phenazopyridine and Urinary Tract Infections studies

Phenazopyridine: A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
phenazopyridine : A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.

Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the analgesic effect, efficacy and tolerability of phenazopyridine in combination with fosfomycin for the treatment of acute uncomplicated cystitis in working-age female."	9.41	[Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study]. ( Bunova, NE; Davidov, MI; Lunev, AA; Meltsina, MN; Metelkin, AM; O, PR, 2021)
"Trimethoprim-sulfamethoxazole (TMP-SMX) and phenazopyridine are individually associated with methemoglobinemia through a series of altered reduction-oxidation reactions."	8.31	A Case That Will Take Your Breath Away: Acquired Methemoglobinemia Related to Trimethoprim-Sulfamethoxazole and Phenazopyridine Ingestion for Treatment of Urinary Tract Infection. ( Domagalski, J; Robertson, K; Sharma, V, 2023)
"To report a case of sulfhemoglobinemia in a patient receiving phenazopyridine for a urinary tract infection."	7.73	Phenazopyridine-induced sulfhemoglobinemia. ( Bharadwaj, P; Bowie, VL; Gopalachar, AS, 2005)
"To evaluate the analgesic effect, efficacy and tolerability of phenazopyridine in combination with fosfomycin for the treatment of acute uncomplicated cystitis in working-age female."	5.41	[Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study]. ( Bunova, NE; Davidov, MI; Lunev, AA; Meltsina, MN; Metelkin, AM; O, PR, 2021)
"A multicenter double-blind, randomized, placebo-controlled study with parallel groups to evaluate the efficacy and safety of phenazopyridine in patients with acute uncomplicated cystitis was performed."	5.34	[Efficiency and safety of phenazopyridine for treatment of uncomplicated urinary tract infection: results of multi-center, randomized, placebo-controlled, clinical study]. ( Chibirov, KH; Kagan, OF; Petrov, SB; Slesarevskaya, MN; Topuzov, ME; Voronova, EN, 2020)
"In nine separate clinical trials, 382 patients having symptoms of either prostatitis, acute cystitis, urethritis, and/or trigonitis were randomly assigned to treatment with flavoxate or phenazopyridine."	5.04	Urinary tract disorders. Clinical comparison of flavoxate and phenazopyridine. ( Gould, S, 1975)
"Trimethoprim-sulfamethoxazole (TMP-SMX) and phenazopyridine are individually associated with methemoglobinemia through a series of altered reduction-oxidation reactions."	4.31	A Case That Will Take Your Breath Away: Acquired Methemoglobinemia Related to Trimethoprim-Sulfamethoxazole and Phenazopyridine Ingestion for Treatment of Urinary Tract Infection. ( Domagalski, J; Robertson, K; Sharma, V, 2023)
"To report a case of sulfhemoglobinemia in a patient receiving phenazopyridine for a urinary tract infection."	3.73	Phenazopyridine-induced sulfhemoglobinemia. ( Bharadwaj, P; Bowie, VL; Gopalachar, AS, 2005)
"Three ureteral obstructions were identified intraoperatively and none in the postoperative period."	2.82	Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. ( Alas, AN; Barber, M; Chadi, SA; Davila, GW; Espaillat-Rijo, L; Hurtado, EA; Siff, L; Vaish, S; Zimberg, S, 2016)

Research

Studies (42)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

International Prostate Symptom Score

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (71.43)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (11.90)	29.6817
2010's	4 (9.52)	24.3611
2020's	3 (7.14)	2.80

Authors	Studies
Sharma, V	1
Robertson, K	1
Domagalski, J	1
Petrov, SB	1
Slesarevskaya, MN	1
Chibirov, KH	1
Topuzov, ME	1
Kagan, OF	1
Voronova, EN	1
Davidov, MI	1
Meltsina, MN	1
Bunova, NE	1
Metelkin, AM	1
O, PR	1
Lunev, AA	1
Edson, RS	1
Litin, SC	1
Bundrick, JB	1
Wang, A	1
Nizran, P	1
Malone, MA	1
Riley, T	1
Ghimire, KB	1
Nepal, B	1
Espaillat-Rijo, L	1
Siff, L	1
Alas, AN	1
Chadi, SA	1
Zimberg, S	1
Vaish, S	1
Davila, GW	1
Barber, M	1
Hurtado, EA	1
Singh, NK	1
Mirza, N	1
PIECHOTTKA, E	1
GABOR, EP	1
LOWENSTEIN, L	1
DE LEEUW, NK	1
Gaines, KK	1
Gopalachar, AS	1
Bowie, VL	1
Bharadwaj, P	1
Chan, SY	1
Evans, D	1
Kusunoki, T	1
Kasai, M	1
Nagahara, A	1
Winter, CC	1
Schroeder, WA	1
Powars, D	1
Shelton, JB	1
Shelton, JR	1
Wilson, JB	1
Huisman, TH	1
Bedros, AA	1
Green, ED	1
Zimmerman, RC	1
Ghurabi, WH	1
Colohan, DP	1
Badley, BW	1
Gould, S	1
Wyganowska, G	1
Liwski, R	1
Gietko, G	1
Hausnerová, S	1
Potuzník, V	1
Eggers, B	1
Strothmann, G	1
Weilacher, JS	1
Heifetz, CL	1
Fisher, MW	1
Chrapowicki, T	1
Vlatković, G	1
Babić, I	1
Charles, JC	1
Jones, GW	1
Janda, J	1
Pavlík, V	1
Hradecký, L	1
Trickett, PC	1
Blackard, CE	1
Nicolaidis, AN	1
McEwen, J	1
Paterson, C	1
Martinek, JB	1
Olmer, M	1
Salvadori, JM	1
Ebbinghaus, KD	1
Vergison, R	1
Casselman, J	1
Zillmer, H	1
Schönmetzler, F	1
Archimbaud, JP	1
Moine, C	1
Ohori, T	1
Koshiba, K	1
Kanzaki, M	1
Goto, Y	1
Muramoto, T	1
Inada, T	1
Kitayama, T	1
Shimizu, S	1
Komatsu, Y	1
Fukuyama, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Perioperative Administration of Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery[NCT03524339]	Phase 2/Phase 3	132 participants (Actual)	Interventional	2018-08-01	Completed
Evaluation of Ureteral Jets on Cystoscopy: A Randomized Controlled Trial[NCT02476448]		176 participants (Actual)	Interventional	2015-02-28	Completed
The Use of Dye-less Cystoscopy in Assessing Urinary Tract Integrity During Hysterectomy[NCT05190939]		276 participants (Actual)	Interventional	2018-07-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Total and subscale scores reported. Total score range 0-35, with 0 being less symptomatic and 35 being more symptomatic. Total score is sum of individual questions. Seven subgroups address incomplete bladder emptying, frequency, intermittency, urgency, weak stream, straining, nocturia. Each subgroup is scored 0-5 with 5 being most symptomatic. The last question is independent, rates quality of life from 0 (best) to 6 (worst) (NCT03524339)
Timeframe: Within 1 week of surgery

Postoperative Urinary Retention

Intervention	Points (Median)
Placebo	6
Tamsulosin	7

Failed voiding trial upon removal of catheter (NCT03524339)
Timeframe: Within 72 hours of surgery

Postoperative Urinary Tract Infection

Intervention	Participants (Count of Participants)
Placebo	16
Tamsulosin	5

Treated for urinary tract infection with antibiotics or urinalysis or urine culture suggests infection. (NCT03524339)
Timeframe: Within 6 weeks after surgery

Sent Home With Catheterization

Intervention	Participants (Count of Participants)
Placebo	6
Tamsulosin	4

Urinary retention that required homegoing catheterization (NCT03524339)
Timeframe: within 6 weeks of surgery

Number of Participants With Urinary Tract Infections

Intervention	Participants (Count of Participants)
Placebo	7
Tamsulosin	5

Medical records will be followed prospectively for 6 weeks to assess for incidence of urinary tract infections within different groups. (NCT02476448)
Timeframe: 6 weeks

Article	Year
Urinary tract infections. Primary care, 2013, Volume: 40, Issue:3 Topics: Age Factors; Anesthetics, Local; Anti-Infective Agents, Urinary; Drug Resistance, Microbial; Humans;	2013
Phenazopyridine hydrochloride: the use and abuse of an old standby for UTI. Urologic nursing, 2004, Volume: 24, Issue:3 Topics: Anesthetics, Local; Humans; Patient Education as Topic; Phenazopyridine; Urinary Tract Infections	2004
Phenazopyridine hydrochloride toxicity: a cause of drug-induced methemoglobinemia. JACEP, 1979, Volume: 8, Issue:10 Topics: Acute Kidney Injury; Adolescent; Aged; Aminopyridines; Anemia, Hemolytic; Animals; Chemical and Drug	1979

Article	Year
[Efficiency and safety of phenazopyridine for treatment of uncomplicated urinary tract infection: results of multi-center, randomized, placebo-controlled, clinical study]. Urologiia (Moscow, Russia : 1999), 2020, Issue:3 Topics: Adult; Anti-Bacterial Agents; Cystitis; Double-Blind Method; Female; Humans; Phenazopyridine; Treatm	2020
[Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study]. Urologiia (Moscow, Russia : 1999), 2021, Issue:3 Topics: Anti-Bacterial Agents; Cystitis; Female; Fosfomycin; Humans; Phenazopyridine; Urinary Tract Infectio	2021
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology, 2016, Volume: 128, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Aged; Attitude of Health Personnel; Cystoscopy; F	2016
Urinary tract disorders. Clinical comparison of flavoxate and phenazopyridine. Urology, 1975, Volume: 5, Issue:5 Topics: Acute Disease; Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Cystitis; Female; Flavonoid	1975
[Microbiological study of the effectivity of urovalidine (author's transl)]. Ceskoslovenska epidemiologie, mikrobiologie, imunologie, 1973, Volume: 22, Issue:6 Topics: Anti-Infective Agents, Urinary; Clinical Trials as Topic; Drug Combinations; Humans; Oxazoles; Phena	1973
[Urovalidin administered to children (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1974, Jun-11, Volume: 63, Issue:23 Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Chronic Disease; Clinical Trials as Topic; Drug	1974
[Treatment of urinary tract infections in children by Urovalidin]. Lijecnicki vjesnik, 1974, Volume: 96, Issue:10 Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Cycloserine; Drug Combinations; Drug	1974
Ancillary use of phenazopyridine (Pyridium) in urinary tract infections. Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:7 Topics: Adult; Female; Humans; Male; Methylene Blue; Phenazopyridine; Urinary Tract Infections	1970
Use of azo-sulfonamide for the prevention of urinary tract symptoms and bacteriuria following cystourethroscopic examination. The Journal of urology, 1972, Volume: 107, Issue:4 Topics: Adult; Aged; Anesthetics, Local; Azo Compounds; Bacteriuria; Cystoscopy; Diazepam; Drug Combinations	1972

Article	Year
A Case That Will Take Your Breath Away: Acquired Methemoglobinemia Related to Trimethoprim-Sulfamethoxazole and Phenazopyridine Ingestion for Treatment of Urinary Tract Infection. WMJ : official publication of the State Medical Society of Wisconsin, 2023, Volume: 122, Issue:4 Topics: Aged; Eating; Female; Humans; Methemoglobinemia; Phenazopyridine; Trimethoprim, Sulfamethoxazole Dru	2023
Clinical Pearls in Infectious Diseases 2017. Disease-a-month : DM, 2017, Volume: 63, Issue:6 Topics: Administration, Intravaginal; Adult; Aged; Anti-Bacterial Agents; Body Piercing; Campylobacter Infec	2017
Dyspnea after treatment of recurrent urinary tract infection. Cleveland Clinic journal of medicine, 2013, Volume: 80, Issue:11 Topics: Aged; Anti-Infective Agents, Urinary; Drug Therapy, Combination; Dyspnea; Female; Follow-Up Studies;	2013
Elderly woman with orange urine and purple hands. Mayo Clinic proceedings, 2008, Volume: 83, Issue:7 Topics: Aged; Color; Enzyme Inhibitors; Female; Follow-Up Studies; Hand; Humans; Injections, Intravenous; Me	2008
[Treatment of infections of the urinary tract with pyridium]. Munchener medizinische Wochenschrift (1950), 1954, Nov-26, Volume: 96, Issue:48 Topics: Analgesics; Humans; Phenazopyridine; Urinary Tract Infections	1954
HEMOLYTIC ANEMIA INDUCED BY PHENYLAZO-DIAMINO-PYRIDINE (PYRIDIUM). Canadian Medical Association journal, 1964, Oct-03, Volume: 91 Topics: Anemia; Anemia, Hemolytic; Anti-Infective Agents, Local; Blood Transfusion; Geriatrics; Glucosephosp	1964
Urinary tract infection drug helps pain, hinders cure. Health news (Waltham, Mass.), 2004, Volume: 10, Issue:8 Topics: Anesthetics, Local; Female; Humans; Pain; Phenazopyridine; Urinary Tract Infections	2004
Phenazopyridine-induced sulfhemoglobinemia. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:6 Topics: Administration, Oral; Female; Humans; Middle Aged; Phenazopyridine; Sulfhemoglobinemia; Urinary Trac	2005
Red urine in a returning traveller. International journal of STD & AIDS, 2005, Volume: 16, Issue:11 Topics: Adult; Anesthetics, Local; Anti-Bacterial Agents; Color; Escherichia coli; Escherichia coli Infectio	2005
[Clinical experience of "urobiotic" for urinary infections]. Hinyokika kiyo. Acta urologica Japonica, 1966, Volume: 12, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Female; Humans; Male; Middle Aged; Oxytetra	1966
Long-term drug therapy for urinary tract infections. The Ohio State medical journal, 1967, Volume: 63, Issue:4 Topics: Adult; Anesthetics, Local; Child; Humans; Mandelic Acids; Nitrofurantoin; Phenazopyridine; Sulfameth	1967
An unusual phenotypic expression of Hb-Leiden. Biochemical genetics, 1982, Volume: 20, Issue:11-12 Topics: Anemia, Hemolytic; Child; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Male; Phenazopyridine;	1982
Phenazopyridine-induced hepatitis. British medical journal, 1976, Oct-09, Volume: 2, Issue:6040 Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Phenazopyridin	1976
[Urovalidine in the treatment of urinary tract infections]. Polskie Archiwum Medycyny Wewnetrznej, 1975, Volume: 54, Issue:4 Topics: Drug Combinations; Female; Humans; Male; Oxazoles; Phenazopyridine; Pyridines; Urinary Tract Infecti	1975
[Febrile exanthema after nitrofurantoin administration]. Zeitschrift fur Hautkrankheiten, 1974, Aug-15, Volume: 49, Issue:16 Topics: Aged; Drug Combinations; Drug Hypersensitivity; Exanthema; Female; Fever; Humans; Nitrofurantoin; Ph	1974
[Initial therapy in acute urinary tract infection]. Zeitschrift fur Allgemeinmedizin, 1972, Jan-20, Volume: 48, Issue:2 Topics: Acute Disease; Aged; Anesthetics, Local; Aniline Compounds; Anti-Bacterial Agents; Azo Compounds; Ba	1972
Phenazopyridine-sulfonamide combination antibacterial therapy in mice. Antimicrobial agents and chemotherapy, 1973, Volume: 3, Issue:1 Topics: Anesthetics, Local; Animals; Drug Therapy, Combination; Escherichia coli Infections; Mice; Phenazopy	1973
Comparative study of macrodantin and pyridium in controlling morbidity following surgery of the lower urinary tract. Journal of the National Medical Association, 1972, Volume: 64, Issue:6 Topics: Adolescent; Adult; Aged; Anesthetics, Local; Azo Compounds; Bacterial Infections; Child; Child, Pres	1972
[Urovalidin Bracco in the therapy of urinary tract infections in children]. Ceskoslovenska pediatrie, 1973, Volume: 28, Issue:8 Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Cycloserine; Drug Combinations; Drug Evaluation;	1973
[Terizidone and phenazopyridine--an effective preparation for treatment of infections of the urinary tract during pregnancy (author's transl)]. Ceskoslovenska gynekologie, 1973, Volume: 38, Issue:9 Topics: Anesthetics, Local; Anti-Infective Agents; Drug Combinations; Female; Humans; Imines; Oxazoles; Phen	1973
Drugs and false-positive screening tests for porphyria. British medical journal, 1972, Feb-12, Volume: 1, Issue:5797 Topics: Adult; Anesthetics, Local; Azo Compounds; False Positive Reactions; Female; Humans; Phenazopyridine;	1972
[Significance of sulfonamides in the treatment of urinary tract infections. Experiences with Harnosal]. Therapie der Gegenwart, 1971, Volume: 110, Issue:12 Topics: Aniline Compounds; Drug Combinations; Female; Humans; Male; Phenazopyridine; Sulfamethizole; Sulfath	1971
Uropol for urinary infections. Drug and therapeutics bulletin, 1970, Jan-02, Volume: 8, Issue:1 Topics: Anesthetics, Local; Aniline Compounds; Azo Compounds; Child, Preschool; Female; Humans; Phenazopyrid	1970
[Advantage of azocline in the treatment of urinary infections]. Marseille medical, 1970, Volume: 107, Issue:1 Topics: Adult; Aged; Anesthetics, Local; Aniline Compounds; Anti-Infective Agents, Urinary; Azo Compounds; F	1970
[Ambulatory treatment of urinary tract infections]. Die Medizinische Welt, 1970, Nov-21, Volume: 47 Topics: Adolescent; Adult; Aged; Ambulatory Care; Anti-Infective Agents, Urinary; Child; Female; Humans; Mal	1970
[Clinical study of Ro 4-4309 (uro-gantanol) in infection of the kidney and urinary tract]. Acta urologica Belgica, 1967, Volume: 35, Issue:3 Topics: Adolescent; Adult; Aged; Anesthetics, Local; Azo Compounds; Child; Drug Synergism; Female; Humans; K	1967
[Tonometric studies on the bladder and ureter before and after administration of N-sulfanylcarbamide and pheylaze-diamine-pyridine hydrochloride]. Arzneimittel-Forschung, 1967, Volume: 17, Issue:7 Topics: Adult; Anesthetics, Local; Anti-Infective Agents, Urinary; Azo Compounds; Depression, Chemical; Fema	1967
[Azocline treatment of urinary infections caused by common germs, in a present-day urological practice]. Lyon medical, 1968, Nov-17, Volume: 220, Issue:46 Topics: Adolescent; Adult; Aged; Azo Compounds; Humans; Middle Aged; Phenazopyridine; Pyridines; Sulfathiazo	1968
[Clinical effect of "urobiotic" for the treatment of urinary tract infections]. Hinyokika kiyo. Acta urologica Japonica, 1965, Volume: 11, Issue:6 Topics: Humans; Oxytetracycline; Phenazopyridine; Sulfamethizole; Urinary Tract Infections	1965
[A clinical evaluation of urobiotic in the treatment of urinary tract infections]. Hinyokika kiyo. Acta urologica Japonica, 1966, Volume: 12, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Child; Female; Humans; Male; Middle Aged; O	1966

phenazopyridine and Urinary Tract Infections