phenelzine has been researched along with Disease Models, Animal in 15 studies
Phenelzine: One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In ongoing studies of the neuroprotective properties of monoamine oxidase inhibitors, we found that phenelzine provided robust neuroprotection in the gerbil model of transient forebrain ischemia, with drug administration delayed up to 3 h post reperfusion." | 3.73 | Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine. ( Baker, G; Khan, MA; Moskal, JR; Tanay, VA; Todd, KG; Wood, PL, 2006) |
| "Phenelzine-treated mice showed decreased levels of pro-inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the injured spinal cord during the acute phase of inflammation." | 1.48 | Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury. ( Li, R; Sahu, S; Schachner, M, 2018) |
| "Phenelzine (PZ) is a U." | 1.46 | Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection. ( Cebak, JE; Hall, ED; Hill, RL; Singh, IN; Wang, JA, 2017) |
| " The results show that phenelzine is indeed capable of attenuating neuropathic pain behaviors in acute, delayed, and chronic administration schedules after injury in a rat model of SCI." | 1.43 | Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury. ( Acosta, G; Butler, B; Cao, P; Chen, Z; McCain, R; Ouyang, Z; Park, J; Shi, R; Tang, J; Vega-Alvarez, S; Zhang, W; Zheng, L, 2016) |
| "MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) has been used as an animal model to investigate the mechanisms of pain in MS." | 1.43 | Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis. ( Baker, G; Caliaperumal, J; Colbourne, F; Kerr, BJ; Paylor, JW; Potter, LE; Suh, JS; Tenorio, G; Winship, I, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Llewellyn, GN | 1 |
| Alvarez-Carbonell, D | 1 |
| Chateau, M | 1 |
| Karn, J | 1 |
| Cannon, PM | 1 |
| Li, R | 1 |
| Sahu, S | 1 |
| Schachner, M | 1 |
| Tan, AHY | 1 |
| Tu, W | 1 |
| McCuaig, R | 1 |
| Hardy, K | 1 |
| Donovan, T | 1 |
| Tsimbalyuk, S | 1 |
| Forwood, JK | 1 |
| Rao, S | 1 |
| Benson, CA | 1 |
| Wong, G | 1 |
| Tenorio, G | 2 |
| Baker, GB | 1 |
| Kerr, BJ | 2 |
| Chen, Z | 1 |
| Park, J | 1 |
| Butler, B | 1 |
| Acosta, G | 1 |
| Vega-Alvarez, S | 1 |
| Zheng, L | 1 |
| Tang, J | 1 |
| McCain, R | 1 |
| Zhang, W | 1 |
| Ouyang, Z | 1 |
| Cao, P | 1 |
| Shi, R | 1 |
| Potter, LE | 1 |
| Paylor, JW | 1 |
| Suh, JS | 1 |
| Caliaperumal, J | 1 |
| Colbourne, F | 1 |
| Baker, G | 2 |
| Winship, I | 1 |
| Cebak, JE | 1 |
| Singh, IN | 1 |
| Hill, RL | 1 |
| Wang, JA | 1 |
| Hall, ED | 1 |
| Ekuni, D | 1 |
| Firth, JD | 1 |
| Nayer, T | 1 |
| Tomofuji, T | 1 |
| Sanbe, T | 1 |
| Irie, K | 1 |
| Yamamoto, T | 1 |
| Oka, T | 1 |
| Liu, Z | 1 |
| Vielkind, J | 1 |
| Putnins, EE | 1 |
| Inagaki, H | 1 |
| Kiyokawa, Y | 1 |
| Takeuchi, Y | 1 |
| Mori, Y | 1 |
| Will, CC | 1 |
| Aird, F | 1 |
| Redei, EE | 1 |
| Wood, PL | 1 |
| Khan, MA | 1 |
| Moskal, JR | 1 |
| Todd, KG | 1 |
| Tanay, VA | 1 |
| Simpson, CF | 1 |
| Boucek, RJ | 1 |
| Gambarana, C | 1 |
| Scheggi, S | 1 |
| Tagliamonte, A | 1 |
| Tolu, P | 1 |
| De Montis, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase Ib Safety and Pharmacokinetics (PK)/ Pharmacodynamics (PD) Study to Determine the Dosage of Abraxane in Combination With Phenelzine Sulfate in Metastatic or Inoperable Locally Advanced Breast Cancer[NCT03505528] | Phase 1 | 8 participants (Actual) | Interventional | 2017-08-17 | Completed | ||
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for phenelzine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Topics: AIDS Dementia Complex; Animals; Anti-HIV Agents; Bone Marrow Cells; Brain; Busulfan; Cell Differenti | 2018 |
Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury.
Topics: Analysis of Variance; Animals; Biogenic Amines; Cytokines; Disease Models, Animal; Dose-Response Rel | 2018 |
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Topics: Animals; Cell Differentiation; Co-Repressor Proteins; Cytokines; Disease Models, Animal; Flavin-Aden | 2019 |
The MAO inhibitor phenelzine can improve functional outcomes in mice with established clinical signs in experimental autoimmune encephalomyelitis (EAE).
Topics: Analysis of Variance; Animals; CD4 Antigens; Central Nervous System; Chromatography, High Pressure L | 2013 |
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
Topics: Animals; Behavior, Animal; Contusions; Disease Models, Animal; Hydralazine; Hyperalgesia; Male; Neur | 2016 |
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis.
Topics: Animals; Antidepressive Agents; Calcium-Binding Proteins; Disease Models, Animal; Encephalomyelitis, | 2016 |
Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection.
Topics: Acrolein; Aldehydes; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Disease Models, Animal; Ma | 2017 |
Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model.
Topics: Alveolar Bone Loss; Animals; Chronic Disease; Disease Models, Animal; Epithelial Cells; Hydrogen Per | 2009 |
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Clonidine; Disease Mod | 2010 |
Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Breeding; Depressive Disorder; Desipram | 2003 |
Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine.
Topics: Acrolein; Aldehydes; Animals; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Gerbil | 2006 |
The B-aminopropionitrile-fed turkey: a model for detecting potential drug action on arterial tissue.
Topics: Aminopropionitrile; Animals; Aorta, Abdominal; Aortic Aneurysm; Aortic Diseases; Disease Models, Ani | 1983 |
Animal models for the study of antidepressant activity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |