phenanthroindolizidine and Neoplasms

phenanthroindolizidine has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for phenanthroindolizidine and Neoplasms

Article	Year
Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities. Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 The asymmetric total synthesis of the strongly cytotoxic phenanthroindolizidine alkaloid 3 was achieved. Using the same route, various derivatives were also synthesized. Cytotoxicity of those synthetic compounds was evaluated and compounds 19, 23, and 27 demonstrated potent cytotoxicities similar to that of 3. The in vivo antitumor efficacy of selected compounds was also evaluated and 23 demonstrated moderate antitumor efficacy. Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indolizidines; Indolizines; Neoplasms; Phenanthrolines; Structure-Activity Relationship	2011

Article

Year

Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities.

Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

The asymmetric total synthesis of the strongly cytotoxic phenanthroindolizidine alkaloid 3 was achieved. Using the same route, various derivatives were also synthesized. Cytotoxicity of those synthetic compounds was evaluated and compounds 19, 23, and 27 demonstrated potent cytotoxicities similar to that of 3. The in vivo antitumor efficacy of selected compounds was also evaluated and 23 demonstrated moderate antitumor efficacy.

Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indolizidines; Indolizines; Neoplasms; Phenanthrolines; Structure-Activity Relationship

2011