phenanthrenes and Influenza--Human

phenanthrenes has been researched along with Influenza--Human* in 2 studies

Other Studies

2 other study(ies) available for phenanthrenes and Influenza--Human

Article	Year
Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus. BMC complementary and alternative medicine, 2017, May-22, Volume: 17, Issue:1 Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need to develop new drugs. This study aimed to evaluate the anti-influenza viral activity and possible mechanisms of 12 phenanthrenes from the medicinal plant Bletilla striata (Orchidaceae family).. Twelve phenanthrenes were isolated and identified from B. striata. Influenza virus A/Sydney/5/97 (H3N2) propagated in embryonated chicken eggs was used. Phenanthrenes mixed with the virus were incubated at 37 °C for 1 h and then inoculated into 9-day-old embryonated chicken eggs via the allantoic route to survey the antiviral activity in vivo. A (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS)-based assay was performed to evaluate the reduction of cytopathic effect induced by H3N2 on Madin-Darby canine kidney (MDCK) cells. The hemagglutination inhibition assay was used to study the blockage of virus receptors by the phenanthrenes, and the neuraminidase (NA) inhibition assay to evaluate the effects of the release of virus. The synthesis of influenza viral matrix protein mRNA in response to compound treatment was measured by real-time polymerase chain reaction.. This study showed that phenanthrenes 1, 2, 3, 4, 6, 9, 10, 11, and 12 significantly inhibited the viruses in vivo, with inhibition rates of 20.7, 79.3, 17.2, 34.5, 34.5, 34.5, 44.8, 75.9, and 34.5%, respectively. In MDCK models, the phenanthrenes did not show significant antiviral activity when administered as pretreatment, while phenanthrenes 2, 3, 4, 6, 7 10, and 11 exhibited inhibitory activities as simultaneous treatment with 50% inhibition concentration (IC. Phenanthrenes from B. striata had strong anti-influenza viral activity in both embryonated eggs and MDCK models, and diphenanthrenes seemed to have stronger inhibition activity compared with monophenanthrenes. Topics: Antiviral Agents; Humans; Influenza A Virus, H3N2 Subtype; Influenza, Human; Orchidaceae; Phenanthrenes; Plant Extracts; Plants, Medicinal; Virus Replication	2017
[On the antiviral action of the naphthyl-, coumaroyl-, and phenanthryl-derivatives of glyoxal. II. Activity on the influenza A-PR8 virus in vitro and in embryonated and deembryonated chick eggs]. Bollettino della Societa italiana di biologia sperimentale, 1962, Dec-31, Volume: 38 Topics: 4-Aminobenzoic Acid; Alphainfluenzavirus; Animals; Antiviral Agents; Biphenyl Compounds; Chickens; Eggs; Glyoxal; Humans; In Vitro Techniques; Indans; Influenza A virus; Influenza, Human; Naphthalenes; Orthomyxoviridae; Phenanthrenes	1962

Article

Year

Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus.

BMC complementary and alternative medicine, 2017, May-22, Volume: 17, Issue:1

Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need to develop new drugs. This study aimed to evaluate the anti-influenza viral activity and possible mechanisms of 12 phenanthrenes from the medicinal plant Bletilla striata (Orchidaceae family).. Twelve phenanthrenes were isolated and identified from B. striata. Influenza virus A/Sydney/5/97 (H3N2) propagated in embryonated chicken eggs was used. Phenanthrenes mixed with the virus were incubated at 37 °C for 1 h and then inoculated into 9-day-old embryonated chicken eggs via the allantoic route to survey the antiviral activity in vivo. A (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS)-based assay was performed to evaluate the reduction of cytopathic effect induced by H3N2 on Madin-Darby canine kidney (MDCK) cells. The hemagglutination inhibition assay was used to study the blockage of virus receptors by the phenanthrenes, and the neuraminidase (NA) inhibition assay to evaluate the effects of the release of virus. The synthesis of influenza viral matrix protein mRNA in response to compound treatment was measured by real-time polymerase chain reaction.. This study showed that phenanthrenes 1, 2, 3, 4, 6, 9, 10, 11, and 12 significantly inhibited the viruses in vivo, with inhibition rates of 20.7, 79.3, 17.2, 34.5, 34.5, 34.5, 44.8, 75.9, and 34.5%, respectively. In MDCK models, the phenanthrenes did not show significant antiviral activity when administered as pretreatment, while phenanthrenes 2, 3, 4, 6, 7 10, and 11 exhibited inhibitory activities as simultaneous treatment with 50% inhibition concentration (IC. Phenanthrenes from B. striata had strong anti-influenza viral activity in both embryonated eggs and MDCK models, and diphenanthrenes seemed to have stronger inhibition activity compared with monophenanthrenes.

Topics: Antiviral Agents; Humans; Influenza A Virus, H3N2 Subtype; Influenza, Human; Orchidaceae; Phenanthrenes; Plant Extracts; Plants, Medicinal; Virus Replication

2017

[On the antiviral action of the naphthyl-, coumaroyl-, and phenanthryl-derivatives of glyoxal. II. Activity on the influenza A-PR8 virus in vitro and in embryonated and deembryonated chick eggs].

Bollettino della Societa italiana di biologia sperimentale, 1962, Dec-31, Volume: 38

Topics: 4-Aminobenzoic Acid; Alphainfluenzavirus; Animals; Antiviral Agents; Biphenyl Compounds; Chickens; Eggs; Glyoxal; Humans; In Vitro Techniques; Indans; Influenza A virus; Influenza, Human; Naphthalenes; Orthomyxoviridae; Phenanthrenes

1962