phenanthrenes and Coronary-Restenosis

To investigate the effectiveness and safety of triptolide-eluting stents implanted in porcine coronary arteries for restenosis prevention, and its effect on the expression of proliferating cell nuclear antigen (PCNA) and P27(kip1).. Ten triptolide-eluting stents and 10 stainless steel stents (control) were implanted in 20 porcine coronary arteries at random. Four weeks later, angiography of the arteries was performed along with also histopathological and immunochemical examinations.. The in-stent minimal lumen diameter of triptolide group was significantly greater, and the neointimal area significantly smaller, than those of the control group (P<0.05). PCNA expression was significantly lower while P27(kip1) protein significantly higher in triptolide group than in the control group (P<0.05).. Triptolide-eluting stent can effectively inhibit neointimal formation to prevent restenosis in porcine coronary artery 4 weeks after implantation, probably by inhibiting P27(kip1) expression and consequently vascular smooth muscle cell proliferation.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coronary Restenosis; Coronary Vessels; Cyclin-Dependent Kinase Inhibitor p27; Diterpenes; Drug-Eluting Stents; Epoxy Compounds; Immunohistochemistry; Male; Phenanthrenes; Proliferating Cell Nuclear Antigen; Random Allocation; Swine; Time Factors; Tunica Intima

Topics: Animals; Coronary Restenosis; Diterpenes; Epoxy Compounds; Iliac Artery; Male; Phenanthrenes; Rabbits; Stents; Tunica Intima

To observe change of iliac artery SMC collagen fiber after balloon injury in tanshinone II A treatment group.. Thirty male pure breed New Zealand white rabbits were underwent experimental balloon injury in left iliac artery. Then the rabbits were assigned into treatment group (n = 15) and control group (n = 15). Tanshinone II A sulfonic acid natrium was injected intravenously in treatment group. Saline was venously injected in control group. The balloon injured arteries were harvested in the 7th, 14th, and 28th days after surgery.. Analysis of Collagen fibers staining found that a weak positive staining was shown at the 7th day post-operation in both groups,while a strong positive result was seen at the 14th day in control group. Positive results were even shown at the 14th day in treatment group,but less strong than that of the control. At the 28th day post-operation, collagen fiber staining become weak in treatment group, but increased in the control. Difference between both group in the 28th day post-operation was significant (P = 0.017). Time-dependence tendency of collagen fiber changing was statistically significant (P = 0.005).. Tanshinone II A suppress stack of extracellular matrix after balloon injury so as to prevent restenosis.

Topics: Abietanes; Animals; Catheterization; Collagen; Coronary Restenosis; Disease Models, Animal; Iliac Artery; Male; Muscle, Smooth, Vascular; Phenanthrenes; Plants, Medicinal; Rabbits; Salvia; Tunica Intima; Tunica Media