phenethyl isothiocyanate has been researched along with Prostatic Neoplasms in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (47.73) | 29.6817 |
| 2010's | 22 (50.00) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Hudlikar, R; Kong, AN; Kuo, HC; Li, S; Liu, X; Peter, R; Sargsyan, D; Wang, L; Wu, R; Yin, R | 1 |
| Goodin, S; He, Y; Huang, H; Li, D; Liu, W; Xiang, H; Xu, XT; Zhang, K; Zhang, L; Zheng, X | 1 |
| Kong, AN; Sargsyan, D; Wang, C; Wu, R; Yang, Y; Zhang, C | 1 |
| Aggarwal, M; Asif, N; Berry, D; Chung, FL; Cruz, I; Kallakury, B; Pham, Q; Saxena, R; Sinclair, E; Tan, J; Wang, TTY | 1 |
| Chen, D; Chen, XM; Gong, AY; Solelo Leon, D; Young, CY; Yu, C | 1 |
| Hahm, ER; Sakao, K; Singh, SV | 1 |
| Amjad, AI; Chinni, SR; Parikh, R; Sakao, K; Singh, SV; Vyas, AR | 1 |
| Khor, TO; Kim, H; Kong, AN; Li, W; Shu, L; Wu, R; Zhang, C | 1 |
| Cang, S; Chen, Y; Chiao, JW; Han, L; Liu, C; Liu, D; Lu, Q; Solangi, Z; Yang, P | 1 |
| Boyanapalli, SS; Fuentes, F; Gonzalez, XP; Guo, Y; Kong, AN; Li, W; Pung, D; Ramirez, CN | 1 |
| Chiao, FB; Chiao, JW; Dai, W; Fang, Y; Feng, J; Liu, D; Liu, XM; Puccio, GM; Wang, LG | 1 |
| He, M; Kawamura, T; Vanaja, DK; Yin, P; Young, CY | 1 |
| Bommareddy, A; Fisher, AL; Hahm, ER; Jiang, Y; Powolny, AA; Singh, SV; Xiao, D | 1 |
| Gong, A; He, M; Karnes, RJ; Krishna Vanaja, D; Yin, P; Young, CY | 1 |
| Bhattacharya, RK; Mukherjee, S; Roy, M | 1 |
| Singh, SV; Xiao, D | 3 |
| Hwang, ES; Lee, HJ | 1 |
| Bommareddy, A; Hahm, ER; Kelley, EE; Kim, SH; Moura, MB; Normolle, D; Powolny, AA; Singh, SV; Van Houten, B; Xiao, D | 1 |
| Chiao, JW; Wang, LG | 1 |
| Powolny, AA; Singh, SV | 1 |
| Beumer, JH; Bommareddy, A; Hahm, ER; Nelson, JB; Normolle, DP; Powolny, AA; Singh, SV | 1 |
| Chen, YY; Chung, JG; Hsia, TC; Huang, YT; Ji, BC; Ko, YC; Tang, NY; Wu, SH; Yang, JL; Yang, JS; Yu, CS | 1 |
| Hahm, ER; Kim, SH; Sakao, K; Sehrawat, A; Singh, SV | 1 |
| Desineni, S; Hahm, ER; Sakao, K; Singh, SV | 1 |
| Hudson, TS; Hursting, SD; Kim, YS; Perkins, SN; Wang, TC; Wang, TT; Young, HA | 1 |
| Li, C; Li, RW; Wang, TT | 1 |
| Chen, D; Chen, XM; Deng, C; Eischeid, AN; Gong, AY; Xiao, J; Young, CY | 1 |
| Chen, YR; Han, J; Kong, AN; Kori, R; Tan, TH | 1 |
| Chiao, JW; Chung, FL; Conaway, CC; Liu, D; Ramaswamy, G; Wang, L; Wu, H | 1 |
| Johnson, CS; Singh, SV; Trump, DL; Xiao, D | 1 |
| Choi, S; Lew, KL; Nelson, JB; Singh, SV; Xiao, D; Zeng, Y | 1 |
| Chen, C; Gélinas, C; Kong, AN; Shen, G; Xu, C | 1 |
| Choi, S; Lee, YJ; Singh, SV; Xiao, D | 1 |
| Gopalkrishnan, A; Keum, YS; Kim, JH; Kong, AN; Nair, S; Shen, G; Xu, C; Yuan, X | 1 |
| Conney, A; Keum, YS; Kim, JH; Kong, AN; Reddy, B; Xu, C | 1 |
| Conney, AH; Gopalakrishnan, A; Hu, R; Keum, YS; Khor, TO; Kim, JH; Kong, AN; Lin, W; Reddy, B; Shen, G; Xu, C; Zheng, X | 1 |
| Chiao, JW; Liu, XM; Wang, LG | 1 |
| Dhir, R; Lew, KL; Marynowski, SW; Singh, SV; Xiao, D; Xiao, H; Zeng, Y | 1 |
| Beklemisheva, A; Chiao, JW; Feng, J; Ferrari, AC; Liu, XM; Wang, LG | 1 |
| Khor, TO; Kim, JH; Kong, AN; Li, W; Ma, J; Pan, Z; Shen, G; Xu, C; Yu, S; Yuan, X | 1 |
| Barve, A; Hao, X; Keum, YS; Khor, TO; Kong, AN; Reddy, B; Yang, CS | 1 |
| Ahmed, T; Amin, S; Arshad, R; Chiao, JW; Chung, F; Conaway, CC; Krzeminski, J | 1 |
1 review(s) available for phenethyl isothiocyanate and Prostatic Neoplasms
| Article | Year |
|---|---|
Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review).
Topics: Animals; Anticarcinogenic Agents; Epigenesis, Genetic; Humans; Isothiocyanates; Male; Prostatic Neoplasms | 2010 |
43 other study(ies) available for phenethyl isothiocyanate and Prostatic Neoplasms
| Article | Year |
|---|---|
DNA methylome, transcriptome, and prostate cancer prevention by phenethyl isothiocyanate in TRAMP mice.
Topics: Animals; Anticarcinogenic Agents; DNA Methylation; Epigenome; Female; Gene Expression Regulation, Neoplastic; Isothiocyanates; Male; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Prostatic Neoplasms | 2021 |
Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells.
Topics: Androgens; Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Chalcones; Drug Therapy, Combination; Humans; Isothiocyanates; Male; Mice; Mice, SCID; Prostatic Neoplasms | 2018 |
Transcriptomic Analysis of Histone Methyltransferase Setd7 Knockdown and Phenethyl Isothiocyanate in Human Prostate Cancer Cells.
Topics: Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Histone-Lysine N-Methyltransferase; Humans; Isothiocyanates; Male; Prostatic Neoplasms; Transcriptome | 2018 |
p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition.
Topics: Animals; Anticarcinogenic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Isothiocyanates; Male; Mice; Mutation; Phosphorylation; Prostatic Neoplasms; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2019 |
Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF.
Topics: Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Humans; Isothiocyanates; Male; MicroRNAs; p300-CBP Transcription Factors; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Up-Regulation | 2013 |
In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Gene Knockdown Techniques; Humans; Isothiocyanates; Male; Mice; Prostatic Neoplasms; RNA Interference; RNA, Small Interfering; Vimentin | 2013 |
CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Chemoprevention; Humans; Isothiocyanates; Male; Mice; Mice, Transgenic; Molecular Targeted Therapy; Prostatic Neoplasms; Receptors, CXCR4; RNA, Small Interfering; Sulfoxides; Xenograft Model Antitumor Assays | 2015 |
Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194.
Topics: Bone Morphogenetic Protein 1; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Neoplasm Invasiveness; Prostatic Neoplasms | 2016 |
Establishment of prostate cancer spheres from a prostate cancer cell line after phenethyl isothiocyanate treatment and discovery of androgen-dependent reversible differentiation between sphere and neuroendocrine cells.
Topics: Anticarcinogenic Agents; Cell Differentiation; Cell Line, Tumor; Humans; Isothiocyanates; Male; Neoplastic Stem Cells; Neuroendocrine Cells; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | 2016 |
Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Tumor Suppressor Proteins | 2016 |
De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc.
Topics: Blotting, Western; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Histone Deacetylases; Humans; Isothiocyanates; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Sp1 Transcription Factor | 2008 |
Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.
Topics: Anticarcinogenic Agents; Antioxidants; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cysteine; Flow Cytometry; G2 Phase; Humans; Isothiocyanates; Leupeptins; Male; Prostatic Neoplasms; Protein Isoforms; Tubulin | 2009 |
Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Caenorhabditis elegans; Cell Line, Tumor; Humans; Isothiocyanates; Male; Mice; Mice, Nude; Microtubule-Associated Proteins; Monomeric GTP-Binding Proteins; Neuropeptides; Oncogene Protein v-akt; Phosphorylation; Prostatic Neoplasms; Protein Kinases; Ras Homolog Enriched in Brain Protein; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2009 |
Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Cell Division; Cell Line, Tumor; Cell Proliferation; G2 Phase; Humans; Interleukin-6; Isothiocyanates; Janus Kinase 2; Male; Phosphorylation; Prostatic Neoplasms; Receptors, Androgen; STAT3 Transcription Factor | 2009 |
Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Caspases; Cell Line, Tumor; Cytochromes c; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Humans; Isothiocyanates; Male; Prostatic Neoplasms; Protein Kinase C; Telomerase | 2009 |
Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Docetaxel; Drug Interactions; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Male; Mice; Mice, Nude; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Taxoids | 2010 |
p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cytoplasm; Fibroblasts; Histones; Humans; Isothiocyanates; Male; Mice; Mice, Knockout; Neoplasm Transplantation; Phosphorylation; Prostatic Neoplasms; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2010 |
Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Brassicaceae; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin B1; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression; Glucosinolates; Humans; Isothiocyanates; Male; Phytotherapy; Plant Extracts; Prostatic Neoplasms | 2010 |
Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.
Topics: Anticarcinogenic Agents; Cell Death; Cell Line, Tumor; Electron Transport Complex III; Humans; Isothiocyanates; Male; Oxidative Phosphorylation; Prostatic Neoplasms; Reactive Oxygen Species | 2010 |
Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes.
Topics: Antioxidants; Blotting, Western; Cell Line, Tumor; Gene Expression Profiling; Humans; Hydrogen Peroxide; Isothiocyanates; Male; Oxidative Stress; Polymerase Chain Reaction; Prostatic Neoplasms; Reactive Oxygen Species | 2010 |
Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Autophagy; Blotting, Western; Cadherins; Clusterin; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Immunohistochemistry; In Situ Nick-End Labeling; Incidence; Isothiocyanates; Lung Neoplasms; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Prostatic Neoplasms; Tumor Burden; Up-Regulation; Vegetables | 2011 |
Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspases; Cell Division; Cell Proliferation; Comet Assay; Cytochromes c; DNA Damage; Flow Cytometry; Fluorescent Antibody Technique; G2 Phase; Humans; Isothiocyanates; Male; Membrane Potential, Mitochondrial; Mitochondria; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 2011 |
Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.
Topics: Cell Line, Tumor; Cell Movement; Humans; Immunohistochemistry; Isothiocyanates; Male; Prostatic Neoplasms; Receptors, Notch; RNA Interference | 2011 |
Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo.
Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Isothiocyanates; Male; Mice; Mice, Transgenic; Prostatic Neoplasms | 2012 |
Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment.
Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Cell Growth Processes; Cell-Matrix Junctions; Humans; Immunohistochemistry; Isothiocyanates; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Xenograft Model Antitumor Assays | 2012 |
Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Diet; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Mice, Nude; Prostate; Prostatic Neoplasms; Signal Transduction; Transcriptome; Transplantation, Heterologous | 2013 |
miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein.
Topics: Blotting, Western; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Male; MicroRNAs; Oligonucleotides, Antisense; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Receptors, Cytoplasmic and Nuclear; RNA; Transcription, Genetic; Up-Regulation | 2012 |
Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.
Topics: Adenosine Triphosphate; Apoptosis; Blotting, Western; DNA Fragmentation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Down-Regulation; Humans; Isothiocyanates; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Propidium; Prostatic Neoplasms; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Separation; Coloring Agents; Cyclin D; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Flow Cytometry; G1 Phase; Humans; Isothiocyanates; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Neoplasm Transplantation; Neoplasms; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; S Phase; Time Factors; Tumor Suppressor Proteins; Up-Regulation; Vegetables | 2004 |
Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Apoptosis; bcl-X Protein; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine Proteinase Inhibitors; G2 Phase; Gene Expression Regulation; Humans; Isothiocyanates; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Transfection | 2004 |
Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.
Topics: Adenocarcinoma; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Immunoblotting; Intracellular Membranes; Isothiocyanates; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; Mitochondria; Neoplasms; Plant Preparations; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Vegetables | 2005 |
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Topics: Anticarcinogenic Agents; bcl-X Protein; Cell Line, Tumor; Cell Survival; Cyclin D1; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; I-kappa B Proteins; Isothiocyanates; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Sulfoxides; Thiocyanates; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2005 |
Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.
Topics: Apoptosis; Carcinogens; Cell Line, Tumor; Cell Survival; Humans; Isothiocyanates; Male; Mitogen-Activated Protein Kinases; Prostatic Neoplasms | 2005 |
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Extracellular Signal-Regulated MAP Kinases; Food Preservatives; Humans; Isothiocyanates; JNK Mitogen-Activated Protein Kinases; Male; Prostatic Neoplasms; Signal Transduction; Sulfoxides; Thiocyanates; Transcription Factor AP-1; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2006 |
Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Cell Proliferation; Curcumin; Drug Interactions; ErbB Receptors; Humans; Isothiocyanates; Luciferases; Male; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Transfection; Tumor Cells, Cultured | 2006 |
Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Curcumin; Immunocompromised Host; Immunohistochemistry; Infusions, Parenteral; Isothiocyanates; Male; Mice; Prostatic Neoplasms; Transplantation, Heterologous | 2006 |
Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate.
Topics: Androgen Receptor Antagonists; Anticarcinogenic Agents; Cell Line, Tumor; Cycloheximide; Humans; Isothiocyanates; Leupeptins; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen; Sp1 Transcription Factor; Transcription, Genetic | 2006 |
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Male; Membrane Potentials; Mice; Mice, Nude; Mitochondria; Neoplasm Transplantation; Prostatic Neoplasms; Reactive Oxygen Species | 2006 |
Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer.
Topics: Acetylation; Anticarcinogenic Agents; Butyrates; Chromatin; CpG Islands; Deoxycytidine; DNA Methylation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Isothiocyanates; Male; Neoplasms, Hormone-Dependent; Promoter Regions, Genetic; Prostatic Neoplasms; Transcription, Genetic; Tumor Cells, Cultured | 2007 |
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
Topics: Active Transport, Cell Nucleus; Antioxidants; Cell Death; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heme Oxygenase-1; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; JNK Mitogen-Activated Protein Kinases; Kelch-Like ECH-Associated Protein 1; Male; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; NF-E2-Related Factor 2; Phosphorylation; Prostatic Neoplasms; Response Elements; Tumor Cells, Cultured | 2006 |
Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; bcl-Associated Death Protein; Caspase 3; Cell Proliferation; Curcumin; Diet; Disease Models, Animal; Drug Therapy, Combination; Forkhead Box Protein O1; Forkhead Transcription Factors; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Time Factors | 2008 |
Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate.
Topics: Anticarcinogenic Agents; Cell Cycle; Cell Division; Humans; Isothiocyanates; Male; Prostatic Neoplasms; Tumor Cells, Cultured | 2000 |
Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.
Topics: Anticarcinogenic Agents; Apoptosis; Enzyme Activation; Humans; Isothiocyanates; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |