phencyclidine has been researched along with Seizures in 76 studies
*Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (43.42) | 18.7374 |
| 1990's | 25 (32.89) | 18.2507 |
| 2000's | 13 (17.11) | 29.6817 |
| 2010's | 5 (6.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Costa, B; Jacobson, AE; Mattson, MV; Rice, KC; Rogawski, MA; Thurkauf, A; Yamaguchi, S | 1 |
| Boldt, KG; Brine, GA; Buchwald, WF; Carroll, FI; Cone, EJ; Vaupel, DB; Yousefnejad, D | 1 |
| Bigge, CF; Colbry, NL; Hays, SJ; Johnson, G; Lescosky, LJ; Malone, TC; Michael, A; Novak, PM; Ortwine, DF; Reily, MD | 1 |
| Abdullahi, M; Ajumobi, OO; Anagbogu, IN; Aworh, MK; Davis, L; Gitta, S; Idris, S; Mohammed, A; Mohammed, S; Nguku, P; Nsubuga, P; Poggensee, G; Tsofo, A; Umar-Tsafe, N; Yango, M | 1 |
| George, U; Thomas, VV | 1 |
| Mutani, R | 1 |
| Udall, JN | 1 |
| Fein, BT; Kamin, PB | 1 |
| Anderson, WH; Bui, HH; Falcone, JF; Gleason, SD; Kato, A; Kuo, MS; Li, X; Stutz, PV; Thompson, LK; Valli, SN; Witkin, JM | 1 |
| Bac, P; Gressens, P; Maurois, P; Pages, N; Stables, JP; Stanicki, D; Vamecq, J; Vanden Eynde, JJ | 1 |
| Hrnčić, D; Mladenović, D; Nikolić, T; Petronijević, N; Radonjić, N; Rašić-Marković, A; Stanojlović, O | 1 |
| Holland, T; Killian, C; Lajtha, A; Lipovac, MN; Poleksic, A | 1 |
| Mikhaleva, I; Mirković, S; Stanojlović, O; Zivanović, D | 1 |
| Cha, JY; Jhoo, JH; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, PH; Nabeshima, T; Shin, EJ | 1 |
| Leung, LS; Ma, J; Rajakumar, N; Shen, B | 1 |
| Mirkovic, S; Stanojlovic, O; Susic, V; Zivanovic, D | 1 |
| Hivanović, D; Stanojlović, O; Susić, V | 1 |
| Harris, AJ; Honey, A; Jones, DN; Jones, GA; Kelly, FM; Kew, JN; Maycox, PR; Melarange, RA; Murdock, PR; Robbins, MJ; Rocheville, M; Rourke, C; Rupniak, T; Soffin, EM; Starr, KR; Strum, J | 1 |
| García-Algar, O; Marchei, E; Martín, I; Pellegrini, M; Pichini, S; Vall, O | 1 |
| Djurić, D; Hrncić, D; Mladenović, D; Radosavljević, T; Rasić, A; Stanojlović, O; Susić, V; Vucević, D | 1 |
| Dustman, RE; Schlehuber, C; Shearer, DE; Snyder, EW | 1 |
| Geller, A | 1 |
| Passarelli, F; Sagratella, S; Scotti de Carolis, A | 1 |
| Chaturvedi, AK | 1 |
| Duncan, PM; Freeman, FG; Jarvis, MF | 1 |
| Borne, RF; Hackett, RB; Obrosky, KW; Waters, IW | 1 |
| Boren, JL; Consroe, PF | 1 |
| Bowyer, JF; Winters, WD | 1 |
| Honoré, T; Jacobsen, P; Swedberg, MD | 1 |
| Dumont, M; Lemaire, S; Merali, Z; Shukla, VK | 1 |
| Moshe, SL; Sircar, R; Veliskova, J | 1 |
| Albanese, R; Hogan, MV; Reith, M; Wieraszko, A | 1 |
| Baubichon, D; Blanchet, G; Burckhart, MF; Carpentier, P; Lallement, G; Pernot-Marino, I | 1 |
| Bonhaus, DW; Kraus, JE; McNamara, JO; Nadler, JV; Yeh, GC | 1 |
| Baubichon, D; Blanchet, G; Carpentier, P; Foquin-Tarricone, A; Lallement, G; Pernot-Marino, I; Piras, A | 1 |
| Jacobsen, P; Klockgether, T; Löschmann, PA; Turski, L | 1 |
| Markovic, O; Susić, V | 1 |
| Baubichon, D; Blanchet, G; Carpentier, P; Delamanche, IS; Denoyer, M; Lallement, G; Pernot-Marino, I | 1 |
| Freedman, L; Hudzik, TJ; Palmer, GC | 1 |
| Sircar, R | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 1 |
| Brooks, WJ; Leboutillier, JC; Petit, TL; Weeks, AC | 1 |
| Stanojlovic, O; Susic, V; Zivanovic, D | 3 |
| Löscher, W; Potschka, H | 1 |
| Carpentier, P; de Groot, DM; Foquin, A; Kamenka, JM; Lallement, G; Lerner-Natoli, M; Rondouin, G | 1 |
| De Vry, J; Horváth, E; Schreiber, R | 1 |
| Bierman, EP; Bruijnzeel, PL; Carpentier, P; de Groot, DM; Kulig, BM; Lallement, G; Melchers, BP; Philippens, IH; van Huygevoort, AH | 1 |
| Binet, EF; Crosley, CJ | 1 |
| Heath, RG | 1 |
| Dorand, RD | 1 |
| Pierson, M; Swann, J | 1 |
| Kamata, O; Nakanishi, H; Ukai, K; Yamamoto, K | 1 |
| Davis, WM; Hackett, RB; Obrosky, KW; Waters, IW | 1 |
| Colpaert, FC; Koek, W | 1 |
| Pezzola, A; Popoli, P; Scotti de Carolis, A | 1 |
| Bonhaus, DW; McNamara, JO; Nadler, JV; Yeh, GC | 1 |
| Bolger, GT; O'Neill, SK | 1 |
| Wann, KT; Wardley-Smith, B | 1 |
| Debler, EA; Jacobson, AE; Lajtha, A; Lipovac, MN; Reith, ME; Rice, KC; Zlokovic, BV | 1 |
| Iversen, SD; Oles, RJ; Preston, C; Singh, L; Tricklebank, MD | 1 |
| Arnolde, SM; Nevins, ME | 1 |
| Jacobson, AE; Mattson, MV; Rice, KC; Rogawski, MA; Thurkauf, A; Yamaguchi, S | 1 |
| Colpaert, FC; Kamenka, JM; Koek, W; Woods, JH | 1 |
| Leccese, AP; Turgeon, SM | 1 |
| Jackson, JE | 1 |
| Alldredge, BK; Lowenstein, DH; Simon, RP | 1 |
| Leander, JD; Rathbun, RC; Zimmerman, DM | 1 |
| Niglio, T; Sagratella, S; Scotti de Carolis, A | 1 |
| Olney, JW | 1 |
| Buterbaugh, GG; Michelson, HB | 1 |
| Niglio, T; Ortolani, E; Pézzola, A; Sagratella, S; Scotti de Carolis, A | 1 |
| Klingman, GI; Spain, JW | 1 |
| Bohner, B; Chen, G; Ensor, CR | 1 |
76 other study(ies) available for phencyclidine and Seizures
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues.
Topics: Animals; Anticonvulsants; Binding Sites; Brain; Chemical Phenomena; Chemistry; Cyclohexylamines; Electric Stimulation; Male; Mice; Motor Activity; Phencyclidine; Seizures; Structure-Activity Relationship | 1990 |
Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol.
Topics: Animals; Ataxia; Biotransformation; Dogs; Hydroxylation; Male; Mice; Phencyclidine; Seizures; Species Specificity; Stereoisomerism | 1981 |
Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor.
Topics: Animals; Binding Sites; Fluorenes; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism; Structure-Activity Relationship | 1993 |
High concentration of blood lead levels among young children in Bagega community, Zamfara - Nigeria and the potential risk factor.
Topics: Child, Preschool; Cross-Sectional Studies; Disease Outbreaks; Dust; Environmental Exposure; Family Characteristics; Gold; Health Surveys; Humans; Infant; Lead; Lead Poisoning; Mass Screening; Mining; Nigeria; Population Surveillance; Risk Factors; Seizures; Soil | 2014 |
Magnetic resonance finding in a seizure: truly hair-raising!
Topics: Artifacts; Brain; Dust; Ferric Compounds; Hair; Humans; Magnetic Resonance Imaging; Male; Metals; Occupational Exposure; Seizures; Waxes; Young Adult | 2010 |
[Rhinencephalic experimental epilepsy produced with cobalt: recordings in depth].
Topics: Amygdala; Animals; Cats; Cobalt; Dust; Electroencephalography; Foreign Bodies; Limbic System; Seizures | 1967 |
Convulsions secondary to desensitization antigen relieved by intravenous epinephrine: a case report.
Topics: Adult; Antigen-Antibody Reactions; Antigens; Desensitization, Immunologic; Dust; Epilepsy; Epinephrine; Female; Histamine Release; Humans; Injections, Intravenous; Pollen; Prednisone; Seizures | 1974 |
Allergy, convulsive disorders and epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Desensitization, Immunologic; Diet; Dust; Electroencephalography; Epilepsy; Food Hypersensitivity; Fungi; Humans; Hypersensitivity; Infant; Middle Aged; Pollen; Seizures; Skin Tests | 1968 |
Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§.
Topics: Acetylcholine; Amphetamines; Animals; Biogenic Monoamines; Body Temperature; Brain; Calcium Channels; Central Nervous System Stimulants; Cyclic AMP; Excitatory Amino Acid Antagonists; Exploratory Behavior; Histamine; Hyperkinesis; Lipids; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Phencyclidine; Receptors, AMPA; Seizures; Sulfonamides; Swimming; Thiophenes; Time Factors | 2015 |
1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action.
Topics: Animals; Anticonvulsants; Antioxidants; Benzamidines; Binding Sites; Body Temperature; Brain; Mice; Models, Molecular; Molecular Conformation; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Ontogenetic influence on rat susceptibility to lindane seizure after pretreatment with phencyclidine.
Topics: Animals; Animals, Newborn; Brain; Disease Susceptibility; Electroencephalography; Hexachlorocyclohexane; Phencyclidine; Puberty; Rats; Rats, Wistar; Seizures | 2013 |
The possible role of glutamate uptake in metaphit-induced seizures.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Caudate Nucleus; Dextrans; Female; Glutamic Acid; Guinea Pigs; Hippocampus; Kinetics; Male; Parietal Lobe; Phencyclidine; Seizures | 2003 |
Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Convulsants; Delta Sleep-Inducing Peptide; Electroencephalography; Epilepsy, Reflex; Epilepsy, Tonic-Clonic; Male; Phencyclidine; Rats; Rats, Wistar; Running; Seizures | 2004 |
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Behavior, Animal; Blotting, Northern; Blotting, Western; Calcium Channels, L-Type; Cell Count; Densitometry; Dose-Response Relationship, Drug; Drug Interactions; Electrophoretic Mobility Shift Assay; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Morphinans; Motor Activity; Phencyclidine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reaction Time; RNA; Seizures | 2004 |
The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Brain Injuries; Cell Count; Choline O-Acetyltransferase; Cholinergic Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; GABA Agonists; Hippocampus; Immunohistochemistry; Immunotoxins; Male; Muscimol; N-Glycosyl Hydrolases; Neural Inhibition; Parvalbumins; Phencyclidine; Rats; Rats, Long-Evans; Reflex, Acoustic; Ribosome Inactivating Proteins, Type 1; Saporins; Seizures; Septum Pellucidum | 2004 |
Ontogenetic study of metaphit-induced audiogenic seizures in rats.
Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Brain; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy, Reflex; Female; Genetic Predisposition to Disease; Male; Neural Pathways; Phencyclidine; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission | 2005 |
[Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid].
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Male; Phencyclidine; Rats; Rats, Wistar; Seizures | 2002 |
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.
Topics: Amphetamine; Animals; Anticonvulsants; Anxiety; Autoreceptors; Benzoates; Brain; Central Nervous System Stimulants; Dentate Gyrus; Disease Models, Animal; Electroshock; Glycine; Humans; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Seizures; Synapses; Synaptic Transmission | 2007 |
Are false-positive phencyclidine immunoassay instant-view multi-test results caused by overdose concentrations of Ibuprofen, metamizol, and dextromethorphan?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Child, Preschool; Dextromethorphan; Diagnosis, Differential; Dipyrone; Drug Overdose; False Positive Reactions; Female; Humans; Ibuprofen; Immunoassay; Infant, Newborn; Male; Phencyclidine; Seizures | 2007 |
Moderate body hypothermia alleviates behavioral and EEG manifestations of audiogenic seizures in metaphit-treated rats.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Body Temperature; Brain; Disease Models, Animal; Electroencephalography; Hypothermia, Induced; Male; Phencyclidine; Rats; Rats, Wistar; Seizures | 2007 |
Phencyclidine-induced alterations of rat electrophysiology.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Evoked Potentials, Visual; Male; Muridae; Phencyclidine; Seizures; Synaptic Transmission; Visual Cortex | 1981 |
The social, psychological and medical management of intoxication.
Topics: Arrhythmias, Cardiac; Delusions; Diazepam; Hallucinations; Hallucinogens; Humans; Hypnotics and Sedatives; Naloxone; Narcotics; Nonprescription Drugs; Phencyclidine; Poisoning; Seizures; Solvents; Stimulation, Chemical | 1984 |
An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits.
Topics: Animals; Electroencephalography; Male; Pentylenetetrazole; Phencyclidine; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Seizures; Species Specificity; Trimethadione | 1983 |
Effects of mecamylamine, nicotine, atropine and physostigmine on the phencyclidine-induced behavioral toxicity.
Topics: Animals; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Phencyclidine; Physostigmine; Seizures | 1984 |
Phencyclidine raises kindled seizure thresholds.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Kindling, Neurologic; Muridae; Phencyclidine; Seizures; Sensory Thresholds | 1982 |
Acute phencyclidine poisoning in the unanesthetized dog: pathophysiologic profile of acute lethality.
Topics: Animals; Blood Gas Analysis; Dogs; Female; Hemodynamics; Male; Motor Activity; Oxygen Consumption; Phencyclidine; Pupil; Respiration; Seizures; Time Factors | 1981 |
Behavioral effects of phencyclidine (PCP) in the dog: a possible animal model of PCP toxicity in humans.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dogs; Male; Phencyclidine; Seizures | 1981 |
The effects of various anesthetics on amygdaloid kindled seizures.
Topics: 4-Butyrolactone; Amygdala; Anesthetics; Animals; Central Nervous System; Electroencephalography; Hydroxybutyrates; Ketamine; Male; Pentylenetetrazole; Phencyclidine; Rats; Seizures; Sodium Oxybate | 1981 |
Anticonvulsant, anxiolytic and discriminative effects of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX).
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Excitatory Amino Acid Antagonists; Female; Male; Mice; Mice, Inbred DBA; Morphine; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 1995 |
N-methyl-D-aspartate receptor antagonist activity and phencyclidine-like behavioral effects of the pentadecapeptide, [Ser1]histogranin.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Phencyclidine; Proteins; Rats; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Pentylenetetrazole; Phencyclidine; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 1994 |
Metaphit amplifies long-term potentiation (LTP) in the mouse hippocampus.
Topics: Animals; Evoked Potentials, Auditory; Female; Hippocampus; Male; Mice; Mice, Inbred C57BL; Noise; Phencyclidine; Seizures; Time Factors | 1995 |
Modulation of soman-induced neuropathology with an anticonvulsant regimen.
Topics: Animals; Anticonvulsants; Atropine; Hippocampus; Male; Olfactory Pathways; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Soman | 1994 |
Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.
Topics: Animals; Base Sequence; Glycine; Hippocampus; Kindling, Neurologic; Male; Molecular Probes; Molecular Sequence Data; Phencyclidine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reference Values; Seizures | 1994 |
Coadministration of atropine, NBQX and TCP against soman-induced seizures.
Topics: Animals; Atropine; Drug Synergism; Electroencephalography; Male; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Soman | 1994 |
The antiparkinsonian agent budipine is an N-methyl-D-aspartate antagonist.
Topics: Amino Acids; Anesthesia; Animals; Antiparkinson Agents; Binding, Competitive; Brain Chemistry; H-Reflex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Seizures; Spinal Cord | 1993 |
Potentiation of metaphit-induced audiogenic seizures by REM sleep deprivation in rats.
Topics: Acoustic Stimulation; Animals; Body Weight; Brain; Dose-Response Relationship, Drug; Eating; Male; Motor Activity; Phencyclidine; Rats; Rats, Wistar; Seizures; Sleep Deprivation; Sleep, REM; Social Environment | 1993 |
Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an omega 3 site ligand.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Diseases; Excitatory Amino Acid Antagonists; Hippocampus; Isoquinolines; Ligands; Male; Oxazines; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Soman | 1993 |
Acute reactions to drugs of abuse.
Topics: Acute Disease; Administration, Inhalation; Amphetamine; Cannabinoids; Central Nervous System Diseases; Cocaine; Drug Contamination; Hallucinogens; Humans; Hypnotics and Sedatives; Illicit Drugs; Narcotics; Nitric Oxide; Phencyclidine; Seizures; Substance-Related Disorders; Sympathomimetics | 1996 |
Remacemide hydrochloride and ARL 15896AR lack abuse potential: additional differences from other uncompetitive NMDA antagonists.
Topics: Acetamides; Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Electroshock; Humans; Injections, Intravenous; Male; Phencyclidine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Seizures; Self Administration; Stereotyped Behavior; Substance-Related Disorders | 1996 |
Repeated postnatal phencyclidine administration in female juvenile rat delays onset of puberty but has no effect on pentylenetetrazol-induced seizure-susceptibility.
Topics: Animals; Animals, Newborn; Disease Susceptibility; Estrus; Female; Ovulation; Pentylenetetrazole; Phencyclidine; Rats; Rats, Sprague-Dawley; Seizures; Sexual Maturation; Vagina | 1995 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Kynurenic Acid; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord | 1997 |
Altered NMDA sensitivity and learning following chronic developmental NMDA antagonism.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Maze Learning; Mental Recall; Neuronal Plasticity; Phencyclidine; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Seizures; Synapses | 1997 |
APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Convulsants; Electroencephalography; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
The anticonvulsant potency of (+/-)-2-Amino-7-phosphonoheptanoic acid and (+/-)-2-amino-5-phosphonovaleric acid against metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Rats; Rats, Wistar; Seizures | 1998 |
Corneal kindling in mice: behavioral and pharmacological differences to conventional kindling.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Brain; Cornea; Excitatory Amino Acid Antagonists; Female; Kindling, Neurologic; Male; Mice; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Seizures; Sex Characteristics; Stereotyped Behavior; Time Factors | 1999 |
N-Methyl-D-aspartic acid- and metaphit-induced audiogenic seizures in rat model of seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar; Seizures | 2000 |
Effects of thienylphencyclidine (TCP) on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neurotoxicity.
Topics: Animals; Brain; Convulsants; Electroencephalography; Guinea Pigs; Male; Motor Activity; Neuroprotective Agents; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Seizures; Soman; Time Factors | 2001 |
Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Brain Ischemia; Cerebral Cortex; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Infarction, Middle Cerebral Artery; Male; Mice; Naphthalenes; Neural Inhibition; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate; Reflex, Startle; Seizures; Self Stimulation; Stereotyped Behavior | 2001 |
Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour.
Topics: Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Discrimination Learning; Electroencephalography; Guinea Pigs; Male; Muscarinic Antagonists; Neuroprotective Agents; Phencyclidine; Pyridostigmine Bromide; Receptors, N-Methyl-D-Aspartate; Seizures; Soman | 2001 |
Cerebrovascular complications in phencyclidine intoxication.
Topics: Cerebrovascular Disorders; Child; Hemiplegia; Humans; Male; Phencyclidine; Seizures | 1979 |
Brain function in epilepsy: midbrain, medullary, and cerebellar interaction with the rostral forebrain.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cobalt; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Haplorhini; Limbic System; Lysergic Acid Diethylamide; Medulla Oblongata; Mesencephalon; Olivary Nucleus; Pentylenetetrazole; Phencyclidine; Seizures | 1976 |
Phencyclidine ingestion: therapy review.
Topics: Atropine; Child, Preschool; Diuretics; Humans; Kidney Function Tests; Liver Function Tests; Male; Naloxone; Phencyclidine; Respiration; Seizures | 1977 |
Sensitization to noise-mediated induction of seizure susceptibility by MK-801 and phencyclidine.
Topics: Acoustic Stimulation; Aging; Animals; Disease Susceptibility; Dizocilpine Maleate; Female; Male; Noise; Phencyclidine; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1991 |
Inhibitory effects of NMDA receptor antagonists on hypoxia-induced seizures in dietary Mg(2+)-deficient mice.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Hippocampus; Hypoxia; Magnesium Deficiency; Male; Membrane Potentials; Mice; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Seizures | 1991 |
Factors in the lethality of i.v. phencyclidine in conscious dogs.
Topics: Animals; Dogs; Female; Heart; Infusions, Intravenous; Male; Pancuronium; Phencyclidine; Phenytoin; Respiration, Artificial; Seizures; Time Factors | 1991 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
An EEG and behavioural study on the interactions of clonidine with phencyclidine and ketamine in rats.
Topics: Animals; Brain; Clonidine; Drug Interactions; Electroencephalography; Ketamine; Male; Muscle Tonus; Phencyclidine; Prazosin; Rats; Rats, Inbred Strains; Seizures; Stereotyped Behavior | 1990 |
N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
Topics: Animals; Convulsants; Electric Stimulation; Glycine; Hippocampus; Illicit Drugs; Ion Channels; Kindling, Neurologic; Male; Neuronal Plasticity; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Phencyclidine and MK-801: a behavioral and neurochemical comparison of their interactions with dihydropyridine calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Convulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Nifedipine; Phencyclidine; Receptors, Nicotinic; Seizures | 1989 |
The effects of non-competitive NMDA receptor antagonists on rats exposed to hyperbaric pressure.
Topics: Animals; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Hyperbaric Oxygenation; Ketamine; Male; Myoclonus; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Tremor | 1989 |
Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice.
Topics: Acoustic Stimulation; Animals; Injections; Injections, Intravenous; Mice; Mice, Inbred BALB C; Orbit; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Time Factors | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Anticonvulsant activities of 1-phenylcyclohexylamine and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Cyclohexylamines; Isoquinolines; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Seizures; Tetrahydroisoquinolines | 1989 |
The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801.
Topics: Animals; Behavior, Animal; Cocaine; Columbidae; Dextroamphetamine; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Haloperidol; Ketamine; Methylphenidate; Mice; Phencyclidine; Rats; Seizures; Structure-Activity Relationship | 1989 |
Phencyclidine (PCP) reduces the intensity of caffeine-induced convulsions in rats.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Female; Phencyclidine; Rats; Rats, Inbred Strains; Seizures | 1989 |
Phencyclidine pharmacokinetics after a massive overdose.
Topics: Adult; Coma; Humans; Male; Phencyclidine; Rhabdomyolysis; Seizures | 1989 |
Seizures associated with recreational drug abuse.
Topics: Adult; Amphetamines; Cocaine; Drug Combinations; Female; Heroin; Humans; Lysergic Acid Diethylamide; Male; Marijuana Abuse; Phencyclidine; Seizures; Status Epilepticus; Substance-Related Disorders; Time Factors | 1989 |
Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-D-aspartic acid antagonism.
Topics: Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ketamine; Male; Penicillins; Pentobarbital; Phencyclidine; Physostigmine; Rabbits; Receptors, Opioid; Receptors, sigma; Seizures | 1985 |
Inciting excitotoxic cytocide among central neurons.
Topics: Action Potentials; Animals; Brain; Cell Survival; Chick Embryo; Cholinergic Fibers; Disease Models, Animal; Edema; Epilepsies, Partial; Folic Acid; Hippocampus; Hypoxia; Kainic Acid; Ketamine; Microscopy, Electron; Parasympathomimetics; Phencyclidine; Piperidines; Seizures; Synaptic Transmission; Thalamus | 1986 |
Anticonvulsant properties of phencyclidine and ketamine.
Topics: Animals; Anticonvulsants; Hippocampus; Ketamine; Kindling, Neurologic; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phencyclidine; Phenobarbital; Seizures | 1986 |
Phencyclidine-like effect of cyclazocine on pentylentetrazol-induced seizures in laboratory animals.
Topics: Animals; Anticonvulsants; Cyclazocine; Electrodes, Implanted; Electroencephalography; Female; Humans; Male; Mice; Motor Activity; Pentylenetetrazole; Phencyclidine; Rabbits; Rats; Rats, Inbred Strains; Seizures; Species Specificity; Stereotyped Behavior | 1985 |
Continuous intravenous infusion of phencyclidine in unrestrained rats results in the rapid induction of tolerance and physical dependence.
Topics: Animals; Body Temperature; Body Weight; Drug Tolerance; Exploratory Behavior; Humans; Infusions, Parenteral; Male; Morphine Dependence; Motor Activity; Phencyclidine; Rats; Rats, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
The pharmacology of 2-(ethylamino)-2-(2-thienyl)-cyclohexanone-HCl (CI-634).
Topics: Anesthesia, General; Animals; Blood Pressure; Cardiovascular System; Catalepsy; Cats; Central Nervous System; Columbidae; Cyclohexanes; Dogs; Drug Synergism; Guinea Pigs; Haplorhini; Heart; Heart Rate; Humans; Hypertension; Mice; Motor Activity; Norepinephrine; Pentylenetetrazole; Phencyclidine; Phenethylamines; Rabbits; Rats; Seizures; Species Specificity; Tachycardia; Thiamylal | 1969 |