phenanthrenes and Schistosomiasis

To evaluate the clinical efficacy of sodium tanshinone IIA sulfonate (STS) in the treatment of advanced schistosomiasis.. Fifty cases with advanced schistosomiasis admitted to the Touzao Township Hospital of Dongtai City during the period from November 2012 to November 2013 were treated with STS for 10 days, and the internal diameter of the portal vein, levels of ALT, AST, gamma-GT, PIIIP, CIV, HA and LN were measured and compared before and after the administration of STS.. The mean levels of all serological parameters except HA were within the normal range before STS treatment, while the highest positive rate was detected in gamma-GT (26.0%) and HA (54.0%). Following the STS treatment, the mean levels of all parameters and the positive rates reduced, with the greatest reduction observed in gamma-GT (36.7%) and HA (37.8%); however, the mean HA level was still higher than the normal range. The mean internal diameter of the portal vein reduced from (10.5 +/- 1.7) mm before the STS treatment to (9.8 +/- 1.3) mm after the STS administration, with a significant diffrtence (P < 0.05).. STS appears effective in the treatment of advanced schistosomiasis.

Topics: Aged; Biomarkers; Female; Humans; Male; Phenanthrenes; Schistosomiasis; Therapeutics

To evaluate the clinical efficiency of tanshinone IIA-sulfonate (STS) in the treatment of liver fibrosis of advanced schistosomiasis.. A total of 73 advanced schistosomiasis patients were selected into a treatment group and 55 cases of advanced schistosomiasis were selected into a control group, and dipstick dye immunoassay assay (DDIA) for schistosomiasis and HBsAg of all the patients were negative. The patients in the treatment group received STS for 14 days, and all the patients in both groups received the conventional liver-protecting treatment for 14 days. All the patients in both groups received the measurements of portal vein, 4 indicators of liver fibrosis (P III P, C IV, HA, LN), and 3 indicators of serum enzyme activities (ALT, AST, gamma-GT).. After the treatments, the inside diameters of the portal vein and the degrees of the positive results of indicators of serum enzyme activities of all the patients of both groups decreased, but there were no statistically significant differences compared with those before the treatment. In the treatment group, the degrees of the positive results of indicators of liver fibrosis decreased somewhat, but there were no statistically significant differences compared with those before the treatment except C IV. In the control group, the degrees of the positive results of indicators of liver fibrosis fluctuated. In the treatment group, the indicator of liver fibrosis, CIV improved and the 2 indicators of liver fibrosis, PIIIP and HA improved significantly, but the indicators of serum enzyme activities did not improve.. STS is effective in the treatment of liver fibrosis of advanced schistosomiasis.

Topics: Animals; Drugs, Chinese Herbal; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Phenanthrenes; Schistosoma; Schistosomiasis