phenazopyridine has been researched along with Bladder Pain Syndrome in 6 studies
Phenazopyridine: A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
phenazopyridine : A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug-induced methemoglobinemia is a well-described entity but has not been previously associated with elevated troponins in the absence of cardiac symptoms." | 1.40 | Troponin leak associated with drug-induced methemoglobinemia. ( Cannon, RD; Jacoby, JL; Wagner, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shatila, W | 1 |
| Clark, A | 1 |
| Cannon, RD | 2 |
| Wagner, M | 2 |
| Jacoby, JL | 2 |
| Senthilkumaran, S | 1 |
| Jena, NN | 1 |
| Ananth, C | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Panzera, AK | 1 |
| Rovner, E | 1 |
| Propert, KJ | 1 |
| Brensinger, C | 1 |
| Wein, AJ | 1 |
| Foy, M | 1 |
| Kirkemo, A | 1 |
| Landis, JR | 1 |
| Kusek, JW | 1 |
| Nyberg, LM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Preemptive Pudendal Nerve Block Prior to Hydrodistension for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS): a Prospective, Double-blinded, Randomized Control Trial[NCT02517996] | 18 participants (Actual) | Interventional | 2015-02-28 | Terminated (stopped due to Preliminary results were promising when interim analysis performed but terminated due to primary investigators left recruitment site.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"To determine the change in interstitial cystitis symptom index at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC symptom index questionnaire consists of 4 questions on IC symptoms. 2 of the questions have 6 answer choices ranging from 0-never, to 5-almost always. 1 question has 6 answer choices ranging from 0-never to 5-usually. 1 question has 7 answer choices ranging from 0-never to 6-5 or more times. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 21. A higher score indicates greater severity of IC symptoms." (NCT02517996)
Timeframe: Baseline, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 12.5 | 11.43 | 11.8 | 10 |
| Normal Saline | 10 | 9 | 8.67 | 5 |
"To determine the change in pain at 2 hours, 2 weeks, 6 weeks, and 3 months postoperatively in patients undergoing hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline) using the visual analog scale (VAS).~VAS consists of a 10cm horizontal line with the minimum endpoint labeled no pain (0) and maximum labeled worst pain ever (10). Patients placed a mark on the point that corresponds to the level of pain severity they felt. The cm distance from the low end of the VAS to the patient's mark is used as the numerical index of the intensity of pain. Pain scores of 3.0-5.4 cm are moderate, over 5.4 indicates severe pain." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Pre operative VAS score | Post operative VAS score | 2 week post operative VAS scores | 6 week post operative VAS score | 12 weeks post operative VAS score | |
| 1% Lidocaine | 3.125 | 3.75 | 2.7 | 3 | 2.6 |
| Normal Saline | 4.5 | 5 | 4.8 | 4.33 | 2 |
"To determine the change in pelvic urgency, pain and frequency (PUF) questionnaire at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The Pelvic Urgency, Pain, and Frequency Patient Symptom Scale asks 11 questions, 7 on PUF symptoms, 4 on how bothersome PUF symptoms are. Symptom questions include 3, 4, or 5 ranked answers, with higher answers indicating more voids, or greater frequency of pain. The bother questions each of 4 ranked answers from 0-never, to 3-always. The symptom score is added, the bother score is added, and then the total score is added. The total PUF score is then reported. The minimum score is 0 and the maximum score is 35, and a higher score indicates greater symptoms and higher bother from pelvic pain and frequency." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 22.63 | 18.83 | 18.2 | 17.2 |
| Normal Saline | 19 | 17.4 | 16.7 | 14 |
"To determine the change in problem index (O'Leary Sant) at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC problem index questionnaire consists of 4 questions on how much of a problem a patient's IC symptoms cause them. Each question has 5 answer choices ranging from 0-no problem, to 4-big problem. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 16. A higher score indicates that IC symptoms cause more problems for the patient." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 11.75 | 9.71 | 10 | 9.6 |
| Normal Saline | 9.43 | 8.6 | 7.33 | 6 |
1 review available for phenazopyridine and Bladder Pain Syndrome
| Article | Year |
|---|---|
Interstitial cystitis/painful bladder syndrome.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antidepressiv | 2007 |
5 other studies available for phenazopyridine and Bladder Pain Syndrome
| Article | Year |
|---|---|
Unexplained hypoxia in a woman presenting with acute on chronic abdominal pain.
Topics: Abdominal Pain; Adult; Anesthetics, Local; Cystitis, Interstitial; Female; Humans; Hypoxia; Methemog | 2013 |
Troponin leak associated with drug-induced methemoglobinemia.
Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Cystitis, Interstitial; Female; Humans; Methemog | 2014 |
Troponin leak-Janus face of polypharmacy.
Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Cystitis, Interstitial; Female; Humans; Methemog | 2014 |
Author's response to troponin leak-Janus face of polypharmacy.
Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Cystitis, Interstitial; Female; Humans; Methemog | 2014 |
Treatments used in women with interstitial cystitis: the interstitial cystitis data base (ICDB) study experience. The Interstitial Cystitis Data Base Study Group.
Topics: Amitriptyline; Cohort Studies; Cystitis, Interstitial; Cystoscopy; Dilatation; Female; Food, Formula | 2000 |