phencyclidine has been researched along with Cognition Disorders in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.30) | 18.7374 |
| 1990's | 5 (5.49) | 18.2507 |
| 2000's | 31 (34.07) | 29.6817 |
| 2010's | 48 (52.75) | 24.3611 |
| 2020's | 4 (4.40) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, D; Han, X; Huan, J; Lu, X; Niu, Q; Song, J; Wang, L; Xu, S; Zhang, H; Zhang, Y | 1 |
| Farahat, SA; Farghaly, M; Hussein, M; Kishk, NA; Taha, FM; Zawilla, NH | 1 |
| Hannan, GJ; Summers, JJ; Summers, MJ; White, TF | 1 |
| Bushnell, PJ; Jaeger, RJ | 1 |
| Burgess, M; Grayson, B; Harte, MK; Landreth, K; Lorusso, JM; Neill, JC; Watson, L | 1 |
| Chang, L; Fujita, Y; Hashimoto, K; Pu, Y; Qu, Y; Tan, Y; Wang, S; Wang, X | 1 |
| Dawson, N; Diógenes, MJ; Ferreira, CB; Fonseca-Gomes, J; Freitas, CF; Mouro, FM; Sebastião, AM; Simões do Couto, F; Tanqueiro, SR | 1 |
| Arias, HR; Manetti, D; Romanelli, MN; Wadenberg, MG | 1 |
| Brosda, J; Fink, H; Franke, RT; Pertz, HH; Tarland, E | 1 |
| Piyabhan, P; Wetchateng, T | 2 |
| Aida, T; Hida, H; Hiraoka, Y; Kitagaki, S; Mori, K; Noda, Y; Ozaki, N; Tanaka, K; Uchida, M; Yamada, K; Yoshimi, A | 1 |
| Piyabhan, P; Sireeratawong, S; Wetchateng, T | 1 |
| Bastlund, JF; Boll, JB; Bundgaard, C; Dekermendjian, K; Eskildsen, J; Frederiksen, K; Laursen, M; Papke, RL; Redrobe, JP; Sams, AG | 1 |
| Gartside, SE; Marston, HM; McQuade, R; Wallace, J | 1 |
| Bastlund, JF; Bundgaard, C; Carnerup, M; Christoffersen, CT; Jørgensen, M; Lerdrup, L; Montezinho, LP; Plath, N; Redrobe, JP | 1 |
| Aerts, N; Fellini, L; Steckler, T; Talpos, JC | 1 |
| Fujita, Y; Futamura, T; Hashimoto, K; Kikuchi, T; Ohgi, Y; Yoshimi, N | 1 |
| Biguet, NF; Ingallinesi, M; Le Bouil, L; Mallet, J; Mannoury la Cour, C; Meloni, R; Millan, MJ; Ravassard, P; Thi, AD | 1 |
| Hirota, Y; Ishii, K; Kubo, K; Nabeshima, T; Nagai, T; Nakajima, K; Noda, M; Yamada, K | 1 |
| Fujita, Y; Hashimoto, K; Iyo, M; Matsuura, A | 1 |
| Cui, D; Ma, YY; Mao, P; Zhao, XD | 1 |
| Abe, K; Aoki, T; Chaki, S; Iijima, M; Kaku, A; Kambe, D; Karasawa, J; Kawakita, Y; Okubo, T; Okuyama, S; Sekiguchi, Y; Shibata, T; Shimazaki, T; Yamamoto, S | 1 |
| Ballard, TM; Haman, M; Janhunen, SK; Kumar, G; Lerdrup, L; Plath, N; Ruby, T; Steckler, T; Svärd, H; Talpos, J; Wyler, R | 1 |
| Fujita, Y; Hashimoto, K; Hashimoto, R; Ishima, T; Ohi, K; Shirai, Y; Suganuma, H; Takeda, M; Ushida, Y; Yamamori, H; Yasuda, Y | 1 |
| Horiguchi, M; Meltzer, HY; Miyauchi, M; Neugebauer, NM; Oyamada, Y | 1 |
| Baguley, TD; Ellman, JA; Foscue, E; Kurup, P; Lombroso, PJ; Nairn, AC; Xu, J | 1 |
| Meltzer, HY; Miyauchi, M; Neugebauer, NM; Oyamada, Y | 1 |
| Massey, BW; Meltzer, HY; Michael, E; Rajagopal, L | 1 |
| Adham, N; Ferguson, P; Grayson, B; Gyertyán, I; Kiss, B; Neill, JC | 1 |
| Carr, GV; Detrait, ER; Lamberty, Y; Weinberger, DR | 1 |
| Bantreil, X; Bojarski, AJ; Chaumont-Dubel, S; Colacino, E; Grychowska, K; Kos, T; Lamaty, F; Marin, P; Martinez, J; Partyka, A; Pawłowski, M; Popik, P; Satała, G; Subra, G; Wesołowska, A; Zajdel, P | 1 |
| Amitai, N; Markou, A | 2 |
| Dilks, LS; Hixson, S; Marceaux, JC | 1 |
| Di Marzo, V; Guidali, C; Parolaro, D; Petrosino, S; Realini, N; Rubino, T; Vigano, D | 1 |
| Fejgin, K; Finnerty, N; Klamer, D; Lowry, J; Pålsson, E; Wass, C | 1 |
| Idris, NF; McLean, SL; Neill, JC; Woolley, ML | 1 |
| Fujita, Y; Hashimoto, K; Horio, M; Ishima, T; Iyo, M; Kohno, M; Kunitachi, S; Shirayama, Y; Tanibuchi, Y | 1 |
| McLean, SL; Neill, JC; Thomas, D; Woolley, ML | 1 |
| Fujita, Y; Hashimoto, K; Ishima, T; Iyo, M; Kohno, M; Takatsu, Y; Tanibuchi, Y | 1 |
| Dias, R; Goetghebeur, P; Pedersen, CS | 1 |
| Arnt, J; Bang-Andersen, B; Brennum, LT; Grayson, B; Idris, N; Neill, J; Witten, LM | 1 |
| Arnt, J; Bang-Andersen, B; Bymaster, FP; Cohen, MP; DeLapp, NW; Giethlen, B; Grayson, B; Kreilgaard, M; McKinzie, DL; Neill, JC; Nelson, DL; Nielsen, SM; Poulsen, MN; Schaus, JM; Witten, LM | 1 |
| Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ | 1 |
| McVie, A; Morris, BJ; Pratt, JA; Thomson, DM | 1 |
| Cole, S; Grayson, B; Idris, NF; Neill, JC; Sood, P; Young, AM | 1 |
| Rodefer, JS; Saland, SK | 1 |
| Alvaro, GS; Antolini, M; Bison, S; Gill, CH; Gozzi, A; Gunthorpe, MJ; Hollands, E; Idris, N; Large, CH; Neill, JC; Quarta, D; Read, KD; Sartori, I | 1 |
| Horiguchi, M; Huang, M; Meltzer, HY | 1 |
| Elsworth, JD; Hajszan, T; Leranth, C; Roth, RH | 1 |
| Elsworth, JD; Groman, SM; Jentsch, JD; Marston, H; Roth, RH; Shahid, M; Valles, R; Wong, E | 1 |
| Kubo, K; Nabeshima, T; Nakajima, K; Tanaka, DH; Toriumi, K | 1 |
| Hou, J; Kristiansen, LV; Owczarek, S; Secher, T | 1 |
| Bruun, AT; Bundgaard, C; de Jong, IE; Didriksen, M; Elster, L; Frederiksen, K; Larsen, PH; Redrobe, JP; Smith, GP | 1 |
| Gendle, DF; Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ | 1 |
| McGregor, C; Roseman, AS; Thornton, JE | 1 |
| Fujita, Y; Hashimoto, K; Horio, M | 1 |
| Adelekun, AE; Hannaway, KE; Horiguchi, M; Jayathilake, K; Meltzer, HY | 1 |
| Heresco-Levy, U; Javitt, DC; Umbricht, D; Zukin, SR | 1 |
| Adham, N; Chang, G; Gyertyán, I; Kiss, B; Schmauss, C; Zimnisky, R | 1 |
| Broberg, BV; Fabricius, K; Kaalund, SS; Karlsen, AS; Pakkenberg, B; Plath, N; Riise, J; Secher, T | 1 |
| Abdul-Monim, Z; Neill, JC; Reynolds, GP | 3 |
| Bühler, KG; Johnson, KM; Lavecchia, KL; Wiley, JL | 1 |
| INGLIS, J | 1 |
| Bristow, LJ; Campbell, UC; Conn, PJ; Hernandez, L; Kinney, GG; Lalwani, K | 1 |
| Castner, SA; Goldman-Rakic, PS; Williams, GV | 1 |
| Fujita, Y; Hashimoto, K; Iyo, M; Shimizu, E | 1 |
| Fujita, Y; Hashimoto, K; Iyo, M | 1 |
| Avenet, P; Bergis, OE; Duarte, C; Griebel, G; Gueudet, C; Oury-Donat, F; Pichat, P; Santucci, V; Scatton, B; Steinberg, R; Stemmelin, J; Terranova, JP; Urani, A; Voltz, C | 1 |
| Dunn, MJ; Killcross, S | 2 |
| Fujita, Y; Hagiwara, H; Hashimoto, K; Ishima, T; Iyo, M | 1 |
| Auclair, AL; Bardin, L; Bruins Slot, L; Colpaert, F; Depoortère, R; Kleven, MS; Newman-Tancredi, A; Vacher, B | 1 |
| Arnt, J; Didriksen, M; Skarsfeldt, T | 1 |
| Amitai, N; Markou, A; Semenova, S | 1 |
| Fujita, Y; Hashimoto, K; Ishima, T; Iyo, M; Kobashi, T; Matsuo, M; Takahagi, M; Tsukada, H | 1 |
| Grayson, B; Idris, NF; Neill, JC | 1 |
| Fujita, Y; Hagiwara, H; Hashimoto, K; Ishima, T; Iyo, M; Kunitachi, S; Zhang, L | 1 |
| Fujita, Y; Hagiwara, H; Hashimoto, K; Ishima, T; Iyo, M; Kunitachi, S; Shirayama, Y | 1 |
| Marshall, KM; Neill, JC; Rhaman, F; Sutcliffe, JS | 1 |
| Dias, R; Goetghebeur, P | 1 |
| Cochran, SM; Egerton, A; McGregor, S; Morris, BJ; Pratt, JA; Reid, L | 1 |
| Conn, LM; Lion, JR | 1 |
| Nakazato, A; Ogawa, S; Okuyama, S; Tomizawa, K | 1 |
| Araki, H; Ogawa, S; Okuyama, S; Otomo, S | 1 |
| Elsworth, JD; Jentsch, JD; Redmond, DE; Roth, RH; Taylor, JR; Youngren, KD | 1 |
| Elsworth, JD; Jentsch, JD; Redmond, DE; Roth, RH; Taylor, JR | 1 |
| Sams-Dodd, F | 1 |
8 review(s) available for phencyclidine and Cognition Disorders
| Article | Year |
|---|---|
Hazards to health from environmental lead exposure: a review of recent literature.
Topics: Absorption; Animals; Body Burden; Bone and Bones; Central Nervous System Diseases; Child, Preschool; Cognition Disorders; Dogs; Dust; Environmental Exposure; Female; Gasoline; Hair; Haplorhini; Hematologic Diseases; Humans; Infant; Infant, Newborn; Intelligence; Kinetics; Lead; Lead Poisoning; Learning Disabilities; Mice; Pregnancy; Rats; Sheep; Tissue Distribution; Tooth; Urban Population | 1986 |
Prefrontal dysfunction and a monkey model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Haplorhini; Phencyclidine; Prefrontal Cortex; Psychomotor Performance; Schizophrenia | 2015 |
The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia.
Topics: Animals; Attention; Cognition Disorders; Disease Models, Animal; Male; Phencyclidine; Rats; Reversal Learning; Schizophrenia | 2015 |
Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophrenia.
Topics: Animals; Choice Behavior; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Humans; Neuropsychological Tests; Phencyclidine; Reaction Time; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2010 |
Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Brain; Brain Mapping; Cerebral Cortex; Cognition Disorders; Contingent Negative Variation; Disease Models, Animal; Drug Synergism; Glycine; Hippocampus; Humans; Ketamine; Perception; Phencyclidine; Psychoses, Substance-Induced; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2012 |
Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia.
Topics: Amphetamine; Animals; Cognition Disorders; Dopamine; Glutamic Acid; Humans; Memory, Short-Term; Models, Animal; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2004 |
Pharmacologic approaches to violence.
Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Cognition Disorders; Crisis Intervention; Dystonia; Emergency Services, Psychiatric; Haloperidol; Humans; Mood Disorders; Neurocognitive Disorders; Personality Disorders; Phencyclidine; Violence | 1984 |
Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity.
Topics: Animals; Antipsychotic Agents; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Neural Networks, Computer; Phencyclidine; Psychotic Disorders; Rats; Reproducibility of Results; Schizophrenia; Social Behavior Disorders; Stereotyped Behavior | 1999 |
1 trial(s) available for phencyclidine and Cognition Disorders
| Article | Year |
|---|---|
Neuropsychological effects of formaldehyde use.
Topics: Adult; Brain; Cannabinoids; Cognition Disorders; Drug Synergism; Fixatives; Formaldehyde; Humans; Illicit Drugs; Intelligence; Male; Marijuana Abuse; Neuropsychological Tests; Phencyclidine; Phencyclidine Abuse; Problem Solving; Substance-Related Disorders; Thinking; Vocabulary | 2008 |
82 other study(ies) available for phencyclidine and Cognition Disorders
| Article | Year |
|---|---|
Blood pressure mediated the effects of cognitive function impairment related to aluminum exposure in Chinese aluminum smelting workers.
Topics: Aluminum; Aluminum Oxide; Blood Pressure; Cognition; Cognition Disorders; Cognitive Dysfunction; Dust; Humans; Hypertension; Male | 2022 |
Occupational exposure to aluminum and its amyloidogenic link with cognitive functions.
Topics: Adult; Air Pollutants, Occupational; Aluminum; Amyloidosis; Case-Control Studies; Chemical Industry; Cognition Disorders; Cross-Sectional Studies; Dust; Humans; Middle Aged; Occupational Exposure; Young Adult | 2014 |
The effect of occupational exposure to manganese dust and fume on neuropsychological functioning in Australian smelter workers.
Topics: Adult; Air Pollutants, Occupational; Australia; Cognition Disorders; Dust; Humans; Linear Models; Male; Manganese; Middle Aged; Neuropsychological Tests; Occupational Diseases; Occupational Exposure; Predictive Value of Tests | 2011 |
Handling prevents and reverses cognitive deficits induced by sub-chronic phencyclidine in a model for schizophrenia in rats.
Topics: Animals; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Female; Phencyclidine; Rats; Schizophrenia | 2023 |
Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling.
Topics: Allosteric Regulation; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Ketamine; Male; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Phencyclidine; Protein-Tyrosine Kinases; Signal Transduction | 2020 |
Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2021 |
Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat.
Topics: Acrylamides; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Furans; Galantamine; Male; Phencyclidine; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors | 2017 |
Effects of 2-bromoterguride, a dopamine D
Topics: Animals; Antipsychotic Agents; Apomorphine; Cognition Disorders; Dopamine Agonists; Lisuride; Male; Memory Disorders; Phencyclidine; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Recognition, Psychology; Reflex, Startle; Schizophrenic Psychology; Social Behavior | 2018 |
Bacopa monnieri (Brahmi) Prevents Cognitive Deficit by Maintaining CA2/3 VGLUT1 Density of Sub-Chronic Phencyclidine Rat Model of Schizophrenia in Normal Level.
Topics: Animals; Bacopa; Behavior, Animal; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Neostriatum; Neuroprotective Agents; Nootropic Agents; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Vesicular Glutamate Transport Protein 1 | 2016 |
Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Emotions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Female; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2019 |
Cognitive enhancement effects of Bacopa monnieri (Brahmi) on novel object recognition and NMDA receptor immunodensity in the prefrontal cortex and hippocampus of sub-chronic phencyclidine rat model of schizophrenia.
Topics: Animals; Bacopa; Cognition; Cognition Disorders; Disease Models, Animal; Hallucinogens; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Nootropic Agents; Phencyclidine; Phytotherapy; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2013 |
Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral ad
Topics: Administration, Oral; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition Disorders; Cyclopropanes; Dose-Response Relationship, Drug; Drug Discovery; Humans; Molecular Structure; Phencyclidine; Phenylethyl Alcohol; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 2014 |
Evidence that aetiological risk factors for psychiatric disorders cause distinct patterns of cognitive deficits.
Topics: Animals; Bipolar Disorder; Body Weight; Cognition Disorders; Corticosterone; Executive Function; Female; Male; Neuropsychological Tests; Phencyclidine; Pregnancy; Pregnancy Complications, Infectious; Rats, Inbred Strains; Reversal Learning; Risk Factors; Schizophrenia; Schizophrenic Psychology; Task Performance and Analysis | 2014 |
In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Cognition Disorders; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Excitatory Amino Acid Antagonists; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Humans; Hyperkinesis; Male; Mice; Mice, Inbred DBA; Phencyclidine; Phosphodiesterase Inhibitors; Rats; Recognition, Psychology; Recombinant Proteins; Schizophrenia; Schizophrenic Psychology; Sensory Gating | 2014 |
A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment.
Topics: Amphetamine; Animals; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Ketamine; Male; Paired-Associate Learning; Phencyclidine; Psychomotor Performance; Random Allocation; Rats; Reaction Time; Scopolamine; Touch | 2014 |
Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.
Topics: Animals; Cognition Disorders; Male; Mice; Mice, Inbred ICR; Phencyclidine; Quinolones; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Thiophenes | 2014 |
Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Gene Knockdown Techniques; Gene Silencing; Male; MicroRNAs; Motor Activity; Nucleus Accumbens; Phencyclidine; Random Allocation; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Schizophrenia; Social Behavior | 2015 |
Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Cognition Disorders; Extracellular Matrix Proteins; GABAergic Neurons; Infusions, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Nerve Tissue Proteins; Neurons; Phencyclidine; Prefrontal Cortex; Receptors, LDL; Reelin Protein; Sensory Gating; Serine Endopeptidases | 2015 |
Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chromatography, Liquid; Cognition Disorders; D-Amino-Acid Oxidase; Drug Interactions; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Models, Animal; Motor Activity; Phencyclidine; Prepulse Inhibition; Quinolones; Receptors, N-Methyl-D-Aspartate; Serine; Sodium Benzoate | 2015 |
Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cognition; Cognition Disorders; Disease Models, Animal; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Memory; Mice; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior | 2015 |
Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood.
Topics: Adolescent; Adult; Animals; Brassica; Child; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Mice; Middle Aged; NF-E2-Related Factor 2; Oxidative Stress; Phencyclidine; Plant Extracts; Prefrontal Cortex; Schizophrenia; Seedlings; Sulfoxides | 2015 |
Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Isoindoles; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Psychotropic Drugs; Pyridines; Pyrimidines; Random Allocation; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Schizophrenic Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Time | 2016 |
Bacopa monnieri (Brahmi) Enhanced Cognitive Function and Prevented Cognitive Impairment by Increasing VGLUT2 Immunodensity in Prefrontal Cortex of Sub-Chronic Phencyclidine Rat Model of Schizophrenia.
Topics: Animals; Bacopa; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Nootropic Agents; Phencyclidine; Phytotherapy; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Vesicular Glutamate Transport Protein 1 | 2015 |
Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.
Topics: Animals; Benzothiepins; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cognition Disorders; CREB-Binding Protein; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Motor Activity; Neurons; Phencyclidine; Phosphorylation; Protein Tyrosine Phosphatases; Receptors, N-Methyl-D-Aspartate; RNA Interference; Ubiquitination | 2016 |
Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Benzamides; Bridged Bicyclo Compounds; Cognition Disorders; Disease Models, Animal; Female; Lurasidone Hydrochloride; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Phencyclidine; Random Allocation; Rats, Long-Evans; Receptors, Nicotinic | 2016 |
Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice.
Topics: Animals; Cognition Disorders; Executive Function; Isoindoles; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Phenols; Piperazines; Pyrimidines; Reaction Time; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Reversal Learning; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Sulfonamides | 2016 |
Effects of cariprazine, a novel antipsychotic, on cognitive deficit and negative symptoms in a rodent model of schizophrenia symptomatology.
Topics: Animals; Antipsychotic Agents; Cognition; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Exploratory Behavior; Female; Motor Activity; Nootropic Agents; Phencyclidine; Piperazines; Rats; Recognition, Psychology; Risperidone; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
Brain catechol-O-methyltransferase (COMT) inhibition by tolcapone counteracts recognition memory deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic mice.
Topics: Animals; Benzophenones; Blood-Brain Barrier; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cognition Disorders; Dopamine; Dose-Response Relationship, Drug; Male; Memory Disorders; Mice; Mice, Transgenic; Nitriles; Nitrophenols; Phencyclidine; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recognition, Psychology; Tolcapone | 2016 |
Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; CHO Cells; Cognition Disorders; Cricetulus; Cyclic AMP; Disease Models, Animal; HEK293 Cells; Humans; Male; Neuroblastoma; Phencyclidine; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Sulfones | 2016 |
Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration.
Topics: Animals; Attention; Cognition; Cognition Disorders; Data Interpretation, Statistical; Drug Implants; Excitatory Amino Acid Antagonists; Male; Nicotine; Nicotinic Agonists; Phencyclidine; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Serial Learning | 2009 |
Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Cognition Disorders; Disease Models, Animal; Endocannabinoids; Male; Phencyclidine; Rats; Receptor, Cannabinoid, CB1; Schizophrenia | 2009 |
Prefrontal GABA(B) receptor activation attenuates phencyclidine-induced impairments of prepulse inhibition: involvement of nitric oxide.
Topics: Acoustic Stimulation; Animals; Baclofen; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electrochemistry; Enzyme Inhibitors; GABA Agonists; Male; Mice; Mice, Inbred Strains; Neural Inhibition; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phencyclidine; Prefrontal Cortex; Receptors, GABA-B; Reflex, Startle; Signal Transduction | 2009 |
D(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Neuropsychological Tests; Phencyclidine; Receptors, Dopamine D1; Recognition, Psychology | 2009 |
Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Anisoles; Brain; Cell Membrane; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Hippocampus; Immunohistochemistry; Indans; Male; Mice; Mice, Inbred ICR; Phencyclidine; Physostigmine; Piperidines; Propylamines; Receptors, sigma; Recognition, Psychology; Sigma-1 Receptor; Tritium | 2009 |
Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Phencyclidine; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reversal Learning; Schizophrenia; Serotonin Antagonists; Serotonin Receptor Agonists | 2009 |
Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: a possible role of alpha1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Cognition; Cognition Disorders; Dibenzothiazepines; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Phencyclidine; Prazosin; Quetiapine Fumarate; Receptors, Adrenergic, alpha-1; Time Factors | 2009 |
Chronic infusion of PCP via osmotic mini-pumps: a new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance.
Topics: Animals; Antipsychotic Agents; Attention; Behavior, Animal; Behavioral Sciences; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Hallucinogens; Infusion Pumps, Implantable; Male; Modafinil; Neuropharmacology; Neuropsychological Tests; Neurosciences; Phencyclidine; Rats; Schizophrenia; Schizophrenic Psychology | 2009 |
Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.
Topics: Animals; Antipsychotic Agents; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorobenzenes; Imidazoles; Indoles; Memory Disorders; Phencyclidine; Piperidines; Quinolines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reversal Learning; Schizophrenia; Sulfones | 2010 |
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
Topics: Animals; Benzylamines; Cells, Cultured; Cognition Disorders; Cricetinae; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Indoles; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Recognition, Psychology; Serotonin Antagonists | 2010 |
Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: implications for therapy of cognitive dysfunction in schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Cognition; Cognition Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Half-Life; Learning; Nicotinic Agonists; Phencyclidine; Random Allocation; Rats; Receptors, Nicotinic; Reversal Learning; Schizophrenia; Tachyphylaxis | 2011 |
Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine.
Topics: Animals; Antipsychotic Agents; Attention; Choice Behavior; Clozapine; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; GABA Antagonists; Male; Phencyclidine; Rats; Rats, Long-Evans; Reaction Time; Receptors, N-Methyl-D-Aspartate; Signal Detection, Psychological; Time Factors | 2011 |
PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia.
Topics: Animals; Benzamides; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine D4; Recognition, Psychology; Schizophrenic Psychology | 2011 |
Environmental enrichment ameliorates phencyclidine-induced cognitive deficits.
Topics: Animals; Behavior, Animal; Cognition Disorders; Environmental Exposure; Hallucinogens; Humans; Male; Phencyclidine; Rats; Rats, Long-Evans | 2011 |
The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia.
Topics: Animals; Cognition Disorders; Female; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reversal Learning; Schizophrenia; Sodium Channel Blockers; Treatment Outcome | 2011 |
The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.
Topics: Animals; Cognition Disorders; Exploratory Behavior; Female; Phencyclidine; Phenols; Random Allocation; Rats; Rats, Long-Evans; Receptors, Serotonin; Recognition, Psychology; Serotonin Antagonists; Sulfonamides | 2011 |
Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys.
Topics: Animals; Chlorocebus aethiops; Cognition; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Male; Microscopy, Electron, Transmission; Phencyclidine; Prefrontal Cortex; Schizophrenia; Schizophrenic Psychology; Synapses | 2011 |
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration.
Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Chlorocebus aethiops; Cognition Disorders; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Male; Phencyclidine; Psychomotor Performance; Reversal Learning; Treatment Outcome | 2012 |
GABAergic precursor transplantation into the prefrontal cortex prevents phencyclidine-induced cognitive deficits.
Topics: Animals; Animals, Newborn; Cognition Disorders; Embryonic Stem Cells; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Phencyclidine; Prefrontal Cortex; Pregnancy | 2011 |
Phencyclidine treatment increases NR2A and NR2B N-methyl-D-aspartate receptor subunit expression in rats.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Phencyclidine; Pregnancy; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Up-Regulation | 2011 |
Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats.
Topics: Amphetamine; Animals; Benzodiazepines; Central Nervous System Stimulants; CHO Cells; Cognition Disorders; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperkinesis; Imidazoles; Male; Oocytes; Parvalbumins; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-A; Schizophrenia; Xenopus laevis | 2012 |
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Brain; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Drug Interactions; Female; Half-Life; Hallucinogens; Isoxazoles; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Phencyclidine; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tissue Distribution | 2012 |
Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats.
Topics: Analysis of Variance; Animals; Cognition Disorders; Disease Models, Animal; Estradiol; Estrogens; Exploratory Behavior; Female; Hallucinogens; Motor Activity; Neuropsychological Tests; Ovariectomy; Phencyclidine; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Statistics, Nonparametric; Time Factors | 2012 |
Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Brain; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Exploratory Behavior; Male; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurons; Phencyclidine; Pyrazoles; Receptor, Metabotropic Glutamate 5; Recognition, Psychology; Schizophrenia | 2013 |
Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Isoindoles; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Thiazoles; Urea | 2012 |
Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse.
Topics: Analysis of Variance; Animals; Attention; Cognition Disorders; Drug Partial Agonism; Male; Maze Learning; Memory, Episodic; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Knockout; Phencyclidine; Piperazines; Receptors, Dopamine D3; Recognition, Psychology; Set, Psychology | 2013 |
Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats.
Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Cell Count; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Male; Motor Activity; Neuroglia; Neurons; Parvalbumins; Phencyclidine; Phosphopyruvate Hydratase; Rats; RNA, Messenger; Schizophrenia; Social Isolation | 2013 |
The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Haloperidol; Injections, Intraperitoneal; Phencyclidine; Piperazines; Rats; Reversal Learning; Social Isolation; Thiazoles | 2003 |
Pharmacological challenge reveals long-term effects of perinatal phencyclidine on delayed spatial alternation in rats.
Topics: Animals; Animals, Newborn; Cognition Disorders; Dose-Response Relationship, Drug; Female; Phencyclidine; Pregnancy; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spatial Behavior; Time | 2003 |
SENSORY DEPRIVATION AND COGNITIVE DISORDER.
Topics: Anesthetics; Catalepsy; Cognition; Cognition Disorders; Drug Therapy; Hallucinogens; Hospitalization; Humans; Models, Theoretical; Neurophysiology; Pharmacology; Phencyclidine; Psychoanalytic Interpretation; Psychophysiology; Schizophrenic Psychology; Sensory Deprivation | 1965 |
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.
Topics: Animals; Cognition Disorders; Dose-Response Relationship, Drug; Drug Synergism; Hippocampus; Male; Maze Learning; Memory; Phencyclidine; Pyridines; Rats; Rats, Long-Evans; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Exploratory Behavior; Hallucinogens; Haloperidol; Male; Mice; Mice, Inbred ICR; Phencyclidine; Time Factors | 2005 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Anisoles; Antipsychotic Agents; Behavior, Animal; Choice Behavior; Cognition Disorders; Dehydroepiandrosterone Sulfate; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Fluvoxamine; Mice; Mice, Inbred ICR; Motor Activity; Nootropic Agents; Phencyclidine; Piperazines; Propylamines; Receptors, sigma; Retention, Psychology; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor | 2007 |
The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Reversal Learning | 2006 |
SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Agonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recognition, Psychology; Schizophrenia | 2007 |
Clozapine but not haloperidol treatment reverses sub-chronic phencyclidine-induced disruption of conditional discrimination performance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Cognition Disorders; Conditioning, Operant; Discrimination Learning; Dopamine; Excitatory Amino Acid Antagonists; Goals; Haloperidol; Male; Phencyclidine; Prefrontal Cortex; Rats | 2006 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: role of alpha7 nicotinic receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cognition Disorders; Excitatory Amino Acid Antagonists; Indoles; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Ondansetron; Phencyclidine; Receptors, Nicotinic; Recognition, Psychology; Serotonin Antagonists; Tropisetron | 2006 |
Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Clozapine; Cognition; Cognition Disorders; Conditioning, Classical; Conditioning, Operant; Discrimination Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Flupenthixol; Haloperidol; Male; Phencyclidine; Predictive Value of Tests; Rats; Reproducibility of Results; Serotonin Antagonists | 2007 |
Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat.
Topics: Animals; Behavior, Animal; Cognition Disorders; Conditioning, Operant; Dentate Gyrus; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Hallucinogens; Hippocampus; Immunohistochemistry; Interneurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Rats; Reversal Learning; Schizophrenia | 2007 |
F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. III. Activity in models of cognition and negative symptoms.
Topics: Amnesia; Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Benzylamines; Cognition Disorders; Cyclopentanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Models, Animal; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D3; Receptors, Dopamine D4; Reflex; Reflex, Startle; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Receptor Agonists | 2007 |
Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Maze Learning; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenic Psychology | 2007 |
Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.
Topics: Animals; Antipsychotic Agents; Attention; Benzodiazepines; Clozapine; Cognition Disorders; Dibenzothiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Impulsive Behavior; Male; Olanzapine; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Wistar; Reaction Time; Risperidone; Schizophrenia | 2007 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711.
Topics: Aconitine; Analysis of Variance; Animals; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cognition Disorders; Drug Administration Schedule; Drug Interactions; Male; Mice; Mice, Inbred ICR; Nicotinic Antagonists; Phencyclidine | 2008 |
Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Female; Motor Activity; Phencyclidine; Rats; Recognition, Psychology | 2007 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cognition Disorders; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Exploratory Behavior; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Minocycline; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2008 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Body Temperature; Cognition Disorders; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Isoindoles; Male; Mice; Mice, Inbred ICR; Pattern Recognition, Visual; Phencyclidine; Piperazines; Protein Binding; Pyridines; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Time Factors | 2008 |
Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats.
Topics: Animals; Cognition Disorders; Estradiol; Female; Hippocampus; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2008 |
Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study.
Topics: Animals; Antipsychotic Agents; Attention; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition Disorders; Conditioning, Operant; Discrimination, Psychological; Excitatory Amino Acid Antagonists; Haloperidol; Imidazoles; Indoles; Male; Modafinil; Phencyclidine; Psychomotor Performance; Rats; Risperidone; Schizophrenic Psychology | 2009 |
Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats.
Topics: Amphetamine; Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Cognition Disorders; Discrimination, Psychological; Dopamine; Frontal Lobe; Hallucinogens; Hyperkinesis; Male; Neostriatum; Phencyclidine; Rats; Rats, Long-Evans; Reflex, Startle; Schizophrenic Psychology; Social Behavior | 2008 |
Effect of NE-100, a novel sigma receptor ligand, on phencyclidine- induced delayed cognitive dysfunction in rats.
Topics: Animals; Anisoles; Cognition Disorders; Ligands; Male; Maze Learning; Phencyclidine; Propylamines; Rats; Rats, Wistar; Receptors, sigma; Time Factors | 1995 |
Effect of NE-100, a novel sigma receptor ligand, on phencyclidine-induced cognitive dysfunction.
Topics: Animals; Anisoles; Anti-Anxiety Agents; Cognition Disorders; Drug Interactions; Ligands; Male; Phencyclidine; Physical Exertion; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma; Ritanserin; Swimming | 1994 |
Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys.
Topics: Animals; Chlorocebus aethiops; Cognition Disorders; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Hallucinogens; Haloperidol; Imidazoles; Male; Phencyclidine; Prefrontal Cortex; Pyrimidines; Receptors, Dopamine D4 | 1999 |
Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits.
Topics: Animals; Biogenic Monoamines; Chlorocebus aethiops; Cognition; Cognition Disorders; Corpus Striatum; Dopamine; Female; Frontal Lobe; Hallucinogens; Male; Phencyclidine; Serotonin; Synaptic Transmission; Time Factors | 1999 |