phenanthridone has been researched along with Brain Ischemia in 4 studies
phenanthridone: coal tar derivative; structure given in first source
phenanthridone : A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined the neuroprotective effects of the PARP inhibitors benzamide, 6(5H)-phenanthridinone, and 3,4-dihydro-5-[4-1(1-piperidinyl)buthoxy]-1(2H)-isoquinolinone in three rodent models of cerebral ischemia." | 3.71 | Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. ( Chiarugi, A; Cozzi, A; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Pellicciari, R; Peruginelli, F; Picca, R; Romagnoli, P, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferraris, D | 2 |
| Ko, YS | 1 |
| Pahutski, T | 1 |
| Ficco, RP | 2 |
| Serdyuk, L | 1 |
| Alemu, C | 1 |
| Bradford, C | 1 |
| Chiou, T | 1 |
| Hoover, R | 1 |
| Huang, S | 1 |
| Lautar, S | 2 |
| Liang, S | 2 |
| Lin, Q | 2 |
| Lu, MX | 2 |
| Mooney, M | 1 |
| Morgan, L | 2 |
| Qian, Y | 1 |
| Tran, S | 1 |
| Williams, LR | 2 |
| Wu, QY | 1 |
| Zhang, J | 2 |
| Zou, Y | 1 |
| Kalish, V | 1 |
| Dain, D | 1 |
| Ginski, M | 1 |
| Lee-Wisdom, K | 1 |
| Thomas, B | 1 |
| Zhou, Y | 1 |
| Kalish, VJ | 1 |
| Chiarugi, A | 2 |
| Meli, E | 2 |
| Calvani, M | 1 |
| Picca, R | 2 |
| Baronti, R | 1 |
| Camaioni, E | 1 |
| Costantino, G | 1 |
| Marinozzi, M | 1 |
| Pellegrini-Giampietro, DE | 2 |
| Pellicciari, R | 2 |
| Moroni, F | 2 |
| Peruginelli, F | 1 |
| Cozzi, A | 1 |
| Romagnoli, P | 1 |
4 other studies available for phenanthridone and Brain Ischemia
| Article | Year |
|---|---|
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
Topics: Animals; Aza Compounds; Brain Ischemia; Dogs; Enzyme Inhibitors; Haplorhini; Humans; In Vitro Techni | 2003 |
Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries.
Topics: Animals; Benzimidazoles; Benzodiazepines; Binding Sites; Brain Ischemia; Caco-2 Cells; Diabetes Mell | 2003 |
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Isoquinolines; Mice; Neuroprotecti | 2003 |
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.
Topics: Animals; Apoptosis; Benzamides; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Line; Cerebral | 2001 |