Page last updated: 2024-10-28

phenelzine and Bipolar Disorder

phenelzine has been researched along with Bipolar Disorder in 51 studies

Phenelzine: One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.

Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Research Excerpts

ExcerptRelevanceReference
" Among the more important recent discoveries are the efficacy of the tricyclic antidepressants for panic disorder and agoraphobia with panic attacks; the use of the monoamine oxidase inhibitors for the above disorders and for atypical depression and hysteroid dysphoria; the use of propranolol for anxiety disorders and for uncontrollable violent outbursts; the antianxiety and antipanic effects of clonidine; and the usefulness of lithium in treating schizophrenia and schizoaffective disorder and for emotionally unstable character disorders."4.76Newer uses for older psychotropic medications. ( Liebowitz, MR, 1982)
"All 10 patients tolerated the addition of an MAOI well, and mean self-rated side effect scores did not change significantly."2.68Addition of monoamine oxidase inhibitors to carbamazepine: preliminary evidence of safety and antidepressant efficacy in treatment-resistant depression. ( Ketter, TA; Parekh, PI; Post, RM; Worthington, K, 1995)
"Evidence supports the use of MAOIs in major depressive disorder, certain anxiety disorders and, to lesser extent, bipolar depression."2.53MAOIs - does the evidence warrant their resurrection? ( Bosanac, P; Castle, D; Menkes, D, 2016)
" Antidepressant monotherapy was found to be a safe and effective treatment for bipolar-II depression."1.34Efficacy and safety of antidepressant monotherapy in the treatment of bipolar-II depression. ( Agosti, V; Stewart, JW, 2007)
"84 per patients) and a total of 125 side effect reports were noted in 39 of 42 phenelzine patients (2."1.28Common side effects associated with monoamine oxidase inhibitors. ( Froese, C; Keller, FD; Remick, RA, 1989)
"Some types of bipolar depression may be considered as atypical if accompanied by reversed vegetative change."1.26Atypical depression. ( Davidson, JR; Miller, RD; Sullivan, JL; Turnbull, CD, 1982)

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-199039 (76.47)18.7374
1990's7 (13.73)18.2507
2000's2 (3.92)29.6817
2010's3 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shao, W1
Brown, T1
Ayub, S1
Frayne, J1
Nguyen, T1
Kohan, R1
De Felice, N1
Rampono, J1
Menkes, D1
Bosanac, P1
Castle, D1
Lattanzi, L1
Danesi, R1
Lastella, M1
Mungai, F1
Di Paolo, A1
Tuccori, M1
Cassano, GB1
Del Tacca, M1
AZUCENA CIALZETA, B1
KOCHOVA, E1
GREENBLATT, M1
GROSSER, GH1
WECHSLER, H1
SAINSBURY, MJ1
Agosti, V1
Stewart, JW2
Liebowitz, MR2
Silberman, EK1
Sullivan, JL2
Jonas, JM1
Pope, HG1
Hudson, JI1
Satlin, A1
Thomas, JM1
Rubin, EH1
Mattsson, A1
Seltzer, RL1
Quitkin, FM3
McGrath, P2
Stewart, J1
Howard, A1
Keitner, GI1
Pickar, D2
Murphy, DL2
Cohen, RM1
Campbell, IC1
Lipper, S1
Davidson, JR1
Miller, RD1
Turnbull, CD1
Teas, GA1
Greden, JF1
Carroll, BJ1
Ketter, TA1
Post, RM1
Parekh, PI1
Worthington, K1
McGrath, PJ1
Tricamo, E2
Nunes, EN1
Dassylva, B1
Shulman, KI1
Tailor, SA1
Walker, SE1
Gardner, DM1
Gillin, JC1
Wyatt, RJ1
Cohen, R1
Farkas, T1
Dunner, DL1
Fieve, RR1
Beckmann, H1
Lovett Doust, JW1
Mikhalenko, IN1
Kiseleva, LP1
Lapin, IP1
Baumbacher, G1
Hansen, MS1
Hartmann, PM1
Kusalic, M1
Ghadirian, AM1
Modai, I1
Beigel, Y1
Cygielman, G1
Remick, RA1
Froese, C1
Keller, FD1
Bowden, CL1
Seleshi, E1
Javors, MA1
Rihmer, Z1
Gombos, I1
Hada, Z1
Gyorgy, S1
Aroto, M1
Goldman, LS1
Tiller, JA1
Lieber, AL1
Rabkin, JG1
Harrison, W1
Dubovsky, SL1
Franks, RD1
Schrier, D1
Goff, DC1
Blackwell, B1
Shepherd, M1
Pritchard, DW1
Rump, EE1
Grivell, PD1
Raskin, A1
Schulterbrandt, JG1
Reatig, N1
Crook, TH1
Odle, D1
Gayford, JJ1
Parker, AL1
Phillips, EM1
Rowsell, AR1
Bowers, MB1
Morris, JB1
Beck, AT1
Feldstein, A1
Hoagland, H1
Rivera Oktem, M1
Freeman, H1
Bratfos, O1
Haug, JO1

Reviews

4 reviews available for phenelzine and Bipolar Disorder

ArticleYear
MAOIs - does the evidence warrant their resurrection?
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2016, Volume: 24, Issue:4

    Topics: Anxiety Disorders; Bipolar Disorder; Depressive Disorder, Major; Depressive Disorder, Treatment-Resi

2016
Newer uses for older psychotropic medications.
    Hospital & community psychiatry, 1982, Volume: 33, Issue:4

    Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive

1982
Atypical depression.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:3

    Topics: Alprazolam; Anxiety Disorders; Benzodiazepines; Bipolar Disorder; Character; Chronic Disease; Clinic

1984
Abuse of monoamine oxidase inhibitors.
    The American journal of drug and alcohol abuse, 1992, Volume: 18, Issue:4

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Hospitalization; Humans; Male; Middle Aged; Mo

1992

Trials

7 trials available for phenelzine and Bipolar Disorder

ArticleYear
Atypical depression.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:3

    Topics: Alprazolam; Anxiety Disorders; Benzodiazepines; Bipolar Disorder; Character; Chronic Disease; Clinic

1984
Monoamine oxidase inhibitors in bipolar endogenous depressives.
    Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:2

    Topics: Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Electroshock; Humans; Monoamine Oxi

1981
Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients.
    Archives of general psychiatry, 1982, Volume: 39, Issue:5

    Topics: Acute Disease; Adult; Affective Disorders, Psychotic; Bipolar Disorder; Clorgyline; Depressive Disor

1982
Addition of monoamine oxidase inhibitors to carbamazepine: preliminary evidence of safety and antidepressant efficacy in treatment-resistant depression.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:10

    Topics: Adult; Bipolar Disorder; Carbamazepine; Depressive Disorder; Double-Blind Method; Drug Administratio

1995
L-tryptophan in depression.
    Biological psychiatry, 1976, Volume: 11, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Biological Transport, Active; Bipolar Disorder; Clinical Tr

1976
Depression subtypes and response to phenelzine, diazepam, and a placebo. Results of a nine hospital collaborative study.
    Archives of general psychiatry, 1974, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Depression; Diazepam; Drug E

1974
MAO inhibition and antidepressant activity.
    International journal of neuropsychiatry, 1965, Volume: 1, Issue:4

    Topics: Adult; Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depression; Humans; Isocar

1965

Other Studies

41 other studies available for phenelzine and Bipolar Disorder

ArticleYear
Phenelzine Withdrawal-Associated Psychosis and Mania.
    Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:4

    Topics: Adult; Antidepressive Agents; Bipolar Disorder; Humans; Male; Monoamine Oxidase Inhibitors; Phenelzi

2017
The comprehensive management of pregnant women with major mood disorders: a case study involving phenelzine, lithium, and quetiapine.
    Archives of women's mental health, 2014, Volume: 17, Issue:1

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Cesarean Section; Dibenzothiaz

2014
Serotonin syndrome and the T102-->C polymorphism of the 5-HT2A receptor: a case report.
    Bipolar disorders, 2008, Volume: 10, Issue:5

    Topics: Adult; Alleles; Antidepressive Agents; Bipolar Disorder; Diagnosis, Differential; Dose-Response Rela

2008
[Phenelzine associated with psychotherapy in depression].
    La Semana medica, 1962, Oct-01, Volume: 121

    Topics: Bipolar Disorder; Depression; Depressive Disorder; Humans; Phenelzine; Psychotherapy; Psychotic Diso

1962
[EXCRETION OF CATECHOLAMINES AND FLUORESCENT METABOLITES IN THE URINE IN PSYCHOTICS DURING ADMINISTRATION OF SOME PHARMACOTHERAPEUTIC AGENTS].
    Activitas nervosa superior, 1963, Volume: 5

    Topics: Adolescent; Bipolar Disorder; Catecholamines; Chlorpromazine; Humans; Insulin; Mental Disorders; Phe

1963
DIFFERENTIAL RESPONSE OF HOSPITALIZED DEPRESSED PATIENTS TO SOMATIC THERAPY.
    The American journal of psychiatry, 1964, Volume: 120

    Topics: Bipolar Disorder; Depression; Depressive Disorder; Depressive Disorder, Major; Electroconvulsive The

1964
ELECTROPLEXY IN FIRST ATTACKS OF DEPRESSION OVER THE AGE OF FIFTY.
    The Medical journal of Australia, 1964, Jun-20, Volume: 1

    Topics: Amitriptyline; Bipolar Disorder; Cerebrovascular Disorders; Depression; Depressive Disorder; Drug Th

1964
Efficacy and safety of antidepressant monotherapy in the treatment of bipolar-II depression.
    International clinical psychopharmacology, 2007, Volume: 22, Issue:5

    Topics: Antidepressive Agents; Bipolar Disorder; Data Interpretation, Statistical; Dose-Response Relationshi

2007
Undiagnosed vomiting in an older woman: unsuspected bulimia.
    The American journal of psychiatry, 1984, Volume: 141, Issue:7

    Topics: Bipolar Disorder; Feeding and Eating Disorders; Female; Humans; Hyperphagia; Imipramine; Middle Aged

1984
Case report of a toxic reaction from a combination of tryptophan and phenelzine.
    The American journal of psychiatry, 1984, Volume: 141, Issue:2

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; D

1984
MAOI-induced rapid cycling bipolar affective disorder in an adolescent.
    The American journal of psychiatry, 1981, Volume: 138, Issue:5

    Topics: Adolescent; Bipolar Disorder; Depressive Disorder; Humans; Lithium; Lithium Carbonate; Male; Phenelz

1981
Phenelzine treatment without switch to mania.
    The American journal of psychiatry, 1982, Volume: 139, Issue:3

    Topics: Adult; Bipolar Disorder; Female; Humans; Phenelzine

1982
Atypical depression.
    Archives of general psychiatry, 1982, Volume: 39, Issue:5

    Topics: Adult; Age Factors; Amitriptyline; Anxiety; Bipolar Disorder; Depressive Disorder; Double-Blind Meth

1982
Toxic delirium resulting from combination antidepressant therapy.
    The American journal of psychiatry, 1981, Volume: 138, Issue:8

    Topics: Amitriptyline; Bipolar Disorder; Delirium; Drug Therapy, Combination; Humans; Male; Middle Aged; Phe

1981
Decrease in speech pause times with treatment of endogenous depression.
    Biological psychiatry, 1980, Volume: 15, Issue:4

    Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Drug Therapy, Combination; Electroconvulsi

1980
Paradoxical mood shifts to euthymia or hypomania upon withdrawal of antidepressant agents.
    Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:3

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male;

1993
Verapamil may cause depression.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:4

    Topics: Bipolar Disorder; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Middle Aged; Phene

1993
Tap (draft) beer and monoamine oxidase inhibitor dietary restrictions.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1997, Volume: 42, Issue:3

    Topics: Adult; Beer; Bipolar Disorder; Contraindications; Depressive Disorder; Dose-Response Relationship, D

1997
Schizophrenia: perchance a dream?
    International review of neurobiology, 1975, Volume: 17

    Topics: Acute Disease; Adolescent; Adult; Bipolar Disorder; Chronic Disease; Depression; Dreams; Female; Hum

1975
Implications of monoamine oxidase inhibitor-induced hypomania.
    Archives of general psychiatry, 1978, Volume: 35, Issue:11

    Topics: Adult; Bipolar Disorder; Depression; Humans; Isocarboxazid; Male; Phenelzine

1978
Phenelzine in depressed patients. Effects on urinary MHPG excretion in relation to clinical response.
    Neuropsychobiology, 1977, Volume: 3, Issue:1

    Topics: Adult; Bipolar Disorder; Blood Platelets; Female; Glycols; Humans; Male; Methoxyhydroxyphenylglycol;

1977
Cerebral circulation and EEG alpha frequency in relation to daily fluctuations in psychotic behavior.
    The Journal of nervous and mental disease, 1976, Volume: 162, Issue:3

    Topics: Adult; Alpha Rhythm; Bipolar Disorder; Circadian Rhythm; Female; Humans; Longitudinal Studies; Menst

1976
[Absecence of the antidepressant action of lithium under clinical and experimental conditions].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:8

    Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Drug Interaction

1976
Mania or hypomania after withdrawal from antidepressants.
    The Journal of family practice, 1990, Volume: 30, Issue:4

    Topics: Adult; Amitriptyline; Bipolar Disorder; Depressive Disorder; Female; Humans; Lithium; Phenelzine; Su

1990
Paradoxical mood changes during pharmacotherapy of bipolar patients.
    Biological psychiatry, 1990, May-15, Volume: 27, Issue:10

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Imipramine; Lithium; Phenelzine; Subst

1990
Urinary amine metabolite excretion in a patient with adrenergic hyperactivity state: reaction to phenelzine withdrawal and combined treatment.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:2

    Topics: Bipolar Disorder; Delirium; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Meta

1986
Common side effects associated with monoamine oxidase inhibitors.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:3-4

    Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Humans; Hypotension; Middle Aged; Phenelzine; Tr

1989
Mania associated with high percentage of inhibition of monoamine oxidase.
    The American journal of psychiatry, 1989, Volume: 146, Issue:1

    Topics: Bipolar Disorder; Depressive Disorder; Female; Humans; Middle Aged; Monoamine Oxidase; Phenelzine

1989
Dexamethasone suppression test and response to MAOI treatment.
    The Journal of clinical psychiatry, 1989, Volume: 50, Issue:3

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Dexamethasone; Female; Hospitalization; Humans; Hydroc

1989
Hypomania related to phenelzine and isoetharine interaction in one patient.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:4

    Topics: Aged; Amino Alcohols; Bipolar Disorder; Depressive Disorder; Drug Interactions; Drug Therapy, Combin

1987
Treatment of rapid cycling bipolar patients.
    The American journal of psychiatry, 1987, Volume: 144, Issue:12

    Topics: Bipolar Disorder; Carbamazepine; Drug Therapy, Combination; Humans; Isocarboxazid; Lithium; Phenelzi

1987
Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management.
    Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:1

    Topics: Adult; Bipolar Disorder; Body Weight; Erectile Dysfunction; Female; Humans; Hypertension; Imipramine

1985
Phenelzine-induced hypomania: effect of verapamil.
    Biological psychiatry, 1985, Volume: 20, Issue:9

    Topics: Bipolar Disorder; Female; Humans; Middle Aged; Phenelzine; Verapamil

1985
Psychosis following phenelzine discontinuation.
    Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:6

    Topics: Adult; Anxiety; Bipolar Disorder; Depression; Female; Humans; Phenelzine; Psychoses, Substance-Induc

1985
Two cases of hypomania following the addition of L-tryptophan to a monoamine oxidase inhibitor.
    The American journal of psychiatry, 1985, Volume: 142, Issue:12

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Monoamine O

1985
Prophylactic lithium: another therapeutic myth? An examination of the evidence to date.
    Lancet (London, England), 1968, May-04, Volume: 1, Issue:7549

    Topics: Amitriptyline; Bipolar Disorder; Haloperidol; Humans; Imipramine; Lithium; Phenelzine; Trifluoperazi

1968
Time series for symptom-clusters in a case of manic-depressive illness.
    The Australian and New Zealand journal of psychiatry, 1972, Volume: 6, Issue:4

    Topics: Benztropine; Bipolar Disorder; Electroconvulsive Therapy; Female; Humans; Lithium; Middle Aged; Nort

1972
Whole blood 5 -hydroxytryptamine during treatment of endogenous depressive illness.
    The British journal of psychiatry : the journal of mental science, 1973, Volume: 122, Issue:570

    Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Electroconvulsive Therapy; Female; Humans; Male; Middl

1973
Lumbar CSF 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes.
    The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5

    Topics: Adult; Affective Symptoms; Amitriptyline; Animals; Bipolar Disorder; Brain Chemistry; Cats; Depressi

1974
The efficacy of antidepressant drugs. A review of research (1958-1972).
    Archives of general psychiatry, 1974, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depression; Dibenza

1974
Electroconvulsive therapy and antidepressant drugs in manic-depressive disease. Treatment results at discharge and 3 months later.
    Acta psychiatrica Scandinavica, 1965, Volume: 41, Issue:4

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Electroconvulsive Therapy; Fema

1965