phenelfamycin-e has been researched along with Clostridium-Infections* in 1 studies
1 other study(ies) available for phenelfamycin-e and Clostridium-Infections
Article | Year |
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Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model.
Phenelfamycins A, B, C, E, F and unphenelfamycin make up a recently isolated group of elfamycin-type antibiotics. All of the phenelfamycins were active against Gram-positive anaerobes, including Clostridium difficile. Phenelfamycin A was also active in vitro against Neisseria gonorrhoeae and Streptococci. Phenelfamycin A was found to be effective in prolonging the survival of hamsters in an animal model of C. difficile enterocolitis. After oral administration of phenelfamycin A to hamsters, antibiotic was detected in the caecal contents but not in the blood. Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacteria; Clostridium Infections; Cricetinae; Enterocolitis; Male; Mesocricetus; Vancomycin | 1989 |