phenelzine has been researched along with Obsessive-Compulsive Disorder in 17 studies
Phenelzine: One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is now well documented that fluoxetine is a viable treatment option for patients with obsessive-compulsive disorder (OCD), and there is a small body of evidence indicating that monoamine oxidase inhibitors may be effective in at least a subset of patients." | 9.08 | Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder. ( Baer, L; Buttolph, ML; Jenike, MA; Minichiello, WE; Rauch, SL, 1997) |
| "A double-blind clinical trial of clomipramine versus phenelzine was carried out on 30 patients suffering from DSM-III obsessive-compulsive disorder." | 9.07 | Clomipramine versus phenelzine in obsessive-compulsive disorder. A controlled clinical trial. ( Bulbena, A; Marcos, T; Menchón, JM; Olivares, J; Vallejo, J, 1992) |
| "Leukopenia, a rare but serious side effect of many psychotropic agents including monoamine oxidase inhibitors (MAOIs), has not been reported in the literature in association with phenelzine." | 7.67 | A case report of leukopenia associated with phenelzine. ( Gilman, HE; Russakoff, LM; Tipermas, A, 1984) |
| "It is now well documented that fluoxetine is a viable treatment option for patients with obsessive-compulsive disorder (OCD), and there is a small body of evidence indicating that monoamine oxidase inhibitors may be effective in at least a subset of patients." | 5.08 | Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder. ( Baer, L; Buttolph, ML; Jenike, MA; Minichiello, WE; Rauch, SL, 1997) |
| "A double-blind clinical trial of clomipramine versus phenelzine was carried out on 30 patients suffering from DSM-III obsessive-compulsive disorder." | 5.07 | Clomipramine versus phenelzine in obsessive-compulsive disorder. A controlled clinical trial. ( Bulbena, A; Marcos, T; Menchón, JM; Olivares, J; Vallejo, J, 1992) |
| "Leukopenia, a rare but serious side effect of many psychotropic agents including monoamine oxidase inhibitors (MAOIs), has not been reported in the literature in association with phenelzine." | 3.67 | A case report of leukopenia associated with phenelzine. ( Gilman, HE; Russakoff, LM; Tipermas, A, 1984) |
| "Isocarboxazid was replaced by placebo, using double-blind procedure." | 2.67 | Efficacy of combined antidepressant therapy in resistant neurotic disorder. ( Murphy, S; Tyrer, P, 1990) |
| " Administering the monoamine oxidase inhibitor phenelzine in high dosage led to complete alleviation of his depression in 10 weeks, and 3 weeks afterwards the OCN was markedly improved." | 1.27 | A remarkable response of chronic severe obsessive-compulsive neurosis to phenelzine. ( Mahgoub, OM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mahgoub, N | 1 |
| Asemota, B | 1 |
| Alexopoulos, GS | 1 |
| Tipermas, A | 1 |
| Gilman, HE | 1 |
| Russakoff, LM | 1 |
| Jenike, MA | 2 |
| Surman, OS | 1 |
| Cassem, NH | 1 |
| Zusky, P | 1 |
| Anderson, WH | 1 |
| Davis, JM | 1 |
| Nasr, S | 1 |
| Spira, N | 1 |
| Vogel, C | 1 |
| Isberg, RS | 1 |
| Baer, L | 1 |
| Minichiello, WE | 1 |
| Rauch, SL | 1 |
| Buttolph, ML | 1 |
| Golwyn, DH | 1 |
| Sevlie, CP | 1 |
| Koran, LM | 1 |
| Leventhal, JL | 1 |
| Fireman, B | 1 |
| Jacobson, A | 1 |
| Vallejo, J | 1 |
| Olivares, J | 1 |
| Marcos, T | 1 |
| Bulbena, A | 1 |
| Menchón, JM | 1 |
| Carrasco, JL | 1 |
| Hollander, E | 1 |
| Schneier, FR | 1 |
| Liebowitz, MR | 1 |
| Tyrer, P | 1 |
| Murphy, S | 1 |
| Pascual, J | 1 |
| Combarros, O | 1 |
| Berciano, J | 1 |
| Baxter, LR | 1 |
| Thompson, JM | 1 |
| Schwartz, JM | 1 |
| Guze, BH | 1 |
| Phelps, ME | 1 |
| Mazziotta, JC | 1 |
| Selin, CE | 1 |
| Moss, L | 1 |
| Mahgoub, OM | 1 |
| Jacobson, JN | 1 |
| Jain, VK | 1 |
| Swinson, RP | 1 |
| Thomas, JG | 1 |
| Annesley, PT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical, Neurocognitive and Neuroimaging Variables Associated With Response to Treatment in Patients With OCD[NCT03993535] | Phase 4 | 250 participants (Actual) | Interventional | 2018-10-10 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for phenelzine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Anxiety: differential diagnosis and treatment from a biologic perspective.
Topics: Agoraphobia; Anxiety Disorders; Clinical Trials as Topic; Diagnosis, Differential; Diazepam; Double- | 1981 |
Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder.
Topics: Adult; Drug Administration Schedule; Female; Fluoxetine; Humans; Male; Monoamine Oxidase Inhibitors; | 1997 |
Clomipramine versus phenelzine in obsessive-compulsive disorder. A controlled clinical trial.
Topics: Adult; Clomipramine; Depressive Disorder; Dexamethasone; Dose-Response Relationship, Drug; Double-Bl | 1992 |
Efficacy of combined antidepressant therapy in resistant neurotic disorder.
Topics: Adult; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Diazepam; Do | 1990 |
13 other studies available for phenelzine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
The effect of riluzole augmentation in a patient with treatment-resistant obsessive-compulsive disorder, taking two other glutaminergic agents.
Topics: Adult; Clonazepam; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Fructose; GABA Modu | 2011 |
A case report of leukopenia associated with phenelzine.
Topics: Adult; Depressive Disorder; Female; Humans; Leukopenia; Obsessive-Compulsive Disorder; Phenelzine | 1984 |
Monoamine oxidase inhibitors in obsessive-compulsive disorder.
Topics: Adult; Anxiety Disorders; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Panic; P | 1983 |
A comparison of phenelzine and imipramine in an obsessive-compulsive patient.
Topics: Female; Humans; Imipramine; Middle Aged; Obsessive-Compulsive Disorder; Phenelzine | 1981 |
Fluoxetine versus phenelzine in obsessive-compulsive disorder.
Topics: Antidepressive Agents; Controlled Clinical Trials as Topic; Drug Administration Schedule; Fluoxetine | 1999 |
Pharmacotherapy of obsessive-compulsive disorder in a health maintenance organization.
Topics: Adolescent; Adult; Antidepressive Agents; California; Child; Drug Therapy; Female; Humans; Male; Med | 2000 |
Treatment outcome of obsessive compulsive disorder with comorbid social phobia.
Topics: Adult; Clomipramine; Comorbidity; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Obsess | 1992 |
Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment.
Topics: Adult; Clomipramine; Humans; Male; Obsessive-Compulsive Disorder; Phenelzine; Status Epilepticus | 1987 |
Trazodone treatment response in obsessive-compulsive disorder--correlated with shifts in glucose metabolism in the caudate nuclei.
Topics: Adult; Blood Glucose; Caudate Nucleus; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; | 1987 |
A remarkable response of chronic severe obsessive-compulsive neurosis to phenelzine.
Topics: Adult; Chronic Disease; Humans; Male; Obsessive-Compulsive Disorder; Phenelzine | 1987 |
Anorgasmia caused by an MAOI.
Topics: Adult; Female; Humans; Obsessive-Compulsive Disorder; Orgasm; Phenelzine; Sexual Dysfunctions, Psych | 1987 |
Phenelzine in obsessional neurosis.
Topics: Adult; Humans; Male; Obsessive-Compulsive Disorder; Phenelzine | 1970 |
Nardil response in a chronic obsessive compulsive.
Topics: Adolescent; Adult; Child; Chlordiazepoxide; Chronic Disease; Humans; Male; Middle Aged; Obsessive-Co | 1969 |