycemia; India; Lactic Acid; Male; Phenformin; Reference Values; Urea | 2000 |
A comparison of the predictive power for overall blood glucose control of a 'good' fasting level in type 2 diabetic patients on diet alone or with oral agents.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diet, Diabetic; Fasting; Female; Glyburide; Humans; Male; Middle Aged; Phenformin; Time Factors | 1992 |
The hyperlactatemic effect of biguanides: a comparison between phenformin and metformin during a 6-month treatment.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; Phenformin; Time Factors | 1989 |
The controversial American University Group Diabetes Study--a look at sulfonylurea and biguanide therapy.
Topics: Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Patient Compliance; Phenformin; Tolbutamide | 1985 |
29 other study(ies) available for phenformin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Lactates; Male; Mice; Naphthalenes; Rats; Rats, Zucker; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1990 |
Molecular insights of anti-diabetic compounds and its hyaluronic acid conjugates against aldose reductase enzyme through molecular modeling and simulations study-a novel treatment option for inflammatory diabetes.
Topics: Aldehyde Reductase; Diabetes Mellitus, Type 2; Humans; Hyaluronic Acid; Inflammation; Insulin Resistance; Ligands; Metformin; Molecular Docking Simulation; Molecular Dynamics Simulation; Phenformin; Sitagliptin Phosphate | 2023 |
Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type II Diabetes Mellitus.
Topics: Adult; Aged; Amobarbital; Biopsy; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cicatrix; Constriction, Pathologic; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Glottis; Glycolysis; Humans; Hypoglycemic Agents; Iatrogenic Disease; Intubation, Intratracheal; Laryngostenosis; Male; Metformin; Middle Aged; Muscle Contraction; Myofibroblasts; Oxidative Phosphorylation; Phenformin; Primary Cell Culture; Trachea; Tracheal Stenosis; Tracheostomy; Young Adult | 2021 |
Metformin's Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glycerolphosphate Dehydrogenase; Humans; Male; Metformin; Mice; Mice, Inbred BALB C; Mitochondria; NAD; Oxidation-Reduction; Phenformin; Rats | 2021 |
Use of biguanides and the risk of colorectal cancer: a register-based cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biguanides; Cohort Studies; Colorectal Neoplasms; Comorbidity; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Netherlands; Phenformin; Population; Registries; Risk Factors; Young Adult | 2013 |
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Topics: Adenylyl Cyclases; AMP-Activated Protein Kinases; Animals; Biguanides; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Enzyme Activation; Glucagon; Glucose; Hepatocytes; Hypoglycemic Agents; Liver; Metformin; Mice; Phenformin; Phosphorylation; Signal Transduction | 2013 |
Severe acidosis in a patient with type 2 diabetes mellitus, hypertension, and renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypertension; Hypoglycemic Agents; Kidney Failure, Chronic; Male; Middle Aged; Phenformin | 2003 |
Phenethylbiguanide in diabetic patients; clinical and metabolic effects.
Topics: Diabetes Mellitus, Type 2; Diet, Diabetic; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Nausea; Obesity; Phenformin; Vomiting | 1959 |
Phenformin induced lactic acidosis in an elderly NIDDM patient.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Phenformin | 1994 |
Hypoglycemia caused by maprotiline in a patient taking oral antidiabetics.
Topics: Administration, Oral; Aged; Diabetes Mellitus, Type 2; Drug Interactions; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Maprotiline; Phenformin | 1994 |
Lipoprotein abnormalities in well-treated type II diabetic patients.
Topics: Aged; Analysis of Variance; Apolipoproteins; Cholesterol; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Phenformin; Reference Values; Regression Analysis; Triglycerides | 1993 |
Phenformin-associated lactic acidosis due to imported phenformin.
Topics: Acidosis, Lactic; Aged; Blood Glucose; China; Diabetes Mellitus, Type 2; Fluid Therapy; Humans; Hypoglycemic Agents; Male; Panax; Phenformin; Plants, Medicinal; Respiration, Artificial; United States | 1996 |
Fatal lactic acidosis from imported phenformin--report of two cases.
Topics: Acidosis, Lactic; Aged; China; Diabetes Mellitus, Type 2; Fatal Outcome; Humans; Hypoglycemic Agents; Male; Phenformin; Singapore | 1996 |
[Insufficient correction of blood bicarbonate levels in biguanide lactic acidosis treated with CVVH and bicarbonate replacement fluids].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Bicarbonates; Buffers; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fatal Outcome; Female; Fluid Therapy; Hemofiltration; Humans; Hypoglycemic Agents; Phenformin | 1997 |
Lactic acidosis in metformin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Middle Aged; Phenformin; Retrospective Studies; Risk Factors | 1999 |
Phenformin induced lactic acidosis in an elderly NIDDM patient.
Topics: Acidosis, Lactic; Aged; Asthma; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Phenformin | 1995 |
[Lactic acidosis, hyperamylasemia, and phenformin].
Topics: Acidosis, Lactic; Aged; Amylases; Diabetes Mellitus, Type 2; Female; Humans; Middle Aged; Phenformin | 1992 |
Effect of bed time intermediate acting insulin in NIDDM subjects refractory to a combination of sulphonylureas and biguanides.
Topics: Biguanides; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Combinations; Female; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Injections, Subcutaneous; Insulin, Long-Acting; Lipids; Male; Metformin; Middle Aged; Phenformin; Sulfonylurea Compounds; Time Factors | 1992 |
Biguanide related lactic acidosis: incidence and risk factors.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Biguanides; Contraindications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Emergencies; Female; Humans; Incidence; Male; Metformin; Mexico; Middle Aged; Odds Ratio; Phenformin; Prospective Studies; Retrospective Studies; Risk Factors; Sulfonylurea Compounds | 1992 |
[Median-term (4 months) treatment with glibenclamide + metformin substituting for glibenclamide + fenformin lowers the lacticemia levels in type-2 diabetics (NIDDM)].
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Glyburide; Glycated Hemoglobin; Glycosuria; Humans; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Phenformin | 1992 |
Metabolic acidosis in a diabetic man.
Topics: Acidosis, Lactic; Chronic Disease; Combined Modality Therapy; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypertension; Male; Middle Aged; Phenformin | 1990 |
Biguanide-induced lactic acidosis.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Follow-Up Studies; Humans; Lactates; Lactic Acid; Male; Phenformin; Prospective Studies | 1990 |
[Lactic acidosis caused by phenformin: the most recent].
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Phenformin | 1989 |
[Effect of antidiabetics on post-exercise alaninemia in patients with non-insulin-dependent diabetes mellitus (type 2)].
Topics: Adult; Alanine; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Exercise; Exercise Test; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Phenformin; Tolbutamide | 1989 |
[Evaluation of the late ineffectiveness of sulfonylurea derivatives in patients with diabetes mellitus hospitalized at the Gastroenterology and Metabolic Disease Clinic, Medical Academy, in Warsaw 1976-1987].
Topics: Adult; Age Factors; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Resistance; Drug Therapy, Combination; Female; Hospitalization; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Time Factors | 1989 |
The effects of diabetes mellitus, exercise, and single doses of biguanides upon lactate metabolism in man.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Exercise Test; Fasting; Female; Humans; Lactates; Male; Metformin; Middle Aged; Oxidation-Reduction; Phenformin; Phenotype; Pyruvates | 1986 |
Plasma biguanide levels are correlated with metabolic effects in diabetic patients.
Topics: Aged; Blood Glucose; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus, Type 2; Female; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Pyruvates; Triglycerides | 1987 |
Improvement of insulin action is an important part of the antidiabetic effect of metformin.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Erythrocytes; Humans; Insulin; Metformin; Phenformin; Receptor, Insulin | 1985 |
[Alteration of blood lactic acid levels in biguanide therapy in diabetics].
Topics: Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Lactates; Lactic Acid; Metformin; Middle Aged; Phenformin | 1985 |