phenanthrenes has been researched along with Cocarcinogenesis* in 6 studies
6 other study(ies) available for phenanthrenes and Cocarcinogenesis
| Article | Year |
|---|---|
Induction of hepatic nodules in the rat by aristolochic acid.
Aristolochic acid (AA), used as an anti-inflammatory agent in the past, is known to be mutagenic and carcinogenic to several organs of the rat, including forestomach, renal pelvis and urinary bladder. However, despite the induction of DNA adducts in the liver, no carcinogenic potential of AA has been reported in the latter organ. The present study was based on the rationale that the lack of carcinogenicity of AA to the liver could be because this chemical may not be necrogenic at the doses examined and liver cell proliferation has been established as an essential component for initiation of liver carcinogenesis in the rat. The results indicated that AA is non-necrogenic to the rat liver. However, a single non-necrogenic dose of AA (10 mg/kg b.w., i.p.) given 18 hours after 2/3 partial hepatectomy initiated liver cell carcinogenesis. The initiated cells are promotable with 1% dietary orotic acid, a liver tumor promoter, to form glutathione-S-transferase 7-7 positive hepatic foci and nodules. Topics: Animals; Aristolochic Acids; Carcinogens; Cell Division; Cocarcinogenesis; Hepatectomy; Liver; Liver Neoplasms; Male; Necrosis; Orotic Acid; Phenanthrenes; Rats; Rats, Inbred F344 | 1993 |
Chrysene.
Topics: Animals; Carcinogens, Environmental; Chemical Phenomena; Chemistry; Chrysenes; Cocarcinogenesis; Cricetinae; Cricetulus; Ducks; Female; Male; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Neoplasms, Experimental; Phenanthrenes; Pregnancy; Rats; Rats, Inbred Strains; Reproduction; Risk | 1983 |
1-, 2-, 3-, 4-, 5- and 6-Methylchrysenes.
Topics: Animals; Carcinogens, Environmental; Chemical Phenomena; Chemistry; Chrysenes; Cocarcinogenesis; Female; Male; Mice; Mutagenicity Tests; Neoplasms, Experimental; Phenanthrenes; Risk; Skin Neoplasms | 1983 |
Phenanthrene.
Topics: Animals; Carcinogens, Environmental; Chemical Phenomena; Chemistry; Cocarcinogenesis; Female; Male; Mutagenicity Tests; Neoplasms, Experimental; Phenanthrenes; Rats; Risk | 1983 |
Exceptionally high tumor-initiating activity of benzo(c)phenanthrene bay-region diol-epoxides on mouse skin.
Topics: Animals; Carcinogens; Cocarcinogenesis; Mice; Neoplasms, Experimental; Phenanthrenes; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Comparative mutagenicity, tumor-initiating activity, carcinogenicity, and in vitro metabolism of fluorinated 5-methylchrysenes.
Topics: Animals; Carcinogens; Chrysenes; Cocarcinogenesis; Drug Evaluation, Preclinical; Female; In Vitro Techniques; Male; Mice; Microsomes, Liver; Mutagens; Neoplasms, Experimental; Phenanthrenes; Rats; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |