phenanthrenes and Sarcoma-180

phenanthrenes has been researched along with Sarcoma-180* in 5 studies

Other Studies

5 other study(ies) available for phenanthrenes and Sarcoma-180

ArticleYear
Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008, Volume: 70, Issue:3

    Triptolide (TP) possesses both anti-tumour and immuno-suppressive activities. Its immuno-suppressive activity may be disadvantageous for the therapy of cancers. A novel polymeric micelle system containing TP (TP-PM) was constructed by the solvent evaporation method using methoxypolyethylene glycol-poly(d,l-lactic acid)-block copolymer as the carrier, and was characterised using photon correlation spectroscopy, transmission electron microscopy and high performance liquid chromatography. The anti-tumour and immuno-modulation effects of TP-PM were evaluated in sarcoma 180-bearing mice and A2780 cells. Results demonstrated that TP-PM had an average diameter of 78.9 nm, encapsulation efficiency of 66.7%, core-shell morphology and a long-term stability. TP-PM could significantly inhibit tumour growth via intravenous injections at the dose levels of 0.0375, 0.075 and 0.15 mg/kg, and their inhibition rates were 42.5%, 46.0% and 49.9%, respectively; they showed similar cytotoxicity against A2780 cells compared to that of TP. Simultaneously, TP-PM had no effect on the thymus index, spleen index, spleen lymphocyte proliferation and the TNF-alpha and IL-2 levels in serum as compared with TP. Therefore, TP encapsulated in polymeric micelles does not demonstrate immuno-suppressive activity but does not lose its anti-tumour effect. These results show that polymeric micelles are a promising carrier for cancer therapy using TP.

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Diterpenes; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Epoxy Compounds; Female; Humans; Immunosuppressive Agents; Injections, Intravenous; Male; Mice; Micelles; Particle Size; Phenanthrenes; Polyesters; Polyethylene Glycols; Sarcoma 180; Solubility; Technology, Pharmaceutical; Time Factors

2008
The antitumoral activity of some derivatives of 6-aminochrysene.
    European journal of cancer, 1970, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Female; Mammary Neoplasms, Experimental; Mice; Phenanthrenes; Rats; Rhabdomyosarcoma; Sarcoma 180

1970
SOME DICHLOROACETYL DERIVATIVES AND THEIR ANTITUMOR ACTIVITY.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Chemistry, Pharmaceutical; Diethylstilbestrol; Hexestrol; Inositol; ortho-Aminobenzoates; Pharmacology; Phenanthrenes; Research; Sarcoma 180

1964
THE ANTILEUKEMIA ACTIVITY OF TYLOCREBRINE.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Adenocarcinoma; Alkaloids; Animals; Antineoplastic Agents; Leukemia L1210; Mice; Pharmacology; Phenanthrenes; Research; Sarcoma 180; Tetrahydroisoquinolines

1964
Inhibition of the mouse Crocker sarcoma 180 with phenanthrene derivatives.
    Acta - Unio Internationalis Contra Cancrum, 1955, Volume: 11, Issue:2

    Topics: Animals; Mice; Phenanthrenes; Sarcoma 180; Sarcoma, Experimental

1955