phenanthrenes and HIV-Infections

phenanthrenes has been researched along with HIV-Infections* in 2 studies

Other Studies

2 other study(ies) available for phenanthrenes and HIV-Infections

Article	Year
Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana. Planta medica, 2003, Volume: 69, Issue:2 Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannular conformations of the isolated protopine-type alkaloids. The known benzo[ c]phenanthridine (+/-)-6-acetonyldihydrochelerythrine (5) exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. Topics: Alkaloids; Anti-HIV Agents; Argemone; Benzophenanthridines; Berberine Alkaloids; HIV Infections; HIV-1; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Phenanthrenes; Phytotherapy; Plant Extracts; Structure-Activity Relationship	2003
[Health assessments of a military company stationed on the Maroni River in French Guiana]. Medecine tropicale : revue du Corps de sante colonial, 1999, Volume: 59, Issue:1 Over a 5 month period (October 1996 to February 1997), a rotating company of 146 servicemen belonging to the Navy Airborne 6th Regiment were assigned along the Maroni River in French Guyana. During this mission, the medical personnel treated 387 local residents. Etiologies comprised 51 malaria attacks including 46 involving Plasmodium falciparum and 4 rattlesnake envenomations. The most common cause of consultation by military personnel was mycotic and staphylococcal skin infections, but 5 cases involving poor acclimatization were treated during the hot and dry season. Seven malaria attacks involving Plasmodium falciparum including 2 that were severe occurred despite prophylaxis using chloroquine-proguanil. Treatment with halofantrine was successful in all but one case which required combined chemotherapy using quinine and doxycycline. Five cases of cutaneous leishmaniasis were observed in subjects involved in jungle training. No case of HIV infection was detected upon returning home since most personnel either followed the recommendation to abstain from sex (51 p. 100) or used a condom (90 p. 100 of personnel who had sexual relations). These data illustrate the health risks for mainland French nationals in the region of the Maroni River and underline the need for preventive measures and education. Topics: Acclimatization; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Condoms; Crotalid Venoms; Crotalus; Dermatomycoses; Doxycycline; France; French Guiana; Health Education; HIV Infections; Humans; Leishmaniasis, Cutaneous; Malaria, Falciparum; Military Personnel; Phenanthrenes; Quinine; Risk Factors; Sexual Abstinence; Snake Bites; Staphylococcal Skin Infections; Tropical Medicine	1999

Article

Year

Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.

Planta medica, 2003, Volume: 69, Issue:2

Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannular conformations of the isolated protopine-type alkaloids. The known benzo[ c]phenanthridine (+/-)-6-acetonyldihydrochelerythrine (5) exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively.

Topics: Alkaloids; Anti-HIV Agents; Argemone; Benzophenanthridines; Berberine Alkaloids; HIV Infections; HIV-1; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Phenanthrenes; Phytotherapy; Plant Extracts; Structure-Activity Relationship

2003

[Health assessments of a military company stationed on the Maroni River in French Guiana].

Medecine tropicale : revue du Corps de sante colonial, 1999, Volume: 59, Issue:1

Over a 5 month period (October 1996 to February 1997), a rotating company of 146 servicemen belonging to the Navy Airborne 6th Regiment were assigned along the Maroni River in French Guyana. During this mission, the medical personnel treated 387 local residents. Etiologies comprised 51 malaria attacks including 46 involving Plasmodium falciparum and 4 rattlesnake envenomations. The most common cause of consultation by military personnel was mycotic and staphylococcal skin infections, but 5 cases involving poor acclimatization were treated during the hot and dry season. Seven malaria attacks involving Plasmodium falciparum including 2 that were severe occurred despite prophylaxis using chloroquine-proguanil. Treatment with halofantrine was successful in all but one case which required combined chemotherapy using quinine and doxycycline. Five cases of cutaneous leishmaniasis were observed in subjects involved in jungle training. No case of HIV infection was detected upon returning home since most personnel either followed the recommendation to abstain from sex (51 p. 100) or used a condom (90 p. 100 of personnel who had sexual relations). These data illustrate the health risks for mainland French nationals in the region of the Maroni River and underline the need for preventive measures and education.

Topics: Acclimatization; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Condoms; Crotalid Venoms; Crotalus; Dermatomycoses; Doxycycline; France; French Guiana; Health Education; HIV Infections; Humans; Leishmaniasis, Cutaneous; Malaria, Falciparum; Military Personnel; Phenanthrenes; Quinine; Risk Factors; Sexual Abstinence; Snake Bites; Staphylococcal Skin Infections; Tropical Medicine

1999