Compounds > phenethyl isothiocyanate
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phenethyl isothiocyanate and Lung Neoplasms

phenethyl isothiocyanate has been researched along with Lung Neoplasms in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.64)18.7374
1990's24 (43.64)18.2507
2000's13 (23.64)29.6817
2010's13 (23.64)24.3611
2020's3 (5.45)2.80

Authors

AuthorsStudies
Lai, B; Liang, H; Yuan, Q1
Boldry, EJ; Carmella, SG; Hatsukami, DK; Hecht, SS; Tessier, K; Tretyakova, NY; Wang, R; Yuan, JM1
Cao, L; Chen, M; Guo, X; Ren, Y; Wu, X; Xu, K; Zhang, Q1
Di Pasqua, AJ; Sun, M1
Cao, L; Meng, Z; Song, Q; Wang, H; Wang, L; Wu, X; Xu, K; Zhang, Q1
Chen, CY; Chen, HY; Cheng, ZY; Chou, YC; Chueh, FS; Chung, JG; Hsia, TC; Hsiao, YT; Huang, YP; Jiang, YW; Peng, SF1
Dang, UJ; Di Pasqua, AJ; Shi, Y; Sun, M1
Di Pasqua, AJ; Jay, M; Shi, Y; Yang, YT1
Dey, M; Knudsen, D; Liu, Y; Upadhyaya, B; Wang, D1
Chung, FL; Mi, L1
Balansky, R; D'Agostini, F; De Flora, S; Izzotti, A; Mastracci, L; Pennisi, TM; Steele, VE1
Balansky, R; De Flora, S; Ganchev, G; Iltcheva, M; Steele, VE1
Li, Y; Liu, B; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y1
Han, W; Shi, M; Spivack, SD; Tan, XL; Tang, H1
Beumer, JH; Bommareddy, A; Hahm, ER; Nelson, JB; Normolle, DP; Powolny, AA; Singh, SV1
Li, Y; Liu, B; Wu, H; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y1
Chung, FL; Mi, L; Veenstra, TD; Xiao, Z1
Gackowska, L; Grzanka, A; Klimaszewska, A; Pawlik, A; Szczepanski, MA; Zuryn, A1
Hu, KS; Huang, P; Li, XB; Luo, HY; Wu, WJ; Xu, RH; Yang, J; Zeng, ZL; Zhang, Y1
Bliss, RL; Hecht, SS; Kenney, PM; McIntee, EJ; Upadhyaya, P; Wang, M1
Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM1
Chun, JA; Hollenberg, PF; von Weymarn, LB1
Chen, HL; Lai, BT; Liu, MQ; Xia, D; Yang, F; Ye, B; Zhang, YX1
Chung, FL; Conrads, TP; Goldman, R; Govind, S; Hood, BL; Mi, L; Saha, DT; Veenstra, TD; Wang, X1
Anderson, MW; Crist, KA; Kelloff, GJ; Lubet, RA; Matzinger, SA; Pereira, MA; Steele, VE; Stoner, GD; You, M1
Hecht, SS; Isaacs, S; Trushin, N1
Amin, S; Hecht, SS; Lin, JM; Trushin, N1
Adam-Rodwell, G; Morse, MA; Stoner, GD2
Chung, FL; Eklind, KI; Morse, MA; Xu, Y1
Chung, FL; Furukawa, F; Hayashi, Y; Ikezaki, S; Nishikawa, A; Takahashi, M; Tanakamaru, ZY1
Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E1
Akerkar, SA; Borukhova, A; Carmella, SG; Chung, FL; Hecht, SS; Richie, JP; Skowronski, L1
Chung, FL; Furukawa, F; Hayashi, Y; Ikezaki, S; Nishikawa, A; Takahashi, M; Tanakamaru, Z; Uneyama, C1
Akerkar, S; Borukhova, A; Carmella, SG; Hecht, SS; Rigotty, J; Rivenson, A; Trushin, N1
Hecht, SS3
Chen, L; Mohr, SN; Yang, CS1
Foiles, PG; Hecht, SS; Miglietta, LM; Staretz, ME1
Akerkar, SA; Borukhova, A; Carmella, SG; Hecht, SS1
Espiritu, I; Willits, NH; Witschi, H; Yu, M1
Furukawa, F; Hirose, M; Ikeda, T; Imazawa, T; Kasahara, K; Miyauchi, M; Nakamura, H; Nishikawa, A; Tanakamaru, Z1
Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M1
Hecht, SS; Kenney, PM; Liang, H; Staretz, ME; Sticha, KR; Wang, M1
Yang, CS1
Amin, S; Chiao, JW; Chung, FL; Conaway, CC; Dai, W; Reinhardt, J; Wang, CX; Whysner, J; Yang, YM1
Espiritu, I; Pinkerton, KE; Suffia, M; Witschi, H1
Amin, SG; Chung, FL; Eklind, KI; Morse, MA1
Chung, FL; Eklind, KI; Morse, MA1
Amin, SG; Chung, FL; Hecht, SS; Morse, MA; Reinhardt, JC; Stoner, GD1
Chung, FL; Hecht, SS; Morse, MA1
Amin, SG; Chung, FL; Hecht, SS; Morse, MA1
Amin, SG; Chung, FL; Conran, PB; Hecht, SS; Mandal, S; Morse, MA; Stoner, GD; Wang, CX1

Reviews

5 review(s) available for phenethyl isothiocyanate and Lung Neoplasms

ArticleYear
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea.
    Annals of the New York Academy of Sciences, 1993, May-28, Volume: 686

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catechin; DNA; DNA Damage; Indoles; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Rats; Rats, Inbred F344; Tea; Thiocyanates; Vegetables

1993
Chemoprevention of lung cancer by isothiocyanates.
    Advances in experimental medicine and biology, 1996, Volume: 401

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitrosamines

1996
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke.
    Environmental health perspectives, 1997, Volume: 105 Suppl 4

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Humans; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Rats

1997
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
    The Journal of nutrition, 1999, Volume: 129, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Isothiocyanates; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Vegetables

1999
Inhibition of carcinogenesis and toxicity by dietary constituents.
    Advances in experimental medicine and biology, 2001, Volume: 500

    Topics: Acetaminophen; Allyl Compounds; Analgesics, Non-Narcotic; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzene; Cytochrome P-450 CYP2E1 Inhibitors; Diet; Disease Models, Animal; Enzyme Inhibitors; Garlic; Humans; Isothiocyanates; Lung Neoplasms; Sulfides; Sulfones; Sulfur Compounds; Tea; Vegetables

2001

Trials

2 trial(s) available for phenethyl isothiocyanate and Lung Neoplasms

ArticleYear
Effects of 2-Phenethyl Isothiocyanate on Metabolism of 1,3-Butadiene in Smokers.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:1

    Topics: Administration, Oral; Adult; Anticarcinogenic Agents; Butadienes; Carcinogens; Cigarette Smoking; Feeding Behavior; Female; Genotyping Techniques; Glutathione Transferase; Humans; Isothiocyanates; Lung Neoplasms; Male; Middle Aged; Smokers

2020
Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers.
    Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:6

    Topics: Acetaminophen; Administration, Oral; Adult; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Food-Drug Interactions; Humans; Isothiocyanates; Lung Neoplasms; Male; Middle Aged; Oxidation-Reduction; Reference Values; Vegetables

1996

Other Studies

48 other study(ies) available for phenethyl isothiocyanate and Lung Neoplasms

ArticleYear
Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.
    Journal of natural products, 2008, Volume: 71, Issue:11

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Apoptosis; Brassica; Cell Cycle; Dose-Response Relationship, Drug; Humans; Isothiocyanates; Lung Neoplasms; Mice; Sulfoxides; Thiocyanates; Transplantation, Heterologous

2008
Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non-small cell lung cancer cells via endoplasmic reticulum stress-mediated degradation of Mcl-1.
    Molecular carcinogenesis, 2020, Volume: 59, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Female; Gefitinib; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Oxidative Stress; Reactive Oxygen Species; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
A Method for Liposome Co-encapsulation of Phenethyl Isothiocyanate and Cisplatin and Determining Its Toxicity Against Lung and Lung Cancer Cells.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2279

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Humans; Isothiocyanates; Liposomes; Lung Neoplasms

2021
Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells.
    Molecular carcinogenesis, 2018, Volume: 57, Issue:4

    Topics: A549 Cells; Animals; Anticarcinogenic Agents; Autophagy; Beclin-1; Cell Line, Tumor; Cell Movement; Humans; Isothiocyanates; Janus Kinase 2; Lung Neoplasms; Mice; Molecular Structure; Neoplasm Metastasis; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays

2018
Phenethyl Isothiocyanate Induces Apoptotic Cell Death Through the Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells
    Anticancer research, 2018, Volume: 38, Issue:4

    Topics: Apoptosis; Calcium Signaling; Cell Line, Tumor; Drug Resistance, Neoplasm; Gefitinib; Humans; Isothiocyanates; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Quinazolines; Reactive Oxygen Species; Signal Transduction

2018
Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer.
    Molecules (Basel, Switzerland), 2019, Feb-22, Volume: 24, Issue:4

    Topics: A549 Cells; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Compounding; Drug Synergism; Humans; Isothiocyanates; Liposomes; Lung Neoplasms; Nanoparticles

2019
Enhanced toxicity of cisplatin with chemosensitizer phenethyl isothiocyanate toward non-small cell lung cancer cells when delivered in liposomal nanoparticles.
    Chemical research in toxicology, 2014, Jun-16, Volume: 27, Issue:6

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Isothiocyanates; Liposomes; Lung Neoplasms; Molecular Structure; Nanoparticles; Particle Size; Structure-Activity Relationship; Surface Properties

2014
Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells.
    BMC cancer, 2014, Aug-15, Volume: 14

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Culture Techniques; Cell Proliferation; HeLa Cells; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Receptors, TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays

2014
Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
    Nutrition and cancer, 2008, Volume: 60 Suppl 1

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine; DNA Damage; Humans; Isothiocyanates; Lung Neoplasms; Oxidative Stress; Protein Binding; Protein Carbonylation; Sulfoxides; Thiocyanates; Tubulin

2008
Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:6

    Topics: Adenoma; Age Factors; Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Bone Marrow Cells; Budesonide; Carcinoma; DNA Adducts; Drug Screening Assays, Antitumor; Epithelial Cells; Female; Isothiocyanates; Lung; Lung Diseases; Lung Neoplasms; Male; Mice; Precancerous Conditions; Pregnancy; Time Factors; Tobacco Smoke Pollution

2009
Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.
    International journal of cancer, 2010, Mar-01, Volume: 126, Issue:5

    Topics: Acetylcysteine; Animals; Animals, Newborn; Anticarcinogenic Agents; Budesonide; Disease Models, Animal; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Tobacco Smoke Pollution

2010
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
    BMC cancer, 2010, Jun-09, Volume: 10

    Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Humans; Inhibitory Concentration 50; Isothiocyanates; Lung Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; NF-kappa B; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transfection; Twist-Related Protein 1

2010
Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.
    The Journal of nutrition, 2010, Volume: 140, Issue:8

    Topics: Anticarcinogenic Agents; Brassica; Bronchi; Camellia sinensis; Catechin; Cell Division; Cell Line; Cell Line, Tumor; Epithelial Cells; Gene Expression; Glutathione S-Transferase pi; Humans; Isothiocyanates; Lung; Lung Neoplasms; NAD(P)H Dehydrogenase (Quinone); Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfoxides; Thiocyanates

2010
Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.
    Journal of the National Cancer Institute, 2011, Apr-06, Volume: 103, Issue:7

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Autophagy; Blotting, Western; Cadherins; Clusterin; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Immunohistochemistry; In Situ Nick-End Labeling; Incidence; Isothiocyanates; Lung Neoplasms; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Prostatic Neoplasms; Tumor Burden; Up-Regulation; Vegetables

2011
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.
    The British journal of nutrition, 2011, Volume: 106, Issue:12

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin B1; Gene Expression; Humans; Isothiocyanates; Lung Neoplasms; MAP Kinase Signaling System; Neoplasm Metastasis; Transcription Factor AP-1

2011
Proteomic analysis of covalent modifications of tubulins by isothiocyanates.
    The Journal of nutrition, 2012, Volume: 142, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cysteine; Diet; Electrophoresis, Gel, Two-Dimensional; Humans; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Microtubules; Mitosis; Phytotherapy; Plant Extracts; Protein Binding; Protein Isoforms; Proteomics; Tubulin

2012
Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:10

    Topics: Actins; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Cytoskeleton; Dose-Response Relationship, Drug; Humans; Isothiocyanates; Lung Neoplasms; Time Factors; Tubulin

2012
β-phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotype.
    Biochemical pharmacology, 2013, Feb-15, Volume: 85, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glutathione; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Nude; Neoplasms, Experimental; Organoplatinum Compounds; Oxaliplatin; Platinum Compounds

2013
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.
    Carcinogenesis, 2002, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cysteine; Disease Models, Animal; Female; Inositol; Isothiocyanates; Lung Neoplasms; Mice; Thiocarbamates

2002
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
    Cancer research, 2005, Sep-15, Volume: 65, Issue:18

    Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates

2005
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
    Carcinogenesis, 2006, Volume: 27, Issue:4

    Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Chemoprevention; Cytochrome P-450 CYP2A6; Humans; Isothiocyanates; Lung Neoplasms; Mixed Function Oxygenases; Smoking

2006
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.
    BMC cancer, 2007, May-29, Volume: 7

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Isothiocyanates; Lung Neoplasms; Nicotiana; Nitrosamines; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar

2007
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.
    Cancer research, 2007, Jul-01, Volume: 67, Issue:13

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cattle; Cell Line, Tumor; DNA Damage; Humans; Isothiocyanates; Lung Neoplasms; Oxidative Stress; Protein Binding; Reactive Oxygen Species; Serum Albumin, Bovine; Sulfoxides; Thiocyanates

2007
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Base Sequence; Carcinogens; Codon; Crosses, Genetic; DNA Primers; Female; Genes, p53; Genes, ras; Isothiocyanates; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred Strains; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Species Specificity

1995
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Stomach Neoplasms

1994
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
    Cancer letters, 1993, Nov-01, Volume: 74, Issue:3

    Topics: Animals; Benzo(a)pyrene; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Pyridines; Skin Neoplasms; Stomach Neoplasms

1993
The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lung.
    Cancer letters, 1993, Jul-30, Volume: 71, Issue:1-3

    Topics: Animals; Benzo(a)pyrene; DNA; Drug Interactions; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Nitrosamines; Thiocyanates

1993
Lung tumors in strain A mice: application for studies in cancer chemoprevention.
    Journal of cellular biochemistry. Supplement, 1993, Volume: 17F

    Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Disease Models, Animal; DNA; DNA Damage; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; Male; Methylation; Mice

1993
Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:2

    Topics: Animals; Body Weight; Cricetinae; Female; Isothiocyanates; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Mesocricetus; Nitrosamines; Organ Size; Pancreatic Neoplasms

1996
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
    Cancer research, 1996, Feb-15, Volume: 56, Issue:4

    Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms

1996
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995, Volume: 4, Issue:8

    Topics: Adult; Anticarcinogenic Agents; Carcinogens; Female; Follow-Up Studies; Glucuronates; Humans; Isothiocyanates; Lung Neoplasms; Male; Nitrosamines; Prognosis; Smoking; Vegetables

1995
Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
    Carcinogenesis, 1996, Volume: 17, Issue:6

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Cricetinae; Female; Isothiocyanates; Lung Neoplasms; Mesocricetus; Nitrosamines; Pancreatic Neoplasms

1996
Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:8

    Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; DNA Adducts; Isothiocyanates; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344

1996
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.
    Cancer research, 1997, Jan-15, Volume: 57, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Isothiocyanates; Lung; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344

1997
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:2

    Topics: Anticarcinogenic Agents; Biomarkers; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Creatinine; Enzyme Inhibitors; Glucuronates; Humans; Inactivation, Metabolic; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Nicotine; Nitrosamines; Proteus mirabilis; Pyridines

1997
Clinical development plan: phenethyl isothiocyanate.
    Journal of cellular biochemistry. Supplement, 1996, Volume: 26

    Topics: Animals; Anticarcinogenic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dogs; Drug Approval; Humans; Isothiocyanates; Lung Neoplasms; Mice; Neoplasms, Experimental; Rats; Research Design

1996
The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice.
    Carcinogenesis, 1998, Volume: 19, Issue:10

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Nicotiana; Plants, Toxic; Smoke; Tea

1998
Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.
    Cancer letters, 1999, Jul-01, Volume: 141, Issue:1-2

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Body Weight; Carcinogenicity Tests; Cricetinae; Dietary Supplements; Female; Isothiocyanates; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Neoplasms, Experimental; Nitrosamines; Pancreatic Neoplasms

1999
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Cancer letters, 2000, Mar-13, Volume: 150, Issue:1

    Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Drug Therapy, Combination; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines

2000
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
    Carcinogenesis, 2000, Volume: 21, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorometry; Inhibitory Concentration 50; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes, Liver

2000
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
    Cancer research, 2002, Jan-01, Volume: 62, Issue:1

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transcription Factor AP-1; Tumor Suppressor Protein p53

2002
Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.
    Carcinogenesis, 2002, Volume: 23, Issue:2

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Aspirin; Blotting, Western; Cell Nucleus; Cyclin D1; Cyclin D2; Cyclins; Cyclohexenes; Dexamethasone; Free Radical Scavengers; Immunohistochemistry; Inositol; Isothiocyanates; Limonene; Lung; Lung Neoplasms; Male; Mice; Nicotiana; Organoselenium Compounds; Tea; Terpenes; Time Factors

2002
Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice.
    Cancer letters, 1992, Feb-14, Volume: 62, Issue:1

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Drug Administration Schedule; Female; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Thiocyanates

1992
New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine.
    Cancer research, 1992, May-01, Volume: 52, Issue:9 Suppl

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Humans; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Structure; Nitrosamines; Rats; Rats, Inbred F344; Thiocyanates

1992
Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice.
    Cancer letters, 1990, Volume: 49, Issue:3

    Topics: Animals; Body Weight; Carcinogens; Female; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Thiocyanates

1990
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
    Basic life sciences, 1990, Volume: 52

    Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Nose Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Thiocyanates

1990
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
    Cancer research, 1989, Jun-01, Volume: 49, Issue:11

    Topics: Adenoma; Animals; Cricetinae; Cyanates; Female; Guanine; Isocyanates; Isothiocyanates; Lung; Lung Neoplasms; Mice; Microsomes; Nitrosamines; Thiocyanates

1989
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.
    Cancer research, 1989, Feb-01, Volume: 49, Issue:3

    Topics: Alkylation; Animals; Biological Assay; Diet; DNA; Isothiocyanates; Liver Neoplasms; Lung Neoplasms; Methylation; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates

1989