phenanthridone has been researched along with Allergic Encephalomyelitis in 2 studies
phenanthridone: coal tar derivative; structure given in first source
phenanthridone : A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated the effect of the PARP-1 inhibitors 6(5H)-phenanthridinone and benzamide as well as that of benzoic acid, an inactive analogue of benzamide, on development of experimental allergic encephalomyelitis (EAE) in rats." | 3.71 | Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. ( Chiarugi, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavone, L | 1 |
| Aldinucci, A | 1 |
| Ballerini, C | 1 |
| Biagioli, T | 1 |
| Moroni, F | 1 |
| Chiarugi, A | 2 |
2 other studies available for phenanthridone and Allergic Encephalomyelitis
| Article | Year |
|---|---|
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
Topics: Analysis of Variance; Animals; Antigen Presentation; Autoimmunity; Cell Movement; Cells, Cultured; C | 2011 |
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.
Topics: Adenosine Triphosphate; Animals; Benzamides; Benzoic Acid; Dose-Response Relationship, Drug; Encepha | 2002 |