phencyclidine has been researched along with Schizophrenia in 395 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (5.06) | 18.7374 |
| 1990's | 42 (10.63) | 18.2507 |
| 2000's | 130 (32.91) | 29.6817 |
| 2010's | 174 (44.05) | 24.3611 |
| 2020's | 29 (7.34) | 2.80 |
| Authors | Studies |
|---|---|
| Abreu-Villaça, Y; Couto, LA; Dutra-Tavares, AC; Filgueiras, CC; Maia, JG; Manhães, AC; Ribeiro-Carvalho, A; Semeão, KA | 1 |
| Dwyer, DM; Griesius, S; Hall, J; Humby, T; Mellor, JR; Pass, R; Robinson, ESJ; Thomas, KL; Waldron, S; Wilkinson, LS | 1 |
| Brown, J; Di Cicco, G; Fletcher, J; Grayson, B; Harte, M; Iacovelli, L; Neill, JC; Ngomba, RT; Rimmer, L; Wall, MJ | 1 |
| Chang, MH; Chiou, LC; Cook, J; Knutson, DE; Kubota, H; Lee, HJ; Lee, MT; Mihovilovic, M; Mouri, A; Nabeshima, T; Sieghart, W; Wu, CY | 1 |
| Bécamel, C; Delagrange, M; Doyle, JP; Heintz, N; Iyer, K; Paul, MA; Selimi, F; Sigoillot, SM; Urrieta-Chávez, B; Usardi, A; Veleanu, M | 1 |
| Deng, W; Guo, W; Hu, X; Li, T; Ma, X; Ni, P; Qi, X; Wang, Q; Wei, L; Yu, X; Zhao, L | 1 |
| Barrera-Conde, M; Bergé, D; de la Torre, R; Garcia-Quintana, J; Gomis-Gonzalez, M; Martínez-Sadurní, L; Perez, V; Pujades, M; Robledo, P; Trabsa, A; Veza-Estévez, E | 1 |
| Aggarwal, S; Barnes, SA; Dillon, DG; Tranter, MM; Young, JW | 1 |
| Burgess, M; Grayson, B; Harte, MK; Landreth, K; Lorusso, JM; Neill, JC; Watson, L | 1 |
| Abreu-Villaça, Y; Dutra-Tavares, AC; Filgueiras, CC; Manhães, AC; Mello, FF; Ribeiro-Carvalho, A; Semeão, KA; Silva, JO; Souza, TP | 1 |
| Abreu-Villaça, Y; Dutra-Tavares, AC; Filgueiras, CC; Manhães, AC; Ribeiro-Carvalho, A; Rodríguez-Vega, A; Semeão, KA; Souza, TP | 1 |
| Brown, SJ; du Bois, TM; Huang, XF; Katsifis, A; Lum, JS; Mattner, F; Newell, KA | 1 |
| Gigg, J; Harte, MK; McEwan, F; Neill, J; Smausz, R | 1 |
| Fan, ZL; Hu, KH; Li, X; Sui, JF; Wu, B; Wu, GY; Yao, J; Zhou, ZH | 1 |
| Giuffrida, A; Martinez, AA; Seillier, A | 2 |
| Burgess, M; Grayson, B; Idris, NF; Mitsadali, I; Neill, J; Watson, L | 1 |
| Brown, AM; Dawe-Lane, E; Evans, C; Fowler, M; King, MV; Newton-Mann, E; Shortall, SE | 1 |
| Adell, A | 1 |
| Yavas, E; Young, AMJ | 1 |
| Bikovski, L; Goldshmit, Y; Offen, D; Perets, N; Ruban, A; Sofer, T; Tsivion-Visbord, H | 1 |
| Arioka, Y; Goto, S; Kitagaki, S; Kushima, I; Mamiya, T; Mouri, A; Noda, Y; Ozaki, N; Uchida, M; Yamada, S; Yoshimi, A | 1 |
| Babin, D; Castagné, V; Hamieh, AM; Hernier, AM; Sablé, E | 1 |
| Hata, T; Hiraga, T; Koizumi, H; Mouri, A; Nabeshima, T; Oharomari, LK; Okamoto, M; Shima, T; Soya, H; Yook, JS | 1 |
| Bastlund, JF; Eneberg, E; Gerdjikov, TV; Hayes, J; Kehler, J; Langgard, M; Laursen, B; Rasmussen, LK | 1 |
| Kim, HR; Martina, M; Meltzer, HY; Rajagopal, L | 1 |
| Goto, S; Ito, T; Kitagaki, S; Mamiya, T; Mouri, A; Noda, Y; Ozaki, N; Soeda, K; Uchida, M; Yoshimi, A | 1 |
| Ferdinand, JM; Peters, KZ; Yavas, E; Young, AMJ | 1 |
| Miry, O; Moghadam, AA; Stanton, PK; Vose, LR; Zhang, XL | 1 |
| Dawson, N; Diógenes, MJ; Ferreira, CB; Fonseca-Gomes, J; Freitas, CF; Mouro, FM; Sebastião, AM; Simões do Couto, F; Tanqueiro, SR | 1 |
| Chen, M; Guo, M; Huang, H; Li, Z; Lu, M; Wang, J; Xie, L; Zheng, S; Zhu, X | 1 |
| Dai, Z; Liu, J; Sui, Y; Wang, X | 1 |
| Coen, KM; Fletcher, PJ; Lê, AD; Li, Z | 1 |
| Forsberg, MM; Gröhn, O; Ihalainen, J; Lehtonen, M; Leikas, JV; Paasonen, J; Salo, RA; Savolainen, K | 1 |
| Meltzer, HY; Miyauchi, M; Neugebauer, NM | 1 |
| Guest, PC; Ma, D | 1 |
| Bhat, L; Cantillon, M; Huang, M; Kwon, S; Meltzer, HY; Michael, E; Rajagopal, L | 1 |
| Harte, MK; McLean, SL; Neill, JC; Young, AM | 1 |
| Dalby, NO; Hovelsø, N; Kjaerby, C; Sotty, F | 1 |
| Li, X; Sui, JF; Tian, CY; Wu, B; Wu, GY; Yang, YS; Zhang, HM; Zhao, XD | 1 |
| Csernansky, JG; Dong, H; Meltzer, HY; Neugebauer, NM; Rodríguez, G; Yao, KL | 1 |
| Conn, PJ; Dickerson, JW; Ghoshal, A; Grueter, BA; Joffe, ME; Lindsley, CW; Moran, SP; Rook, JM; Xiang, Z | 1 |
| Giuffrida, A; Seillier, A | 3 |
| Balla, A; Javitt, DC; Lakatos, P; Lee, M; Sehatpour, P; Sershen, H | 1 |
| Doron, R; Golani, I; Kremer, I; Shamir, A; Tadmor, H | 1 |
| Nishikawa, T; Shiwaku, H; Umino, A; Umino, M | 1 |
| Aksić, M; Jevtić Dožudić, G; Nikolić, T; Petronijević, M; Petronijević, N; Radonjić, NV; Sopta, J; Stojković, T; Velimirović, M | 1 |
| Dang, DK; Jang, CG; Jeong, JH; Kim, HC; Ko, SK; Lee, YJ; Nabeshima, T; Nah, SY; Shin, EJ; Toriumi, K; Tran, TV | 1 |
| Amitai, N; Powell, SB; Young, JW | 1 |
| Christensen, KV; Christoffersen, CT; Clausen, D; Didriksen, M; Egebjerg, J; Fejgin, K; Kallunki, P; Larsen, PH; Lauridsen, JB; Mørk, A; Nielsen, J; Nielsen, V; Sotty, F; Werge, TM; Yavich, L | 1 |
| Nishikawa, T; Umino, A; Umino, M | 1 |
| Feng, J; Jia, M; Liu, J; Wen, X; Zhang, G; Zhang, W | 1 |
| Brosda, J; Tarland, E | 1 |
| Liu, Q; Liu, T; Ma, Y; Shan, L; Xu, F; Zhang, M; Zhang, Y; Zhang, Z; Zhao, X | 1 |
| Fried, J; Paine, TA; Riordan, AJ; Schaler, AW; Thornton, JE | 1 |
| Furutani, M; Harada, K; Marcus, MM; Moriyama, A; Okabe, M; Svensson, TH; Yamamoto, N; Yamazaki, M; Yarimizu, J | 1 |
| Adham, N; Gyertyán, I; Ichinose, F; Kehr, J; Kiss, B; Yoshitake, S; Yoshitake, T | 1 |
| Meltzer, HY; Rajagopal, L; Soni, D | 1 |
| Amirikian, B; Blackman, RK; Chafee, MV; Crowe, DA; DeNicola, AL; Netoff, TI; Zick, JL | 1 |
| Piyabhan, P; Wetchateng, T | 3 |
| Bertron, JL; Lindsley, CW; Seto, M | 1 |
| He, J; Li, X; Liu, F; Wang, W; Xu, Z; Zheng, H; Zu, Q | 1 |
| Freudenreich, O; McCain, CF; Namey, LB | 1 |
| Huang, M; Kwon, S; Meltzer, HY; Michael, E; Rajagopal, L | 1 |
| Jang, CG; Jeong, JH; Kim, DJ; Kim, HC; Lee, YJ; Nabeshima, T; Park, SJ; Sharma, N; Shin, EJ; Tran, HQ; Tran, TV | 1 |
| de la Fuente Revenga, M; Dunn, CM; González-Maeso, J; Hideshima, KS; Hojati, A; Miles, MF; On, DM; Pais, AB; Pais, AC; Sánchez-González, A; Saunders, JM; Shin, JM; Wolstenholme, JT | 1 |
| Chen, T; He, L; Jia, XF; Li, YX; Ye, ZH | 1 |
| Bernardo, A; Daya, R; Dyck, B; Ho, J; Mishra, RK; Thomson, S; Tian, Y | 1 |
| Chen, W; Guo, S; He, Y; Hu, T; Jiang, X; Shen, J; Tian, G; Wang, Y; Wang, Z; Wu, C; Xie, Y; Xu, M; Yang, F; Zhao, Q; Zhu, F | 1 |
| Fujigaki, H; Mouri, A; Nabeshima, T; Saito, K; Yamamoto, Y | 1 |
| Fu, J; Li, B; Li, C; Li, J; Ma, Y; Mao, Y; Wang, J; Xiong, F; Yu, H; Zhang, B; Zhao, X; Zhou, Z | 1 |
| Al-Ali, AM; Young, AMJ | 1 |
| Kimura, H; Kunugi, A; Suzuki, A; Suzuki, M; Suzuki, N; Tanaka, M | 1 |
| Aida, T; Hida, H; Hiraoka, Y; Kitagaki, S; Mori, K; Noda, Y; Ozaki, N; Tanaka, K; Uchida, M; Yamada, K; Yoshimi, A | 1 |
| Campbell, JE; Campbell, UC; Dedic, N; Hanania, T; Hopkins, SC; Jones, PG; Koblan, KS; Large, TH; Leahy, E; Lew, R; Shao, L; Spear, KL | 1 |
| Aznar, S; Klein, AB; Knudsen, GM; Mikkelsen, JD; Ratner, C; Santini, MA | 1 |
| Hida, H; Mouri, A; Noda, Y | 1 |
| Esmaeili, B; Grace, AA | 1 |
| Bolger, FB; Finnerty, NJ; Lowry, JP; Pålsson, E | 1 |
| Bjelke, B; Broberg, BV; Glenthøj, BY; Madsen, KH; Olsen, CK; Paulson, OB; Plath, N; Søgaard, LV | 1 |
| Aoyama, Y; Fukushima, T; Ichiba, H; Iizuka, H; Koshikawa, M; Matsumoto, Y; Nabeshima, T; Watanabe, S | 1 |
| Jodo, E | 1 |
| Artigas, F; Celada, P; Kargieman, L; Lladó-Pelfort, L; Riga, MS; Santana, N; Troyano-Rodriguez, E | 1 |
| Bartha, A; Gaszner, G | 1 |
| Avenet, P; Bergis, O; Boulay, D; Griebel, G; Ho-Van, S | 1 |
| Piyabhan, P; Sireeratawong, S; Wetchateng, T | 1 |
| Bahn, S; Chan, MK; Ernst, A; Guest, PC; Holmes, E; Peters, F; Tsang, TM; Wesseling, H | 1 |
| Kaalund, SS; Karlsen, AS; Møller, M; Pakkenberg, B; Plath, N | 1 |
| Frohlich, J; Van Horn, JD | 1 |
| Gartside, SE; Marston, HM; McQuade, R; Wallace, J | 1 |
| Bidder, M; Gil-Ad, I; Kramer, M; Portnoy, M; Taler, M; Tarasenko, I; Weizman, A | 1 |
| Alexander, SP; Fone, KC; Gaskin, PL | 1 |
| Beck, HC; Hansen, HH; Jensen, ON; Mikkelsen, JD; Palmowski, P; Rogowska-Wrzesinska, A; Williamson, J | 1 |
| Bastlund, JF; Bundgaard, C; Carnerup, M; Christoffersen, CT; Jørgensen, M; Lerdrup, L; Montezinho, LP; Plath, N; Redrobe, JP | 1 |
| Parachikova, AI; Pedersen, CS; Plath, N; Sørensen, DB | 1 |
| Biguet, NF; Ingallinesi, M; Le Bouil, L; Mallet, J; Mannoury la Cour, C; Meloni, R; Millan, MJ; Ravassard, P; Thi, AD | 1 |
| Fellini, L; Gibbs, S; Kumar, G; Steckler, T; Talpos, J | 1 |
| Horiguchi, M; Meltzer, HY; Miyauchi, M; Oyamada, Y; Rajagopal, L | 1 |
| Diano, S; Elsworth, JD; Groman, SM; Jentsch, JD; Kim, JD; Leranth, C; Redmond, DE; Roth, RH | 1 |
| Aguilar, DD; Chen, L; Lodge, DJ | 1 |
| Gerdjikov, TV; Stubbendorff, C; Valencia, M; Young, AM | 1 |
| Hansen, AK; Krych, L; Larsen, C; Nielsen, DS; Pedersen, CS; Pedersen, TB; Plath, N; Pyndt Jørgensen, B; Redrobe, JP; Sørensen, DB | 1 |
| Barnes, SA; Buonincontri, G; Caprioli, D; Dalley, JW; Fletcher, PC; Harte, MK; Jupp, B; Mar, AC; Neill, JC; Robbins, TW; Sawiak, SJ | 1 |
| Angrisano, T; Bertolino, A; Chiariotti, L; D'Argenio, V; de Bartolomeis, A; Di Maio, A; Errico, F; Galbusera, A; Gozzi, A; Guerri, G; Iasevoli, F; Keller, S; Napolitano, F; Salvatore, F; Sforazzini, F; Squillace, M; Usiello, A; Vitucci, D | 1 |
| Cui, D; Ma, YY; Mao, P; Zhao, XD | 1 |
| Abe, K; Aoki, T; Chaki, S; Iijima, M; Kaku, A; Kambe, D; Karasawa, J; Kawakita, Y; Okubo, T; Okuyama, S; Sekiguchi, Y; Shibata, T; Shimazaki, T; Yamamoto, S | 1 |
| Maher, P; Martínez-Bartolomé, S; McClatchy, DB; Park, SK; Powell, SB; Savas, JN; Yates, JR | 1 |
| Artigas, F; Castañé, A; Santana, N | 1 |
| Amano, Y; Hamaguchi, W; Hattori, K; Kikuchi, S; Masuda, N; Mihara, T; Miyamoto, S; Moriguchi, H; Narazaki, F; Seo, R; Shiina, Y | 1 |
| Bahn, S; Guest, PC; Holmes, E; Rahmoune, H; Want, EJ; Wesseling, H | 1 |
| Ballard, TM; Haman, M; Janhunen, SK; Kumar, G; Lerdrup, L; Plath, N; Ruby, T; Steckler, T; Svärd, H; Talpos, J; Wyler, R | 1 |
| Lodge, D; Mercier, MS | 1 |
| Fujita, Y; Hashimoto, K; Hashimoto, R; Ishima, T; Ohi, K; Shirai, Y; Suganuma, H; Takeda, M; Ushida, Y; Yamamori, H; Yasuda, Y | 1 |
| Conn, PJ; Daniels, JS; Dickerson, JW; Ghoshal, A; Jalan-Sakrikar, N; Jones, CK; Lamsal, A; Lindsley, CW; Melancon, BJ; Morrison, RD; Niswender, CM; Noetzel, MJ; Poslusney, MS; Rook, JM; Roop, GN; Stauffer, SR; Wood, MR; Xiang, Z | 1 |
| Caron, MG; Chen, M; Dulman, RS; Jin, J; Park, SM; Rodriguiz, RM; Schmerberg, CM; Wetsel, WC | 1 |
| Bolbecker, AR; Krishnan, GP; Leishman, E; Millward, JB; Morzorati, SL; O'Donnell, BF; Rass, O; Vohs, JL | 1 |
| Egecioglu, E; Engel, JA; Jerlhag, E; Smith, RG; Svensson, L | 1 |
| Alberati, D; Borroni, E; Glavis-Bloom, C; Goonawardena, AV; Heiss, J; Trube, G; Wallace, TL | 1 |
| Li, M; Mulholland, MM; Schulz, TD; Swalve, N | 1 |
| Aguilar, DD; Giuffrida, A; Lodge, DJ | 1 |
| Adham, N; Ferguson, P; Grayson, B; Gyertyán, I; Kiss, B; Neill, JC | 1 |
| Adham, N; Fone, KCF; Gyertyán, I; King, MV; Kiss, B; Watson, DJG | 1 |
| Huang, XF; Yu, Y; Zhang, Q | 1 |
| Engel, M; Frank, E; Huang, XF; Matosin, N; Newell, KA; Snikeris, P | 1 |
| Giuffrida, A; Matricon, J; Seillier, A | 1 |
| Doostdar, N; Neill, JC; Sahin, C | 1 |
| Bahn, S; Cooper, JD; Cox, DA; Ernst, A; Gottschalk, MG; Wesseling, H | 1 |
| Alexander, SP; Fone, KC; Gaskin, PL; Toledo-Rodriguez, M | 1 |
| Naowaboot, J; Piyabhan, P; Wannasiri, S | 1 |
| Neill, JC; Reynolds, GP | 1 |
| Andrews, JL; Fernandez, F; Huang, XF; Lum, JS; Matosin, N; Newell, KA; Ooi, L | 1 |
| Pitsikas, N | 1 |
| Bhattacharya, A; Calovi, S; Csölle, C; Haller, J; Hanuska, A; Kató, E; Köles, L; Koványi, B; Sperlágh, B | 1 |
| Gil-Ad, I; Krivoy, A; Taler, M; Tarasenko, I; Weizman, A | 1 |
| Call, T; Hammer, RP; Kimmel, PC; Maple, AM | 1 |
| Andrews, JL; Fernandez-Enright, F; Goodfellow, FJ; Huang, XF; Matosin, N; Newell, KA; Snelling, MK | 1 |
| Peters, SM; Pinter, IJ; Spruijt, BM; Tuffnell, JA; van der Harst, JE | 1 |
| Asif-Malik, A; Dautan, D; Gerdjikov, TV; Young, AMJ | 1 |
| Anastasio, NC; Johnson, KM | 1 |
| Alonso, R; Avenet, P; Bergis, O; Biton, B; Boulay, D; Cohen, C; Coste, A; Dargazanli, G; Desvignes, C; Estenne-Bouhtou, G; George, P; Griebel, G; Lanneau, C; Oury-Donat, F; Pichat, P; Rogacki, N; Scatton, B; Sevrin, M; Steinberg, R; Stemmelin, J; Terranova, JP; Vigé, X | 1 |
| Ballantyne, P; Huang, XF; Newell, K; Nguyen, V; Zavitsanou, K | 1 |
| Elliott, JJ; Harte, MK; Jenkins, TA; McKibben, CE; Reynolds, GP | 1 |
| Guan, HC; Seeman, P | 1 |
| Hori, E; Maior, R; Maior, RS; Mao, CV; Nishijo, H; Ono, T | 1 |
| Di Marzo, V; Guidali, C; Parolaro, D; Petrosino, S; Realini, N; Rubino, T; Vigano, D | 1 |
| Elsworth, JD; Jentsch, JD; Roth, RH; Sanchez, D | 1 |
| Amitai, N; Markou, A; Semenova, S | 2 |
| He, W; Li, M; Mead, A | 1 |
| Biedermann, F; Fleischhacker, WW | 1 |
| Hareyama, N; Ichinose, H; Ikeda, K; Kurokawa, T; Mochizuki, H; Nakajima, M; Nakao, K; Yoshikawa, S | 1 |
| Broberg, BV; Dias, R; Glenthøj, BY; Larsen, DB; Olsen, CK | 1 |
| Choi, YK; Neill, JC; Shahid, M; Snigdha, S; Tarazi, FI | 1 |
| Feldon, J; Singer, P; Yee, BK | 1 |
| Mouri, A; Nabeshima, T; Noda, Y; Waki, Y | 1 |
| Adams, W; Ayton, S; van den Buuse, M | 1 |
| McLean, SL; Neill, JC; Thomas, D; Woolley, ML | 1 |
| Bolognani, F; Botta, P; Bullock, WM; Perrone-Bizzozero, NI; Valenzuela, CF | 1 |
| Mizoguchi, H; Nakatani-Pawlak, A; Tatsumi, Y; Yamaguchi, K; Yoneda, Y | 1 |
| Cai, W; Chen, X; Cheng, J; Guo, Y; Jin, G; Yang, Y; Zhang, H; Zhen, X | 1 |
| Dias, R; Goetghebeur, P; Pedersen, CS | 1 |
| Hiraoka, S; Kajii, Y; Kuroda, Y; Nishikawa, T; Umino, A | 1 |
| Arnt, J; Bang-Andersen, B; Brennum, LT; Grayson, B; Idris, N; Neill, J; Witten, LM | 1 |
| Fadda, P; Fattore, L; Fratta, W; Frau, R; Spano, MS | 1 |
| Boules, M; Li, Z; Peris, J; Richelson, E; Williams, K | 1 |
| Danysz, W; Gravius, A; Pietraszek, M; Schlumberger, C | 1 |
| Bahn, S; Cheng, TM; Guest, PC; Harris, LW; Lió, P; Lu, YE; Ma, D; Rahmoune, H; Stelzhammer, V; Umrania, Y; Wang, L; Wayland, MT | 1 |
| Blau, C; Fagan, AJ; Harte, M; Harvey, RP; Kerskens, C; Lai, D; O'Leary, C; O'Sullivan, GJ; O'Tuathaigh, CM; Reynolds, GP; Tighe, O; Waddington, JL | 1 |
| Chen, J; Li, M; Wang, Z | 1 |
| Harte, MK; Jenkins, TA; Reynolds, GP | 1 |
| Dwyer, DM; Gilmour, G; Lydall, ES | 1 |
| Binelli, G; Di Marzo, V; Guidali, C; Parolaro, D; Petrosino, S; Realini, N; Rubino, T; Viganò, D; Zamberletti, E | 1 |
| Bian, SZ; Gu, ZL; Jiang, XG; Liu, WL; Sun, ZH; Zhang, J | 1 |
| Amitai, N; Markou, A | 2 |
| Bastlund, JF; Broberg, BV; Fejgin, K; Glenthøj, BY; Oranje, B; Plath, N | 1 |
| Allen, JA; Cho, SJ; Jensen, NH; Kozikowski, AP; Roth, BL; Svennebring, AM | 1 |
| Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ | 1 |
| Bach, JH; Jung, BD; Kim, HC; Kim, JM; Kim, S; Nabeshima, T; Nguyen, TT; Nguyen, XK; Shin, EJ; Whang, WK; Yamada, K | 1 |
| Boules, M; Gordillo, A; Li, S; Li, Z; Richelson, E; Williams, K | 1 |
| Javitt, DC | 5 |
| Guo, L; Hanig, JP; Liu, F; Patterson, TA; Paule, MG; Qian, F; Sadovova, N; Shi, L; Slikker, W; Wang, C; Wen, Z; Zhang, X; Zou, X | 1 |
| Dias, R; Goetghebeur, PJ; Lerdrup, L; Sylvest, A | 1 |
| Klamer, D; Lowry, J; Pålsson, E | 1 |
| Hansen, HH; Mikkelsen, JD; Thomsen, MS | 1 |
| Damgaard, T; Hansen, SL; Neill, JC; Plath, N | 1 |
| Basu, AC; Benneyworth, MA; Coyle, JT; Roseman, AS | 1 |
| Fejgin, K; Klamer, D; Pålsson, E; Svensson, L | 1 |
| Nishikawa, T | 2 |
| Nabeshima, T | 2 |
| Krolikowski, KA; Neale, JH; Olszewski, RT; Profaci, CP | 1 |
| Alvaro, GS; Antolini, M; Bison, S; Gill, CH; Gozzi, A; Gunthorpe, MJ; Hollands, E; Idris, N; Large, CH; Neill, JC; Quarta, D; Read, KD; Sartori, I | 1 |
| Dawson, N; Higham, DJ; Macintyre, L; Morris, BJ; Pratt, JA; Watson, DG; Xiao, X | 1 |
| Boyette-Davis, J; Fuchs, PN | 1 |
| Kennedy, MD; Morris, BJ; Pratt, JA; Steward, LJ | 1 |
| Elsworth, JD; Hajszan, T; Leranth, C; Roth, RH | 1 |
| Arinami, T; Deng, X; Fukumaki, Y; Hashimoto, K; Inada, T; Itokawa, M; Iwata, N; Kunugi, H; Kuroki, T; Nakahara, T; Ninomiya, H; Ozaki, N; Shibata, H; Someya, T; Takaki, H; Tochigi, M; Ujike, H; Wang, L; Watanabe, Y | 1 |
| Adell, A; Jiménez-Sánchez, L; López-Gil, X; Romón, T | 1 |
| Hou, J; Kristiansen, LV; Owczarek, S; Secher, T | 1 |
| Hrupka, B; Pemberton, DJ; Pollard, M; Shaban, H; Steckler, T; Varin, C | 1 |
| Bruun, AT; Bundgaard, C; de Jong, IE; Didriksen, M; Elster, L; Frederiksen, K; Larsen, PH; Redrobe, JP; Smith, GP | 1 |
| Gross, G; Mezler, M; Mueller, BK; Relo, AL; van Gaalen, MM | 1 |
| Bate, ST; Jones, DN; Kalinichev, M | 1 |
| Bzdega, T; Neale, JH; Olszewski, RT | 1 |
| Domino, EF; Luby, ED | 1 |
| Aerts, N; Alsaif, M; Amess, B; Bahn, S; Ernst, A; Guest, PC; Harris, LW; Lenaerts, I; Martins-de-Souza, D; Peeters, PJ; Rahmoune, H | 1 |
| Mattsson, A; Olson, L; Savage, S | 1 |
| Bolton, MM; Heaney, CF; Kinney, JW; Magcalas, CM; Murtishaw, AS; Sabbagh, JJ | 1 |
| Bzdega, T; Moffett, JR; Neale, JH; Olszewski, RT; Zuo, D | 1 |
| Fujita, Y; Hashimoto, K; Horio, M | 1 |
| Bahn, S; Ernst, A; Garcia-Perez, I; Guest, PC; Holmes, E; Kluge, W; Ma, D; Sarnyai, Z; Schwarz, E; Tsang, TM | 1 |
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| Furukawa, H; Mouri, A; Nabeshima, T; Nakamura, T; Nitta, A; Noda, A; Noda, Y; Tokura, T; Yura, Y | 1 |
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| Fujita, Y; Hagiwara, H; Hashimoto, K; Ishima, T; Iyo, M; Kunitachi, S; Zhang, L | 1 |
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61 review(s) available for phencyclidine and Schizophrenia
| Article | Year |
|---|---|
Brain NMDA Receptors in Schizophrenia and Depression.
Topics: Animals; Brain; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Ketamine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2020 |
DARK Classics in Chemical Neuroscience: Phencyclidine (PCP).
Topics: Glutamic Acid; Hallucinogens; History, 20th Century; History, 21st Century; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2018 |
Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia.
Topics: Animals; Brain; Humans; Kynurenine; Phencyclidine; Schizophrenia; Signal Transduction; Tryptophan | 2019 |
Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Disease Models, Animal; Gene-Environment Interaction; Humans; Mice; Nerve Tissue Proteins; Neuregulin-1; Nuclear Receptor Subfamily 4, Group A, Member 2; Peptides; Phencyclidine; Phenotype; Point Mutation; Schizophrenia; Schizophrenic Psychology | 2013 |
The role of the hippocampo-prefrontal cortex system in phencyclidine-induced psychosis: a model for schizophrenia.
Topics: Animals; Disease Models, Animal; Hippocampus; Humans; Phencyclidine; Prefrontal Cortex; Psychotic Disorders; Rats; Schizophrenia | 2013 |
Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain; Disease Models, Animal; Humans; Indophenol; Phencyclidine; Prefrontal Cortex; Schizophrenia; Schizophrenic Psychology; Thalamic Nuclei | 2013 |
Reviewing the ketamine model for schizophrenia.
Topics: Age of Onset; Animals; Dopamine; gamma-Aminobutyric Acid; Humans; Ketamine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2014 |
Prefrontal dysfunction and a monkey model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Haplorhini; Phencyclidine; Prefrontal Cortex; Psychomotor Performance; Schizophrenia | 2015 |
The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia.
Topics: Animals; Attention; Cognition Disorders; Disease Models, Animal; Male; Phencyclidine; Rats; Reversal Learning; Schizophrenia | 2015 |
Ketamine and phencyclidine: the good, the bad and the unexpected.
Topics: Animals; Antidepressive Agents; Excitatory Amino Acid Antagonists; Humans; Ketamine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2015 |
Modelling the cognitive and neuropathological features of schizophrenia with phencyclidine.
Topics: Animals; Antipsychotic Agents; Cognition; gamma-Aminobutyric Acid; Humans; Interneurons; Parvalbumins; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2016 |
The Role of Nitric Oxide Synthase Inhibitors in Schizophrenia.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Humans; Ketamine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phencyclidine; Schizophrenia | 2016 |
Antipsychotics in the early stage of development.
Topics: Antipsychotic Agents; Dopamine; Glutamic Acid; Humans; Ketamine; Phencyclidine; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Receptors, Serotonin; Schizophrenia; Serotonin; Severity of Illness Index; Synaptic Transmission | 2009 |
[Development of animal models for schizophrenia based on clinical evidence: expectation for psychiatrists].
Topics: Animals; Disease Models, Animal; Evidence-Based Medicine; Humans; Mice; Mice, Transgenic; Nerve Tissue Proteins; Phencyclidine; Phencyclidine Abuse; Polymorphism, Single Nucleotide; Psychiatry; Schizophrenia | 2009 |
[Receptor antagonist of NMDA and animal models of schizophrenia].
Topics: Animals; Behavior, Animal; Brain; Consciousness Disorders; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Ketamine; Mice; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2009 |
Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophrenia.
Topics: Animals; Choice Behavior; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Humans; Neuropsychological Tests; Phencyclidine; Reaction Time; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2010 |
Glutamatergic theories of schizophrenia.
Topics: Animals; Brain; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Nerve Net; Phencyclidine; Prefrontal Cortex; Psychological Theory; Receptors, Dopamine D2; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2010 |
[Development of a novel pharmacotherapy targeted at the N-methyl-D-aspartate receptor-D-serine system for schizophrenia].
Topics: Animals; Clinical Trials as Topic; Drug Design; Glycine; Humans; Molecular Targeted Therapy; Phencyclidine; Psychotropic Drugs; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2010 |
Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Brief Psychiatric Rating Scale; Cerebral Cortex; Disease Models, Animal; Dopamine; Emotions; Glutamic Acid; Humans; Ketamine; Neurosciences; Phencyclidine; Psychoses, Substance-Induced; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses; Translational Research, Biomedical | 2012 |
Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Brain; Brain Mapping; Cerebral Cortex; Cognition Disorders; Contingent Negative Variation; Disease Models, Animal; Drug Synergism; Glycine; Hippocampus; Humans; Ketamine; Perception; Phencyclidine; Psychoses, Substance-Induced; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2012 |
Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness.
Topics: Animals; Antipsychotic Agents; Behavior; Behavior, Animal; Brain; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Haloperidol; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, Dopamine; Receptors, Glutamate; Receptors, Serotonin; Schizophrenia | 2002 |
Phencyclidine (PCP): a dangerous drug, but useful in schizophrenia research.
Topics: Hallucinogens; Humans; Models, Neurological; Phencyclidine; Research; Schizophrenia; Schizophrenic Psychology | 2002 |
[Genetic study on schizophrenia and its recurrence utilizing pharmacological models].
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Disease Models, Animal; Dopamine Agents; Humans; Ketamine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Recurrence; Schizophrenia | 2002 |
[PSYCHODYSLEPTIC DRUGS. II. SOME PROBLEMS RELATED TO THEIR USE].
Topics: Cerebral Cortex; Chemical Phenomena; Chemistry; Classification; Dosage Forms; Drug Combinations; Electroencephalography; Glycolates; Hallucinogens; Humans; Indoles; Lysergic Acid Diethylamide; Mescaline; Phencyclidine; Piperidines; Psychopharmacology; Pyrrolidines; Schizophrenia; Toxicology | 1964 |
Alpha-adrenoceptor modulation hypothesis of antipsychotic atypicality.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Humans; Mood Disorders; Phencyclidine; Receptors, Adrenergic, alpha; Schizophrenia | 2003 |
Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia.
Topics: Amphetamine; Animals; Cognition Disorders; Dopamine; Glutamic Acid; Humans; Memory, Short-Term; Models, Animal; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2004 |
The role of the extracellular signal-regulated kinase pathway in cerebellar abnormalities in schizophrenia.
Topics: Animals; Cerebellum; Disease Models, Animal; Humans; Mitogen-Activated Protein Kinases; Neurons; Phencyclidine; Schizophrenia; Signal Transduction | 2004 |
Glutamate as a therapeutic target in psychiatric disorders.
Topics: Animals; Disease Models, Animal; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Mental Disorders; Phencyclidine; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2004 |
[Role of magnesium ions on the regulation of NMDA receptor--a pharmacopathology of memantine].
Topics: Alzheimer Disease; Binding Sites; Brain Ischemia; Dizocilpine Maleate; Humans; Magnesium; Memantine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2004 |
A GABAergic cortical deficit dominates schizophrenia pathophysiology.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Dendrites; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hallucinogens; Humans; Neuronal Plasticity; Neurons; Phencyclidine; Pyramidal Cells; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Reelin Protein; Schizophrenia | 2004 |
PCP: from pharmacology to modelling schizophrenia.
Topics: Animals; Hallucinogens; Humans; Models, Biological; Phencyclidine; Phencyclidine Abuse; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2005 |
[Phencyclidine--angel dust].
Topics: Diagnosis, Differential; Hallucinogens; Humans; Phencyclidine; Phencyclidine Abuse; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2005 |
[Dysfunction of glutamatergic systems and potential animal models of schizophrenia].
Topics: Animals; Disease Models, Animal; Glutamates; Mice; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2006 |
[Update on the animal models of schizophrenia].
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Drug Design; Excitatory Amino Acid Antagonists; Glycine; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2006 |
Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cognition; Disease Models, Animal; Glutamic Acid; Mice; Motor Activity; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Signal Transduction | 2006 |
Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
Topics: Animals; Antipsychotic Agents; Brain; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis.
Topics: Animals; Behavior, Animal; Calcineurin; Cognition; Disease Models, Animal; Gait; Glutamic Acid; Humans; Inhibition, Psychological; Mice; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Neuregulin-1; Phencyclidine; Receptors, Lysophosphatidic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2007 |
[Behavioral evaluation in animal models of schizophrenia].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Learning; Mice; Phencyclidine; Schizophrenia | 2007 |
Modelling prefrontal cortex deficits in schizophrenia: implications for treatment.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Humans; Phencyclidine; Prefrontal Cortex; Psychoses, Substance-Induced; Schizophrenia | 2008 |
[Drugs acting on D3 receptors in neuropsychiatric disorders: facts and prospects. Implication for schizophrenia and its treatment in the regulation of BDNF-dependence on D3 receptor expression].
Topics: Brain-Derived Neurotrophic Factor; Excitatory Amino Acid Antagonists; Humans; Phencyclidine; Receptors, Dopamine D3; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
Psychiatric and medical syndromes associated with phencyclidine (PCP) abuse.
Topics: Adolescent; Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Brain; Child; Delirium; Humans; Male; Mental Disorders; Phencyclidine; Phencyclidine Abuse; Schizophrenia | 1981 |
[The phencyclidine-N-methyl-D-aspartate theory of schizophrenia: clinical applications].
Topics: Humans; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1994 |
[Physiological function of sigma receptors: central pharmacological effects of sigma ligands].
Topics: Acetylcholine; Animals; Binding Sites; Brain; Dopamine; Humans; Ligands; Neuropeptides; Phencyclidine; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia | 1994 |
Delineating biochemical and functional properties of sigma receptors: emerging concepts.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain Neoplasms; Down-Regulation; Humans; Ligands; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Up-Regulation | 1993 |
The phencyclidine-glutamate model of schizophrenia.
Topics: Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Phencyclidine; Schizophrenia | 1995 |
The N-methyl-D-aspartate receptor and schizophrenia.
Topics: Brain; Dopamine; Excitatory Amino Acid Antagonists; Humans; Ketamine; Models, Neurological; Phencyclidine; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1996 |
Glutamate in schizophrenia: clinical and research implications.
Topics: Aging; Citric Acid Cycle; Dopamine; Glutamic Acid; Humans; Phencyclidine; Receptors, Amino Acid; Receptors, Glutamate; Schizophrenia | 1997 |
The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia.
Topics: Animals; Brain Chemistry; Cognition; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1999 |
Olanzapine: preclinical pharmacology and recent findings.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Cholinergic Antagonists; Clozapine; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Humans; Maze Learning; Motor Activity; Muscarinic Antagonists; Olanzapine; Pharmaceutical Vehicles; Phencyclidine; Pirenzepine; Schizophrenia; Scopolamine; Social Isolation | 1999 |
Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity.
Topics: Animals; Antipsychotic Agents; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Neural Networks, Computer; Phencyclidine; Psychotic Disorders; Rats; Reproducibility of Results; Schizophrenia; Social Behavior Disorders; Stereotyped Behavior | 1999 |
Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization.
Topics: Animals; Brain Chemistry; Cocaine-Related Disorders; Hallucinogens; Humans; Methamphetamine; Phencyclidine; Predictive Value of Tests; Psychoses, Substance-Induced; Recurrence; Schizophrenia; Sensory Thresholds; Sympathomimetics | 1999 |
Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action.
Topics: Amphetamines; Amygdala; Animals; Behavior; Brain Mapping; Central Nervous System Stimulants; Cognition; Corpus Striatum; Depression; Dopamine; Dopamine Agonists; Emotions; Haplorhini; Humans; Learning; Limbic System; Mammals; Memory; Mental Disorders; Neural Pathways; Neurotransmitter Agents; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Psychotropic Drugs; Receptors, Neurotransmitter; Reward; Schizophrenia; Substance-Related Disorders | 2000 |
Advances in schizophrenia.
Topics: Antipsychotic Agents; Brain; Brain Chemistry; Dopamine; Excitatory Amino Acid Antagonists; Genetic Linkage; Humans; Phencyclidine; Risk Factors; Schizophrenia | 2001 |
Glutamatergic mechanisms in schizophrenia.
Topics: Animals; Dopamine; Glutamic Acid; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2002 |
Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia.
Topics: Amphetamine; Animals; Dopamine Agents; Gene Expression Regulation; Hallucinogens; Humans; Phencyclidine; Psychoses, Substance-Induced; Schizophrenia | 2002 |
[Glutamate hypothesis of schizophrenia and targets for new antipsychotic drugs].
Topics: Animals; Antipsychotic Agents; Corpus Callosum; Dizocilpine Maleate; Drug Design; Glutamates; Glutathione; Glycine; Gyrus Cinguli; Humans; Phencyclidine; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2002 |
Recent advances in the phencyclidine model of schizophrenia.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Memory; Mice; Paired-Associate Learning; Phencyclidine; Phencyclidine Abuse; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Schizophrenia; Schizophrenic Psychology | 1991 |
Phencyclidine, NMDA receptor and schizophrenia.
Topics: Animals; Binding Sites; Phencyclidine; Rats; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1991 |
Clinical implications of PCP, NMDA and opiate receptors.
Topics: Animals; Antipsychotic Agents; Brain; Humans; Phencyclidine; Phencyclidine Abuse; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Schizophrenia; Schizophrenic Psychology; Violence | 1989 |
Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia.
Topics: Animals; Humans; Male; Phencyclidine; Psychoses, Substance-Induced; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Schizophrenia; Schizophrenic Psychology | 1987 |
Dopamine and the action of opiates: a reevaluation of the dopamine hypothesis of schizophrenia. With special consideration of the role of endogenous opioids in the pathogenesis of schizophrenia.
Topics: Brain; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Endorphins; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Morphine; Naloxone; Phencyclidine; Prolactin; Receptors, Dopamine; Receptors, Opioid; Schizophrenia; Substantia Nigra; Synaptic Transmission | 1985 |
2 trial(s) available for phencyclidine and Schizophrenia
| Article | Year |
|---|---|
A schizophrenia rat model induced by early postnatal phencyclidine treatment and characterized by Magnetic Resonance Imaging.
Topics: Age Factors; Animals; Animals, Newborn; Blood Gas Analysis; Blood Volume; Brain; Brain Mapping; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Magnetic Resonance Imaging; Male; Multivariate Analysis; Phencyclidine; Rats; Schizophrenia; Time Factors | 2013 |
Sernyl, ditran, and their antagonists: succinate and THA.
Topics: Acridines; Adult; Anesthetics; Bipolar Disorder; Brain Diseases; Clinical Trials as Topic; Drug Antagonism; Female; Hallucinogens; Humans; Male; Middle Aged; Phencyclidine; Psychotic Disorders; Schizophrenia; Succinates | 1966 |
332 other study(ies) available for phencyclidine and Schizophrenia
| Article | Year |
|---|---|
Does nicotine exposure during adolescence modify the course of schizophrenia-like symptoms? Behavioral analysis in a phencyclidine-induced mice model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Locomotion; Male; Mice; Motor Activity; Nicotine; Phencyclidine; Recognition, Psychology; Schizophrenia; Sensory Gating | 2021 |
Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.
Topics: Animals; Disease Models, Animal; Guanylate Kinases; Haploinsufficiency; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Phencyclidine; Rats; Schizophrenia; Social Behavior; Tumor Suppressor Proteins | 2022 |
The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia.
Topics: Allosteric Regulation; Animals; Cognition; Niacinamide; Oxazoles; Phencyclidine; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Schizophrenia | 2022 |
Targeting α6GABA
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Methamphetamine; Mice; Phencyclidine; Rats; Receptors, GABA-A; Schizophrenia | 2022 |
Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia.
Topics: Animals; Connective Tissue Growth Factor; Disease Models, Animal; Hallucinogens; Mice; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Purkinje Cells; Receptors, Phencyclidine; Schizophrenia; Synapses | 2022 |
Fingolimod ameliorates schizophrenia-like cognitive impairments induced by phencyclidine in male rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2023 |
Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Cyclin-Dependent Kinase 5; Disks Large Homolog 4 Protein; Mice; Phencyclidine; Psychotic Disorders; Schizophrenia | 2023 |
Reinforcement learning deficits exhibited by postnatal PCP-treated rats enable deep neural network classification.
Topics: Animals; Phencyclidine; Rats; Reversal Learning; Reward; Schizophrenia; Synaptic Transmission | 2023 |
Handling prevents and reverses cognitive deficits induced by sub-chronic phencyclidine in a model for schizophrenia in rats.
Topics: Animals; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Female; Phencyclidine; Rats; Schizophrenia | 2023 |
Neonatal phencyclidine as a model of sex-biased schizophrenia symptomatology in adolescent mice.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Olanzapine; Phencyclidine; Schizophrenia | 2023 |
Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.
Topics: Animals; Disease Models, Animal; Female; Male; Mice; Nicotine; Phencyclidine; Prefrontal Cortex; Schizophrenia; Synaptic Transmission | 2023 |
Increased translocator protein (TSPO) binding throughout neurodevelopment in the perinatal phencyclidine rodent model of schizophrenia.
Topics: Animals; Brain; Carrier Proteins; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia | 2019 |
Synaptic biomarker reduction and impaired cognition in the sub-chronic PCP mouse model for schizophrenia.
Topics: Animals; Biomarkers; Cognitive Dysfunction; Disks Large Homolog 4 Protein; Female; Frontal Lobe; Glutamate Decarboxylase; Hippocampus; Male; Mice; Parvalbumins; Phencyclidine; Rats; Recognition, Psychology; Schizophrenia; Synaptosomal-Associated Protein 25 | 2020 |
Optogenetic inhibition of ventral hippocampal neurons alleviates associative motor learning dysfunction in a rodent model of schizophrenia.
Topics: Animals; Behavior, Animal; Conditioning, Eyelid; Deep Brain Stimulation; Disease Models, Animal; Hallucinogens; Hippocampus; Learning Disabilities; Male; Neurons; Optogenetics; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2019 |
Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dronabinol; Endocannabinoids; Glycogen Synthase Kinase 3 beta; Male; Motor Activity; Neurons; Phencyclidine; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Ventral Tegmental Area | 2020 |
Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Female; Longitudinal Studies; Memory Disorders; Phencyclidine; Physical Conditioning, Animal; Rats; Recognition, Psychology; Running; Schizophrenia | 2020 |
Calbindin Deficits May Underlie Dissociable Effects of 5-HT
Topics: Animals; Behavior, Animal; Calbindins; Cognition; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Phencyclidine; Receptors, Metabotropic Glutamate; Receptors, Serotonin; Schizophrenia; Serotonin | 2020 |
Repeated phencyclidine disrupts nicotinic acetylcholine regulation of dopamine release in nucleus accumbens: Implications for models of schizophrenia.
Topics: Animals; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Nucleus Accumbens; Phencyclidine; Rats; Rats, Wistar; Receptors, Nicotinic; Schizophrenia | 2020 |
Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia.
Topics: Animals; Disease Models, Animal; Extracellular Vesicles; Humans; Mesenchymal Stem Cells; Mice; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2020 |
Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice.
Topics: Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Dependency, Psychological; Disease Models, Animal; Female; Humans; Male; Mice; Middle Aged; Nicotine; Nucleus Accumbens; Phencyclidine; Schizophrenia; Social Interaction | 2020 |
Neonatal phencyclidine and social isolation in the rat: effects of clozapine on locomotor activity, social recognition, prepulse inhibition, and executive functions deficits.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Executive Function; Locomotion; Male; Phencyclidine; Prepulse Inhibition; Rats; Rats, Wistar; Recognition, Psychology; Reversal Learning; Schizophrenia; Schizophrenic Psychology; Social Isolation | 2021 |
Preventive role of regular low-intensity exercise during adolescence in schizophrenia model mice with abnormal behaviors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Female; Homovanillic Acid; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Phencyclidine; Phosphorylation; Physical Conditioning, Animal; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2021 |
Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
Topics: Animals; Conditioning, Operant; Cyclic Nucleotide Phosphodiesterases, Type 1; Disease Models, Animal; Female; Goals; Hallucinogens; Phencyclidine; Phosphodiesterase Inhibitors; Prefrontal Cortex; Rats; Schizophrenia | 2021 |
Depolarizing GABA
Topics: Animals; Bumetanide; Cognitive Dysfunction; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2021 |
Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Mice; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Receptors, Nicotinic; Schizophrenia; Smoking; Social Behavior | 2021 |
Modulation of stimulated dopamine release in rat nucleus accumbens shell by GABA in vitro: Effect of sub-chronic phencyclidine pretreatment.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Nucleus Accumbens; Phencyclidine; Rats; Rats, Wistar; Schizophrenia | 2021 |
Pairing of neonatal phencyclidine exposure and acute adolescent stress in male rats as a novel developmental model of schizophrenia.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia; Stress, Psychological | 2021 |
Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2021 |
The potential of the P2X7 receptor as a therapeutic target in a sub-chronic PCP-induced rodent model of schizophrenia.
Topics: Animals; Animals, Newborn; Drug Delivery Systems; Hallucinogens; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Niacinamide; Phencyclidine; Piperazines; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Rodentia; Schizophrenia | 2021 |
Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1.
Topics: Andrographis paniculata; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Diterpenes; Epistasis, Genetic; Inflammation; Kelch-Like ECH-Associated Protein 1; Male; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Phencyclidine; Phytotherapy; Schizophrenia; Signal Transduction | 2021 |
Acquisition of nicotine self-administration in amphetamine and phencyclidine models of schizophrenia: A role for stress?
Topics: Amphetamine; Animals; Disease Models, Animal; Learning; Male; Motor Activity; Nicotine; Nicotinic Agonists; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Self Administration; Stress, Psychological; Tobacco Use Disorder | 2018 |
Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hallucinogens; Image Processing, Computer-Assisted; Interpersonal Relations; Locomotion; Magnetic Resonance Imaging; Male; Microdialysis; Oxygen; Phencyclidine; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology | 2017 |
Dopamine D
Topics: Animals; Antipsychotic Agents; Benzamides; Clozapine; Cognitive Dysfunction; Female; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D4; Schizophrenia; Serotonin 5-HT1 Receptor Agonists | 2017 |
Generation of the Acute Phencyclidine Rat Model for Proteomic Studies of Schizophrenia.
Topics: Acute Disease; Animals; Brain Chemistry; Disease Models, Animal; Hormones; Immunoassay; Inflammation; Locomotion; Male; Nerve Tissue Proteins; Phencyclidine; Proteomics; Rats; Rats, Sprague-Dawley; Schizophrenia; Serum | 2017 |
RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia.
Topics: Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Cerebral Cortex; Conditioning, Operant; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Male; Memory; Mice, Inbred C57BL; Motor Activity; Neurotransmitter Agents; Phencyclidine; Psychotic Disorders; Random Allocation; Reversal Learning; Schizophrenia; Schizophrenic Psychology | 2017 |
Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: A preliminary investigation.
Topics: Animals; Behavior, Animal; Cognition; Cognitive Dysfunction; Disease Models, Animal; Dopamine; Female; Phencyclidine; Prefrontal Cortex; Rats; Recognition, Psychology; Schizophrenia | 2017 |
Phencyclidine administration during neurodevelopment alters network activity in prefrontal cortex and hippocampus in adult rats.
Topics: Animals; Animals, Newborn; Cortical Synchronization; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Gamma Rhythm; Hippocampus; Male; Neural Pathways; Phencyclidine; Prefrontal Cortex; Random Allocation; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Theta Rhythm | 2017 |
Prolonged deficits of associative motor learning in cynomolgus monkeys after long-term administration of phencyclidine.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Female; Macaca fascicularis; Male; Motor Activity; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Time | 2017 |
Δ9-tetrahydrocannabinol (Δ9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice.
Topics: Animals; Animals, Newborn; Dronabinol; Drug Synergism; Female; Hallucinogens; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Tissue Proteins; Phencyclidine; Psychomotor Performance; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Reflex, Startle; Schizophrenia; Schizophrenic Psychology | 2017 |
Role of mGlu
Topics: Animals; Antipsychotic Agents; Cholinergic Agents; Cognition; Mice, Inbred C57BL; Neuronal Plasticity; Phencyclidine; Prefrontal Cortex; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2017 |
Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Cannabinoids; Carbamates; Disease Models, Animal; Exploratory Behavior; Interpersonal Relations; Male; Phencyclidine; Piperidines; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2017 |
Rodent Mismatch Negativity/theta Neuro-Oscillatory Response as a Translational Neurophysiological Biomarker for N-Methyl-D-Aspartate Receptor-Based New Treatment Development in Schizophrenia.
Topics: Animals; Antipsychotic Agents; Auditory Cortex; Auditory Perception; Electrodes, Implanted; Evoked Potentials; Excitatory Amino Acid Agents; Glycine; Phencyclidine; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Theta Rhythm | 2018 |
ErbB signaling antagonist ameliorates behavioral deficit induced by phencyclidine (PCP) in mice, without affecting metabolic syndrome markers.
Topics: Animals; Animals, Outbred Strains; Antipsychotic Agents; Clozapine; Disease Models, Animal; ErbB Receptors; Male; Metabolic Syndrome; Mice, Inbred ICR; Morpholines; Phencyclidine; Protein Kinase Inhibitors; Pyrimidines; Schizophrenia; Schizophrenic Psychology; Signal Transduction | 2018 |
Phencyclidine-induced dysregulation of primary cilia in the rodent brain.
Topics: Animals; beta Catenin; Brain; CA1 Region, Hippocampal; Cerebral Cortex; Cilia; Cognition; Disease Models, Animal; Dopamine; Dopamine Agonists; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine.
Topics: Animals; Antipsychotic Agents; Bone and Bones; Bone Density; Clozapine; Corticosterone; Female; Haloperidol; Interleukin-6; Male; Phencyclidine; Rats, Wistar; Schizophrenia; Sex Characteristics; Tumor Necrosis Factor-alpha | 2017 |
Ginsenoside Re protects against phencyclidine-induced behavioral changes and mitochondrial dysfunction via interactive modulation of glutathione peroxidase-1 and NADPH oxidase in the dorsolateral cortex of mice.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Ginsenosides; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NADPH Oxidases; Oxidative Stress; Panax; Phencyclidine; Protective Agents; Schizophrenia; Schizophrenic Psychology | 2017 |
Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia.
Topics: Affect; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motivation; N-Methylaspartate; Phencyclidine; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Reward; Schizophrenia; Social Isolation | 2019 |
A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission.
Topics: Abnormalities, Multiple; Amphetamine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Chromosome Deletion; Chromosomes, Human, Pair 1; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Excitatory Amino Acid Antagonists; Megalencephaly; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Phencyclidine; Phenotype; Prepulse Inhibition; Quinpirole; Receptors, Dopamine; Schizophrenia; Ventral Tegmental Area | 2017 |
Effects of selective calcium-permeable AMPA receptor blockade by IEM 1460 on psychotomimetic-induced hyperactivity in the mouse.
Topics: Adamantane; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Receptors, AMPA; Schizophrenia | 2018 |
Downregulation of 5-hydroxytryptamine
Topics: Animals; Attention; Central Nervous System Stimulants; Cognition; Disease Models, Animal; Down-Regulation; Executive Function; Gene Knockdown Techniques; Impulsive Behavior; Male; Maze Learning; Memory; Methamphetamine; Mice, Inbred C57BL; Motor Activity; Phencyclidine; Prefrontal Cortex; Random Allocation; Receptors, Serotonin; Schizophrenia; Schizophrenic Psychology | 2018 |
Male rats treated with subchronic PCP show intact olfaction and enhanced interest for a social odour in the olfactory habituation/dishabituation test.
Topics: Animals; Discrimination, Psychological; Disease Models, Animal; Excitatory Amino Acid Antagonists; Exploratory Behavior; Habituation, Psychophysiologic; Male; Motivation; Olfactory Perception; Pattern Recognition, Physiological; Phencyclidine; Psychological Tests; Random Allocation; Rats, Sprague-Dawley; Schizophrenia; Social Behavior; Time Factors | 2018 |
Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats.
Topics: Animals; Antipsychotic Agents; Brain; Disease Models, Animal; Female; Male; Neurons; Olanzapine; Olfactory Bulb; Olfactory Perception; Perceptual Disorders; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Sex Factors | 2018 |
Estradiol and luteinizing hormone regulate recognition memory following subchronic phencyclidine: Evidence for hippocampal GABA action.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Estradiol; Female; Glutamate Decarboxylase; Hippocampus; Luteinizing Hormone; Memory; Memory Disorders; Memory, Short-Term; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recognition, Psychology; Schizophrenia | 2018 |
Functional mechanism of ASP5736, a selective serotonin 5-HT
Topics: Action Potentials; Animals; Cognitive Dysfunction; Discrimination, Psychological; Dopamine; Dopaminergic Neurons; gamma-Aminobutyric Acid; Guanidines; Interneurons; Isoquinolines; Male; Phencyclidine; Prefrontal Cortex; Rats; Receptors, Serotonin; Schizophrenia; Schizophrenic Psychology; Serotonin Antagonists; Ventral Tegmental Area | 2018 |
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor acti
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Locomotion; Male; Microdialysis; Norepinephrine; Phencyclidine; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Serotonin | 2018 |
Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction.
Topics: Animals; Antipsychotic Agents; Cognition; Drug Therapy, Combination; Interpersonal Relations; Isoindoles; Lurasidone Hydrochloride; Male; Mice, Inbred C57BL; Neurotransmitter Agents; Phencyclidine; Piperazines; Pregnenolone; Pyrimidines; Random Allocation; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2018 |
Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia.
Topics: Action Potentials; Animals; Cognition; Cortical Synchronization; Excitatory Amino Acid Antagonists; Executive Function; Macaca mulatta; Neural Pathways; Neurons; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Task Performance and Analysis; Time Factors | 2018 |
Bacopa monnieri (Brahmi) Prevents Cognitive Deficit by Maintaining CA2/3 VGLUT1 Density of Sub-Chronic Phencyclidine Rat Model of Schizophrenia in Normal Level.
Topics: Animals; Bacopa; Behavior, Animal; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Neostriatum; Neuroprotective Agents; Nootropic Agents; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Vesicular Glutamate Transport Protein 1 | 2016 |
Chronic administration of quetiapine attenuates the phencyclidine-induced recognition memory impairment and hippocampal oxidative stress in rats.
Topics: Animals; Antipsychotic Agents; Female; Hippocampus; Oxidative Stress; Phencyclidine; Quetiapine Fumarate; Rats, Sprague-Dawley; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Tyrosine | 2018 |
Lamotrigine Cross-Reactivity With Phencyclidine in Rapid Urine Toxicology in a Research Study.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; False Positive Reactions; Female; Humans; Immunoassay; Lamotrigine; Mass Spectrometry; Perphenazine; Phencyclidine; Schizophrenia; Triazines | 2018 |
TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABA
Topics: Animals; Cognitive Dysfunction; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Pyridazines; Reversal Learning; Schizophrenia; Triazoles | 2018 |
Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47
Topics: Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Chromones; Clozapine; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Morpholines; NADPH Oxidases; Oxidative Stress; Phencyclidine; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Schizophrenia; Signal Transduction | 2018 |
Role of mGlu2 in the 5-HT
Topics: Animals; Antipsychotic Agents; Clozapine; Frontal Lobe; Male; Mice; Mice, Knockout; Phencyclidine; Psychomotor Agitation; Psychotic Disorders; Receptor, Serotonin, 5-HT2A; Receptors, Metabotropic Glutamate; Schizophrenia | 2018 |
The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Donepezil; Excitatory Amino Acid Antagonists; Male; Maze Learning; Mice; Mice, Inbred ICR; Nootropic Agents; Phencyclidine; Schizophrenia | 2018 |
Reduced expression of synapsin II in a chronic phencyclidine preclinical rat model of schizophrenia.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hallucinogens; Locomotion; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Social Behavior; Synapsins | 2019 |
Continuation of structure-activity relationship study of novel benzamide derivatives as potential antipsychotics.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred ICR; Motor Activity; Phencyclidine; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Schizophrenia; Structure-Activity Relationship | 2019 |
Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys.
Topics: Animals; Excitatory Amino Acid Antagonists; Locomotion; Macaca mulatta; Male; Memory, Short-Term; Phencyclidine; Psychomotor Performance; Reaction Time; Schizophrenia; Spatial Memory | 2019 |
Disruption of latent inhibition by subchronic phencyclidine pretreatment in rats.
Topics: Animals; Behavior, Animal; Cognition; Conditioning, Operant; Disease Models, Animal; Female; Memory; Motor Activity; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2019 |
Preclinical characterization of AMPA receptor potentiator TAK-137 as a therapeutic drug for schizophrenia.
Topics: Animals; Cognition; Disease Models, Animal; Dizocilpine Maleate; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Gene Expression Regulation; Haplorhini; Male; Maze Learning; Methamphetamine; Mice; Phencyclidine; Rats; Receptors, AMPA; Schizophrenia; Thiadiazines | 2019 |
Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Emotions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Female; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2019 |
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D
Topics: Animals; Cortical Excitability; Hallucinogens; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Psychotropic Drugs; Pyrans; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, G-Protein-Coupled; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Sleep, REM | 2019 |
Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia.
Topics: AIDS-Related Complex; Amphetamines; Analysis of Variance; Animals; Autoradiography; Disease Models, Animal; Gene Expression Regulation; Genes, Immediate-Early; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Receptors, Serotonin, 5-HT2; RNA, Messenger; Schizophrenia; Serotonin Receptor Agonists; Signal Transduction; Time Factors | 2013 |
Afferent drive of medial prefrontal cortex by hippocampus and amygdala is altered in MAM-treated rats: evidence for interneuron dysfunction.
Topics: Action Potentials; Amygdala; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Interneurons; Male; Methylazoxymethanol Acetate; Neural Inhibition; Neural Pathways; Neurotoxins; Phencyclidine; Prefrontal Cortex; Rats; Schizophrenia | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
An investigation of hypofrontality in an animal model of schizophrenia using real-time microelectrochemical sensors for glucose, oxygen, and nitric oxide.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electrochemical Techniques; Glucose; Hallucinogens; Male; Nitric Oxide; Oxygen; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia | 2013 |
Decreased L-tryptophan concentration in distinctive brain regions of mice treated repeatedly with phencyclidine.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Isothiocyanates; Male; Mice; Oxadiazoles; Phencyclidine; Schizophrenia; Tryptophan | 2013 |
Psychiatric intensive care of dementia praecox.
Topics: Acute Disease; Adult; Aggression; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Catatonia; Critical Care; Diagnosis, Differential; Drug Therapy, Combination; Frontotemporal Dementia; Hallucinogens; Humans; Male; Paranoid Disorders; Phencyclidine; Phencyclidine Abuse; Schizophrenia; Schizophrenic Psychology; Subacute Sclerosing Panencephalitis; Substance Abuse Detection | 2013 |
Phencyclidine decreases tickling-induced 50-kHz ultrasound vocalizations in juvenile rats: a putative model of the negative symptoms of schizophrenia?
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia; Ultrasonics; Vocalization, Animal | 2013 |
Cognitive enhancement effects of Bacopa monnieri (Brahmi) on novel object recognition and NMDA receptor immunodensity in the prefrontal cortex and hippocampus of sub-chronic phencyclidine rat model of schizophrenia.
Topics: Animals; Bacopa; Cognition; Cognition Disorders; Disease Models, Animal; Hallucinogens; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Nootropic Agents; Phencyclidine; Phytotherapy; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2013 |
A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology.
Topics: Animals; Brain; Disease Models, Animal; Frontal Lobe; Humans; Magnetic Resonance Imaging; Male; Mass Spectrometry; Metabolomics; Phencyclidine; Proteomics; Rats; Rats, Sprague-Dawley; Schizophrenia | 2013 |
Expression of presynaptic markers in a neurodevelopmental animal model with relevance to schizophrenia.
Topics: Animals; Animals, Newborn; Biomarkers; Brain; Disease Models, Animal; Enzyme Inhibitors; In Situ Hybridization; Male; Phencyclidine; Rats; Schizophrenia; Synaptophysin; Synaptosomal-Associated Protein 25 | 2013 |
Evidence that aetiological risk factors for psychiatric disorders cause distinct patterns of cognitive deficits.
Topics: Animals; Bipolar Disorder; Body Weight; Cognition Disorders; Corticosterone; Executive Function; Female; Male; Neuropsychological Tests; Phencyclidine; Pregnancy; Pregnancy Complications, Infectious; Rats, Inbred Strains; Reversal Learning; Risk Factors; Schizophrenia; Schizophrenic Psychology; Task Performance and Analysis | 2014 |
A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia.
Topics: Alanine; Amphetamine; Animals; Antipsychotic Agents; Anxiety; Benzodiazepines; Brain; Central Nervous System Stimulants; Depression; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Olanzapine; Phencyclidine; Psychomotor Agitation; Schizophrenia; Social Behavior | 2014 |
Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Conditioning, Psychological; Disease Models, Animal; Emotions; Excitatory Amino Acid Antagonists; Freezing Reaction, Cataleptic; Male; Memory; Motor Activity; Neuropsychological Tests; Pattern Recognition, Visual; Phencyclidine; Prepulse Inhibition; Rats; Schizophrenia; Social Isolation | 2014 |
Acute phencyclidine treatment induces extensive and distinct protein phosphorylation in rat frontal cortex.
Topics: Amino Acid Sequence; Animals; Calcium; Disease Models, Animal; Energy Metabolism; Hallucinogens; Homeostasis; Humans; Male; Molecular Sequence Data; Nerve Tissue Proteins; Phencyclidine; Phosphopeptides; Phosphorylation; Prefrontal Cortex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2014 |
In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Cognition Disorders; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Excitatory Amino Acid Antagonists; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Humans; Hyperkinesis; Male; Mice; Mice, Inbred DBA; Phencyclidine; Phosphodiesterase Inhibitors; Rats; Recognition, Psychology; Recombinant Proteins; Schizophrenia; Schizophrenic Psychology; Sensory Gating | 2014 |
PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Quinuclidines; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology; Social Behavior; Thiophenes | 2014 |
Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Gene Knockdown Techniques; Gene Silencing; Male; MicroRNAs; Motor Activity; Nucleus Accumbens; Phencyclidine; Random Allocation; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Schizophrenia; Social Behavior | 2015 |
Re-evaluating the PCP challenge as a pre-clinical model of impaired cognitive flexibility in schizophrenia.
Topics: Animals; Cognition; Conditioning, Operant; Disease Models, Animal; Male; Phencyclidine; Rats; Reversal Learning; Schizophrenia; Schizophrenic Psychology | 2014 |
Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Haloperidol; Isoindoles; Memory Disorders; Phencyclidine; Piperazines; Piperidines; Pyrimidines; Random Allocation; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Urea | 2015 |
Neuroprotective effects of Bacopa monnieri (Brahmi) on novel object recognition and NMDAR1 immunodensity in the prefrontal cortex, striatum and hippocampus of sub-chronic phencyclidine rat model of schizophrenia.
Topics: Animals; Bacopa; Behavior, Animal; Brain; Cognition; Hippocampus; Immunohistochemistry; Male; Neostriatum; Neuroprotective Agents; Phencyclidine; Phytotherapy; Plant Extracts; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2014 |
Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex.
Topics: Age Factors; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chlorocebus aethiops; Cognition; Disease Models, Animal; Disease Susceptibility; Dopamine; Female; Male; Memory, Short-Term; Phencyclidine; Prefrontal Cortex; Schizophrenia; Schizophrenic Psychology; Sex Factors; Spinal Cord; Synapses; Time Factors | 2014 |
Increasing endocannabinoid levels in the ventral pallidum restore aberrant dopamine neuron activity in the subchronic PCP rodent model of schizophrenia.
Topics: Animals; Basal Forebrain; Benzamides; Carbamates; Central Nervous System Agents; Disease Models, Animal; Dopaminergic Neurons; Endocannabinoids; Hippocampus; Male; Microelectrodes; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Sodium Channel Blockers; Tetrodotoxin; Ventral Tegmental Area | 2014 |
Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats.
Topics: Animals; Cortical Synchronization; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Schizophrenia | 2015 |
Investigating the long-term effect of subchronic phencyclidine-treatment on novel object recognition and the association between the gut microbiota and behavior in the animal model of schizophrenia.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Exploratory Behavior; Gastrointestinal Tract; Hallucinogens; Male; Microbiota; Motor Activity; Phencyclidine; Rats; Recognition, Psychology; Schizophrenia | 2015 |
Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia.
Topics: Animals; Attention; Auditory Perception; Brain; Disease Models, Animal; Gray Matter; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Organ Size; Phencyclidine; Prepulse Inhibition; Rats; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Visual Perception | 2014 |
A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice.
Topics: Adult; Animals; Behavior, Animal; Brain; Case-Control Studies; D-Aspartate Oxidase; Disease Models, Animal; DNA Methylation; Excitatory Amino Acid Antagonists; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Middle Aged; Motor Activity; Phencyclidine; Prefrontal Cortex; Prepulse Inhibition; Schizophrenia | 2015 |
Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cognition; Cognition Disorders; Disease Models, Animal; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Memory; Mice; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior | 2015 |
Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex.
Topics: Acoustic Stimulation; Animals; Disease Models, Animal; Long-Term Potentiation; Male; Phencyclidine; Phosphorylation; Prefrontal Cortex; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Sensory Gating; Signal Transduction | 2016 |
PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Hippocampus; Male; Memory, Short-Term; Mice; Motor Activity; Neostriatum; Phencyclidine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Reversal Learning; Schizophrenia | 2015 |
Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Behavior, Animal; Benzimidazoles; Binding Sites; Crystallography, X-Ray; Disease Models, Animal; Hallucinogens; Humans; Male; Mice; Mice, Inbred ICR; Pattern Recognition, Visual; Phencyclidine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Photochemical Processes; Protein Binding; Pyridines; Quinolines; Schizophrenia; Ultraviolet Rays | 2015 |
Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model.
Topics: Animals; Apoptosis; Chromatography, Liquid; Cytokines; Disease Models, Animal; Frontal Lobe; Hallucinogens; Hippocampus; Humans; Male; Mass Spectrometry; Metabolome; Metabolomics; Oxidative Stress; Phencyclidine; Proteome; Proteomics; Rats, Sprague-Dawley; Schizophrenia; Signal Transduction; Superoxide Dismutase; Synaptic Transmission | 2015 |
Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood.
Topics: Adolescent; Adult; Animals; Brassica; Child; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Mice; Middle Aged; NF-E2-Related Factor 2; Oxidative Stress; Phencyclidine; Plant Extracts; Prefrontal Cortex; Schizophrenia; Seedlings; Sulfoxides | 2015 |
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
Topics: Animals; Antipsychotic Agents; Cognition; Disease Models, Animal; Long-Term Synaptic Depression; Male; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Phencyclidine; Pyridines; Pyrroles; Receptor, Muscarinic M1; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.
Topics: Animals; Antipsychotic Agents; Arrestins; beta-Arrestins; Catalepsy; Disease Models, Animal; Dopamine Agents; Drug Evaluation, Preclinical; Female; Glutamic Acid; Male; Mice, 129 Strain; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Phencyclidine; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
Phencyclidine Disrupts the Auditory Steady State Response in Rats.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Biomarkers; Brain; Computer Simulation; Electrodes; Electroencephalography; Enzyme Inhibitors; Evoked Potentials, Auditory; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2015 |
Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Male; Phencyclidine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Sensory Gating; Signal Transduction; Triazoles | 2015 |
Alterations in High-Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Sustained Attention Following NMDA Receptor Antagonism.
Topics: Animals; Attention; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Antagonists; Frontal Lobe; Gamma Rhythm; Macaca fascicularis; Male; Parietal Lobe; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2016 |
Bacopa monnieri (Brahmi) Enhanced Cognitive Function and Prevented Cognitive Impairment by Increasing VGLUT2 Immunodensity in Prefrontal Cortex of Sub-Chronic Phencyclidine Rat Model of Schizophrenia.
Topics: Animals; Bacopa; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Nootropic Agents; Phencyclidine; Phytotherapy; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Vesicular Glutamate Transport Protein 1 | 2015 |
Effects of the phencyclidine model of schizophrenia and nicotine on total and categorized ultrasonic vocalizations in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Male; Nicotine; Phencyclidine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Schizophrenia; Smoking; Ultrasonics; Vocalization, Animal | 2016 |
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dronabinol; Endocannabinoids; Hippocampus; Male; Phencyclidine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Up-Regulation | 2016 |
Effects of cariprazine, a novel antipsychotic, on cognitive deficit and negative symptoms in a rodent model of schizophrenia symptomatology.
Topics: Animals; Antipsychotic Agents; Cognition; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Exploratory Behavior; Female; Motor Activity; Nootropic Agents; Phencyclidine; Piperazines; Rats; Recognition, Psychology; Risperidone; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Modulators; Cyclohexanols; Discrimination, Psychological; Disease Models, Animal; Endocannabinoids; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Odorants; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior Disorders; Social Perception | 2016 |
The dopamine D₃-preferring D₂/D₃ dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antipsychotic Agents; Aripiprazole; Association Learning; Developmental Disabilities; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Interpersonal Relations; Locomotion; Male; Memory Disorders; Phencyclidine; Piperazines; Rats; Recognition, Psychology; Schizophrenia | 2016 |
Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromosome Pairing; Dendritic Spines; Glycogen Synthase Kinase 3; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuregulin-1; Neuronal Outgrowth; Neuronal Plasticity; Neurons; Olanzapine; Phencyclidine; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptophysin | 2016 |
mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia.
Topics: Amino Acids; Animals; Antipsychotic Agents; Benzodiazepines; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nucleus Accumbens; Olanzapine; Phencyclidine; Prefrontal Cortex; Protein Binding; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2016 |
Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597.
Topics: Amidohydrolases; Animals; Benzamides; Brain; Carbamates; Endocannabinoids; Exploratory Behavior; Male; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
Towards the development of improved tests for negative symptoms of schizophrenia in a validated animal model.
Topics: Affect; Animals; Behavior, Animal; Disease Models, Animal; Female; Phencyclidine; Rats; Reward; Schizophrenia; Schizophrenic Psychology | 2016 |
Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Humans; Ketamine; Machine Learning; Male; Mice, Transgenic; Phencyclidine; Prefrontal Cortex; Protein Interaction Maps; Proteomics; Psychotic Disorders; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tandem Mass Spectrometry | 2016 |
Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; GABAergic Neurons; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Hippocampus; Lamotrigine; Locomotion; Male; Oligonucleotide Array Sequence Analysis; Phencyclidine; Phenotype; Prepulse Inhibition; Rats, Inbred Strains; Recognition, Psychology; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Social Isolation; Sodium Channel Blockers; Synaptic Transmission; Time Factors; Triazines; Weaning | 2016 |
Bacopa monnieri (Brahmi) improved novel object recognition task and increased cerebral vesicular glutamate transporter type 3 in sub-chronic phencyclidine rat model of schizophrenia.
Topics: Animals; Bacopa; Brain; Disease Models, Animal; Male; Phencyclidine; Plant Extracts; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Vesicular Glutamate Transport Proteins | 2016 |
Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.
Topics: Animals; Female; Gene Expression Regulation, Developmental; Hippocampus; Male; Neurogenesis; Phencyclidine; Prefrontal Cortex; Protein Multimerization; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Schizophrenia | 2016 |
The role of P2X7 receptors in a rodent PCP-induced schizophrenia model.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Mice; Mice, Knockout; Niacinamide; Phencyclidine; Piperazines; Purinergic P2X Receptor Antagonists; Pyramidal Cells; Receptors, Purinergic P2X7; Schizophrenia | 2016 |
Trans-generation enrichment of clozapine-responsiveness trait in mice using a subchronic hypo-glutamatergic model of schizophrenia:A preliminary study.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Female; Frontal Lobe; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Schizophrenia; Selective Breeding; Social Behavior | 2017 |
Effects of Repeated Ropinirole Treatment on Phencyclidine-Induced Hyperlocomotion, Prepulse Inhibition Deficits, and Social Avoidance in Rats.
Topics: Animals; Avoidance Learning; Dopamine Agonists; Hyperkinesis; Indoles; Male; Phencyclidine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior; Treatment Outcome | 2017 |
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies.
Topics: Adult; Aged; Animals; Animals, Newborn; Disease Models, Animal; Excitatory Amino Acid Antagonists; F-Box Proteins; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Phencyclidine; Postmortem Changes; Protein Inhibitors of Activated STAT; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Schizophrenia; Ubiquitin Thiolesterase; Ubiquitin-Conjugating Enzymes; Ubiquitins | 2017 |
Short- and long-term behavioral analysis of social interaction, ultrasonic vocalizations and social motivation in a chronic phencyclidine model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hallucinogens; Interpersonal Relations; Male; Motivation; Phencyclidine; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Ultrasonic Waves; Vocalization, Animal | 2017 |
Altered cortico-striatal crosstalk underlies object recognition memory deficits in the sub-chronic phencyclidine model of schizophrenia.
Topics: Action Potentials; Animals; Disease Models, Animal; Female; Hallucinogens; Memory Disorders; Neural Pathways; Neurons; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Recognition, Psychology; Schizophrenia | 2017 |
Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-D-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Blotting, Western; Cerebral Cortex; Down-Regulation; Excitatory Amino Acid Antagonists; Female; Male; Motor Activity; Neostriatum; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Subcellular Fractions | 2008 |
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Discrimination, Psychological; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Gerbillinae; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Recognition, Psychology; Reflex, Startle; Schizophrenia; Stereoisomerism; Swimming | 2008 |
Rapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: implications for schizophrenia.
Topics: Amygdala; Animals; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Limbic System; Muscarinic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptor Aggregation; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Time Factors | 2008 |
Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Hallucinogens; Hippocampus; Interpersonal Relations; Male; Motor Activity; Parvalbumins; Phencyclidine; Rats; Schizophrenia; Time Factors | 2008 |
Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2High receptors: D2 basis for schizophrenia.
Topics: Amino Acids; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Corpus Striatum; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Humans; Phencyclidine; Protein Binding; Protein Isoforms; Rats; Receptors, Dopamine D2; Schizophrenia | 2008 |
A primate model of schizophrenia using chronic PCP treatment.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Synergism; Female; Hallucinogens; Interpersonal Relations; Macaca fascicularis; Male; Phencyclidine; Schizophrenia; Social Behavior | 2008 |
Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Cognition Disorders; Disease Models, Animal; Endocannabinoids; Male; Phencyclidine; Rats; Receptor, Cannabinoid, CB1; Schizophrenia | 2009 |
Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Disease Models, Animal; Dopamine; Guanfacine; Imidazoles; Isoindoles; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Schizophrenia | 2008 |
Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure.
Topics: Animals; Antipsychotic Agents; Clozapine; Hallucinogens; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reward; Schizophrenia; Self Stimulation; Time Factors | 2009 |
Olanzapine and risperidone disrupt conditioned avoidance responding in phencyclidine-pretreated or amphetamine-pretreated rats by selectively weakening motivational salience of conditioned stimulus.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Benzodiazepines; Conditioning, Psychological; Dextroamphetamine; Disease Models, Animal; Drug Interactions; Motivation; Motor Activity; Olanzapine; Phencyclidine; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Schizophrenic Psychology | 2009 |
Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Extracellular Space; Hyperkinesis; Male; Morphinans; Naltrexone; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Schizophrenia; Serotonin; Spiro Compounds | 2009 |
Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.
Topics: Animals; Antipsychotic Agents; Attention; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Indoles; Male; Phencyclidine; Piperidines; Rats; Schizophrenia | 2009 |
Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia.
Topics: Adult; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Male; Phencyclidine; Protein Isoforms; Random Allocation; Rats; Receptors, Dopamine; Receptors, Serotonin; Schizophrenia | 2009 |
Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice.
Topics: Amphetamine; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Phencyclidine; Phenotype; Reflex, Startle; Schizophrenia; Species Specificity | 2009 |
Serotonergic lesions of the dorsal hippocampus differentially modulate locomotor hyperactivity induced by drugs of abuse in rats: implications for schizophrenia.
Topics: 5,7-Dihydroxytryptamine; Amphetamines; Animals; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Hyperkinesis; Ketamine; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia; Serotonin | 2009 |
Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Phencyclidine; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reversal Learning; Schizophrenia; Serotonin Antagonists; Serotonin Receptor Agonists | 2009 |
Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine.
Topics: Action Potentials; Animals; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Male; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phencyclidine; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Schizophrenia; Synaptic Transmission | 2009 |
Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801.
Topics: Animals; Body Weight; Disease Models, Animal; Dizocilpine Maleate; Male; Memory, Short-Term; Motor Activity; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior; Substance Withdrawal Syndrome | 2009 |
Neonatal phencyclidine treatment in mice induces behavioral, histological and neurochemical abnormalities in adulthood.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Biogenic Monoamines; Brain; Brain Chemistry; Interpersonal Relations; Male; Memory; Mice; Mice, Inbred ICR; Motor Activity; Phencyclidine; Schizophrenia | 2009 |
Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Berberine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Inhibition, Psychological; Interpersonal Relations; Locomotion; Male; Phencyclidine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Recognition, Psychology; Reflex, Startle; Schizophrenia | 2009 |
Chronic infusion of PCP via osmotic mini-pumps: a new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance.
Topics: Animals; Antipsychotic Agents; Attention; Behavior, Animal; Behavioral Sciences; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Hallucinogens; Infusion Pumps, Implantable; Male; Modafinil; Neuropharmacology; Neuropsychological Tests; Neurosciences; Phencyclidine; Rats; Schizophrenia; Schizophrenic Psychology | 2009 |
The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex.
Topics: Adaptor Proteins, Signal Transducing; Age Factors; Animals; Animals, Newborn; Male; Membrane Proteins; Neocortex; Phencyclidine; Rats; Rats, Wistar; Schizophrenia; Transcriptional Activation; Up-Regulation | 2010 |
Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.
Topics: Animals; Antipsychotic Agents; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorobenzenes; Imidazoles; Indoles; Memory Disorders; Phencyclidine; Piperidines; Quinolines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reversal Learning; Schizophrenia; Sulfones | 2010 |
Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats.
Topics: Acoustic Stimulation; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Disease Models, Animal; Drug Administration Routes; Interpersonal Relations; Male; Morpholines; Naphthalenes; Neural Inhibition; Phencyclidine; Psychomotor Performance; Rats; Recognition, Psychology; Reflex, Startle; Schizophrenia; Self Administration; Statistics, Nonparametric | 2010 |
The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex.
Topics: Amino Acids; Animals; Antipsychotic Agents; Biogenic Monoamines; Central Nervous System Agents; Disease Models, Animal; Dopamine; Extracellular Space; Glutamic Acid; Glycine; Male; Motor Activity; Neurotensin; Norepinephrine; Peptide Fragments; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Serotonin | 2010 |
Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia.
Topics: Allosteric Regulation; Animals; Avoidance Learning; Disease Models, Animal; Locomotion; Oxadiazoles; Phencyclidine; Piperidines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Schizophrenia | 2010 |
Identification of targeted analyte clusters for studies of schizophrenia.
Topics: Adult; Animals; Biomarkers; Bipolar Disorder; Cluster Analysis; Depressive Disorder, Major; Disease Models, Animal; Electronic Data Processing; Female; Hallucinogens; Humans; Male; Phencyclidine; Proteomics; Rats; Schizophrenia; Signal Transduction | 2010 |
Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuregulin-1; Phencyclidine; Phenotype; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sex Factors; Social Behavior | 2010 |
Multiple 'hits' during postnatal and early adulthood periods disrupt the normal development of sensorimotor gating ability in rats.
Topics: Age Factors; Animals; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hallucinogens; Male; Maternal Deprivation; Phencyclidine; Pregnancy; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Sensory Gating; Time Factors | 2011 |
Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat.
Topics: Affective Symptoms; Animals; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Hippocampus; Immunohistochemistry; Male; Neurons; Parvalbumins; Phencyclidine; Pleasure; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Sucrose; Taste | 2010 |
Analysis of licking microstructure provides no evidence for a reduction in reward value following acute or sub-chronic phencyclidine administration.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Motor Activity; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Reward; Schizophrenia; Schizophrenic Psychology; Sucrose; Taste; Time Factors | 2010 |
Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Male; Motor Activity; Phencyclidine; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Schizophrenia; Time Factors | 2011 |
Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.
Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Excitatory Amino Acid Agents; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Schizophrenia; Time Factors; Xanthenes | 2010 |
Assessment of auditory sensory processing in a neurodevelopmental animal model of schizophrenia--gating of auditory-evoked potentials and prepulse inhibition.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Evoked Potentials, Auditory; Phencyclidine; Rats; Rats, Inbred Strains; Schizophrenia; Sensory Gating | 2010 |
HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.
Topics: Animals; Cell Line; Clinical Trials as Topic; Cyclopropanes; Drug Design; High-Throughput Screening Assays; Humans; Ligands; Methylamines; Mice; Phencyclidine; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Schizophrenia; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Stereoisomerism; Structure-Activity Relationship | 2010 |
Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: implications for therapy of cognitive dysfunction in schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Cognition; Cognition Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Half-Life; Learning; Nicotinic Agonists; Phencyclidine; Random Allocation; Rats; Receptors, Nicotinic; Reversal Learning; Schizophrenia; Tachyphylaxis | 2011 |
Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor.
Topics: Animals; Citrates; Glucosides; Mice; Phencyclidine; Psychotic Disorders; Receptor, Serotonin, 5-HT1A; Schizophrenia | 2010 |
Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Down-Regulation; Glutamic Acid; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Phencyclidine; Polymerase Chain Reaction; Prefrontal Cortex; Receptors, Neurotensin; RNA, Messenger; Schizophrenia; Schizophrenic Psychology; Swimming; Up-Regulation | 2010 |
Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia.
Topics: Animals; Brain; Cluster Analysis; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fluoresceins; Gene Expression; Gene Expression Profiling; Microarray Analysis; Molecular Sequence Data; Nerve Degeneration; Phencyclidine; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Schizophrenia | 2011 |
Erythropoietin reverses the attentional set-shifting impairment in a rodent schizophrenia disease-like model.
Topics: Animals; Antipsychotic Agents; Attention; Behavior, Animal; Benzhydryl Compounds; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epoetin Alfa; Erythropoietin; Executive Function; Haloperidol; Male; Modafinil; Neuropsychological Tests; Phencyclidine; Rats; Recombinant Proteins; Reward; Schizophrenia; Schizophrenic Psychology | 2010 |
Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Electrochemical Techniques; Enzyme Inhibitors; Ion-Selective Electrodes; Male; Neural Inhibition; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phencyclidine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Signal Transduction; Time Factors; Up-Regulation | 2010 |
α7 nicotinic receptor agonism mitigates phencyclidine-induced changes in synaptophysin and Arc gene expression in the mouse prefrontal cortex.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytoskeletal Proteins; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nicotinic Agonists; Phencyclidine; Prefrontal Cortex; Receptors, Nicotinic; Schizophrenia; Synaptophysin | 2010 |
Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Exploratory Behavior; Female; GABA-A Receptor Agonists; Isoxazoles; Motor Activity; Phencyclidine; Rats; Receptors, GABA-A; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Time Factors | 2011 |
Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; Ketamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Parvalbumins; Phencyclidine; Racemases and Epimerases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2011 |
Prefrontal NMDA receptor antagonism reduces impairments in pre-attentive information processing.
Topics: Animals; Cognition; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraperitoneal; Male; Mice; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Sensory Gating; Signal Transduction | 2011 |
[Development of animal models, and drug discovery for schizophrenia based on the glutamate hypothesis].
Topics: Animals; Disease Models, Animal; Drug Discovery; Glutamic Acid; Humans; Mice; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2010 |
Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.
Topics: Animals; Bridged Bicyclo Compounds; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamate Carboxypeptidase II; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Organophosphorus Compounds; Phencyclidine; Receptors, Metabotropic Glutamate; Reflex, Startle; Schizophrenia; Species Specificity; Urea | 2011 |
The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia.
Topics: Animals; Cognition Disorders; Female; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reversal Learning; Schizophrenia; Sodium Channel Blockers; Treatment Outcome | 2011 |
Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition.
Topics: Algorithms; Animals; Cluster Analysis; Cognition; Disease Models, Animal; Gene Expression Regulation; Genome; Glutamic Acid; Humans; Ligands; Models, Biological; Models, Statistical; Phencyclidine; Principal Component Analysis; Rats; Schizophrenia; Software; Systems Biology | 2011 |
Chronic administration of phencyclidine produces decreased sensitivity to mechanical stimulation in the absence of altered affective behavior: Implications for pain processing in schizophrenia.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Disease Models, Animal; Escape Reaction; Excitatory Amino Acid Antagonists; Ligation; Male; Neuralgia; Pain Perception; Phencyclidine; Physical Stimulation; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Spinal Nerves; Stress, Mechanical | 2011 |
Chronic phencyclidine (PCP)-induced modulation of muscarinic receptor mRNAs in rat brain: impact of antipsychotic drug treatment.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Male; Phencyclidine; Random Allocation; Rats; Receptor, Muscarinic M1; RNA, Messenger; Schizophrenia | 2012 |
Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys.
Topics: Animals; Chlorocebus aethiops; Cognition; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Male; Microscopy, Electron, Transmission; Phencyclidine; Prefrontal Cortex; Schizophrenia; Schizophrenic Psychology; Synapses | 2011 |
Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.
Topics: Adult; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Haplotypes; Humans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Phencyclidine; Polymorphism, Single Nucleotide; Rats; Rats, Wistar; Reproducibility of Results; Schizophrenia; Tissue Plasminogen Activator | 2011 |
Is the acute NMDA receptor hypofunction a valid model of schizophrenia?
Topics: Animals; Corpus Callosum; Disease Models, Animal; Dopamine; Glutamic Acid; Humans; Ketamine; Parvalbumins; Phencyclidine; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Rodentia; Schizophrenia; Serotonin | 2012 |
Phencyclidine treatment increases NR2A and NR2B N-methyl-D-aspartate receptor subunit expression in rats.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Phencyclidine; Pregnancy; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Up-Regulation | 2011 |
Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia.
Topics: Action Potentials; Amygdala; Animals; Area Under Curve; Biophysics; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamate Decarboxylase; Hippocampus; In Vitro Techniques; Male; Memory Disorders; Neurons; Parvalbumins; Patch-Clamp Techniques; Phencyclidine; Quinoxalines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Schizophrenia; Synaptic Transmission; Time Factors | 2012 |
Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats.
Topics: Amphetamine; Animals; Benzodiazepines; Central Nervous System Stimulants; CHO Cells; Cognition Disorders; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperkinesis; Imidazoles; Male; Oocytes; Parvalbumins; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-A; Schizophrenia; Xenopus laevis | 2012 |
NOGO-66 receptor deficient mice show slow acquisition of spatial memory task performance.
Topics: Alzheimer Disease; Amphetamine; Animals; Eating; Female; Fever; Hyperkinesis; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Myelin Proteins; Neuronal Plasticity; Nogo Proteins; Phencyclidine; Restraint, Physical; Schizophrenia; Time Factors | 2012 |
Models of aspects of schizophrenia: behavioral sensitization induced by subchronic phencyclidine administration.
Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hallucinogens; Hyperkinesis; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2009 |
mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamate Carboxypeptidase II; Mice; Mice, Knockout; Motor Activity; Organophosphorus Compounds; Phencyclidine; Receptors, Metabotropic Glutamate; Schizophrenia | 2012 |
Phencyclidine/schizophrenia: one view toward the past, the other to the future.
Topics: Anesthetics; Animals; Disease Models, Animal; History, 20th Century; History, 21st Century; Humans; Illicit Drugs; Neuropharmacology; Phencyclidine; Psychoses, Substance-Induced; Schizophrenia | 2012 |
The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
Topics: Animals; Disease Models, Animal; Frontal Lobe; Fructose-Bisphosphate Aldolase; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Hexokinase; Humans; Male; Metabolic Networks and Pathways; Multivariate Analysis; Phencyclidine; Phosphoglycerate Kinase; Phosphoglycerate Mutase; Phosphopyruvate Hydratase; Rats; Schizophrenia; Triose-Phosphate Isomerase | 2012 |
Cholinergic denervation attenuates phencyclidine-induced c-fos responses in rat cortical neurons.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Brain; Cholinergic Agents; Denervation; Disease Models, Animal; Male; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats; Ribosome Inactivating Proteins, Type 1; Saporins; Schizophrenia | 2012 |
Deficits in emotional learning and memory in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Brain; Conditioning, Classical; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fear; Hindlimb Suspension; Ketamine; Learning Disabilities; Male; Memory Disorders; Phencyclidine; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-B; Schizophrenia; Sensory Gating | 2012 |
Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dopamine; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Neurotransmitter Agents; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia | 2012 |
Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Brain; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Exploratory Behavior; Male; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurons; Phencyclidine; Pyrazoles; Receptor, Metabotropic Glutamate 5; Recognition, Psychology; Schizophrenia | 2013 |
Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.
Topics: Analysis of Variance; Animals; Blood Proteins; Disease Models, Animal; Energy Metabolism; Frontal Lobe; Glucose; Hippocampus; Humans; Insulin; Male; Motor Activity; Multivariate Analysis; Phencyclidine; Proteome; Rats; Rats, Sprague-Dawley; Schizophrenia; Synaptic Transmission | 2012 |
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Benzodiazepines; Body Weight; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Electroencephalography; Hallucinogens; Haloperidol; Humans; Macaca fascicularis; Magnetic Resonance Imaging; Male; Mental Recall; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microinjections; Motor Activity; Mutation; Olanzapine; Oocytes; Oxazoles; Phencyclidine; Phenethylamines; Protein Binding; Pyrrolidinones; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reinforcement, Psychology; Schizophrenia; Swimming; Telemetry; Tritium; Xenopus | 2013 |
Risperidone reverses phencyclidine induced decrease in glutathione levels and alterations of antioxidant defense in rat brain.
Topics: Animals; Antioxidants; Antipsychotic Agents; Brain; Disease Models, Animal; Female; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Male; Phencyclidine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Risperidone; Schizophrenia | 2012 |
Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Isoindoles; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Thiazoles; Urea | 2012 |
Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia.
Topics: Animals; Behavior, Animal; Brain; Demyelinating Diseases; Disease Models, Animal; Motor Activity; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2012 |
The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Dizocilpine Maleate; Gyrus Cinguli; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phencyclidine; Phosphorylation; Prefrontal Cortex; Protein Tyrosine Phosphatases, Non-Receptor; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2012 |
Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats.
Topics: Animals; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Injections, Intravenous; Male; Morpholines; Motor Activity; Naphthalenes; Phencyclidine; Rats; Rats, Inbred Strains; Schizophrenia; Schizophrenic Psychology; Self Administration | 2013 |
Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine.
Topics: Aging; Allosteric Regulation; Animals; Animals, Newborn; Behavior, Animal; Benzamides; Brain; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Microinjections; Oxadiazoles; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior | 2013 |
Twenty-five years of glutamate in schizophrenia: are we there yet?
Topics: Antipsychotic Agents; Glutamic Acid; History, 20th Century; History, 21st Century; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2012 |
Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networks.
Topics: Algorithms; Animals; Autoradiography; Brain; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Excitatory Amino Acid Antagonists; Hippocampus; Male; Neural Pathways; Phencyclidine; Prefrontal Cortex; Radionuclide Imaging; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Processing, Computer-Assisted; Systems Integration; Thalamus | 2014 |
Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats.
Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Cell Count; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Male; Motor Activity; Neuroglia; Neurons; Parvalbumins; Phencyclidine; Phosphopyruvate Hydratase; Rats; RNA, Messenger; Schizophrenia; Social Isolation | 2013 |
Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Coculture Techniques; Gene Expression Regulation; Hippocampus; Humans; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Motor Activity; Phencyclidine; Schizophrenia | 2013 |
Reduction in phencyclidine induced sensorimotor gating deficits in the rat following increased system xc⁻ activity in the medial prefrontal cortex.
Topics: Acetylcysteine; Amino Acid Transport System y+; Amino Acid Transport Systems, Acidic; Animals; Benzoates; Disease Models, Animal; Dose-Response Relationship, Drug; Gait Disorders, Neurologic; Glycine; In Situ Hybridization; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reflex, Startle; RNA, Messenger; Schizophrenia; Sensory Gating | 2013 |
Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats.
Topics: Amino Acids; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membranes; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia | 2002 |
Topiramate antagonizes MK-801 in an animal model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fructose; Hallucinogens; Male; Mice; Neuroprotective Agents; Phencyclidine; Schizophrenia; Schizophrenic Psychology; Topiramate | 2002 |
NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Ketamine; Nitroso Compounds; Phencyclidine; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Sulfur Radioisotopes | 2002 |
Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophrenia.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid Antagonists; Glutamic Acid; Mice; Mice, Inbred BALB C; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Species Specificity; Stress, Psychological; Synaptic Transmission | 2003 |
Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation; Male; Parvalbumins; Phencyclidine; Prefrontal Cortex; Rats; Rats, Long-Evans; Schizophrenia; Thalamus | 2003 |
Effect of AD-5423 on animal models of schizophrenia: phencyclidine-induced behavioral changes in mice.
Topics: Animals; Disease Models, Animal; Immobilization; Male; Mice; Motor Activity; Phencyclidine; Piperazines; Piperidines; Schizophrenia | 2003 |
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Olanzapine; Patch-Clamp Techniques; Phencyclidine; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Blotting, Northern; Blotting, Western; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Middle Aged; Nerve Tissue Proteins; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SAP90-PSD95 Associated Proteins; Schizophrenia | 2003 |
Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Stimulants; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Reaction Time; Schizophrenia | 2003 |
Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Behavior, Animal; Cebus; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Excitatory Amino Acid Antagonists; Female; Haloperidol; Neural Inhibition; Phencyclidine; Reflex, Startle; Schizophrenia | 2003 |
Hyperresponsiveness to phencyclidine in animals lesioned in the amygdala on day 7 of life. Implications for an animal model of schizophrenia.
Topics: Amygdala; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Hypersensitivity; Early Ambulation; Excitatory Amino Acid Antagonists; Exploratory Behavior; Habituation, Psychophysiologic; Hyperkinesis; Male; Motor Activity; Phencyclidine; Rats; Rats, Wistar; Schizophrenia; Stereotyped Behavior | 2003 |
Differential role of serotonergic projections arising from the dorsal and median raphe nuclei in locomotor hyperactivity and prepulse inhibition.
Topics: 5,7-Dihydroxytryptamine; Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Carrier Proteins; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Hyperkinesis; Immunohistochemistry; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Motor Activity; Nerve Tissue Proteins; Neural Inhibition; Phencyclidine; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex, Startle; Schizophrenia; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Time Factors | 2003 |
Schizophrenia-like syndrome inducing agent phencyclidine failed to impair memory for temporal order in rats.
Topics: Animals; Hallucinogens; Male; Maze Learning; Memory; Phencyclidine; Rats; Rats, Long-Evans; Schizophrenia; Time Perception | 2003 |
Study of a new schizophrenomimetic drug; sernyl.
Topics: Anesthetics; Humans; Phencyclidine; Schizophrenia | 1959 |
Comparison of phencyclidine hydrochloride (Sernyl) with other drugs. Simulation of schizophrenic performance with phencyclidine hydrochloride (Sernyl), lysergic acid diethylamide (LSD-25), and amobarbital (Amytal) sodium; II. Symbolic and sequential think
Topics: Amobarbital; Anesthetics; Humans; Lysergic Acid Diethylamide; Phencyclidine; Schizophrenia; Sodium | 1962 |
Comparison of sernyl with other drugs: simulation of schizophrenic performance with sernyl, LSD-25, and amobarbital (amytal) sodium; I. Attention, motor function, and proprioception.
Topics: Amobarbital; Attention; Humans; Lysergic Acid Diethylamide; Phencyclidine; Piperidines; Proprioception; Schizophrenia; Sodium; Sodium, Dietary | 1959 |
Decoding schizophrenia.
Topics: Antipsychotic Agents; Brain; Clozapine; Dopamine; Glutamic Acid; Humans; Neurotransmitter Agents; Perception; Phencyclidine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2004 |
Altered prepulse inhibition in rats treated prenatally with the antimitotic Ara-C: an animal model for sensorimotor gating deficits in schizophrenia.
Topics: Animals; Antineoplastic Agents; Apomorphine; Brain; Cytarabine; Disease Models, Animal; Dopamine Agonists; Drug Interactions; Female; Hallucinogens; Male; Maternal-Fetal Exchange; Phencyclidine; Pregnancy; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia | 2004 |
Strain-specificity in nicotine attenuation of phencyclidine-induced disruption of prepulse inhibition in mice: relevance to smoking in schizophrenia patients.
Topics: Animals; Disease Models, Animal; Hallucinogens; Humans; Male; Mice; Mice, Inbred Strains; Nicotine; Phencyclidine; Schizophrenia; Smoking Prevention; Species Specificity | 2004 |
Psychotomimetic effects of drugs--a common pathway to schizophrenia?
Topics: Amphetamine; Animals; Central Nervous System Agents; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Frontal Lobe; Lysergic Acid Diethylamide; Mice; Models, Animal; Nerve Tissue Proteins; Phencyclidine; Phosphoproteins; Phosphorylation; Receptors, Dopamine; Schizophrenia; Signal Transduction | 2004 |
NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.
Topics: Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Stereotyped Behavior; Urea | 2004 |
Kynurenic acid and schizophrenia.
Topics: Animals; Antipsychotic Agents; Dopamine; Glutamic Acid; Humans; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2003 |
Phencyclidine-induced changes in rat cortical gene expression identified by microarray analysis: implications for schizophrenia.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Oligonucleotide Array Sequence Analysis; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2004 |
(+) MK-801 and phencyclidine induced neurotoxicity do not cause enduring behaviours resembling the positive and negative symptoms of schizophrenia in the rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Male; Motor Activity; Neurotoxicity Syndromes; Phencyclidine; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Stereotyped Behavior | 2004 |
Functional magnetic resonance imaging reveals similar brain activity changes in two different animal models of schizophrenia.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Mapping; Disease Models, Animal; Dose-Response Relationship, Radiation; Image Processing, Computer-Assisted; Inhibition, Psychological; Magnetic Resonance Imaging; Male; Models, Neurological; Oxygen; Phencyclidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle; Schizophrenia | 2005 |
Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition.
Topics: Amphetamine; Animals; Avoidance Learning; Conditioning, Psychological; Male; Mental Processes; Motor Activity; Neural Inhibition; Phencyclidine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Taste | 2005 |
Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia?
Topics: Amphetamine; Animals; Brain; Chromatography, High Pressure Liquid; Dopamine; Glutathione; Hallucinogens; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Microdialysis; Motor Activity; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin | 2005 |
Partial reversal of phencyclidine-induced impairment of prepulse inhibition by secretin.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Behavior, Animal; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fear; Humans; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Secretin | 2005 |
Cannabinoid CB1 receptor dependent effects of the NMDA antagonist phencyclidine in the social withdrawal model of schizophrenia.
Topics: Animals; Ataxia; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Genotype; Humans; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Receptor, Cannabinoid, CB1; Schizophrenia; Schizophrenic Psychology; Social Isolation | 2005 |
Aberrant regulation of NMDA receptors by dopamine D4 signaling in rats after phencyclidine exposure.
Topics: Animals; Electrophysiology; Male; Models, Animal; Patch-Clamp Techniques; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2006 |
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Gene Expression; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Motor Activity; Neurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2006 |
Selective increases in the cytokine, TNFalpha, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: influence of antipsychotic drugs.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; Cytokines; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Gene Expression; Haloperidol; Humans; Immunohistochemistry; Male; Middle Aged; Phencyclidine; Prefrontal Cortex; Rats; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; RNA; Schizophrenia; Tumor Necrosis Factor-alpha | 2006 |
Effects of repeated phencyclidine administration on adult hippocampal neurogenesis in the rat.
Topics: Animals; Behavior, Animal; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Male; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2006 |
Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Cyclic GMP; D-Amino-Acid Oxidase; Disease Models, Animal; Dose-Response Relationship, Radiation; Excitatory Amino Acid Antagonists; Extremities; Female; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neural Inhibition; Neurologic Examination; Phencyclidine; Psychomotor Performance; Quinolones; Reaction Time; Reflex, Startle; Schizophrenia; Sex Factors; Swimming | 2006 |
SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Agonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recognition, Psychology; Schizophrenia | 2007 |
The role of caspase-3 activation in phencyclidine-induced neuronal death in postnatal rats.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Cell Death; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; In Situ Nick-End Labeling; Male; Nerve Degeneration; Organ Culture Techniques; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors | 2007 |
Role of the simultaneous enhancement of NMDA and dopamine D1 receptor-mediated neurotransmission in the effects of clozapine on phencyclidine-induced acute increases in glutamate levels in the rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Haloperidol; Humans; Male; Microdialysis; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2006 |
Neonatal handling prevents the effects of phencyclidine in an animal model of negative symptoms of schizophrenia.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; Exploratory Behavior; Female; Handling, Psychological; Immunoassay; Male; Phencyclidine; Rats; Rats, Wistar; Restraint, Physical; Schizophrenia; Schizophrenic Psychology; Stress, Psychological; Swimming | 2007 |
The amino acid L-lysine blocks the disruptive effect of phencyclidine on prepulse inhibition in mice.
Topics: Amino Acid Transport Systems, Basic; Amino Acids; Animals; Arginine; Behavior, Animal; Biological Transport; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Hallucinogens; Lysine; Male; Mice; Nitric Oxide; Phencyclidine; Reflex; Reflex, Startle; Schizophrenia | 2007 |
The atypical antipsychotic, aripiprazole, blocks phencyclidine-induced disruption of prepulse inhibition in mice.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Mice; Neural Inhibition; Olanzapine; Phencyclidine; Piperazines; Quinolones; Receptors, Dopamine D2; Reflex, Startle; Schizophrenia | 2007 |
Repeated phencyclidine in monkeys results in loss of parvalbumin-containing axo-axonic projections in the prefrontal cortex.
Topics: Analysis of Variance; Animals; Axons; Calbindin 2; Chlorocebus aethiops; Disease Models, Animal; Excitatory Amino Acid Antagonists; Immunohistochemistry; Male; Neuronal Plasticity; Neurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Pyramidal Cells; S100 Calcium Binding Protein G; Schizophrenia | 2007 |
Towards understanding the schizophrenia code: an expanded convergent functional genomics approach.
Topics: Animals; Behavior, Animal; Biomarkers; Clozapine; gamma-Aminobutyric Acid; Gene Expression Regulation; Genetic Linkage; Genomics; Glutamic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neurotransmitter Agents; Phencyclidine; Reproducibility of Results; Schizophrenia | 2007 |
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phencyclidine; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Receptors, Cannabinoid; Reflex, Startle; Rimonabant; Schizophrenia; Sensation Disorders; Synaptic Transmission | 2007 |
Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Galantamine; Interpersonal Relations; Male; Mice; Mice, Inbred ICR; Microdialysis; Nootropic Agents; Phencyclidine; Prefrontal Cortex; Risperidone; Schizophrenia | 2007 |
Differential effects of acute and subchronic clozapine and haloperidol on phencyclidine-induced decreases in voluntary sucrose consumption in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Eating; Hallucinogens; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reward; Schizophrenia; Sucrose | 2007 |
Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat.
Topics: Animals; Behavior, Animal; Cognition Disorders; Conditioning, Operant; Dentate Gyrus; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Hallucinogens; Hippocampus; Immunohistochemistry; Interneurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Rats; Reversal Learning; Schizophrenia | 2007 |
Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine
Topics: Age Factors; Animals; Behavior, Animal; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Male; Methamphetamine; Motor Activity; Neurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dopamine Agonists; Enzyme Activation; Gene Expression; Glycine; Humans; Learning; Male; Mice; Microinjections; Oligonucleotides, Antisense; Phencyclidine; Phosphorylation; Prefrontal Cortex; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
The neuronal pathology of schizophrenia: molecules and mechanisms.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Neurons; Phencyclidine; Schizophrenia | 2007 |
Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine.
Topics: Animals; Behavior, Animal; Cebus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glycine; Glycine Agents; Hallucinogens; Male; Motor Activity; Phencyclidine; Schizophrenia; Stereotyped Behavior; Stress, Psychological | 2007 |
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.
Topics: Amphetamine; Animals; Anticonvulsants; Anxiety; Autoreceptors; Benzoates; Brain; Central Nervous System Stimulants; Dentate Gyrus; Disease Models, Animal; Electroshock; Glycine; Humans; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Seizures; Synapses; Synaptic Transmission | 2007 |
Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.
Topics: Animals; Antipsychotic Agents; Attention; Benzodiazepines; Clozapine; Cognition Disorders; Dibenzothiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Impulsive Behavior; Male; Olanzapine; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Wistar; Reaction Time; Risperidone; Schizophrenia | 2007 |
Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.
Topics: Agonistic Behavior; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamate Carboxypeptidase II; Male; Mice; Phencyclidine; Receptors, Metabotropic Glutamate; Schizophrenia; Stereotyped Behavior; Urea | 2008 |
Effects of schizophrenomimetics on the expression of the CCN1 (CYR 61) gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat.
Topics: Animals; Blotting, Northern; Cysteine-Rich Protein 61; DNA; Down-Regulation; Excitatory Amino Acid Antagonists; Hallucinogens; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neocortex; Oligonucleotide Array Sequence Analysis; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA; Schizophrenia; Schizophrenic Psychology; Up-Regulation | 2007 |
Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Free Radical Scavengers; Glutamic Acid; Glycine; Humans; Interpersonal Relations; Male; Maze Learning; Microdialysis; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Xanthenes | 2008 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cognition Disorders; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Exploratory Behavior; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Minocycline; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2008 |
Synapsin II knockout mice show sensorimotor gating and behavioural abnormalities similar to those in the phencyclidine-induced preclinical animal model of schizophrenia.
Topics: Animals; Arousal; Attention; Disease Models, Animal; Mice; Mice, Knockout; Neural Inhibition; Phencyclidine; Prefrontal Cortex; Reflex, Startle; Schizophrenia; Social Behavior; Stereotyped Behavior; Synapsins | 2007 |
Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction study.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Gene Expression Regulation; Genes, Immediate-Early; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Phencyclidine; Prefrontal Cortex; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Schizophrenia; Transcriptional Activation | 2008 |
Baseline temperature in an animal model of schizophrenia: long-term effects of perinatal phencyclidine administration.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Body Temperature Regulation; Body Weight; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Phencyclidine; Pregnancy; Rats; Rats, Wistar; Schizophrenia | 2008 |
Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Haloperidol; Matched-Pair Analysis; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Schizophrenia; Schizophrenic Psychology; Social Behavior; Social Behavior Disorders; Thiazoles | 2008 |
Postnatal phencyclidine administration selectively reduces adult cortical parvalbumin-containing interneurons.
Topics: Animals; Animals, Newborn; Apoptosis; Bromodeoxyuridine; Calbindin 2; Calbindins; Caspase 3; Cell Count; Cell Proliferation; Cell Survival; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Interneurons; Male; Parvalbumins; Phencyclidine; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Schizophrenia; Time | 2008 |
Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats.
Topics: Animals; Cognition Disorders; Estradiol; Female; Hippocampus; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2008 |
Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.
Topics: Age Factors; Animals; Animals, Newborn; Attention; Behavior, Animal; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Female; Male; Odorants; Phencyclidine; Pregnancy; Rats; Schizophrenia; Sex Factors | 2008 |
Reduced activation of intracellular signaling pathways in rat prefrontal cortex after chronic phencyclidine administration.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Communication; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Male; Neuronal Plasticity; Phencyclidine; Phosphorylation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Schizophrenia; Signal Transduction | 2008 |
Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Male; Maze Learning; Phencyclidine; Pregnancy; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Social Behavior | 2008 |
Effect of phencyclidine in chronic schizophrenics.
Topics: Adult; Anesthetics; Cerebral Cortex; Electroencephalography; Female; Humans; Male; Middle Aged; Phencyclidine; Psychosurgery; Schizophrenia; Thalamus | 1967 |
Sigma receptors and autoimmune mechanisms in schizophrenia: preliminary findings and hypotheses.
Topics: Autoantibodies; Humans; Phencyclidine; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma; Schizophrenia; Substance-Related Disorders; Synaptic Transmission | 1984 |
Is schizophrenia an immunologic receptor disorder?
Topics: Antibody Formation; Autoantibodies; Humans; Immunity, Cellular; Phencyclidine; Receptors, Cell Surface; Receptors, Opioid; Schizophrenia | 1983 |
PCP psychosis in a general hospital.
Topics: Adult; Diagnosis, Differential; Hospitals, Military; Humans; Male; Phencyclidine; Phencyclidine Abuse; Psychoses, Substance-Induced; Schizophrenia; United States | 1982 |
Phencyclidine.
Topics: Behavior; Brain; Humans; Illicit Drugs; Pharmaceutical Preparations; Phencyclidine; Receptors, Drug; Schizophrenia; Structure-Activity Relationship; Substance-Related Disorders | 1980 |
Effects of risperidone on phencyclidine-induced behaviors: comparison with haloperidol and ritanserin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Frontal Lobe; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Isoxazoles; Locomotion; Male; Phencyclidine; Piperidines; Random Allocation; Rats; Rats, Wistar; Risperidone; Ritanserin; Schizophrenia; Serotonin; Stereotyped Behavior | 1994 |
Mode of action of atypical neuroleptics in relation to the phencyclidine model of schizophrenia: role of 5-HT2 receptor and alpha 1-adrenoceptor antagonism [corrected].
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antipsychotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Motor Activity; Neurons; Phencyclidine; Rats; Schizophrenia; Serotonin Antagonists; Time Factors | 1995 |
d-cycloserine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label study.
Topics: Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Cycloserine; Dopamine; Drug Interactions; Female; Humans; Male; Phencyclidine; Psychoses, Substance-Induced; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 1994 |
NE-100, a novel sigma receptor ligand: effect on phencyclidine-induced behaviors in rats, dogs and monkeys.
Topics: Animals; Anisoles; Ataxia; Avoidance Learning; Cerebral Cortex; Dogs; Electroencephalography; Female; Ligands; Macaca mulatta; Male; Phencyclidine; Propylamines; Rats; Rats, Wistar; Receptors, sigma; Schizophrenia | 1994 |
Delayed changes in neural visinin-like calcium-binding protein gene expression caused by acute phencyclidine administration.
Topics: Actins; Animals; Blotting, Northern; Brain; Calcium-Binding Proteins; Excitatory Amino Acid Antagonists; Gene Expression; Male; Nerve Tissue Proteins; Neurocalcin; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; RNA, Messenger; Schizophrenia; Time Factors | 1995 |
Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.
Topics: Animals; Auditory Cortex; Auditory Perception; Bicuculline; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Hearing; Humans; Macaca fascicularis; Memory; Phencyclidine; Pipecolic Acids; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Time Factors | 1996 |
Effects of the PCP analog dizocilpine on sensory gating: potential relevance to clinical subtypes of schizophrenia.
Topics: Animals; Arousal; Attention; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Habituation, Psychophysiologic; Humans; Male; Neural Inhibition; Phencyclidine; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Schizophrenic Psychology | 1996 |
[Behavioral assessment of neuroleptics (3)--Schizophrenia negative symptoms-like model induced by PCP].
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clozapine; Desipramine; Disease Models, Animal; Humans; Immobilization; Mice; Phencyclidine; Risperidone; Schizophrenia; Swimming | 1996 |
Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Phencyclidine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Schizophrenia; Substance-Related Disorders; Synaptosomes | 1997 |
Effects of antidepressants on phencyclidine-induced enhancement of immobility in a forced swimming test in mice.
Topics: Animals; Antidepressive Agents; Depression; Desipramine; Hallucinogens; Hydroxyindoleacetic Acid; Male; Mianserin; Mice; Phencyclidine; Prefrontal Cortex; Schizophrenia; Serotonin; Stress, Physiological; Swimming | 1997 |
Cortical and hippocampal EEG power spectra in animal models of schizophrenia produced with methamphetamine, cocaine, and phencyclidine.
Topics: Adrenergic Agents; Animals; Cerebral Cortex; Cocaine; Disease Models, Animal; Electroencephalography; Hallucinogens; Hippocampus; Male; Methamphetamine; Phencyclidine; Rabbits; Schizophrenia | 1997 |
Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlorocebus aethiops; Clozapine; Cognition; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Humans; Phencyclidine; Prefrontal Cortex; Schizophrenia; Time Factors | 1997 |
Schizophrenia clues from monkeys.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlorocebus aethiops; Clozapine; Cognition; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Memory; Phencyclidine; Prefrontal Cortex; Schizophrenia; Schizophrenic Psychology | 1997 |
Phenomenologic comparison of the idiopathic psychosis of schizophrenia and drug-induced cocaine and phencyclidine psychoses: a retrospective study.
Topics: Adult; Cocaine; Hallucinogens; Humans; Male; Narcotics; Phencyclidine; Psychoses, Substance-Induced; Psychotic Disorders; Retrospective Studies; Schizophrenia; Substance-Related Disorders | 1994 |
Dysregulation of mesoprefrontal dopamine neurons induced by acute and repeated phencyclidine administration in the nonhuman primate: implications for schizophrenia.
Topics: Animals; Clonidine; Dopamine; Frontal Lobe; Functional Laterality; Haplorhini; Humans; Neurons; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Receptors, Adrenergic, alpha-2; Schizophrenia | 1998 |
Does phenylethylamine have a role in schizophrenia?: LSD and PCP up-regulate aromatic L-amino acid decarboxylase mRNA levels.
Topics: Alternative Splicing; Animals; Aromatic-L-Amino-Acid Decarboxylases; Base Sequence; Brain; Cerebellum; Corpus Striatum; Exons; Gene Expression Regulation, Enzymologic; Genetic Variation; Hippocampus; Humans; Lysergic Acid Diethylamide; Male; Molecular Sequence Data; Nucleus Accumbens; Oligonucleotide Probes; Phencyclidine; Phenethylamines; Rats; Rats, Wistar; RNA, Messenger; Schizophrenia; Sequence Deletion; Transcription, Genetic | 1997 |
A test of the predictive validity of animal models of schizophrenia based on phencyclidine and D-amphetamine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dextroamphetamine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Male; Motor Activity; Phencyclidine; Predictive Value of Tests; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Stereotyped Behavior | 1998 |
Subchronic phencyclidine administration increases mesolimbic dopaminergic system responsivity and augments stress- and psychostimulant-induced hyperlocomotion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Brain; Dextroamphetamine; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Drug Administration Schedule; Haloperidol; Limbic System; Male; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Stress, Psychological; Time Factors | 1998 |
Absence of basal ganglia amino acid neuron deficits in schizophrenia in three collections of brains.
Topics: Aged; Amino Acid Transport System X-AG; Analysis of Variance; Aspartic Acid; ATP-Binding Cassette Transporters; Basal Ganglia; Binding Sites; Carrier Proteins; Case-Control Studies; GABA Plasma Membrane Transport Proteins; Humans; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Nipecotic Acids; Organic Anion Transporters; Phencyclidine; Proline; Radioligand Assay; Schizophrenia; Tritium | 1998 |
Haloperidol potentiates the EEG slowing of MK-801 despite blocking its motor effects: implications for the PCP model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Electromyography; Excitatory Amino Acid Antagonists; Hallucinogens; Haloperidol; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia; Sleep, REM | 1998 |
Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.
Topics: Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Motor Activity; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Stereotyped Behavior; Synaptic Transmission | 1998 |
A new route to treating schizophrenia?
Topics: Animals; Bridged Bicyclo Compounds; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Maze Learning; Memory; Phencyclidine; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Schizophrenia | 1998 |
Phencyclidine interferes with the hippocampal gating of nucleus accumbens neuronal activity in vivo.
Topics: Action Potentials; Afferent Pathways; Animals; Excitatory Amino Acid Antagonists; Hallucinogens; Hippocampus; Male; Membrane Potentials; Neurons; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia | 1998 |
Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex.
Topics: Adult; Aged; Aged, 80 and over; Binding, Competitive; Female; Humans; Ketanserin; Male; Middle Aged; Neurons; Neurotransmitter Agents; Nitric Oxide Synthase; Phencyclidine; Prefrontal Cortex; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine; Receptors, GABA-A; Receptors, Serotonin; Schizophrenia; Serotonin Antagonists; Tritium | 1999 |
A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors.
Topics: Animals; Awards and Prizes; Brain; Dopamine; Glycine Agents; Hallucinogens; Male; Microdialysis; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Psychiatry; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors | 1999 |
Clinical Therapeutic Conference: dopaminergic/serotonergic actions of phencyclidine as a model for schizophreniform psychosis.
Topics: Adult; Female; Hallucinogens; Humans; Male; Models, Psychological; Phencyclidine; Psychoses, Substance-Induced; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Schizophrenia | 1997 |
Effects of the serotonin2A/2C receptor agonist and antagonist on phencyclidine-induced dopamine release in rat medial prefrontal cortex.
Topics: Amphetamines; Animals; Dopamine; Hallucinogens; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Serotonin; Schizophrenia; Serotonin Receptor Agonists | 1999 |
Ontogeny of phencyclidine and apomorphine-induced startle gating deficits in rats.
Topics: Age Factors; Animals; Apomorphine; Dose-Response Relationship, Drug; Female; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia | 2000 |
Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Interneurons; Male; Memory Disorders; Memory, Short-Term; Phencyclidine; Rats; Risperidone; Schizophrenia; Spiperone | 2000 |
Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP).
Topics: Acoustic Stimulation; Animals; Electroencephalography; Evoked Potentials, Auditory; Excitatory Amino Acid Antagonists; Hallucinogens; Humans; Macaca fascicularis; Models, Neurological; Phencyclidine; Reaction Time; Schizophrenia | 2000 |
Inhibition of striatal dopamine release by glycine and glycyldodecylamide.
Topics: Aminoquinolines; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Neurons; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Subcellular Fractions; Tritium | 2000 |
Relation between hippocampal gamma waves and behavioral disturbances induced by phencyclidine and methamphetamine.
Topics: Animals; Arousal; Brain Mapping; Central Nervous System Stimulants; Disease Models, Animal; Electroencephalography; Evoked Potentials; Hallucinogens; Hippocampus; Male; Methamphetamine; Motor Activity; Phencyclidine; Psychomotor Performance; Rats; Rats, Long-Evans; Schizophrenia; Septum of Brain | 2000 |
Differential expression of GABA(A) receptor subunit mRNAs and ligand binding sites in rat brain following phencyclidine administration.
Topics: Animals; Behavior, Animal; Binding Sites; Brain; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Neurons; Phencyclidine; Rats; Receptors, GABA-A; RNA, Messenger; Schizophrenia | 2000 |
[Neuropsychopharmacological study on an animal model for negative symptom of schizophrenia induced by repeated phencyclidine treatment].
Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Disease Models, Animal; Glutamates; Immobilization; Mice; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Schizophrenia; Schizophrenic Psychology; Serotonin Receptor Agonists | 2000 |
Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions.
Topics: Animals; Behavior, Animal; Dopamine; Hallucinogens; Immobilization; Male; Mice; Motor Activity; Phencyclidine; Prefrontal Cortex; Schizophrenia; Serotonin; Stress, Physiological | 2000 |
Differential and region-specific activation of mitogen-activated protein kinases following chronic administration of phencyclidine in rat brain.
Topics: Animals; Brain; Brain Stem; Cerebellum; JNK Mitogen-Activated Protein Kinases; Liver; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osmosis; p38 Mitogen-Activated Protein Kinases; Phencyclidine; Phencyclidine Abuse; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2001 |
Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior and c-fos mRNA expression in the brain.
Topics: Animals; Animals, Newborn; Dopamine; Methamphetamine; Neural Pathways; Neurons; Nucleus Accumbens; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Schizophrenia; Stereotyped Behavior; Ventral Tegmental Area | 2001 |
Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophrenia.
Topics: Animals; Discrimination Learning; Disease Models, Animal; Dizocilpine Maleate; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Hallucinogens; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred F344; Schizophrenia | 2000 |
Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Hallucinogens; Haloperidol; Male; Mice; Models, Animal; Phencyclidine; Schizophrenia; Social Behavior; Substance Withdrawal Syndrome | 2001 |
Phencyclidine (PCP)-induced deficits of prepulse inhibition in monkeys.
Topics: Acoustic Stimulation; Animals; Cebus; Excitatory Amino Acid Antagonists; Female; Male; Neural Inhibition; Phencyclidine; Reflex, Startle; Schizophrenia | 2001 |
Atypical antipsychotic effects of quetiapine fumarate in animal models.
Topics: Amphetamine; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Disease Models, Animal; Female; Haloperidol; Immobilization; Male; Mice; Phencyclidine; Rats; Rats, Wistar; Schizophrenia; Schizophrenia, Paranoid | 2000 |
Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment.
Topics: Animals; Brain; Chromogranin A; Chromogranin B; Chromogranins; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Immunohistochemistry; Male; Neuronal Plasticity; Neurons; Neuropeptides; Peptide Fragments; Phencyclidine; Proteins; Psychoses, Substance-Induced; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia; Secretogranin II; Secretory Vesicles; Synaptic Transmission | 2001 |
Elucidating the role of muscarinic receptors in psychosis.
Topics: Alzheimer Disease; Animals; Cell Fractionation; Cell Line; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Antagonists; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Hippocampus; Humans; Male; Memory; Mice; Mice, Knockout; Motor Activity; Muscarinic Agonists; Neurons; Oxotremorine; Phencyclidine; Radioligand Assay; Receptors, Muscarinic; Schizophrenia; Signal Transduction | 2001 |
Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Homovanillic Acid; Male; Motor Activity; Phencyclidine; Psychomotor Agitation; Rats; Rats, Sprague-Dawley; Schizophrenia | 2001 |
Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia.
Topics: Animals; Antipsychotic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Behavior, Animal; Benzodiazepines; Female; Frontal Lobe; Gene Expression; Hallucinogens; Motor Activity; Nerve Degeneration; Neurons; NF-kappa B; Olanzapine; Phencyclidine; Pirenzepine; Pregnancy; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Schizophrenia | 2001 |
Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia.
Topics: Animals; Dopamine; Glutamates; Humans; Ketamine; Lamotrigine; Models, Animal; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Triazines | 2002 |
[A case of schizophrenic psychosis caused by PCP].
Topics: Adolescent; Humans; Male; Phencyclidine; Psychoses, Substance-Induced; Schizophrenia; Sweden | 1978 |
Phencyclidine and schizophrenia.
Topics: Glutamates; Humans; Neurotransmitter Agents; Phencyclidine; Schizophrenia | 1992 |
Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication.
Topics: Antipsychotic Agents; Brain; Brain Mapping; Female; Humans; Illicit Drugs; Male; Middle Aged; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Schizophrenic Psychology | 1991 |
Positron emission tomography study of phencyclidine users as a possible drug model of schizophrenia.
Topics: Adult; Female; Frontal Lobe; Glucose; Humans; Male; Models, Biological; Occipital Lobe; Phencyclidine; Schizophrenia; Substance-Related Disorders; Tomography, Emission-Computed | 1991 |
Initial identification and characterization of sigma receptors on human peripheral blood leukocytes.
Topics: Animals; Guanidines; Haloperidol; Leukocytes; Lymphocyte Activation; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia | 1988 |
Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Valine | 1987 |
[Contents of endogenous phencyclidine-like substances in cerebrospinal fluid of schizophrenic patients].
Topics: Adult; Ataxia; Female; Humans; Male; Middle Aged; Phencyclidine; Radioligand Assay; Schizophrenia | 1988 |
[Effects of phencyclidine, the drug induces psychosis on the central nervous system].
Topics: Animals; Central Nervous System; Humans; Phencyclidine; Phencyclidine Abuse; Psychoses, Substance-Induced; Schizophrenia; Substance-Related Disorders | 1986 |
The effects of drugs on objective measures of thought disorder in schizophrenic patients.
Topics: Anxiety; Bipolar Disorder; Cyclohexanes; Humans; Intelligence Tests; Lysergic Acid Diethylamide; Perception; Phencyclidine; Phenothiazines; Piperidines; Psychoses, Substance-Induced; Reaction Time; Schizophrenia; Schizophrenic Psychology; Thinking | 1972 |